WO2016113754A3 - Novel oral dosage forms of dimethyl fumarate - Google Patents

Novel oral dosage forms of dimethyl fumarate Download PDF

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Publication number
WO2016113754A3
WO2016113754A3 PCT/IN2016/050007 IN2016050007W WO2016113754A3 WO 2016113754 A3 WO2016113754 A3 WO 2016113754A3 IN 2016050007 W IN2016050007 W IN 2016050007W WO 2016113754 A3 WO2016113754 A3 WO 2016113754A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimethyl fumarate
dosage forms
oral dosage
novel oral
relates
Prior art date
Application number
PCT/IN2016/050007
Other languages
French (fr)
Other versions
WO2016113754A2 (en
Inventor
Kocherlakota Chandrashekhar
Banda Nagaraju
Original Assignee
Leiutis Pharmaceuticals Pvt, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiutis Pharmaceuticals Pvt, Ltd. filed Critical Leiutis Pharmaceuticals Pvt, Ltd.
Publication of WO2016113754A2 publication Critical patent/WO2016113754A2/en
Publication of WO2016113754A3 publication Critical patent/WO2016113754A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to granulates of Dimethyl fumarate comprising of gastro resistant or enteric polymers and other excipients. The invention also relates to novel oral dosage forms of Dimethyl fumarate comprising an admixture of Dimethyl fumarate and excipients filled in an enteric coated capsule.
PCT/IN2016/050007 2015-01-14 2016-01-12 Novel oral dosage forms of dimethyl fumarate WO2016113754A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN222/CHE/2015 2015-01-14
IN222CH2015 2015-01-14

Publications (2)

Publication Number Publication Date
WO2016113754A2 WO2016113754A2 (en) 2016-07-21
WO2016113754A3 true WO2016113754A3 (en) 2016-10-06

Family

ID=56406539

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2016/050007 WO2016113754A2 (en) 2015-01-14 2016-01-12 Novel oral dosage forms of dimethyl fumarate

Country Status (1)

Country Link
WO (1) WO2016113754A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016194004A1 (en) 2015-06-01 2016-12-08 Sun Pharmaceutical Industries Ltd. Pharmaceutical compositions of dimethyl fumarate
TR201616998A1 (en) * 2016-11-23 2018-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi DELAYED RELEASE DOSING FORMS WITH DIMETHYL FUMARATE
TR201818293A2 (en) * 2018-11-30 2020-06-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi The delayed release capsule comprising dimethyl fumarate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006037342A2 (en) * 2004-10-08 2006-04-13 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006037342A2 (en) * 2004-10-08 2006-04-13 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester

Also Published As

Publication number Publication date
WO2016113754A2 (en) 2016-07-21

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