WO2006000785A1 - Improvements relating to automatic injection devices - Google Patents

Improvements relating to automatic injection devices Download PDF

Info

Publication number
WO2006000785A1
WO2006000785A1 PCT/GB2005/002487 GB2005002487W WO2006000785A1 WO 2006000785 A1 WO2006000785 A1 WO 2006000785A1 GB 2005002487 W GB2005002487 W GB 2005002487W WO 2006000785 A1 WO2006000785 A1 WO 2006000785A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
plunger
housing
injection device
needle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2005/002487
Other languages
English (en)
French (fr)
Inventor
Stephen Bicknell
Joseph F. Julian
William L. Rudzena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Owen Mumford Ltd
Original Assignee
Owen Mumford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES05758156.3T priority Critical patent/ES2672336T3/es
Priority to AU2005256832A priority patent/AU2005256832B2/en
Priority to MX2012000282A priority patent/MX345765B/es
Priority to MXPA06015056A priority patent/MXPA06015056A/es
Priority to BRPI0512554-5A priority patent/BRPI0512554B1/pt
Priority to IN4769DEN2014 priority patent/IN2014DN04769A/en
Priority to NZ552340A priority patent/NZ552340A/en
Priority to US11/630,507 priority patent/US7938802B2/en
Priority to CA 2571571 priority patent/CA2571571C/en
Priority to KR1020117021471A priority patent/KR101210122B1/ko
Priority to EP05758156.3A priority patent/EP1758627B1/en
Priority to KR20067026814A priority patent/KR101202123B1/ko
Application filed by Owen Mumford Ltd filed Critical Owen Mumford Ltd
Priority to JP2007517459A priority patent/JP2008503296A/ja
Publication of WO2006000785A1 publication Critical patent/WO2006000785A1/en
Anticipated expiration legal-status Critical
Priority to US13/072,289 priority patent/US8162887B2/en
Priority to US13/443,384 priority patent/US8668670B2/en
Priority to US14/109,363 priority patent/US9017287B2/en
Priority to US14/669,616 priority patent/US9764090B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/206—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically with automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion

Definitions

  • automatic injection device which when operated cause the needle of a syringe to be moved forwardly so that it projects from a protective housing prior to actuation of the syringe to express a dose of liquid through the needle. It is important to try to ensure that the syringe is moved bodily forward to expose the needle before the liquid charge is pressurised so that dribbling from the needle does not occur before the actual injection takes place. It is an object of this invention to provide a mechanism which operates in this desired manner.
  • an injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger being in the form of a rod with a longitudinally centrally located flexible projecting portion which, prior to release of said actuating bias member, is situated beyond the other end of the syringe, such that a primary movement of the plunger, under the bias of the actuating bias member, will cause the projecting portion to bear against the other end of the syringe such that the syringe is moved from said first to said second position, whereupon arresting of further movement of the syringe, results in the flexible portion coll
  • the projecting portion will remain in its projecting position (in order to move the syringe from the first to the second position) until the force increases to such an extent which allows the projecting portion to collapse inwardly so that the plunger can then move within the syringe to cause the liquid to be expressed through the syringe.
  • the projecting portion can comprise one or more flexible elbows projecting beyond the normal circumference of the rod, but compressible into said circumference. This could be in the form of two elbows defined either side of a longitudinal slit in the rod. The elbows could be pre-formed as a pair of arms either side of the longitudinal slit between upper and lower solid portions of the rod.
  • the injection device will contain a return bias member acting between the syringe housing and the other end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released.
  • One or more of the bias members provided within the housing can be in the form of a coil spring.
  • the syringe comprises a 3 incorporating a liquid dose held in place by a bung 4 and having a needle 5 through which the dose can be ejected by applying pressure to the bung 4.
  • the 3 has an enlarged head 6.
  • a plunger 7 is biased forwardly by a coil spring 8, but is held back in a latched position (Figure 1) until such time as a trigger shown schematically at 11 is actuated to release the plunger and the spring 8.
  • the syringe 1 Prior to use the syringe 1 is held retracted in the housing 2 by a coil spring 9. It will be seen that the plunger 7 is in the form of a rod having a central portion which defines a pair of projecting elbows 10. These can be pre-formed as part of a moulded plunger 7.
  • the projecting elbow portions 10 are flexible so that they can be moved inwardly to cause that portion of the rod to adopt a circumference similar to that of the rest of the rod.
  • the expanded region formed by the elbows 10 rests against the head 6 of the 3 and the force provided is sufficient to compress the spring 9 until such time as the head 6 abuts the top of the housing 2, whereupon further movement of the 3 is arrested.
  • the continual bias created by the spring 8 then causes the elbows 10 to be compressed inwardly as they enter into the interior of the 3.
  • the plunger With the elbows 10 in the collapsed state, the plunger can then move relatively easily within the 3 so as to act upon the bung 4 and thus cause the contents of the syringe to be ejected through the needle 5.
  • the illustrated configuration of the plunger 7 provides several technical advantages. It can be moulded integrally. Also the collapsing movement of the projecting elbows provides an arrangement which can provide a suitable injection force to cause the needle to enter the skin to a suitable depth, but then provide a relatively low drag against the inner wall of the syringe container so that the major portion of the thrust of the spring for the remainder of its stroke is applied to the bung 4. It will be appreciated that other configurations of collapsing projection could be used in place of the collapsing elbows.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
PCT/GB2005/002487 2004-06-23 2005-06-23 Improvements relating to automatic injection devices Ceased WO2006000785A1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
EP05758156.3A EP1758627B1 (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
MX2012000282A MX345765B (es) 2004-06-23 2005-06-23 Mejoras relacionadas a dispositivos de inyección automática.
MXPA06015056A MXPA06015056A (es) 2004-06-23 2005-06-23 Mejoras relacionadas a dispositivos de inyeccion automatica.
BRPI0512554-5A BRPI0512554B1 (pt) 2004-06-23 2005-06-23 Dispositivo de injeção
IN4769DEN2014 IN2014DN04769A (enExample) 2004-06-23 2005-06-23
NZ552340A NZ552340A (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
US11/630,507 US7938802B2 (en) 2004-06-23 2005-06-23 Automatic injection devices
CA 2571571 CA2571571C (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
KR1020117021471A KR101210122B1 (ko) 2004-06-23 2005-06-23 자동식 주입 장치
ES05758156.3T ES2672336T3 (es) 2004-06-23 2005-06-23 Mejoras relacionadas con dispositivos de inyección automática
AU2005256832A AU2005256832B2 (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices
KR20067026814A KR101202123B1 (ko) 2004-06-23 2005-06-23 자동식 주입 장치
JP2007517459A JP2008503296A (ja) 2004-06-23 2005-06-23 自動注射装置に関する改良
US13/072,289 US8162887B2 (en) 2004-06-23 2011-03-25 Automatic injection devices
US13/443,384 US8668670B2 (en) 2004-06-23 2012-04-10 Automatic injection devices
US14/109,363 US9017287B2 (en) 2004-06-23 2013-12-17 Automatic injection devices
US14/669,616 US9764090B2 (en) 2004-06-23 2015-03-26 Relating to automatic injection devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0414054A GB0414054D0 (en) 2004-06-23 2004-06-23 Improvements relating to automatic injection devices
GB0414054.7 2004-06-23

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/630,507 A-371-Of-International US7938802B2 (en) 2004-06-23 2005-06-23 Automatic injection devices
US13/072,289 Continuation US8162887B2 (en) 2004-06-23 2011-03-25 Automatic injection devices

Publications (1)

Publication Number Publication Date
WO2006000785A1 true WO2006000785A1 (en) 2006-01-05

Family

ID=32800025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/002487 Ceased WO2006000785A1 (en) 2004-06-23 2005-06-23 Improvements relating to automatic injection devices

Country Status (16)

Country Link
US (5) US7938802B2 (enExample)
EP (3) EP2612687A1 (enExample)
JP (5) JP2008503296A (enExample)
KR (2) KR101210122B1 (enExample)
CN (4) CN103083763B (enExample)
AU (1) AU2005256832B2 (enExample)
BR (1) BRPI0512554B1 (enExample)
CA (2) CA2776901A1 (enExample)
ES (1) ES2672336T3 (enExample)
GB (1) GB0414054D0 (enExample)
IN (1) IN2014DN04769A (enExample)
MX (2) MX345765B (enExample)
NZ (3) NZ587235A (enExample)
RU (1) RU2387460C2 (enExample)
WO (1) WO2006000785A1 (enExample)
ZA (1) ZA200700289B (enExample)

Cited By (16)

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USD629509S1 (en) 2006-09-06 2010-12-21 Abbott Biotechnology Ltd. Automatic injection device
US7938802B2 (en) 2004-06-23 2011-05-10 Abbott Biotechnology Ltd. Automatic injection devices
WO2010146358A3 (en) * 2009-06-19 2011-08-18 Ucb Pharma S.A. Auto-injector
RU2438721C2 (ru) * 2006-06-30 2012-01-10 Эбботт Байотекнолоджи Лтд. Автоматическое инъекционное устройство
CN103316402A (zh) * 2006-06-30 2013-09-25 艾伯维生物技术有限公司 自动注射装置
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US9339610B2 (en) 2011-01-24 2016-05-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
US9561328B2 (en) 2009-04-29 2017-02-07 Abbvie Biotechnology Ltd Automatic injection device
USD818587S1 (en) 2016-03-29 2018-05-22 Abbevie Inc. Automatic injection device
US9981087B2 (en) 2011-09-22 2018-05-29 Abbvie Inc. Automatic injection device
USD832424S1 (en) 2011-09-22 2018-10-30 Abbvie Inc. Automatic injection device
EP3355962A4 (en) * 2015-10-01 2019-05-22 Noble International, Inc. Microcartridge
US10413667B2 (en) 2012-08-15 2019-09-17 Sanofi-Aventis Deutschland Gmbh Autoinjector
US10646659B2 (en) 2014-01-30 2020-05-12 Sanofi-Aventis Deutschland Gmbh Medicament delivery device
US10806867B2 (en) 2011-01-24 2020-10-20 E3D Agricultural Cooperative Association Ltd. Injector

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US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
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