WO2004012721A2 - Heissschmelz-tts zur verabreichungvon rotigotin - Google Patents
Heissschmelz-tts zur verabreichungvon rotigotin Download PDFInfo
- Publication number
- WO2004012721A2 WO2004012721A2 PCT/EP2003/008348 EP0308348W WO2004012721A2 WO 2004012721 A2 WO2004012721 A2 WO 2004012721A2 EP 0308348 W EP0308348 W EP 0308348W WO 2004012721 A2 WO2004012721 A2 WO 2004012721A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rotigotine
- tts
- adhesive
- weight
- melt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- External Artificial Organs (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE50303201T DE50303201D1 (de) | 2002-07-30 | 2003-07-29 | Heissschmelz-tts zur verabreichung von rotigotin |
JP2004525355A JP4514608B2 (ja) | 2002-07-30 | 2003-07-29 | ロチゴチンの投与のためのホットメルト型tts |
BR0311437-6A BR0311437A (pt) | 2002-07-30 | 2003-07-29 | Tts de fusão a quente para a administração de rotigotina |
CA2494361A CA2494361C (en) | 2002-07-30 | 2003-07-29 | Hot melt tts for administering rotigotine |
US10/523,908 US9186335B2 (en) | 2002-07-30 | 2003-07-29 | Hot melt TTS for administering rotigotine |
EP03750403A EP1492517B1 (de) | 2002-07-30 | 2003-07-29 | Heissschmelz-tts zur verabreichung von rotigotin |
AU2003269859A AU2003269859B2 (en) | 2002-07-30 | 2003-07-29 | Hot melt TTS for administering rotigotine |
NZ538130A NZ538130A (en) | 2002-07-30 | 2003-07-29 | Hot melt TTS (transdermal therapeutic system) for administering rotigotine continuously |
MXPA04012150A MXPA04012150A (es) | 2002-07-30 | 2003-07-29 | Sistema terapeutico transdermico para administrar rotigotina. |
SI200330281T SI1492517T1 (sl) | 2002-07-30 | 2003-07-29 | TTS z vroco talino za dajanje rotigotina |
IL16607003A IL166070A0 (en) | 2002-07-30 | 2003-07-29 | Hot-melt tts for administering rotigotine |
ZA2005/00457A ZA200500457B (en) | 2002-07-30 | 2005-01-18 | Hot melt tts for administering rotigotine |
NO20050835A NO20050835L (no) | 2002-07-30 | 2005-02-16 | Varmsmelte TTS for administrasjon av rotigotin |
HK06101569.3A HK1081436A1 (en) | 2002-07-30 | 2006-02-06 | Hot melt tts for administering rotigotine |
CY20061101048T CY1105138T1 (el) | 2002-07-30 | 2006-07-28 | Θepμου-τηγματος-δθς για χορηγηση ροτιγκοτινης |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10234673A DE10234673B4 (de) | 2002-07-30 | 2002-07-30 | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
DE10234673.9 | 2002-07-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004012721A2 true WO2004012721A2 (de) | 2004-02-12 |
WO2004012721A3 WO2004012721A3 (de) | 2004-04-08 |
Family
ID=30469194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/008348 WO2004012721A2 (de) | 2002-07-30 | 2003-07-29 | Heissschmelz-tts zur verabreichungvon rotigotin |
Country Status (22)
Country | Link |
---|---|
US (1) | US9186335B2 (de) |
EP (2) | EP1669063A1 (de) |
JP (1) | JP4514608B2 (de) |
KR (1) | KR101041512B1 (de) |
CN (1) | CN100574755C (de) |
AT (1) | ATE324875T1 (de) |
AU (1) | AU2003269859B2 (de) |
BR (1) | BR0311437A (de) |
CA (1) | CA2494361C (de) |
CY (1) | CY1105138T1 (de) |
DE (2) | DE10234673B4 (de) |
DK (1) | DK1492517T3 (de) |
ES (1) | ES2263999T3 (de) |
HK (1) | HK1081436A1 (de) |
IL (1) | IL166070A0 (de) |
MX (1) | MXPA04012150A (de) |
NO (1) | NO20050835L (de) |
PL (1) | PL221308B1 (de) |
PT (1) | PT1492517E (de) |
RU (1) | RU2304434C2 (de) |
WO (1) | WO2004012721A2 (de) |
ZA (1) | ZA200500457B (de) |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006016382A (ja) * | 2004-06-01 | 2006-01-19 | Hisamitsu Pharmaceut Co Inc | 貼付剤 |
JP2008514376A (ja) * | 2004-09-29 | 2008-05-08 | シュウォーツ ファーマ インコーポレイテッド | パーキンソン病のための経皮治療システム |
DE102006059462A1 (de) * | 2006-12-14 | 2008-06-19 | Henkel Kgaa | Hot melt für Mikrowellen-Erwärmung |
DE102008060203A1 (de) | 2008-12-07 | 2010-06-10 | Dietrich Wilhelm Schacht | Wirkstoffstabilisierende flächenförmige Vorrichtung |
US7872041B2 (en) | 2004-03-24 | 2011-01-18 | Ucb Pharma Gmbh | Use of rotigotine for treating and preventing Parkinson's plus syndrome |
US8173155B2 (en) | 2004-06-01 | 2012-05-08 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive patch |
WO2012084969A1 (en) | 2010-12-22 | 2012-06-28 | Hexal Ag | Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition |
US8283376B2 (en) | 2003-12-24 | 2012-10-09 | Ucb Pharma Gmbh | Use of substituted 2-aminotetralins for preventive treatment of parkinson's disease |
WO2013026547A1 (en) | 2011-08-19 | 2013-02-28 | Ucb Pharma Gmbh | Rotigotine in the treatment of hemispatial neglect and other deficits following stroke |
DE102011119043A1 (de) | 2011-11-22 | 2013-05-23 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TDS) mit Rotigotin |
WO2013075822A1 (en) | 2011-11-22 | 2013-05-30 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermal therapeutic system (tts) with rotigotine |
US8609641B2 (en) | 2003-12-18 | 2013-12-17 | Ucb Pharma Gmbh | (S)-2-N-propylamino-5-hydroxytetralin as a D3-agonist |
DE102012013421A1 (de) | 2012-07-03 | 2014-01-09 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TTS) mit Rotigotin |
DE102012013439A1 (de) | 2012-07-03 | 2014-01-23 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System umfassend Rotigotin und Kristallisationsinhibitor |
WO2014079573A1 (en) | 2012-11-22 | 2014-05-30 | Ucb Pharma Gmbh | Multi-day patch for the transdermal administration of rotigotine |
WO2014198423A1 (de) * | 2013-06-14 | 2014-12-18 | Tesa Labtec Gmbh | Dreischichtiges transdermales therapiesystem (tts) |
WO2014198422A1 (de) * | 2013-06-14 | 2014-12-18 | Tesa Labtec Gmbh | Transdermales therapiesystem (tts) mit rotigotin |
US10292942B2 (en) | 2006-06-08 | 2019-05-21 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux |
WO2019234662A1 (en) * | 2018-06-07 | 2019-12-12 | Nal Pharmaceutical Group Limited | Transdermal drug delivery system containing rotigotine |
US11033723B2 (en) | 2013-07-03 | 2021-06-15 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system comprising an electronic component |
US11426359B2 (en) | 2014-05-20 | 2022-08-30 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
US11633367B2 (en) | 2014-05-20 | 2023-04-25 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system containing rotigotine |
US11752110B2 (en) | 2014-05-20 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
Families Citing this family (32)
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---|---|---|---|---|
DE19814084B4 (de) | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
US20040048779A1 (en) * | 2002-05-06 | 2004-03-11 | Erwin Schollmayer | Use of rotigotine for treating the restless leg syndrome |
US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
DE10261696A1 (de) | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
US20050197385A1 (en) * | 2004-02-20 | 2005-09-08 | Schwarz Pharma Ag | Use of rotigotine for treatment or prevention of dopaminergic neuron loss |
TWI392670B (zh) * | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的2-胺基萘滿之於製造用於預防、減緩及/或治療各種類型疼痛之藥物上的用途 |
US20080226698A1 (en) * | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
EP1987815A1 (de) * | 2007-05-04 | 2008-11-05 | Schwarz Pharma Ag | Im Mund-Nasen-Rachenraum verabreichbare pharmazeutische Zusammensetzungen enthaltend Dopaminagonisten zur Vorbeugung und/oder Behandlung von unruhigen Gliedmassen |
EP2170323A2 (de) | 2007-05-30 | 2010-04-07 | Chemagis Ltd. | Kristalline rotigotin-base und herstellungsverfahren dafür |
CN101147739B (zh) * | 2007-07-06 | 2010-12-08 | 北京康倍得医药技术开发有限公司 | 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂 |
ME02275B (me) * | 2007-11-28 | 2016-02-20 | Ucb Pharma Gmbh | Polimorfni oblik rotigotina |
EP2349230A2 (de) * | 2008-10-06 | 2011-08-03 | Mylan Technologies, Inc. | Amorphes transdermales system von rotigotin |
EP2281559A1 (de) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmazeutische Zusammensetzung enthaltend Rotigotin (Salze oder Na), insbesondere für Iontophorese |
DE102009052972A1 (de) * | 2009-11-12 | 2011-09-15 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm |
DK2515887T3 (en) | 2009-12-22 | 2018-09-17 | Ucb Biopharma Sprl | Polyvinylpyrrolidone to stabilize a solid dispersion of the non-crystalline form of rotigotine |
SG183993A1 (en) * | 2010-03-09 | 2012-10-30 | Alkermes Pharma Ireland Ltd | Alcohol resistant enteric pharmaceutical compositions |
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JP5856424B2 (ja) * | 2011-10-05 | 2016-02-09 | 祐徳薬品工業株式会社 | ロチゴチン含有経皮吸収型貼付剤 |
DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
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JP2015522013A (ja) * | 2012-07-06 | 2015-08-03 | エスケー ケミカルス カンパニー リミテッド | ロチゴチン含有経皮吸収製剤 |
WO2014193190A1 (ko) * | 2013-05-30 | 2014-12-04 | 에스케이케미칼 (주) | 로티고틴과 지방산 및 스티렌 점착제를 함유한 경피치료시스템 |
WO2014205325A2 (en) * | 2013-06-20 | 2014-12-24 | Mylan Technologies, Inc. | Storage stable transdermal patch of rotigotine |
KR102364378B1 (ko) * | 2014-05-21 | 2022-02-16 | 에스케이케미칼 주식회사 | 안정성을 향상시킨 로티고틴 함유 경피흡수제제 |
KR20200046461A (ko) * | 2018-10-24 | 2020-05-07 | 에스케이케미칼 주식회사 | 비결정 로티고틴 함유 조성물 및 이의 제조 방법 |
KR102260202B1 (ko) * | 2019-10-30 | 2021-06-03 | 에바바이오 주식회사 | 로티고틴 공융 혼합물 및 이의 용도 |
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- 2003-07-29 AT AT03750403T patent/ATE324875T1/de active
- 2003-07-29 EP EP06005770A patent/EP1669063A1/de not_active Withdrawn
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- 2003-07-29 MX MXPA04012150A patent/MXPA04012150A/es active IP Right Grant
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- 2003-07-29 CN CN03818378A patent/CN100574755C/zh not_active Expired - Fee Related
- 2003-07-29 DK DK03750403T patent/DK1492517T3/da active
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