WO2004002481A1 - Aryl carbonyl derivatives as therapeutic agents - Google Patents
Aryl carbonyl derivatives as therapeutic agents Download PDFInfo
- Publication number
- WO2004002481A1 WO2004002481A1 PCT/DK2003/000449 DK0300449W WO2004002481A1 WO 2004002481 A1 WO2004002481 A1 WO 2004002481A1 DK 0300449 W DK0300449 W DK 0300449W WO 2004002481 A1 WO2004002481 A1 WO 2004002481A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkylene
- compound according
- alkyl
- aryl
- heteroaryl
- Prior art date
Links
- 0 CC(C)c1nc(*)c(*)[s]1 Chemical compound CC(C)c1nc(*)c(*)[s]1 0.000 description 6
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- XSBLZMNJHCCQJK-UHFFFAOYSA-N O=C(Nc1ncc[s]1)Nc1ccccc1Oc(cc1)cc2c1OCO2 Chemical compound O=C(Nc1ncc[s]1)Nc1ccccc1Oc(cc1)cc2c1OCO2 XSBLZMNJHCCQJK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/425—Thiazoles
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
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- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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BR0312023-6A BR0312023A (pt) | 2002-06-27 | 2003-06-27 | Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica |
MXPA05000130A MXPA05000130A (es) | 2002-06-27 | 2003-06-27 | Derivados de aril-carbonilo como agentes terapeuticos. |
KR1020047021359A KR101116627B1 (ko) | 2002-06-27 | 2003-06-27 | 치료제로서 아릴 카르보닐 유도체 |
JP2004548878A JP4881559B2 (ja) | 2002-06-27 | 2003-06-27 | 治療薬としてのアリールカルボニル誘導体 |
KR1020117028716A KR101124245B1 (ko) | 2002-06-27 | 2003-06-27 | 치료제로서 아릴 카르보닐 유도체 |
AU2003243921A AU2003243921B2 (en) | 2002-06-27 | 2003-06-27 | Aryl carbonyl derivatives as therapeutic agents |
ES03761446.8T ES2526192T3 (es) | 2002-06-27 | 2003-06-27 | Activadores de la glucocinasa |
CA2488642A CA2488642C (en) | 2002-06-27 | 2003-06-27 | Aryl carbonyl derivatives as glucokinase activators |
EP03761446.8A EP1531815B1 (en) | 2002-06-27 | 2003-06-27 | Glucokinase activators |
US10/679,887 US7384967B2 (en) | 2002-06-27 | 2003-10-06 | Aryl carbonyl derivatives as therapeutic agents |
IL165532A IL165532A (en) | 2002-06-27 | 2004-12-02 | History of Aryl Carbonyl, Pharmaceutical Preparations Containing Them and Their Use in the Preparation of Medicines for the Treatment of Metabolic Disorders |
NO20050426A NO330920B1 (no) | 2002-06-27 | 2005-01-26 | Fenylureidotiazolylkarboksylsyreforbindelser, farmasoytiske preparater som omfatter forbindelsene, samt anvendelse av forbindelsene til fremstilling av medikamenter |
US11/365,534 US7541373B2 (en) | 2002-06-27 | 2006-03-01 | Aryl carbonyl derivatives as therapeutic agents |
US11/981,997 US8063081B2 (en) | 2002-06-27 | 2007-10-31 | Aryl carbonyl derivatives as therapeutic agents |
US11/982,248 US7897628B2 (en) | 2002-06-27 | 2007-10-31 | Aryl carbonyl derivatives as therapeutic agents |
NO20111028A NO20111028L (no) | 2002-06-27 | 2011-07-15 | Arylkarbonylderivater som terapeutiske midler |
US13/209,565 US20110301158A1 (en) | 2002-06-27 | 2011-08-15 | Aryl carbonyl derivatives as therapeutic agents |
US14/136,825 USRE45670E1 (en) | 2002-06-27 | 2013-12-20 | Aryl carbonyl derivatives as therapeutic agents |
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Cited By (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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WO2005113537A2 (en) * | 2004-05-12 | 2005-12-01 | Bristol-Myers Squibb Company | Urea antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
WO2005121110A1 (en) | 2004-06-05 | 2005-12-22 | Astrazeneca Ab | Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
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WO2007006814A1 (en) | 2005-07-14 | 2007-01-18 | Novo Nordisk A/S | Urea glucokinase activators |
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WO2007007041A1 (en) | 2005-07-09 | 2007-01-18 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
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US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
US7199140B2 (en) | 2001-06-26 | 2007-04-03 | Astrazeneca Ab | Vinyl phenyl derivatives as GLK activators |
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US7214681B2 (en) | 2003-02-11 | 2007-05-08 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
US7230108B2 (en) | 2002-11-19 | 2007-06-12 | Astrazeneca Ab | Quinoline derivatives as glucokinase ligands |
WO2007128761A2 (de) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Verwendungen von dpp iv inhibitoren |
US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
US7399866B2 (en) | 2003-01-14 | 2008-07-15 | Cytokinetics, Inc. | Compounds, compositions, and methods |
WO2008084043A1 (en) * | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
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US7410988B2 (en) | 2004-08-13 | 2008-08-12 | Genentech, Inc. | 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
WO2008104994A2 (en) | 2007-02-28 | 2008-09-04 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
US7432281B2 (en) | 2003-10-07 | 2008-10-07 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
JP2008543972A (ja) * | 2005-06-27 | 2008-12-04 | ブリストル−マイヤーズ スクイブ カンパニー | 血栓症状の治療に有用なp2y1受容体のn−結合複素環式アンタゴニスト |
WO2008149382A1 (en) | 2007-06-08 | 2008-12-11 | Advinus Therapeutics Private Limited | Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application |
EP2048137A1 (en) | 2004-02-18 | 2009-04-15 | AstraZeneca AB | Benzamide derivatives and their use as glucokinase activating agents. |
US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
US7582769B2 (en) | 2005-07-08 | 2009-09-01 | Novo Nordisk A/S | Dicycloalkyl urea glucokinase activators |
WO2009127546A1 (en) | 2008-04-16 | 2009-10-22 | F. Hoffmann-La Roche Ag | Pyrrolidinone glucokinase activators |
US7638536B2 (en) | 2002-01-18 | 2009-12-29 | Astellas Pharma Inc. | 2-Acylaminothiazole derivative or salt thereof |
US7645778B2 (en) | 2005-01-19 | 2010-01-12 | Bristol-Myers Squibb Company | Heteroaryl compounds as P2Y1 receptor inhibitors |
US7700620B2 (en) | 2005-06-27 | 2010-04-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US7709505B2 (en) | 2002-11-19 | 2010-05-04 | Astrazeneca Ab | Benzofuran derivatives, process for their preparation and intermediates thereof |
US7714002B2 (en) | 2005-06-27 | 2010-05-11 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US7718657B2 (en) | 2005-12-16 | 2010-05-18 | Cytokinetics, Inc. | Certain indanyl urea modulators of the cardiac sarcomere |
US7750020B2 (en) | 2004-04-02 | 2010-07-06 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of Type 2 diabetes |
US7781451B2 (en) | 2004-04-02 | 2010-08-24 | Novartis Ag | Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions |
US7795257B2 (en) | 2005-09-30 | 2010-09-14 | Novartis Ag | Organic compounds |
US7812167B2 (en) | 2002-10-03 | 2010-10-12 | Novartis, Ag | Substituted (thiazol-2-yl)-amides or sulfonamides as glucokinase activators useful in the treatment of type 2 diabetes |
US7816382B2 (en) | 2005-06-27 | 2010-10-19 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition |
US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
EP2272834A1 (en) | 2006-10-26 | 2011-01-12 | AstraZeneca AB | Benzoyl amino heterocyclyl compounds as glucokinase (GLK) activators |
US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
WO2011080755A1 (en) | 2009-12-29 | 2011-07-07 | Advinus Therapeutics Private Limited | Fused nitrogen heterocyclic compounds, process of preparation and uses thereof |
US7989455B2 (en) | 2005-12-19 | 2011-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
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US8008332B2 (en) | 2006-05-31 | 2011-08-30 | Takeda San Diego, Inc. | Substituted indazoles as glucokinase activators |
US8034822B2 (en) | 2006-03-08 | 2011-10-11 | Takeda San Diego, Inc. | Glucokinase activators |
WO2011130459A1 (en) | 2010-04-14 | 2011-10-20 | Bristol-Myers Squibb Company | Novel glucokinase activators and methods of using same |
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US8101617B2 (en) | 2004-06-17 | 2012-01-24 | Amgen, Inc. | Disubstituted ureas and uses thereof in treating heart failure |
US8124617B2 (en) | 2005-09-01 | 2012-02-28 | Takeda San Diego, Inc. | Imidazopyridine compounds |
WO2012051450A1 (en) | 2010-10-13 | 2012-04-19 | Takeda Pharmaceutical Company Limited | Method of making azaindazole derivatives |
US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
US8211925B2 (en) | 2006-04-28 | 2012-07-03 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
US8252931B2 (en) | 2005-09-30 | 2012-08-28 | Novartis Ag | Thiazolo[5,4-B]pyridine glucokinase activators |
US8445495B2 (en) | 2005-12-15 | 2013-05-21 | Cytokinetics, Inc. | Certain Chemical entities, compositions and methods |
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US8541588B2 (en) | 2009-01-12 | 2013-09-24 | Pfizer Limited | Sulfonamide derivatives |
US8563730B2 (en) | 2008-05-16 | 2013-10-22 | Takeda San Diego, Inc. | Pyrazole and fused pyrazole glucokinase activators |
WO2014050084A1 (ja) | 2012-09-26 | 2014-04-03 | 興和株式会社 | 新規なフェニルアセトアミド化合物、及びそれを含有する医薬 |
US8809342B2 (en) | 2010-12-23 | 2014-08-19 | Pfizer Inc. | Glucagon receptor modulators |
US8859591B2 (en) | 2011-02-08 | 2014-10-14 | Pfizer Inc. | Glucagon receptor modulators |
US8927577B2 (en) | 2011-07-22 | 2015-01-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
US9108950B2 (en) | 2011-10-03 | 2015-08-18 | Respivert, Ltd. | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as p38 MAP kinase inhibitors |
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US9359313B2 (en) | 2010-05-26 | 2016-06-07 | Vtv Therapeutics Llc | Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator |
US9447076B2 (en) | 2014-02-14 | 2016-09-20 | Respivert Ltd. | Inhibitor of p38 map kinase |
US9475796B2 (en) | 2011-10-03 | 2016-10-25 | Respivert Limited | 1-pyrazolyl-3-((4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as p38 MAP kinase inhibitors |
US9732080B2 (en) | 2006-11-03 | 2017-08-15 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
US9879001B2 (en) | 2013-03-14 | 2018-01-30 | Merck Patent Gmbh | Glycosidase inhibitors |
US10004782B2 (en) | 2012-05-17 | 2018-06-26 | Vtv Therapeutics Llc | Glucokinase activator compositions for the treatment of diabetes |
US10071979B2 (en) | 2010-04-22 | 2018-09-11 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
US10081621B2 (en) | 2010-03-25 | 2018-09-25 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
US10206877B2 (en) | 2014-04-15 | 2019-02-19 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
US10246453B2 (en) | 2016-05-20 | 2019-04-02 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
US10336775B2 (en) | 2014-08-28 | 2019-07-02 | Asceneuron Sa | Glycosidase inhibitors |
US10556902B2 (en) | 2016-02-25 | 2020-02-11 | Asceneuron Sa | Glycosidase inhibitors |
US10696668B2 (en) | 2016-02-25 | 2020-06-30 | Asceneuron Sa | Acid addition salts of piperazine derivatives |
US10745392B2 (en) | 2018-06-13 | 2020-08-18 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
US10752623B2 (en) | 2018-08-31 | 2020-08-25 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors |
US10919911B2 (en) | 2018-04-12 | 2021-02-16 | Terns, Inc. | Tricyclic ASK1 inhibitors |
US10981905B2 (en) | 2018-08-31 | 2021-04-20 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents |
US11174268B2 (en) | 2016-12-09 | 2021-11-16 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compouds and their use as therapeutic agents |
US11213525B2 (en) | 2017-08-24 | 2022-01-04 | Asceneuron Sa | Linear glycosidase inhibitors |
US11247987B2 (en) | 2017-10-06 | 2022-02-15 | Forma Therapeutics, Inc. | Inhibiting ubiquitin specific peptidase 30 |
US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
US11535618B2 (en) | 2018-10-05 | 2022-12-27 | Forma Therapeutics, Inc. | Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors |
WO2023025854A1 (en) * | 2021-08-25 | 2023-03-02 | Basf Se | Herbicidal malonamides |
US11612599B2 (en) | 2016-02-25 | 2023-03-28 | Asceneuron Sa | Glycosidase inhibitors |
US11690841B2 (en) | 2017-09-14 | 2023-07-04 | Queen Mary University Of London | Glycolysis-activating agents for treatment or prevention of disease |
US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
US11827610B2 (en) | 2021-09-15 | 2023-11-28 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
US11833136B2 (en) | 2018-06-12 | 2023-12-05 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
US11958846B2 (en) | 2018-08-17 | 2024-04-16 | Novartis Ag | Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0215212A (pt) * | 2001-12-21 | 2004-12-07 | Novo Nordisk As | Ativador de carboxamida ou sulfonamida de glicoquinase, composto, composição farmacêutica, e, uso de um composto |
KR101116627B1 (ko) * | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
AU2003271669A1 (en) * | 2002-10-03 | 2004-04-23 | Ecole Polytechnique Federale De Lausanne (Epfl) | Substrates for O6 -alkylguanine-DNA alkyltransferase |
US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
US7722536B2 (en) | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
CA3090413C (en) | 2004-06-04 | 2023-10-10 | Abbott Diabetes Care Inc. | Glucose monitoring and graphical representations in a data management system |
US7601725B2 (en) | 2004-07-16 | 2009-10-13 | Sunesis Pharmaceuticals, Inc. | Thienopyrimidines useful as Aurora kinase inhibitors |
US7332529B2 (en) * | 2004-10-26 | 2008-02-19 | Carr Andrew J | Thermoreversible organogelators, compositions and methods of making thereof |
JP2008520744A (ja) | 2004-11-19 | 2008-06-19 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 抗炎症性ピラゾロピリミジン |
JP2008523072A (ja) * | 2004-12-07 | 2008-07-03 | ルーカス ファーマシューティカルズ, インコーポレイテッド | タンパク質キナーゼの阻害剤 |
JP2008523071A (ja) * | 2004-12-07 | 2008-07-03 | ルーカス ファーマシューティカルズ, インコーポレイテッド | Mapキナーゼの尿素インヒビター |
US20070197532A1 (en) * | 2005-11-18 | 2007-08-23 | Cao Sheldon X | Glucokinase activators |
CA2635888A1 (en) * | 2006-01-04 | 2007-07-19 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
NZ571182A (en) | 2006-04-04 | 2010-09-30 | Univ California | Pyrazolo[3,4-d]pyrimidines |
EP2452674B1 (en) * | 2006-08-08 | 2014-03-26 | Akarx, Inc. | Compositions and methods for increasing blood platelet levels in humans |
CN101796017A (zh) * | 2007-09-21 | 2010-08-04 | 塞诺菲-安万特股份有限公司 | (羧基亚烷基苯基)苯基草酰胺、其生产方法以及作为药物的用途 |
US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
NZ587051A (en) | 2008-01-04 | 2012-12-21 | Intellikine Llc | Isoquinolinone derivatives, compositions and methods of inhibiting phosphatidyl inositol-3 kinase (pi3 kinase) |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
WO2009114874A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Benzothiazole kinase inhibitors and methods of use |
US8637542B2 (en) * | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
BRPI0915231A2 (pt) | 2008-07-08 | 2018-06-12 | Intellikine Inc | compostos inibidores de quinase e métodos de uso |
US8703778B2 (en) | 2008-09-26 | 2014-04-22 | Intellikine Llc | Heterocyclic kinase inhibitors |
ES2570429T3 (es) | 2008-10-16 | 2016-05-18 | Univ California | Inhibidores de heteroaril quinasa de anillo condensado |
US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
CA2760791C (en) | 2009-05-07 | 2017-06-20 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
EP2464352A1 (en) * | 2009-08-14 | 2012-06-20 | Eisai Inc. | Use of e5501 for stimulating platelet production |
WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
ES2593256T3 (es) | 2010-05-21 | 2016-12-07 | Infinity Pharmaceuticals, Inc. | Compuestos químicos, composiciones y métodos para las modulaciones de cinasas |
WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN103648499B (zh) | 2011-01-10 | 2017-02-15 | 无限药品股份有限公司 | 用于制备异喹啉酮的方法及异喹啉酮的固体形式 |
US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
CA2842190A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
EP2734520B1 (en) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2013032591A1 (en) | 2011-08-29 | 2013-03-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
CA2846496C (en) | 2011-09-02 | 2020-07-14 | The Regents Of The University Of California | Substituted pyrazolo[3,4-d]pyrimidines and uses thereof |
TWI622578B (zh) | 2011-12-21 | 2018-05-01 | 諾維拉治療公司 | B型肝炎抗病毒劑 |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
BR112015004192B1 (pt) | 2012-08-28 | 2021-02-09 | Janssen Sciences Ireland Uc | sulfamoíl-arilamidas, composição farmacêutica que os compreende e uso das mesmas no tratamento da hepatite b |
JP2015532287A (ja) | 2012-09-26 | 2015-11-09 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ire1の調節 |
EP2906212A4 (en) * | 2012-10-15 | 2016-06-08 | Agios Pharmaceuticals Inc | THERAPEUTIC COMPOUNDS AND COMPOSITIONS |
WO2014131847A1 (en) | 2013-02-28 | 2014-09-04 | Janssen R&D Ireland | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
WO2014151472A1 (en) | 2013-03-15 | 2014-09-25 | Chromocell Corporation | Sodium channel modulators for the treatment of pain |
BR112015025052A2 (pt) | 2013-04-03 | 2021-07-06 | Janssen Sciences Ireland Uc | derivados de n-fenil-carboxamida e o seu uso como medicamentos para o tratamento da hepatite b |
EA035500B1 (ru) | 2013-05-17 | 2020-06-25 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
EP3357906B1 (en) | 2013-07-25 | 2019-12-04 | Janssen Sciences Ireland Unlimited Company | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
MY181928A (en) | 2013-09-10 | 2021-01-14 | Chromocell Corp | Sodium channel modulators for the treatment of pain and diabetes |
CA2925944C (en) | 2013-10-04 | 2023-01-10 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2926950C (en) | 2013-10-10 | 2022-10-11 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase |
MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
WO2015120178A1 (en) | 2014-02-05 | 2015-08-13 | Novira Therapeutics, Inc. | Combination therapy for treatment of hbv infections |
CN105980378B (zh) | 2014-02-06 | 2019-09-27 | 爱尔兰詹森科学公司 | 氨磺酰基吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
EP4066834A1 (en) | 2014-03-19 | 2022-10-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN107847762A (zh) | 2015-03-19 | 2018-03-27 | 诺维拉治疗公司 | 氮杂环辛烷和氮杂环壬烷衍生物以及治疗乙型肝炎感染的方法 |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
CN108349985A (zh) | 2015-09-14 | 2018-07-31 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
EP3356328A1 (en) | 2015-09-29 | 2018-08-08 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis b antiviral agent |
JP6456520B2 (ja) | 2015-12-11 | 2019-01-23 | 帝人ファーマ株式会社 | アミノアゾール誘導体 |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
SG11201808949SA (en) | 2016-04-15 | 2018-11-29 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2017223422A1 (en) | 2016-06-24 | 2017-12-28 | Infinity Pharmaceuticals, Inc. | Combination therapies |
AU2019235522A1 (en) | 2018-03-14 | 2020-09-03 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
WO2019232275A1 (en) * | 2018-05-30 | 2019-12-05 | Washington University | Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof |
MA55020A (fr) | 2019-02-22 | 2021-12-29 | Janssen Sciences Ireland Unlimited Co | Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b |
AR119732A1 (es) | 2019-05-06 | 2022-01-05 | Janssen Sciences Ireland Unlimited Co | Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb |
Citations (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3152136A (en) * | 1958-10-30 | 1964-10-06 | Dow Chemical Co | Dinitroaroyl-nu-pyridyl amides |
US3317534A (en) * | 1963-10-30 | 1967-05-02 | Chugai Pharmaceutical Co Ltd | Benzamidopyrimidines |
DE2117807A1 (de) * | 1970-04-15 | 1971-10-28 | Shell Internationale Research Maatschappij N.V., Den Haag (Niederlande) | Carboxamidderivate |
DE2712630A1 (de) * | 1977-03-23 | 1978-09-28 | Bayer Ag | 1,3,4-thiadiazol-2-yl-harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
US4356108A (en) | 1979-12-20 | 1982-10-26 | The Mead Corporation | Encapsulation process |
US5556969A (en) * | 1994-12-07 | 1996-09-17 | Merck Sharp & Dohme Ltd. | Benzodiazepine derivatives |
WO1997009040A1 (en) | 1995-09-08 | 1997-03-13 | Novo Nordisk A/S | 2-alkylpyrrolidines |
WO1997024328A1 (en) * | 1995-12-27 | 1997-07-10 | Bayer Aktiengesellschaft | 2-amino-heterocycles and therapeutic uses therefor |
WO1997026265A1 (en) | 1996-01-17 | 1997-07-24 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
WO1997041097A2 (en) | 1996-12-31 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
WO1997041119A1 (en) | 1997-05-02 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
WO1997041120A1 (en) | 1996-07-26 | 1997-11-06 | Dr. Reddy's Research Foundation | Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof |
WO1998008871A1 (en) | 1996-08-30 | 1998-03-05 | Novo Nordisk A/S | Glp-1 derivatives |
WO1998045292A1 (en) | 1997-12-02 | 1998-10-15 | Dr. Reddy's Research Foundation | Thiazolidinedione and oxazolidinedione derivatives having antidiabetic, hypolipidaemic and antihypertensive properties |
WO1999001423A1 (en) | 1997-07-01 | 1999-01-14 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
WO1999003861A1 (en) | 1997-07-16 | 1999-01-28 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
WO1999019313A1 (en) | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
WO1999024035A1 (en) * | 1997-11-10 | 1999-05-20 | Bristol-Myers Squibb Company | Benzothiazole protein tyrosine kinase inhibitors |
WO1999032111A1 (en) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
WO1999032106A1 (en) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | Inhibition of raf kinase using substituted heterocyclic ureas |
WO2000023445A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023417A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023415A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023416A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023425A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023451A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000037474A1 (en) | 1998-12-18 | 2000-06-29 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
WO2000039088A1 (en) | 1998-12-23 | 2000-07-06 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
WO2000041121A1 (en) | 1999-01-07 | 2000-07-13 | Ccrewards.Com | Method and arrangement for issuance and management of digital coupons and sales offers |
WO2000042023A1 (en) | 1999-01-18 | 2000-07-20 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
WO2000042026A1 (en) | 1999-01-15 | 2000-07-20 | Novo Nordisk A/S | Non-peptide glp-1 agonists |
WO2000050414A1 (en) | 1999-02-24 | 2000-08-31 | Dr.Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical composition containing them |
WO2000058293A2 (en) | 1999-03-29 | 2000-10-05 | F. Hoffmann-La Roche Ag | Glucokinase activators |
WO2000063153A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000063191A1 (en) | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
WO2000063196A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000063209A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000063192A1 (en) | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and pharmaceutical compositions containing them |
WO2000063193A1 (en) | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
WO2000063190A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000063208A1 (en) | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
WO2000064884A1 (en) | 1999-04-26 | 2000-11-02 | Novo Nordisk A/S | Piperidyl-imidazole derivatives, their preparations and therapeutic uses |
WO2001044216A1 (en) | 1999-12-15 | 2001-06-21 | F. Hoffmann-La Roche Ag | Trans olefinic glucokinase activators |
WO2001057008A1 (en) * | 2000-02-07 | 2001-08-09 | Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
WO2001083478A2 (en) | 2000-05-03 | 2001-11-08 | F. Hoffmann-La Roche Ag | Hydantoin-containing glucokinase activators |
WO2001083465A2 (en) | 2000-05-03 | 2001-11-08 | F. Hoffmann-La Roche Ag | Alkynyl phenyl heteroaromatic glucokinase activators |
WO2001085707A1 (en) | 2000-05-08 | 2001-11-15 | F. Hoffmann-La Roche Ag | Para-amine substituted phenylamide glucokinase activators |
WO2001085706A1 (en) | 2000-05-08 | 2001-11-15 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
WO2002008209A1 (en) | 2000-07-20 | 2002-01-31 | F. Hoffmann-La Roche Ag | Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators |
WO2002014311A2 (en) * | 2000-08-15 | 2002-02-21 | Amgen Inc. | Urea compounds and methods of uses |
EP1211246A1 (en) * | 1999-09-09 | 2002-06-05 | Kumiai Chemical Industry Co., Ltd. | Pyrimidine derivatives and herbicides containing the same |
WO2002046173A1 (en) * | 2000-12-06 | 2002-06-13 | F. Hoffmann-La Roche Ag | Fused heteroaromatic glucokinase activators |
WO2002070494A1 (en) * | 2001-03-02 | 2002-09-12 | Icos Corporation | Aryl and heteroaryl urea chk1 inhibitors for use as radiosensitizers and chamosensitizers |
WO2003055482A1 (en) * | 2001-12-21 | 2003-07-10 | Novo Nordisk A/S | Amide derivatives as gk activators |
WO2003070727A1 (en) * | 2002-02-15 | 2003-08-28 | Amgen Inc. | Thiazolyl urea compounds for the treatment of cancer |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR7428A (US08063081-20111122-C00046.png) | ||||
US2431801A (en) * | 1944-01-11 | 1947-12-02 | George A Gibson | Pressure compensated thermostat |
GB771147A (en) | 1954-06-04 | 1957-03-27 | Merck & Co Inc | Derivatives of urea |
US3067250A (en) | 1959-01-26 | 1962-12-04 | Dow Chemical Co | 4-aryl, 1, 1-di propynyl-semicarbazides |
US3551442A (en) * | 1965-04-06 | 1970-12-29 | Pechiney Saint Gobain | Thiazole derivatives |
ZA6706928B (US08063081-20111122-C00046.png) | 1967-03-23 | |||
CH493195A (de) | 1968-01-23 | 1970-07-15 | Ciba Geigy | Schädlingsbekämpfungsmittel |
US4175081A (en) | 1968-02-01 | 1979-11-20 | Mobil Oil Corporation | 5-Substituted thiadiazole ureas |
GB1195672A (en) | 1968-02-01 | 1970-06-17 | Mobil Oil Corp | Novel Urea Derivatives and Herbicides containing the same |
FR7428M (US08063081-20111122-C00046.png) | 1968-05-06 | 1969-11-12 | ||
CH502762A (de) | 1968-07-17 | 1971-02-15 | Agripat Sa | Neue Thiadiazolyl-harnstoffe enthaltendes herbizides Mittel |
GB1266769A (US08063081-20111122-C00046.png) | 1969-08-15 | 1972-03-15 | ||
BE754783A (fr) | 1969-08-15 | 1971-02-12 | May & Baker Ltd | Derives thiazolyl a usage herbicide leur preparation et les compositions qui les contiennent |
AT297799B (de) | 1970-06-15 | 1972-04-10 | Reichert Optische Werke Ag | Temperaturkompensierte Transistor-Gleichspannungs-Vorverstärkerstufe |
NL7106557A (US08063081-20111122-C00046.png) | 1970-06-15 | 1971-12-17 | ||
IT960595B (it) | 1971-06-16 | 1973-11-30 | Hispaco Ag | Navetta per tessitura |
US3887709A (en) | 1971-09-16 | 1975-06-03 | Zdzislaw Brzozowski | 2-Pyrazoline-1-carboxamide sulfonamide derivatives useful as hypoglycemic agents |
DE2151766C3 (de) | 1971-10-14 | 1981-03-19 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-Thiazolinyl-phenoxycarbonsäureamide |
US3862163A (en) | 1971-10-14 | 1975-01-21 | Schering Ag | Phenoxycarboxylic acid amides |
US3874873A (en) | 1972-03-27 | 1975-04-01 | Fmc Corp | Herbicidal compositions based on 1,2,3-thiadiazol-5-yl ureas |
IL44058A (en) | 1973-02-02 | 1978-10-31 | Ciba Geigy Ag | 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them |
JPS5614643B2 (US08063081-20111122-C00046.png) * | 1973-07-02 | 1981-04-06 | ||
AR206720A1 (es) | 1974-08-30 | 1976-08-13 | Lilly Co Eli | Procedimiento para la preparacion de novedosas n-2-(6-hidroxibenzotiazolil)-n'-fenil(o fenilo substituido)-ureas |
PL106114B1 (pl) | 1976-12-31 | 1979-11-30 | Akad Medyczna | Sposob wytwarzania nowych n-(4-/2-/pirazolo-1-karbonamido/-etylo/-benzenosulfonylo)-mocznikow |
DE2716324A1 (de) * | 1977-04-07 | 1978-10-12 | Schering Ag | 1,2,3-thiadiazol-3-in-5-yliden- harnstoffe, verfahren zur herstellung dieser verbindungen sowie diese enthaltende mittel mit wachstumsregulatorischer wirkung fuer pflanzen |
JPS6033109B2 (ja) | 1977-04-28 | 1985-08-01 | 塩野義製薬株式会社 | 尿素誘導体の合成法 |
US4241072A (en) * | 1979-01-18 | 1980-12-23 | Merck & Co., Inc. | Substituted ureas and processes for their preparation |
DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
IL72093A0 (en) | 1983-06-20 | 1984-10-31 | Lilly Co Eli | N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives |
US4694004A (en) | 1984-07-09 | 1987-09-15 | Fujisawa Pharmaceutical Co., Ltd. | Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
US4808722A (en) | 1985-10-31 | 1989-02-28 | Fmc Corporation | Pyridinylurea N-oxide compounds and agricultural uses |
JPS6456660A (en) | 1987-05-11 | 1989-03-03 | Sumitomo Chemical Co | Urea derivative or its salt, production thereof and germicide for agriculture and horticulture containing said derivative or salt thereof as active ingredient |
JPH0453257Y2 (US08063081-20111122-C00046.png) | 1987-09-30 | 1992-12-15 | ||
MX22406A (es) | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
IE68593B1 (en) | 1989-12-06 | 1996-06-26 | Sanofi Sa | Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them |
RU2021258C1 (ru) | 1991-02-28 | 1994-10-15 | Агролинц Агрархемикалиен ГмбХ | Способ получения несимметрично дизамещенных мочевин |
US5371086A (en) | 1991-03-15 | 1994-12-06 | The Green Cross Corporation | Aminopyridine compounds |
JPH05294935A (ja) | 1991-03-15 | 1993-11-09 | Green Cross Corp:The | アミノピリジン系化合物 |
JPH04334374A (ja) * | 1991-05-07 | 1992-11-20 | Mitsui Toatsu Chem Inc | N−(2−チアゾリル)尿素誘導体、その製造方法および該化合物を含有する殺虫剤 |
CA2134359C (en) | 1992-05-28 | 1997-07-01 | Ernest S. Hamanaka | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
JP3176137B2 (ja) * | 1992-07-02 | 2001-06-11 | 大正製薬株式会社 | ビウレット誘導体 |
JPH06102611A (ja) | 1992-09-22 | 1994-04-15 | Konica Corp | ハロゲン化銀写真感光材料 |
WO1994014801A1 (en) | 1992-12-29 | 1994-07-07 | Smithkline Beecham Plc | Heterocyclic urea derivatives as 5ht2c and 5ht2b antagonists |
GB9302275D0 (en) | 1993-02-05 | 1993-03-24 | Smithkline Beecham Plc | Novel compounds |
US5849769A (en) | 1994-08-24 | 1998-12-15 | Medivir Ab | N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection |
US6579314B1 (en) * | 1995-03-10 | 2003-06-17 | C.R. Bard, Inc. | Covered stent with encapsulated ends |
AU6112896A (en) | 1995-06-07 | 1996-12-30 | Sugen, Inc. | Tyrphostin-like compounds for the treatment of cell prolifer ative disorders or cell differentiation disorders |
US5846990A (en) | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
JPH09124620A (ja) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
CA2197364A1 (en) | 1996-02-15 | 1997-08-16 | Toshikazu Suzuki | Phenol compound and process for preparing the same |
CA2247286A1 (en) | 1996-02-26 | 1997-08-28 | Hirohiko Hasegawa | Sulfonylureidopyrazole derivatives |
TW523506B (en) | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
US5846985A (en) | 1997-03-05 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
SE9702001D0 (sv) | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
US6268384B1 (en) | 1997-08-29 | 2001-07-31 | Vertex Pharmaceuticals Incorporated | Compounds possessing neuronal activity |
TW415942B (en) * | 1997-09-03 | 2000-12-21 | American Home Prod | Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents |
US6225346B1 (en) | 1997-10-24 | 2001-05-01 | Sugen, Inc. | Tyrphostin like compounds |
US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
WO1999025712A1 (fr) | 1997-11-14 | 1999-05-27 | Kowa Company, Ltd. | Nouveaux composes d'amide et medicaments contenant ces derniers |
AU2108099A (en) | 1998-01-30 | 1999-08-16 | Procept, Inc. | Immunosuppressive agents |
UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
US6407124B1 (en) * | 1998-06-18 | 2002-06-18 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
GT199900147A (es) * | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
AU6367399A (en) | 1998-11-02 | 2000-05-22 | Welfide Corporation | Pyrrolidine compounds and medicinal utilization thereof |
WO2000035455A1 (en) | 1998-12-15 | 2000-06-22 | Telik, Inc. | Heteroaryl-aryl ureas as igf-1 receptor antagonists |
AU2914200A (en) | 1999-03-08 | 2000-09-28 | Bayer Aktiengesellschaft | Thiazolyl urea derivatives and their utilization as antiviral agents |
US6610846B1 (en) * | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
US6503949B1 (en) * | 1999-05-17 | 2003-01-07 | Noro Nordisk A/S | Glucagon antagonists/inverse agonists |
MXPA01013406A (es) * | 1999-06-30 | 2003-09-04 | Daiichi Seiyaku Co | Compuestos inhibidores de vla-4. |
US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
US6410533B1 (en) | 2000-02-10 | 2002-06-25 | Genzyme Corporation | Antibacterial compounds |
WO2002000216A1 (en) * | 2000-06-28 | 2002-01-03 | Teva Pharmaceutical Industries Ltd. | Carvedilol |
WO2002040444A1 (en) * | 2000-11-17 | 2002-05-23 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
MXPA03006886A (es) * | 2001-01-31 | 2003-11-13 | Pfizer Prod Inc | Derivados amida de acido tiazolilico, oxazolilico, pirrolilico e imidazolilico utiles como inhibidores de las isozimas pde4. |
EP1256578B1 (en) * | 2001-05-11 | 2006-01-11 | Pfizer Products Inc. | Thiazole derivatives and their use as cdk inhibitors |
JP2003021704A (ja) | 2001-07-10 | 2003-01-24 | Nippon Sheet Glass Co Ltd | 一組の屈折率分布型ロッドレンズ及び該レンズを備えたマイクロ化学システム |
DE60219793T2 (de) * | 2001-07-11 | 2008-01-24 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Verfahren zur Behandlung von Cytokin-Vermittelten Erkrankungen |
US6881746B2 (en) * | 2001-12-03 | 2005-04-19 | Novo Nordick A/S | Glucagon antagonists/inverse agonists |
DE60221627D1 (de) * | 2001-12-21 | 2007-09-20 | Virochem Pharma Inc | Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren |
KR101116627B1 (ko) * | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
TW200505894A (en) | 2003-08-08 | 2005-02-16 | Yamanouchi Pharma Co Ltd | Tetrahydro-2H-thiopyran-4-carboxamide derivative |
DK1723128T3 (da) * | 2004-01-06 | 2013-02-18 | Novo Nordisk As | Heteroarylurinstoffer og deres anvendelse som glucokinaseaktivatorer |
JP4334374B2 (ja) | 2004-03-05 | 2009-09-30 | 株式会社東芝 | 被ばく線量評価方法、被ばく線量評価システムおよび被ばく線量評価プログラム |
CA2614518A1 (en) * | 2005-07-08 | 2007-01-18 | Novo-Nordisk A/S | Dicycloalkyl urea glucokinase activators |
JP4960355B2 (ja) * | 2005-07-14 | 2012-06-27 | ノボ・ノルデイスク・エー/エス | ウレア型グルコキナーゼ活性化剤 |
US8138185B2 (en) * | 2007-01-09 | 2012-03-20 | Novo Nordisk A/S | Urea glucokinase activators |
AU2008204530B2 (en) * | 2007-01-11 | 2013-08-01 | Vtv Therapeutics Llc | Urea glucokinase activators |
-
2003
- 2003-06-27 KR KR1020047021359A patent/KR101116627B1/ko not_active IP Right Cessation
- 2003-06-27 JP JP2004548878A patent/JP4881559B2/ja not_active Expired - Fee Related
- 2003-06-27 CA CA2488642A patent/CA2488642C/en not_active Expired - Fee Related
- 2003-06-27 WO PCT/DK2003/000449 patent/WO2004002481A1/en active Application Filing
- 2003-06-27 EP EP03761446.8A patent/EP1531815B1/en not_active Expired - Lifetime
- 2003-06-27 PL PL374920A patent/PL215132B1/pl unknown
- 2003-06-27 CA CA2744893A patent/CA2744893A1/en not_active Abandoned
- 2003-06-27 BR BR0312023-6A patent/BR0312023A/pt not_active Application Discontinuation
- 2003-06-27 MX MXPA05000130A patent/MXPA05000130A/es active IP Right Grant
- 2003-06-27 EP EP11189145A patent/EP2471533A1/en not_active Withdrawn
- 2003-06-27 AU AU2003243921A patent/AU2003243921B2/en not_active Ceased
- 2003-10-06 US US10/679,887 patent/US7384967B2/en not_active Expired - Fee Related
-
2004
- 2004-12-02 IL IL165532A patent/IL165532A/en active IP Right Grant
-
2007
- 2007-10-31 US US11/981,997 patent/US8063081B2/en not_active Expired - Lifetime
- 2007-10-31 US US11/982,248 patent/US7897628B2/en not_active Expired - Lifetime
-
2010
- 2010-07-16 JP JP2010162302A patent/JP2010265306A/ja active Pending
-
2011
- 2011-04-18 JP JP2011092035A patent/JP2011168609A/ja not_active Withdrawn
- 2011-07-15 NO NO20111028A patent/NO20111028L/no not_active Application Discontinuation
- 2011-08-15 US US13/209,565 patent/US20110301158A1/en not_active Abandoned
-
2013
- 2013-12-20 US US14/136,825 patent/USRE45670E1/en not_active Expired - Fee Related
Patent Citations (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3152136A (en) * | 1958-10-30 | 1964-10-06 | Dow Chemical Co | Dinitroaroyl-nu-pyridyl amides |
US3317534A (en) * | 1963-10-30 | 1967-05-02 | Chugai Pharmaceutical Co Ltd | Benzamidopyrimidines |
DE2117807A1 (de) * | 1970-04-15 | 1971-10-28 | Shell Internationale Research Maatschappij N.V., Den Haag (Niederlande) | Carboxamidderivate |
US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
DE2712630A1 (de) * | 1977-03-23 | 1978-09-28 | Bayer Ag | 1,3,4-thiadiazol-2-yl-harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
US4356108A (en) | 1979-12-20 | 1982-10-26 | The Mead Corporation | Encapsulation process |
US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
US5556969A (en) * | 1994-12-07 | 1996-09-17 | Merck Sharp & Dohme Ltd. | Benzodiazepine derivatives |
WO1997009040A1 (en) | 1995-09-08 | 1997-03-13 | Novo Nordisk A/S | 2-alkylpyrrolidines |
WO1997024328A1 (en) * | 1995-12-27 | 1997-07-10 | Bayer Aktiengesellschaft | 2-amino-heterocycles and therapeutic uses therefor |
WO1997026265A1 (en) | 1996-01-17 | 1997-07-24 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
WO1997041120A1 (en) | 1996-07-26 | 1997-11-06 | Dr. Reddy's Research Foundation | Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof |
WO1998008871A1 (en) | 1996-08-30 | 1998-03-05 | Novo Nordisk A/S | Glp-1 derivatives |
WO1997041097A2 (en) | 1996-12-31 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
WO1997041119A1 (en) | 1997-05-02 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
WO1999001423A1 (en) | 1997-07-01 | 1999-01-14 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
WO1999003861A1 (en) | 1997-07-16 | 1999-01-28 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
WO1999019313A1 (en) | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
WO1999024035A1 (en) * | 1997-11-10 | 1999-05-20 | Bristol-Myers Squibb Company | Benzothiazole protein tyrosine kinase inhibitors |
WO1998045292A1 (en) | 1997-12-02 | 1998-10-15 | Dr. Reddy's Research Foundation | Thiazolidinedione and oxazolidinedione derivatives having antidiabetic, hypolipidaemic and antihypertensive properties |
WO1999032111A1 (en) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
WO1999032106A1 (en) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | Inhibition of raf kinase using substituted heterocyclic ureas |
WO2000023445A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023417A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023415A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023416A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023425A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000023451A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000037474A1 (en) | 1998-12-18 | 2000-06-29 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
WO2000039088A1 (en) | 1998-12-23 | 2000-07-06 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
WO2000041121A1 (en) | 1999-01-07 | 2000-07-13 | Ccrewards.Com | Method and arrangement for issuance and management of digital coupons and sales offers |
WO2000042026A1 (en) | 1999-01-15 | 2000-07-20 | Novo Nordisk A/S | Non-peptide glp-1 agonists |
WO2000042023A1 (en) | 1999-01-18 | 2000-07-20 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
WO2000050414A1 (en) | 1999-02-24 | 2000-08-31 | Dr.Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical composition containing them |
WO2000058293A2 (en) | 1999-03-29 | 2000-10-05 | F. Hoffmann-La Roche Ag | Glucokinase activators |
WO2000063208A1 (en) | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
WO2000063192A1 (en) | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and pharmaceutical compositions containing them |
WO2000063193A1 (en) | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
WO2000063189A1 (en) | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Crystalline r- guanidines, arginine or (l) -arginine (2s) -2- ethoxy -3-{4- [2-(10h -phenoxazin -10-yl)ethoxy]phenyl}propanoate |
WO2000063191A1 (en) | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
WO2000063196A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000063209A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000063190A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000063153A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
WO2000064884A1 (en) | 1999-04-26 | 2000-11-02 | Novo Nordisk A/S | Piperidyl-imidazole derivatives, their preparations and therapeutic uses |
EP1211246A1 (en) * | 1999-09-09 | 2002-06-05 | Kumiai Chemical Industry Co., Ltd. | Pyrimidine derivatives and herbicides containing the same |
WO2001044216A1 (en) | 1999-12-15 | 2001-06-21 | F. Hoffmann-La Roche Ag | Trans olefinic glucokinase activators |
WO2001057008A1 (en) * | 2000-02-07 | 2001-08-09 | Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
WO2001083465A2 (en) | 2000-05-03 | 2001-11-08 | F. Hoffmann-La Roche Ag | Alkynyl phenyl heteroaromatic glucokinase activators |
WO2001083478A2 (en) | 2000-05-03 | 2001-11-08 | F. Hoffmann-La Roche Ag | Hydantoin-containing glucokinase activators |
WO2001085707A1 (en) | 2000-05-08 | 2001-11-15 | F. Hoffmann-La Roche Ag | Para-amine substituted phenylamide glucokinase activators |
WO2001085706A1 (en) | 2000-05-08 | 2001-11-15 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
WO2002008209A1 (en) | 2000-07-20 | 2002-01-31 | F. Hoffmann-La Roche Ag | Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators |
WO2002014311A2 (en) * | 2000-08-15 | 2002-02-21 | Amgen Inc. | Urea compounds and methods of uses |
WO2002046173A1 (en) * | 2000-12-06 | 2002-06-13 | F. Hoffmann-La Roche Ag | Fused heteroaromatic glucokinase activators |
WO2002070494A1 (en) * | 2001-03-02 | 2002-09-12 | Icos Corporation | Aryl and heteroaryl urea chk1 inhibitors for use as radiosensitizers and chamosensitizers |
WO2003055482A1 (en) * | 2001-12-21 | 2003-07-10 | Novo Nordisk A/S | Amide derivatives as gk activators |
WO2003070727A1 (en) * | 2002-02-15 | 2003-08-28 | Amgen Inc. | Thiazolyl urea compounds for the treatment of cancer |
Non-Patent Citations (25)
Title |
---|
"Ann Intern Med", vol. 103, 1985, NIH, pages: 147 |
"Remington: The Science and Practice of Pharmacy", 1995, MACK PUBLISHING CO. |
"Report of the Expert Committee of the Diagnosis and Classification of Diabetes Mellitus", DIABETES CARE, vol. 20, 1997, pages 1183 - 1197 |
AGIUS, L. ET AL., BIOCHEM J., vol. 266, 1990, pages 91 - 102 |
ASFARI M ET AL., ENDOCRINOLOGY, vol. 130, 1992, pages 167 - 178 |
ATWAL ET AL: "Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 4. Structure-Activity Studies on Benzopyranylcyanoguanidines: Replacement of the Benzopyran Portion", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, no. 1, January 1996 (1996-01-01), pages 304 - 313, XP002116120, ISSN: 0022-2623 * |
GIRARD, J. ET AL., ANNU REV NUTR, vol. 17, 1997, pages 325 - 352 |
GROMADA, J. ET AL., PF UGERS ARCH, vol. 435, 1998, pages 583 - 594 |
J. W. BARTON: "Protective Groups In Organic Chemistry", 1973, PLENUM PRESS |
JACKEROTT, M. ET AL., DIABETOLOGIA, vol. 45, 2002, pages 1292 - 1297 |
JETTON, T.L. ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 3641 - 3654 |
KIEFFER, T.J. ET AL., AM J PHYSIOL, vol. 267, 1994, pages E489 - E496 |
KURATA, K. ET AL., METABOLISM: CLINICAL & EXPERIMENTAL, vol. 38, 1989, pages 46 - 51 |
KURATA, K. ET AL., PHYSIOLOGY & BEHAVIOR, vol. 37, 1986, pages 615 - 20 |
LEVIN, B. E. ET AL., BRAIN RESEARCH, vol. 808, 1998, pages 317 - 9 |
LIU, M. ET AL., J. NEUROSCI., vol. 19, 1999, pages 10305 - 10317 |
MANN GV N.ENGI.J.MED, vol. 291, 1974, pages 226 |
MOBBS, C. V. ET AL.: "Endocrinology & Metabolism", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 281, 2001, pages E649 - 54 |
MORRAL, N. ET AL., HUMAN GENE THERAPY, vol. L3, 2002, pages 1561 - 1570 |
PURCHASE C F ET AL: "Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 6, no. 15, 6 August 1996 (1996-08-06), pages 1753 - 1758, XP004135596, ISSN: 0960-894X * |
REGEL E ET AL: "C-ACYLIERUNG VON 5 GLIEDRIGEN N-HETEROCYCLEN, I ACYLIERUNG AN C-2 VON IMIDAZOLEN UND BENZIMIDAZOLEN C-ACYLATION OF 5-MEMBERED N-HETEROCYCLES, I. - ACYLATION AT C-2 OF IMIDAZOLES AND BENZIMIDAZOLES", JUSTUS LIEBIGS ANNALEN DER CHEMIE, VERLAG CHEMIE GMBH. WEINHEIM, DE, 1977, pages 145 - 158, XP009003467, ISSN: 0075-4617 * |
REIMANN, F. ET AL., DIABETES, vol. 51, 2002, pages 2757 - 2763 |
SPANSWICK, D. ET AL., NATURE NEUROSCIENCE, vol. 3, 2000, pages 757 - 8 |
T. W. GREENE: "Protective Groups in Organic Synthesis", 1981, JOHN WILEY AND SONS |
WHITE A D ET AL: "HETEROCYCLIC UREAS: INHIBITORS OF ACYL-COA:CHOLESTEROL O-ACYLTRANSFERASE AS HYPOCHOLESTEROLEMIC AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, no. 22, 25 October 1996 (1996-10-25), pages 4382 - 4395, XP002918005, ISSN: 0022-2623 * |
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US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
US8765764B2 (en) | 2002-01-18 | 2014-07-01 | Astellas Pharma, Inc. | 2-acylaminothiazole derivative or salt thereof |
US7638536B2 (en) | 2002-01-18 | 2009-12-29 | Astellas Pharma Inc. | 2-Acylaminothiazole derivative or salt thereof |
US8338429B2 (en) | 2002-01-18 | 2012-12-25 | Astellas Pharma, Inc. | 2-acylaminothiazole derivative or salt thereof |
US7812167B2 (en) | 2002-10-03 | 2010-10-12 | Novartis, Ag | Substituted (thiazol-2-yl)-amides or sulfonamides as glucokinase activators useful in the treatment of type 2 diabetes |
US7230108B2 (en) | 2002-11-19 | 2007-06-12 | Astrazeneca Ab | Quinoline derivatives as glucokinase ligands |
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US7491826B2 (en) | 2003-01-14 | 2009-02-17 | Cytokinetics, Inc. | Compounds, compositions and methods |
US7399866B2 (en) | 2003-01-14 | 2008-07-15 | Cytokinetics, Inc. | Compounds, compositions, and methods |
US7214681B2 (en) | 2003-02-11 | 2007-05-08 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
WO2004085433A2 (en) * | 2003-03-28 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Positive allosteric modulators of the nicotinic acetylcholine receptor |
WO2004085433A3 (en) * | 2003-03-28 | 2004-12-16 | Upjohn Co | Positive allosteric modulators of the nicotinic acetylcholine receptor |
JP2007508238A (ja) * | 2003-07-07 | 2007-04-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | マロンアミド誘導体 |
JP4750701B2 (ja) * | 2003-07-07 | 2011-08-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | マロンアミド誘導体 |
US7432281B2 (en) | 2003-10-07 | 2008-10-07 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
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US7598391B2 (en) | 2004-01-06 | 2009-10-06 | Novo Nordisk A/S | Heteroaryl-ureas and their use as glucokinase activators |
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US7750020B2 (en) | 2004-04-02 | 2010-07-06 | Novartis Ag | Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of Type 2 diabetes |
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US8110595B2 (en) | 2004-06-17 | 2012-02-07 | Cytokinetics, Inc. | Ureas and their use in the treatment of heart failure |
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US8101617B2 (en) | 2004-06-17 | 2012-01-24 | Amgen, Inc. | Disubstituted ureas and uses thereof in treating heart failure |
US8871769B2 (en) | 2004-06-17 | 2014-10-28 | Cytokinetics, Inc. | Ureas and their use in the treatment of heart failure |
US10035770B2 (en) | 2004-06-17 | 2018-07-31 | Cytokinetics, Incorporated | Compounds, compositions and methods |
US9150564B2 (en) | 2004-06-17 | 2015-10-06 | Cytokinetics, Inc. | Compounds, compositions and methods |
US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
US7410988B2 (en) | 2004-08-13 | 2008-08-12 | Genentech, Inc. | 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
US7795290B2 (en) | 2004-08-13 | 2010-09-14 | Genentech, Inc. | 2-amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
US8148412B2 (en) | 2004-12-03 | 2012-04-03 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
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US7645778B2 (en) | 2005-01-19 | 2010-01-12 | Bristol-Myers Squibb Company | Heteroaryl compounds as P2Y1 receptor inhibitors |
WO2006137527A1 (ja) | 2005-06-23 | 2006-12-28 | Kyowa Hakko Kogyo Co., Ltd. | チアゾール誘導体 |
US7714002B2 (en) | 2005-06-27 | 2010-05-11 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
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US7816382B2 (en) | 2005-06-27 | 2010-10-19 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition |
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US7582769B2 (en) | 2005-07-08 | 2009-09-01 | Novo Nordisk A/S | Dicycloalkyl urea glucokinase activators |
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WO2007007041A1 (en) | 2005-07-09 | 2007-01-18 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
EP2305674A1 (en) | 2005-07-09 | 2011-04-06 | AstraZeneca AB | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
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WO2007006814A1 (en) | 2005-07-14 | 2007-01-18 | Novo Nordisk A/S | Urea glucokinase activators |
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WO2007009578A1 (de) * | 2005-07-15 | 2007-01-25 | Bayer Healthcare Ag | Heterocyclylamid-substituierte thiazole, pyrrole und thiophene |
AU2006272059B2 (en) * | 2005-07-15 | 2012-05-17 | Aicuris Gmbh & Co. Kg | Heterocyclylamide-substituted thiazoles, pyrroles and thiophenes |
KR101352646B1 (ko) | 2005-07-15 | 2014-01-16 | 아이쿠리스 게엠베하 운트 코. 카게 | 헤테로시클릴아미드-치환된 티아졸, 피롤 및 티오펜 |
US8410090B2 (en) | 2005-07-15 | 2013-04-02 | Aicuris Gmbh & Co. Kg | Heterocyclylamide-substituted thiazoles, pyrroles and thiophenes |
US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
US8124617B2 (en) | 2005-09-01 | 2012-02-28 | Takeda San Diego, Inc. | Imidazopyridine compounds |
WO2007039177A2 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
US7795257B2 (en) | 2005-09-30 | 2010-09-14 | Novartis Ag | Organic compounds |
US8252931B2 (en) | 2005-09-30 | 2012-08-28 | Novartis Ag | Thiazolo[5,4-B]pyridine glucokinase activators |
US8871768B2 (en) | 2005-12-15 | 2014-10-28 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
US8445495B2 (en) | 2005-12-15 | 2013-05-21 | Cytokinetics, Inc. | Certain Chemical entities, compositions and methods |
US7718657B2 (en) | 2005-12-16 | 2010-05-18 | Cytokinetics, Inc. | Certain indanyl urea modulators of the cardiac sarcomere |
US8653081B2 (en) | 2005-12-16 | 2014-02-18 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
US8410108B2 (en) | 2005-12-16 | 2013-04-02 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
US7989455B2 (en) | 2005-12-19 | 2011-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
US8034822B2 (en) | 2006-03-08 | 2011-10-11 | Takeda San Diego, Inc. | Glucokinase activators |
US8211925B2 (en) | 2006-04-28 | 2012-07-03 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
EP2351568A2 (de) | 2006-05-04 | 2011-08-03 | Boehringer Ingelheim International GmbH | Verwendungen von dpp iv Inhibitoren |
WO2007128761A2 (de) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Verwendungen von dpp iv inhibitoren |
US8008332B2 (en) | 2006-05-31 | 2011-08-30 | Takeda San Diego, Inc. | Substituted indazoles as glucokinase activators |
US8394843B2 (en) | 2006-05-31 | 2013-03-12 | Takeda California, Inc. | Substituted isoindoles as glucokinase activators |
US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US8492405B2 (en) | 2006-10-18 | 2013-07-23 | Takeda Pharmaceutical Company Limited | Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity |
EP2272834A1 (en) | 2006-10-26 | 2011-01-12 | AstraZeneca AB | Benzoyl amino heterocyclyl compounds as glucokinase (GLK) activators |
US9732080B2 (en) | 2006-11-03 | 2017-08-15 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
WO2008084043A1 (en) * | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
WO2008084044A1 (en) | 2007-01-11 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
US8940900B2 (en) | 2007-02-28 | 2015-01-27 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
WO2008104994A2 (en) | 2007-02-28 | 2008-09-04 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
WO2008149382A1 (en) | 2007-06-08 | 2008-12-11 | Advinus Therapeutics Private Limited | Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application |
WO2009127546A1 (en) | 2008-04-16 | 2009-10-22 | F. Hoffmann-La Roche Ag | Pyrrolidinone glucokinase activators |
US8563730B2 (en) | 2008-05-16 | 2013-10-22 | Takeda San Diego, Inc. | Pyrazole and fused pyrazole glucokinase activators |
US9139598B2 (en) | 2008-05-16 | 2015-09-22 | Takeda California, Inc. | Glucokinase activators |
US8541588B2 (en) | 2009-01-12 | 2013-09-24 | Pfizer Limited | Sulfonamide derivatives |
US8907101B2 (en) | 2009-01-12 | 2014-12-09 | Pfizer Limited | Sulfonamide derivatives |
WO2011080755A1 (en) | 2009-12-29 | 2011-07-07 | Advinus Therapeutics Private Limited | Fused nitrogen heterocyclic compounds, process of preparation and uses thereof |
WO2011095997A1 (en) | 2010-02-08 | 2011-08-11 | Advinus Therapeutics Private Limited | Benzamide compounds as glucokinase activators and their pharmaceutical application |
US10081621B2 (en) | 2010-03-25 | 2018-09-25 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
WO2011130459A1 (en) | 2010-04-14 | 2011-10-20 | Bristol-Myers Squibb Company | Novel glucokinase activators and methods of using same |
US10071979B2 (en) | 2010-04-22 | 2018-09-11 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
US9855251B2 (en) | 2010-05-26 | 2018-01-02 | Vtv Therapeutics Llc | Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator |
US10064846B2 (en) | 2010-05-26 | 2018-09-04 | Vtv Therapeutics Llc | Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator |
US10363244B2 (en) | 2010-05-26 | 2019-07-30 | Vtv Therapeutics Llc | Compositions comprising metformin and a glucokinase activator |
US9359313B2 (en) | 2010-05-26 | 2016-06-07 | Vtv Therapeutics Llc | Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator |
WO2011157682A1 (en) | 2010-06-17 | 2011-12-22 | F. Hoffmann-La Roche Ag | 3-oxo-3,9-dihydro-1h-chromeno[2,3-c]pyrroles as glucokinase activators |
EP2402327A1 (en) | 2010-06-29 | 2012-01-04 | Advinus Therapeutics Private Limited | Acetamide compounds as glucokinase activators, their process and medicinal applications |
US9145407B2 (en) | 2010-07-09 | 2015-09-29 | Pfizer Limited | Sulfonamide compounds |
WO2012051450A1 (en) | 2010-10-13 | 2012-04-19 | Takeda Pharmaceutical Company Limited | Method of making azaindazole derivatives |
US9056834B2 (en) | 2010-12-23 | 2015-06-16 | Pfizer Inc. | Glucagon receptor modulators |
US8933104B2 (en) | 2010-12-23 | 2015-01-13 | Pfizer Inc. | Glucagon receptor modulators |
US8809342B2 (en) | 2010-12-23 | 2014-08-19 | Pfizer Inc. | Glucagon receptor modulators |
US9452999B2 (en) | 2011-02-08 | 2016-09-27 | Pfizer Inc. | Glucagon receptor modulators |
US9073871B2 (en) | 2011-02-08 | 2015-07-07 | Pfizer Inc. | Glucagon receptor modulators |
US8859591B2 (en) | 2011-02-08 | 2014-10-14 | Pfizer Inc. | Glucagon receptor modulators |
US9139538B2 (en) | 2011-07-22 | 2015-09-22 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
US8927577B2 (en) | 2011-07-22 | 2015-01-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
US9724347B2 (en) | 2011-10-03 | 2017-08-08 | Respivert, Ltd. | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP knase inhibitors |
US10738032B2 (en) | 2011-10-03 | 2020-08-11 | Respivert Limited | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-i-yl) ureas as P38 mapkinase inhibitors |
US9993478B2 (en) | 2011-10-03 | 2018-06-12 | Respivert, Ltd. | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors |
US10813932B2 (en) | 2011-10-03 | 2020-10-27 | Respivert Limited | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors |
US9108950B2 (en) | 2011-10-03 | 2015-08-18 | Respivert, Ltd. | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as p38 MAP kinase inhibitors |
US10266519B2 (en) | 2011-10-03 | 2019-04-23 | Respivert Limited | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-I-yl) ureas as P38 mapkinase inhibitors |
US9850231B2 (en) | 2011-10-03 | 2017-12-26 | Respivert Limited | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-I-yl) ureas as P38 mapkinase inhibitors |
US10238658B2 (en) | 2011-10-03 | 2019-03-26 | Respivert Limited | 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as p38 MAP kinase inhibitors |
US9475796B2 (en) | 2011-10-03 | 2016-10-25 | Respivert Limited | 1-pyrazolyl-3-((4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as p38 MAP kinase inhibitors |
US10588943B2 (en) | 2012-05-17 | 2020-03-17 | Vtv Therapeutics Llc | Glucokinase activator compositions for the treatment of diabetes |
US10004782B2 (en) | 2012-05-17 | 2018-06-26 | Vtv Therapeutics Llc | Glucokinase activator compositions for the treatment of diabetes |
WO2014050084A1 (ja) | 2012-09-26 | 2014-04-03 | 興和株式会社 | 新規なフェニルアセトアミド化合物、及びそれを含有する医薬 |
US10301299B2 (en) | 2013-03-14 | 2019-05-28 | Merck Patent Gmbh | Glycosidase inhibitors |
US9879001B2 (en) | 2013-03-14 | 2018-01-30 | Merck Patent Gmbh | Glycosidase inhibitors |
US11634406B2 (en) | 2014-02-14 | 2023-04-25 | Respivert Ltd. | Inhibitor of p38 MAP kinase |
US9884845B2 (en) | 2014-02-14 | 2018-02-06 | Respivert Limited | Pyrazolyl-ureas as kinase inhibitors |
US9624196B2 (en) | 2014-02-14 | 2017-04-18 | Respivert Ltd. | Inhibitor of p38 MAP kinase |
US11142515B2 (en) | 2014-02-14 | 2021-10-12 | Respivert Limited | Pyrazolyl-ureas as kinase inhibitors |
US10815217B2 (en) | 2014-02-14 | 2020-10-27 | Respivert Ltd. | Inhibitor of p38 MAP kinase |
US10045980B2 (en) | 2014-02-14 | 2018-08-14 | Respivert Ltd | Inhibitor of p38 map kinase |
US10294216B2 (en) | 2014-02-14 | 2019-05-21 | Respivert Limited | Pyrazolyl ureas as kinase inhibitors |
US9447076B2 (en) | 2014-02-14 | 2016-09-20 | Respivert Ltd. | Inhibitor of p38 map kinase |
US10206877B2 (en) | 2014-04-15 | 2019-02-19 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
US10336775B2 (en) | 2014-08-28 | 2019-07-02 | Asceneuron Sa | Glycosidase inhibitors |
US11046712B2 (en) | 2014-08-28 | 2021-06-29 | Asceneuron Sa | Glycosidase inhibitors |
US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
US10556902B2 (en) | 2016-02-25 | 2020-02-11 | Asceneuron Sa | Glycosidase inhibitors |
US10696668B2 (en) | 2016-02-25 | 2020-06-30 | Asceneuron Sa | Acid addition salts of piperazine derivatives |
US11612599B2 (en) | 2016-02-25 | 2023-03-28 | Asceneuron Sa | Glycosidase inhibitors |
US11591327B2 (en) | 2016-02-25 | 2023-02-28 | Asceneuron Sa | Acid addition salts of piperazine derivatives |
US10995090B2 (en) | 2016-02-25 | 2021-05-04 | Asceneuron Sa | Substituted dihydrobenzofuran glycosidase inhibitors |
US10815229B1 (en) | 2016-05-20 | 2020-10-27 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
US11299490B2 (en) | 2016-05-20 | 2022-04-12 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
US10246453B2 (en) | 2016-05-20 | 2019-04-02 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
US10662184B2 (en) | 2016-05-20 | 2020-05-26 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
US11174268B2 (en) | 2016-12-09 | 2021-11-16 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compouds and their use as therapeutic agents |
US11213525B2 (en) | 2017-08-24 | 2022-01-04 | Asceneuron Sa | Linear glycosidase inhibitors |
US11690841B2 (en) | 2017-09-14 | 2023-07-04 | Queen Mary University Of London | Glycolysis-activating agents for treatment or prevention of disease |
US11247987B2 (en) | 2017-10-06 | 2022-02-15 | Forma Therapeutics, Inc. | Inhibiting ubiquitin specific peptidase 30 |
US10919911B2 (en) | 2018-04-12 | 2021-02-16 | Terns, Inc. | Tricyclic ASK1 inhibitors |
US11974989B2 (en) | 2018-06-12 | 2024-05-07 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
US11833136B2 (en) | 2018-06-12 | 2023-12-05 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
US11325902B2 (en) | 2018-06-13 | 2022-05-10 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
US10745392B2 (en) | 2018-06-13 | 2020-08-18 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
US11958846B2 (en) | 2018-08-17 | 2024-04-16 | Novartis Ag | Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors |
US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
US10752623B2 (en) | 2018-08-31 | 2020-08-25 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors |
US11639351B2 (en) | 2018-08-31 | 2023-05-02 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents |
US10981905B2 (en) | 2018-08-31 | 2021-04-20 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents |
US11814386B2 (en) | 2018-10-05 | 2023-11-14 | Forma Therapeutics, Inc. | Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors |
US11535618B2 (en) | 2018-10-05 | 2022-12-27 | Forma Therapeutics, Inc. | Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors |
WO2023025854A1 (en) * | 2021-08-25 | 2023-03-02 | Basf Se | Herbicidal malonamides |
US11827610B2 (en) | 2021-09-15 | 2023-11-28 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
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EP1531815A1 (en) | 2005-05-25 |
NO20111028L (no) | 2005-03-29 |
JP4881559B2 (ja) | 2012-02-22 |
US20080119454A1 (en) | 2008-05-22 |
PL374920A1 (en) | 2005-11-14 |
US20080119455A1 (en) | 2008-05-22 |
PL215132B1 (pl) | 2013-10-31 |
IL165532A (en) | 2013-06-27 |
AU2003243921B2 (en) | 2009-05-07 |
US20040122235A1 (en) | 2004-06-24 |
MXPA05000130A (es) | 2005-02-17 |
EP2471533A1 (en) | 2012-07-04 |
CA2744893A1 (en) | 2004-01-08 |
JP2005537333A (ja) | 2005-12-08 |
US7897628B2 (en) | 2011-03-01 |
JP2010265306A (ja) | 2010-11-25 |
US20110301158A1 (en) | 2011-12-08 |
JP2011168609A (ja) | 2011-09-01 |
EP1531815B1 (en) | 2014-09-24 |
IL165532A0 (en) | 2006-01-15 |
US7384967B2 (en) | 2008-06-10 |
CA2488642C (en) | 2011-09-06 |
US8063081B2 (en) | 2011-11-22 |
BR0312023A (pt) | 2005-03-22 |
CA2488642A1 (en) | 2004-01-08 |
KR20050019801A (ko) | 2005-03-03 |
AU2003243921A1 (en) | 2004-01-19 |
KR101116627B1 (ko) | 2012-10-09 |
USRE45670E1 (en) | 2015-09-15 |
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