WO2003070226A1 - Edible pga coating composition - Google Patents

Edible pga coating composition Download PDF

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Publication number
WO2003070226A1
WO2003070226A1 PCT/US2002/013668 US0213668W WO03070226A1 WO 2003070226 A1 WO2003070226 A1 WO 2003070226A1 US 0213668 W US0213668 W US 0213668W WO 03070226 A1 WO03070226 A1 WO 03070226A1
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WO
WIPO (PCT)
Prior art keywords
composition
coating composition
coating
propylene glycol
glycol alginate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/013668
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English (en)
French (fr)
Inventor
Michael Augello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
FMC Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FMC Corp filed Critical FMC Corp
Priority to JP2003569184A priority Critical patent/JP2005526039A/ja
Priority to IL16350702A priority patent/IL163507A0/xx
Priority to EP02806866A priority patent/EP1474113A4/en
Priority to AU2002367695A priority patent/AU2002367695A1/en
Publication of WO2003070226A1 publication Critical patent/WO2003070226A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/343—Products for covering, coating, finishing, decorating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/105—Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
    • C09D105/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
    • C09D105/06—Pectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/284—Alkyl ethers with hydroxylated hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/02—Starch; Degradation products thereof, e.g. dextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Definitions

  • This invention relates to edible, hardenable prompt release coating compositions comprising a film forming amount of low viscosity propylene glycol alginate that serves as the principle, primary or sole film former of the coating composition.
  • the coatings of the present invention can be applied to pharmaceutical, including neutraceutical, and veterinary solid dosage forms, solid substrates such as seeds, animal feed, fertilizers, pesticide tablets and granules, and also to confectionery and foods. They are readily dispersed in aqueous media, and, when applied as a coating, provide high lustre coatings which do not retard or extend release of active ingredient from a coated substrate.
  • a pharmaceutical or veterinary tablet coating Another very important function of a pharmaceutical or veterinary tablet coating is to improve the integrity of the tablet itself. Uncoated tablets are often subject to being abraded or chipped, causing a loss of active ingredient in the process. More dramatically, they may break into two or more pieces. One measure of a useful coating is its ability to prevent any of these physical degradations of tablet structure. The effectiveness of a coating material to prevent abrading, chipping, or breakage of the tablet is determined by friability testing. Confectionery and foods may be coated with a formulation to preserve the confection or food from deteriorating by contact with the oxygen and the moisture in the atmosphere. Coatings also can provide improved appearance and desirable organoleptic properties to the food as well as preventing loss of flavor.
  • Seeds may be coated to preserve the viability of the seeds by protecting against moisture. They may also be coated as a means for increasing particle size to facilitate mechanical planting.
  • a dye can be included in the coating formulation to identify the seeds as to quality, type, or some other designation.
  • a pesticide e.g., a fungicide
  • this coating must not decrease the viability of the seeds or interfere with germination when the seeds are planted in the soil.
  • Animal feed may be coated to improve its flowability, appearance and its resistance to powdering or dusting.
  • the coating may be formulated to include vitamins, hormones, antibiotics, or the like, to benefit the livestock which will consume the feed.
  • Fertilizers in either granular or tableted forms, may be coated to retain the integrity of the form and, especially, to protect the fertilizer from moisture which can cause agglomeration during storage, which could make rapid, even application to the soil difficult or inconvenient.
  • Coating of tableted pesticide formulations serves to maintain the integrity of the tablets or granules until they are placed in water where they rapidly disintegrate, forming a solution or slurry to be applied to the soil or plants.
  • a second, and equally important, function of the coatings on tablets containing pesticides is to prevent human contact with the pesticide, thereby increasing safety for those handling and applying the pesticide.
  • the film former In the preparation of a coating formulation to be sprayed, the film former is usually dissolved or dispersed in a solvent, for example, water, along with the other ingredients of the formulation.
  • a solvent for example, water
  • the coating formulation must frequently be prepared in advance of the time it is to be applied to the tablets. A common procedure is to prepare these coating formulations the day preceding the coating operation in order to assure adequate hydration of the polymers used in them.
  • a particular disadvantage of coatings based primarily on HPMC is that the coating may harden over time and therefore increase tablet disintegration times.
  • An increase in disintegration time delays the bioavailability of the active ingredient at least in proportion to the increase in disintegration time.
  • Many other agents commonly used in coating compositions are also known to delay release of pharmaceutical agents, such as enteric coatings which use polymeric film forming materials which are insoluble in water, or gastric fluid, some of these being specifically selected to by-pass both the stomach and small intestine and provide colonic release.
  • the coatings of this invention meet U.S. Pharmacopoeia standards for rapid or immediate dissolution (U.S.P. monograph 23) of active ingredients from tablets or other solid dosage forms coated with them. They provide prompt release or dissolution consistent with the release rates which is normally obtained with the uncoated tablets or other substrates. Thus, they do not adversely impact or retard release of active ingredients from a substrate coated with them. Further, the coatings of this invention are readily dispersed and rapidly hydrated in aqueous media for application to a coating substrate, and provide elegant coatings which have all the benefits of coatings now in commercial use without the drawbacks that are common to them.
  • a coating composition which comprises a low viscosity propylene glycol alginate as the principle or only film-forming component of the coating composition, optionally in combination with a surface active agent.
  • the coating composition of the present invention utilizes as the primary film former a low viscosity propylene glycol alginate (PGA), a 1% aqueous solution of which has a viscosity in the range of about 1 to 500 mPa-s at 25 °C.
  • the PGA is used in combination with a surface active agent.
  • less than 2% by dry weight of a surface active agent is present in the coating compositions.
  • the coating compositions optionally contain additional ingredients such as a filler, a plasticizer, a coloring agent, or combination of these, and may also contain a small amount of a secondary film former and/or a strengthening polymer as an additional ingredient. More specifically, the present invention provides prompt release, edible, hardenable PGA coating compositions, as well as dry coatings and aqueous dispersions thereof and solid dosage forms coated therewith.
  • the term “edible” is intended to mean food or pharmaceutical grade materials which are approved by regulatory authorities for use in pharmaceutical or food applications.
  • the term “hardenable,” used to describe the coating compositions of this invention is intended to include only those coating compositions that are capable of being dried from an aqueous solution or dispersion thereof into a solid coating which resists abrasive forces, i.e. a hardened coating, as distinguished from those "enrobing" coatings on confections which set up into a soft coating that can be handled and packaged but which do not resist abrasive forces significantly.
  • immediate means that the coatings of this invention meet U.S. Pharmacopoeia standards (U.S.P. monograph 23) for rapid or immediate dissolution of active ingredients from tablets or other solid dosage forms coated with them.
  • U.S. Pharmacopoeia standards U.S.P. monograph 23
  • they provide prompt release or dissolution consistent with the release rates that are normally obtained with uncoated tablets or other substrate. They do not, when placed in water or ingested, adversely impact or retard release or dissolution of tablets or other dosage forms coated with them.
  • Coatings made in accordance with the present invention are substantially or completely disintegrated and/or dissolved within less than 10 minutes after being ingested or placed in aqueous media. These definitions are intended to apply throughout this application unless a contrary meaning is clearly indicated.
  • Propylene glycol alginate provides important film-forming characteristics required to provide an elegant coating which is particularly useful in, for example, coating pharmaceutical and veterinary tablets, caplets, granules, and spheres which contain active ingredients which require release promptly after being placed in aqueous media or ingested.
  • Propylene glycol alginate by itself is known to be a film forming hydrocolloid when an aqueous dispersion thereof is spread on a surface and allowed to dry.
  • the film has heretofore been considered to be too weak for satisfactory coatings.
  • a low viscosity propylene glycol alginate is utilized in high concentrations in combination with a suitable surface active agent, elegant, high performance coating formulations are provided which may readily be applied as an aqueous suspension to coating substrates.
  • a low viscosity propylene glycol alginate may also be used in high concentrations in the absence of a surface active agent to provide elegant, high performance coating formulations.
  • the propylene glycol alginate used in the present invention is a low viscosity propylene glycol alginate which, when present at 1% in water at 25°C produces a aqueous solution having a viscosity in the range of about 1 to 500 mPa-s. It has been found that PGA having a viscosity substantially above about 500 mPa-s is difficult to formulate into suitable coatings, requires numerous additives to produce satisfactory coatings, and tends to be too viscous for practical application to materials to be coated. Low viscosity propylene glycol alginate is commercially available as Profoam® from Pronova and as Duckloid SLF-3 from Kibun.
  • the low viscosity propylene glycol alginate is employed in the coating compositions at about 91%) to about 100% by dry weight of the composition. In other embodiments of the invention, the low viscosity propylene glycol alginate is employed in the coating compositions at about 55%> to about 100% by dry weight of the composition, and less than 2% by dry weight of a surfactant is present in the compositions.
  • Surfactants which are either anionic or nonionic may be used beneficially in the edible, hardenable coating compositions of the present invention.
  • Useful surfactants may be, for example, sodium lauryl sulfate, hydroxylated soy lecithin (lecithin), polysorbates, and block copolymers of propylene oxide and ethylene oxide.
  • Such surface active agents may be employed at up to about 9% by dry weight of the composition.
  • Surfactants such as lecithin assist in redispersion of the dry composition and improving flowability of the coating composition during application, assuring a smooth even coating.
  • the balance of the compositions may comprise certain adjuvants that are commonly utilized in coating compositions, including fillers and/or pigments for colored coatings, and may include a minor amount of secondary film former such as carrageenan or HPMC and/or a strengthening polymer such as hydroxyethylcellulose.
  • Fillers suitable for use in the compositions of the invention include, for example, calcium carbonate, dicalcium phosphate and carbohydrates, such as starch, maltodextrin, lactose, mannitol and other sugars, croscarmellose sodium, or microcrystalline cellulose. Of these, maltodextrin has been found beneficial at up to about 9% by dry weight of the composition, but the other fillers may be used at these levels.
  • Coloring agents and opacifiers may be used in these coating compositions or added to a suspension thereof, including aluminum lakes, insoluble pigments, water-soluble dyes, titanium dioxide, and talc. Such coloring agents may be suitably employed at about 5% up to about 9% by dry weight of the composition. In general such coloring agents may be utilized in addition to or in lieu of a filler. As further illustrated in the examples below, the combined amount of filler and coloring agent may suitably be in the range of up to about 9% by dry weight of the composition. It is also contemplated that certain other additives may be included in or added to the compositions of this invention.
  • a secondary film former such as carrageenan and/or a strengthening polymer such as hydroxyethylcellulose. While such additional additives are generally not required, they may be utilized if desired at about 3% up to about 9% by dry weight of the composition.
  • a small amount of stearic acid or a salt or ester thereof, and/or a conventional plasticizer may also be included at these levels to increase gloss elasticity of the coating, but may be added at other levels as well.
  • Suitable plasticizers include, for example, polyethylene glycol, triacetin, dibutyl sebacate, propylene glycol, sorbitol, glycerin, and triethyl citrate.
  • a coating formulation of this invention may be sold as a dry powder formulation or as a ready-to-use dispersion in water.
  • aqueous dispersions it is preferred that these be prepared under aseptic conditions. Heating the water to an elevated temperature, for example, 85°C, prior to preparation of the dispersion has shown that bacteria, mold, and yeast growth are prevented for at least 48 hours on agar pour plates. Therefore, if the containers for the dispersion are properly sanitized and then kept closed after being filled until the dispersion is used, there is little likelihood of bacteria, mold, or yeast growing in the dispersion.
  • a preservative may be added. A combination of methyl paraben and propyl has been found to be useful in this regard.
  • one embodiment of the composition of this invention comprises from 91% to 100% of said propylene glycol alginate, 2% to 9% lecithin, and 1% to 9% maltodextrin.
  • a second embodiment comprises from about 91 > to 100%) of propylene glycol alginate, 2% to 9% lecithin, and 5% to 9% pigment.
  • Either embodiment may further comprise from 3% to about 9% by dry weight of the composition of a secondary film forming polymer such as carrageenan or a strengthening polymer such as hydroxyethylcellulose.
  • Preservatives, such as methyl paraben at 0.75% to 1.50% and/or propyl paraben at 0.075% to 0.15% may also be present in the formulation.
  • compositions of propylene glycol alginate and less than 2% by dry weight of surfactant comprise from about 55% to about 100% by dry weight of the composition of propylene glycol alginate and less than 2% by dry weight of surfactant, and may comprise a secondary film forming polymer, a strengthening polymer, a plasticizer, one or more fillers, one or more pigments, and one or more preservatives.
  • a particular embodiment of this invention comprises 60% to 15% propylene glycol alginate and 30% to 45% plasticizer, and, more preferably, 65% propylene glycol alginate and 35% plasticizer.
  • the viscosity of the hydrated formulation can be important. It ideally should be low enough to be pumped to a spray unit continuously and then sprayed evenly in a useful pattern onto the substrate being coated.
  • a useful concentration of the dry ingredients in water on a weight percentage basis therefore, may be about 6% to about 15%, advantageously 6.5% to 11%, preferably about 8%) to about 11%>.
  • the preferred edible, hardenable, prompt release coating formulations of this invention may generally be prepared and used according to a simple procedure.
  • Propylene glycol alginate and other dry ingredients including, as appropriate for the desired composition, a surface active agent, a filler, a plasticizer, a secondary polymer, and/or preservatives, are dry blended together to a form dry coating composition.
  • Addition of edible coloring agents, for example, a water-soluble dye or a pigment may precede the hydration step required to prepare the final coating formulation. This dry mixture is then added slowly to the vortex of stirred, purified water. Stirring of this mixture is continued for a sufficient period to allow all of the components to be fully hydrated.
  • a water soluble dye or a pigment may also be added, preferably as a dispersion or solution, to the hydrated coating composition.
  • surfactants, and/or plasticizers may also be added at this stage of the process.
  • a simple propeller mixer provides adequate agitation for rapid hydration.
  • the period of hydration may be as short as 0.5 hours. It may, and preferably should, be longer, but more than 3 hours is not believed to be necessary. Hydration can take place at room temperature or at elevated temperatures as high as 65.5°C (150°F), preferably at a temperature about 48.9°C (120°F).
  • any commercial spray coater may be used to apply the coating.
  • useful coaters are Vector High Coaters manufactured by Vector Corporation and Accela- Coat manufactured by Thomas Engineering.
  • Equipment variables which one skilled in the art can manipulate to provide an elegant coating based on propylene glycol alginate, include inlet temperature, outlet temperature, air flow, speed of rotation of the coating pan, and the rate at which the coating formulation is pumped to the coater. It is important that the inlet and outlet temperatures be controlled so that they are high enough to efficiently dry the coating to prevent the tumbling action of the already-coated tablets from damaging the newly-applied coating before more coating is applied to the same tablets.
  • the level of coating applied to pharmaceutical or veterinary dosage forms is preferably between about 0.5% to about 4% by weight of the uncoated dosage form, more preferably about 2% to about 3.5%, by weight of the uncoated dosage form.
  • This level of coating will provide an elegant, serviceable coating to a wide variety of dosage forms. To apply a heavier coating to tablets would not be economical, and it might adversely affect disintegration of the tablets or other properties. Too light a coating would not provide optimal properties normally expected from a coating.
  • the coating level should be about 5% to about 10% by weight of the uncoated confection.
  • Seed coatings should be in the range of about 3% to about 6% by weight of the uncoated seeds.
  • Fertilizers and pesticide tablets and granules benefit from coating of 1% to about 3%, by weight of the uncoated granules or tablets.
  • the coatings of the present invention may be applied successfully to tablets having a wide variety of active ingredients incorporated therein. For example, it has been reported that multivitamin tablets are difficult to coat because of the lipophilic surface properties of the vitamins. Similarly, ibuprofen is a challenging active ingredient to coat. Tablets comprising both of these difficult-to-coat active ingredients may be readily coated with the coating compositions of this invention, providing elegant tablets. Additionally, the coatings have been applied to tablets that have been debased with letters or a logo without bridging which would hide, or even obliterate, the debossed design.
  • a suitably sized V-Blender is charged with 95.0 grams of PGA SLF-3 (Kibun), 2 grams of sucrose (Domino) and 3 grams of Red,#40 blend (Warner Jen inson) and the materials are blended for 15 minutes. Upon discharging, the blend is screened through a #40 mesh screen. The blend is stored at room temperature in a clean, polylined container.
  • a suitably sized stainless steel vessel equipped with a high speed mixer with blade (#3) is charged with 1,011.0 grams of deionezed water. The above-described blend is added to the vortex of the deionized water and mixed at medium-high speed for 1.0 to 1.5 hours.
  • a Vector LDCS 15" coater is charged with 2.0 kilograms of APAP 500 milligram caplets and the caplets are coated utilizing the parameters below.
  • Table 1 The APAP caplet bed is sprayed until a 3%> weight gain or good color uniformity is achieved.
  • the film coated caplets are discharged into a clean polylined container.
  • a suitably sized V-Blender is charged with 98.0 grams of PGA SLF-3 (Kibun), 1 gram of sucrose (Domino) and 1 gram of Red #40 blend (Warner Jenkinson) and the materials are blended for 15 minutes. Upon discharging, the blend is screened through a #40 mesh screen. The blend is stored at room temperature in a clean, polylined container.
  • a Vector LDCS 15" coater is charged with 2.0 kilograms of APAP 500 milligram caplets and the caplets are coated utilizing the parameters below.
  • the APAP caplet bed is sprayed until a 3% weight gain or good color uniformity is achieved.
  • the film coated caplets are discharged into a clean polylined container.
  • a suitably sized V-Blender is charged with 98.0 grams of PGA SLF-3 (Kibun) and 2 grams of Red #40 blend (Warner Jenkinson) and the materials are blended for 15 minutes. Upon discharging, the blend is screened through a #40 mesh screen. The blend is stored at room temperature in a clean, polylined container.
  • a suitably sized stainless steel vessel equipped with a high speed mixer with blade (#3) is charged with 1,011.0 grams of deionezed water.
  • the above-described blend is added to the vortex of the deionized water and mixed at medium-high speed for 1.0 to 1.5 hours.
  • a Vector LDCS 15" coater is charged with 2.0 kilograms of APAP 500 milligram caplets and the caplets are coated utilizing the parameters below. >
  • the APAP caplet bed is sprayed until a 3% weight gain or good color uniformity is achieved.
  • the film coated caplets are discharged into a clean polylined container.
  • a 15" Vector LDCS coater was charged with 2.0 kilograms of Acetaminophen 500 milligram caplets.
  • the coater was operated at an inlet temperature of 73 - 78°C, an outlet temperature of 34 - 39°C, and 13 RPM.
  • a 3% by weight coating based on the weight of the caplets, was applied.
  • the composition of the coating and physical properties of the coated caplets are shown as Example 5 of Table 4, below.
  • Example 6 The composition of the coating and the physical properties of the coated caplets are shown as Example 6 of Table 4, below.
  • Example 7 The composition of the coating and the physical properties of the coated caplets are shown as Example 6 of Table 4, below.

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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
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  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
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PCT/US2002/013668 2002-02-15 2002-04-22 Edible pga coating composition Ceased WO2003070226A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003569184A JP2005526039A (ja) 2002-02-15 2002-04-22 可食性ｐｇａ被覆組成物
IL16350702A IL163507A0 (en) 2002-02-15 2002-04-22 Edible pga coating
EP02806866A EP1474113A4 (en) 2002-02-15 2002-04-22 EDIBLE PGA COATING COMPOSITION
AU2002367695A AU2002367695A1 (en) 2002-02-15 2002-04-22 Edible pga coating composition

Applications Claiming Priority (2)

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US10/077,338 2002-02-15
US10/077,338 US6932861B2 (en) 2000-11-28 2002-02-15 Edible PGA coating composition

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WO2003070226A1 true WO2003070226A1 (en) 2003-08-28

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EP (1) EP1474113A4 (https=)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007073346A1 (en) * 2005-12-23 2007-06-28 Kjell Stenberg Water-soluble films comprising low-viscosity alginates
EP1954770A4 (en) * 2005-11-29 2012-10-31 Ideal Cures Pvt Ltd AQUEOUS FILM COATING COMPOSITION WITH SODIUM ALGINATE AND ITS PRODUCTION
US10172853B2 (en) 2007-02-11 2019-01-08 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US7910641B2 (en) * 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8518471B2 (en) * 2003-01-21 2013-08-27 Lw Global, Llc Pan spray formulation and delivery system
US7550197B2 (en) 2003-08-14 2009-06-23 Jds Uniphase Corporation Non-toxic flakes for authentication of pharmaceutical articles
US20050075432A1 (en) * 2003-10-07 2005-04-07 Verrall Andrew P. Acidulent film and method of making same
US8469036B2 (en) 2003-11-07 2013-06-25 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
EP1799050A1 (en) * 2004-10-14 2007-06-27 Givaudan SA Formulations for liquid coatings to deliver flavor to food products
CN1331771C (zh) * 2004-11-15 2007-08-15 抚顺华美水处理制剂有限公司 水处理除氯片及其制备方法
JP2009521532A (ja) * 2005-12-27 2009-06-04 モノソル アールエックス リミテッド ライアビリティ カンパニー 活性物質を放出するための、ｐＨ調節されたフィルム
MX2008013507A (es) * 2006-04-21 2008-10-28 Cadbury Adams Usa Llc Composiciones de recubrimiento, composiciones de confiteria y goma de mascar y metodos.
GB2456212B (en) * 2008-01-09 2012-04-25 Lrc Products Lubricant mousse
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
KR20230137362A (ko) 2016-05-05 2023-10-04 어퀘스티브 테라퓨틱스, 아이엔씨. 강화된 전달 에프네프린 조성물
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
EP4422607A4 (en) 2021-10-25 2025-09-03 Aquestive Therapeutics Inc ORAL AND NASAL COMPOSITIONS AND METHODS OF TREATMENT

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725441A (en) * 1984-07-24 1988-02-16 Colorcon, Inc. Maltodextrin coating
US5082684A (en) * 1990-02-05 1992-01-21 Pfizer Inc. Low-calorie fat substitute

Family Cites Families (291)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2134714A (en) 1936-11-25 1938-11-01 Jacob A Glassman Saccharine-aspirin tablet
US2494912A (en) * 1947-01-20 1950-01-17 Kelco Co Higher alkylene glycol esters of alginic acid
GB734414A (en) 1951-05-08 1955-08-03 Hercules Powder Co Ltd Improvements in or relating to preparation and use of finely-divided cellulose esters, ethers and mixed ether-esters
US2881085A (en) 1953-11-09 1959-04-07 Abbott Lab Thin film coating for tablets and the like
US3251824A (en) * 1961-08-22 1966-05-17 Fmc Corp Method of preparing stable aqueous dispersion-forming cellulosic aggregates
US3149039A (en) 1961-10-03 1964-09-15 Dow Chemical Co Thin film coating for tablets and the like and method of coating
US3149040A (en) 1962-04-09 1964-09-15 Dow Chemical Co Thin film coating for tablets and the like and method of coating
US3297535A (en) 1963-02-28 1967-01-10 Hoffmann La Roche Shellac tablet coating compositions and methods of preparation
US3407157A (en) 1965-05-19 1968-10-22 Hoffmann La Roche Tablet coating compositions comprising methyl vinyl ethermaleic anhydride copolymer,plasticizer and surface active agent
US3438797A (en) 1965-10-21 1969-04-15 Jerry Allen Biddle Sr Method of preparing pharmaceutical tablets
GB1135856A (en) * 1966-09-08 1968-12-04 Alginate Ind Ltd A method of modifying alkylene glycol alginates
US3573058A (en) 1967-01-30 1971-03-30 Swift & Co Microcrystalline cellulose compositions co-dried with hydrocolloids
US3576663A (en) 1967-05-29 1971-04-27 Colorcon Coated tablet
US4060598A (en) 1967-06-28 1977-11-29 Boehringer Mannheim G.M.B.H. Tablets coated with aqueous resin dispersions
US3935326A (en) 1967-06-28 1976-01-27 Boehringer Mannheim G.M.B.H. Process for coating tablets with aqueous resin dispersions
US3981984A (en) 1968-04-01 1976-09-21 Colorcon Incorporated Color film coating of tablets and the like
US3649302A (en) * 1969-11-10 1972-03-14 Cpc International Inc Process of producing a ready-to-spread frosting
DE2010416B2 (de) 1970-03-05 1979-03-29 Hoechst Ag, 6000 Frankfurt Oral anwendbare Arzneiform mit Retardwirkung
US3751277A (en) 1971-03-24 1973-08-07 Dow Chemical Co Tablet coating process and composition
US3906086A (en) 1971-07-19 1975-09-16 Richard G Powers Timed-release aspirin
US4009131A (en) 1972-01-17 1977-02-22 The Lubrizol Corporation Powder coating compositions and metal objects coated therewith
US3957966A (en) 1972-05-19 1976-05-18 Gaf Corporation Stabilized vitamin food coatings
BE791458A (fr) 1972-07-31 1973-05-16 Merck & Co Inc Produit microencapsule
US3851574A (en) 1972-12-26 1974-12-03 Pillsbury Co Heat and moisture activated savory coating system for popcorn
FR2211213B1 (https=) 1972-12-26 1976-04-23 Montagne Noire Prod Chim
DE2305023A1 (de) 1973-02-02 1974-08-08 Basf Ag Mattierungsmittel fuer lacke
US3873694A (en) 1973-09-27 1975-03-25 Cpc International Inc Direct compression tabletting composition and pharmaceutical tablets produced therefrom
DE2522493A1 (de) 1974-05-22 1975-12-04 Cabot Corp Oxydationsbestaendige eisenlegierung
DK152371C (da) 1975-01-08 1988-07-25 Ciba Geigy Ag Organisk pigmentpraeparat
US4112215A (en) 1975-03-20 1978-09-05 Rohm Gmbh Copolymeric resin binder powders
JPS51123815U (https=) 1975-04-02 1976-10-07
DE2522483C2 (de) 1975-05-21 1984-06-28 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von lackierten Tabletten
US4011392A (en) 1975-09-02 1977-03-08 The Sherwin-Williams Company Mixed starch esters and the use thereof
JPS52117413U (https=) 1976-03-02 1977-09-06
GB1581841A (en) 1976-06-30 1980-12-31 Douglas D Low calorie edible materials
US4143163A (en) 1976-06-30 1979-03-06 Maxfibe, Inc. Coated fibrous cellulose product and process
DE2656408C2 (de) 1976-12-13 1983-12-15 CIBA-GEIGY AG, 4002 Basel Verfahren zur Herstellung von staubarmen Präparaten und deren Verwendung
GB1594102A (en) 1977-09-26 1981-07-30 Sankyo Co Ingestible coating compositions
DE2820981C2 (de) 1977-09-27 1995-07-06 Colorcon Pharmazeutische Tablette und Verfahren zum Färben einer pharmazeutischen Tablette
US4274830A (en) 1977-09-27 1981-06-23 Colorcon, Inc. Colored medicinal tablet, natural color pigment and method for using the pigment in coloring food, drug and cosmetic products
US4336244A (en) 1977-09-27 1982-06-22 Colorcon, Inc. Colored medicinal tablet, natural color pigment and method for using the pigment in coloring food, drug and cosmetic products
US4263334A (en) * 1978-05-31 1981-04-21 Fmc Corporation Water dispersible cellulosic powder and method of making the same
JPH027925B2 (https=) 1978-10-02 1990-02-21 Purdue Research Foundation
US4330338A (en) 1978-10-02 1982-05-18 Purdue Research Foundation Pharmaceutical coating composition, and preparation and dosages so coated
JPS5562012A (en) 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
US4324554A (en) 1978-11-09 1982-04-13 Merck & Co., Inc. Use of TKP as an antimigrant
US4341563A (en) 1978-11-17 1982-07-27 Sankyo Company Limited Protective coating compositions
JPS5598120A (en) 1979-01-16 1980-07-25 Shin Etsu Chem Co Ltd Preparation of drug having enteric coating
US4316884A (en) 1979-01-25 1982-02-23 Adria Laboratories, Inc. Sustained release pharmaceutical formulation
JPS5620513A (en) 1979-07-31 1981-02-26 Eisai Co Ltd Sugar-coated tablet containing fat-soluble drug
US4257816A (en) 1979-09-17 1981-03-24 Merck & Co., Inc. Novel blend of algin, TKP, and guar gum
US4250195A (en) 1979-09-24 1981-02-10 Life Savers, Inc. Method for applying soft flexible sugar coating to fresh chewing gum and coated chewing gum product
US4252786A (en) 1979-11-16 1981-02-24 E. R. Squibb & Sons, Inc. Controlled release tablet
US4543370A (en) 1979-11-29 1985-09-24 Colorcon, Inc. Dry edible film coating composition, method and coating form
FR2471186A1 (fr) 1979-12-10 1981-06-19 Roussel Uclaf Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation
US4307117A (en) 1980-03-27 1981-12-22 General Foods Corporation Stabilized curcumin colorant
US4475919A (en) 1980-04-28 1984-10-09 Colorcon, Inc. Colored medicinal tablet, natural color pigment and method for using the pigment in coloring food, drug and cosmetic products
US4311717A (en) * 1980-05-19 1982-01-19 Fmc Corporation Stabilizing agent for dry mix food products
US4302440B1 (en) 1980-07-31 1986-08-05 Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof
US4683256A (en) 1980-11-06 1987-07-28 Colorcon, Inc. Dry edible film coating composition, method and coating form
US4340582A (en) 1981-01-15 1982-07-20 Abbott Laboratories Erythromycin base tablets
IE53157B1 (en) 1981-03-09 1988-08-03 Ici Plc Coated coloured intagliated articles
JPS57171428A (en) 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
ZA822995B (en) 1981-05-21 1983-12-28 Wyeth John & Brother Ltd Slow release pharmaceutical composition
US4375468A (en) 1981-07-13 1983-03-01 Verex Laboratories, Inc. Constant order release aspirin composition and method of treating arthritis
US4790881A (en) 1982-03-26 1988-12-13 Warner-Lambert Company Molded hydrophilic polymer
HU187215B (en) 1983-01-26 1985-11-28 Egyt Gyogyszervegyeszeti Gyar Method for producing pharmaceutical product of high actor content and prolonged effect
US4514384A (en) 1983-03-14 1985-04-30 Gallina Damian J Hemorrhoid treatment method
JPS59193831A (ja) 1983-04-18 1984-11-02 Sankyo Co Ltd 腸溶性製剤の製造法
US4505890A (en) 1983-06-30 1985-03-19 E. R. Squibb & Sons, Inc. Controlled release formulation and method
US4576646A (en) 1983-07-06 1986-03-18 Seppic Film-forming compositions for enveloping solid forms, particularly pharmaceutical or food products or seeds, and products obtained, coated with said compositions
FR2548675B1 (fr) 1983-07-06 1987-01-09 Seppic Sa Compositions filmogenes pour enrobage des formes solides de produits pharmaceutiques ou alimentaires et produits obtenus revetus desdites compositions
US4556552A (en) 1983-09-19 1985-12-03 Colorcon, Inc. Enteric film-coating compositions
US4704295A (en) 1983-09-19 1987-11-03 Colorcon, Inc. Enteric film-coating compositions
DK62184D0 (da) 1984-02-10 1984-02-10 Benzon As Alfred Diffusionsovertrukket polydepotpraeparat
CH658188A5 (de) 1984-03-23 1986-10-31 Ciba Geigy Ag Lagerstabile schnellzerfallende pharmazeutische presslinge.
US4828841A (en) 1984-07-24 1989-05-09 Colorcon, Inc. Maltodextrin coating
JPH0742219B2 (ja) 1984-07-26 1995-05-10 ライオン株式会社 口腔用組成物
DE10075031I2 (de) 1984-08-17 2004-07-01 Wellcome Found Zusammensetzung zur kontrollierten Abgabe eines Wirkstoffs.
US4693751A (en) 1984-08-23 1987-09-15 Crompton & Knowles Corporation Titanium dioxide suspension for use in film coating
DE3431861A1 (de) 1984-08-30 1986-03-13 Troponwerke GmbH & Co KG, 5000 Köln Pellet-zubereitung
US4636261A (en) 1984-10-24 1987-01-13 Heinze Richard F Dry lake system
US4652313A (en) 1984-10-24 1987-03-24 Crompton And Knowles Corporation Aqueous lake pigment suspension
US4596602A (en) 1984-11-08 1986-06-24 General Foods Corporation Method of preparing an aqueous maltodextrin solution having microbial stability and decreased haze
EP0181966A1 (en) 1984-11-13 1986-05-28 Gist-Brocades N.V. Compression-coated dispersible tablets
DE3506276C1 (de) 1985-02-22 1986-04-24 Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring Direkttablettiermittel
US4910028A (en) 1985-03-06 1990-03-20 Griffith Laboratories U.S.A., Inc. Honey coated and honey glazed roasted nuts and method for producing same
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
IT1183574B (it) 1985-05-08 1987-10-22 Eurand Spa Metodo per ottenere una sospensione estemporanea omogenea di microcapsule
GB8521494D0 (en) 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
JPH0662400B2 (ja) 1985-11-11 1994-08-17 佐藤製薬株式会社 糖衣被覆錠剤
JPS62125847A (ja) 1985-11-27 1987-06-08 クロンプトン・アンド・ノウルス・コ−ポレ−シヨン 薄塗り技術に有用な水性二酸化チタン懸濁物
JPH0118803Y2 (https=) 1985-12-28 1989-06-01
US4786511A (en) 1986-01-07 1988-11-22 Warner-Lambert Company Coatings for chewing gums containing gum arabic and a soluble calcium salt
DK164199C (da) 1986-05-16 1992-10-19 Chugai Pharmaceutical Co Ltd Sucralfatpraeparat til anvendelse paa oesophagus mucosa
US4802924A (en) * 1986-06-19 1989-02-07 Colorcon, Inc. Coatings based on polydextrose for aqueous film coating of pharmaceutical food and confectionary products
US4859462A (en) 1986-07-30 1989-08-22 Fisons Corporation Polymer-treated ion exchange resins
JPH0780754B2 (ja) 1986-08-06 1995-08-30 エーザイ株式会社 多顆粒型持続性錠剤
US4735659A (en) 1986-08-18 1988-04-05 Phillips Petroleum Company Compositions and a process for preparing water dispersible polymers
JP2798248B2 (ja) 1986-08-28 1998-09-17 コーテックス リミテッド 生物学的活性物質の動物の腸管部位へのデリバリーに有効なマイクロ顆粒状製剤
US4750938A (en) 1986-11-12 1988-06-14 Crompton & Knowles Corporation Aqueous phosphate pigment dispersions
US4913919A (en) 1986-11-18 1990-04-03 Frito-Lay, Inc. Coating composition for comestible products
US4800087A (en) 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
US4981698A (en) 1986-12-23 1991-01-01 Warner-Lambert Co. Multiple encapsulated sweetener delivery system and method of preparation
CA1308357C (en) 1987-01-28 1992-10-06 Tohru Chiba Method for the preparation of a coated solid medicament
US5310572A (en) 1987-02-03 1994-05-10 Dow Corning Corporation Process for forming a coated active agent-containing article
US4959227A (en) 1987-02-17 1990-09-25 Amer Moh S High dietary fiber low lactose liquid food and a method of producing same
US4981707A (en) 1987-03-24 1991-01-01 Ogilvie Mills, Inc. Dextrin-based food-grade adhesive including xanthan or carboxymethylcellulose or mixtures thereof
DE3720757A1 (de) 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
GB8716111D0 (en) * 1987-07-08 1987-08-12 Unilever Plc Edible plastic dispersion
US4820522A (en) 1987-07-27 1989-04-11 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
US4792452A (en) 1987-07-28 1988-12-20 E. R. Squibb & Sons, Inc. Controlled release formulation
US4915954A (en) 1987-09-03 1990-04-10 Alza Corporation Dosage form for delivering a drug at two different rates
US4814181A (en) 1987-09-03 1989-03-21 Alza Corporation Dosage form comprising fast agent delivery followed by slow agent delivery
US4994276A (en) 1988-09-19 1991-02-19 Edward Mendell Co., Inc. Directly compressible sustained release excipient
US5023083A (en) 1987-09-23 1991-06-11 William Drell Azarbine composition
US5068110A (en) 1987-09-29 1991-11-26 Warner-Lambert Company Stabilization of enteric coated dosage form
US5006513A (en) 1987-11-09 1991-04-09 Miles Inc. Antimycotic compositions of nikkomycin compounds and azole antimycotica
US4816298A (en) 1987-11-27 1989-03-28 The Dow Chemical Company Method of making a granular, cold water dispersible coating composition
GB2212396A (en) 1987-12-18 1989-07-26 Procter & Gamble Dietary supplement comprising calcium and delayed release coated iron
DE3929184C2 (de) 1989-09-02 1999-02-04 Sanol Arznei Schwarz Gmbh Oral zu verabreichende pharmazeutische Zubereitung, enthaltend Isosorbiddinitrat, zur Akut- und Langzeitbehandlung der Angina pectoris und Verfahren zu deren Herstellung
US5472710A (en) 1988-04-16 1995-12-05 Schwarz Pharma Ag Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture
US4931285A (en) 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US5024842A (en) 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US5006362A (en) 1988-05-09 1991-04-09 Berwind Pharmaceutical Services, Inc. Branding pharmaceutical dosage forms, food and confectionery products with aqueous ingestible inks
JPH0529205Y2 (https=) 1988-05-12 1993-07-27
US4857337A (en) 1988-05-24 1989-08-15 American Home Products Corp. (Del) Enteric coated aspirin tablets
US4877629A (en) 1988-06-10 1989-10-31 International Flavors & Fragrances Inc. Process for preparing a coated food product
US5009897A (en) 1988-06-24 1991-04-23 Abbott Laboratories Pharmaceutical granules and tablets made therefrom
IE63242B1 (en) 1988-06-24 1995-04-05 Abbott Lab Pharmaceutical granules and tablets made therefrom
US5268182A (en) 1988-06-24 1993-12-07 Abbott Laboratories Sustained-release drug dosage units of terazosin
US5169642A (en) 1988-06-24 1992-12-08 Abbott Laboratories Sustained-release drug dosage units
US5128143A (en) 1988-09-19 1992-07-07 Edward Mendell Co., Inc. Sustained release excipient and tablet formulation
US5169639A (en) 1988-09-19 1992-12-08 Edward Mendell Co., Inc. Controlled release verapamil tablets
US5194464A (en) 1988-09-27 1993-03-16 Takeda Chemical Industries, Ltd. Enteric film and preparatoin thereof
ES2055112T3 (es) 1988-12-29 1994-08-16 Deknatel Tech Corp Revestimiento y mezcla absorbibles.
US5011701A (en) * 1988-12-30 1991-04-30 Kraft General Foods, Inc. Low calorie food products having smooth, creamy, organoleptic characteristics
GB8908250D0 (en) 1989-04-12 1989-05-24 Fisons Plc Formulations
EP0458484A3 (en) * 1989-05-26 1992-12-09 The Kendall Company Rubber-based adhesive tapes
US5047258A (en) * 1989-07-14 1991-09-10 Sterling Drug Inc. Aqueous spray-coating process
CA2011684C (en) 1989-07-31 2000-05-02 Lawrence J. Daher Aqueous film coating
JP2642486B2 (ja) 1989-08-04 1997-08-20 田辺製薬株式会社 難溶性薬物の超微粒子化法
US5059248A (en) 1989-08-11 1991-10-22 Warner-Jenkinson Company, Inc. Stable, fluid, aqueous pigment dispersions for use in film coating tablets and the like
US4983399A (en) 1989-10-18 1991-01-08 Eastman Kodak Company Direct compression carrier composition
FR2653337B1 (fr) 1989-10-23 1992-02-07 Dow Corning Sa Element a liberation prolongee et procede pour le fabriquer.
JP2646851B2 (ja) 1989-10-26 1997-08-27 日本新薬株式会社 胃内滞留製剤
US5215756A (en) 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution
IE82916B1 (en) 1990-11-02 2003-06-11 Elan Corp Plc Formulations and their use in the treatment of neurological diseases
JP3078859B2 (ja) 1990-02-23 2000-08-21 武田薬品工業株式会社 安定な放出制御性製剤用コーティング剤
FR2660317B1 (fr) 1990-03-27 1994-01-14 Seppic Produit filmogene destine a l'enrobage des formes solides; son procede de fabrication et produits revetus de ce produit.
JP3165438B2 (ja) 1990-04-04 2001-05-14 バーウィンド・ファーマス―ティカル・サーヴィスィーズ・インコーポレーテッド 水性のマルトデキストリン及びセルロースポリマーフィルムコーティング
US5368840A (en) 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5213738A (en) 1990-05-15 1993-05-25 L. Perrigo Company Method for making a capsule-shaped tablet
US5089270A (en) 1990-05-15 1992-02-18 L. Perrigo Company Capsule-shaped tablet
DE4018247A1 (de) 1990-06-07 1991-12-12 Lohmann Therapie Syst Lts Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen
US5202137A (en) 1990-06-29 1993-04-13 Berwind Pharmaceutical Services, Inc. Method of inhibiting fat and oil migration from an oily substrate of a food product into a coating layer of a food product
IT1246350B (it) 1990-07-11 1994-11-17 Eurand Int Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili
DK0559702T3 (da) 1990-11-27 1995-05-15 Byk Gulden Lomberg Chem Fab Urapidil-slow-release-præparat
US5098715A (en) 1990-12-20 1992-03-24 Burroughs Wellcome Co. Flavored film-coated tablet
US5591455A (en) 1990-12-20 1997-01-07 Warner-Jenkinson Company, Inc. Wet powder film-forming compositions
WO1992011002A1 (en) 1990-12-20 1992-07-09 Warner-Jenkinson Company Wet powder film-forming compositions
FI933223A7 (fi) 1991-01-16 1993-07-15 Fmc Corp Kantaja aktiivisia aineita varten ja sen avulla valmistettuja kiinteit ä annostusmuotoja
HU209564B (en) 1991-01-30 1994-07-28 Egyt Gyogyszervegyeszeti Gyar Process for producing rapide tablets containing levodopa and carbidopa
GB2253164B (en) 1991-02-22 1994-10-05 Hoechst Uk Ltd Improvements in or relating to electrostatic coating of substrates of medicinal products
NZ241613A (en) 1991-02-27 1993-06-25 Janssen Pharmaceutica Nv Highlighting intagliations in tablets
US5332595A (en) * 1991-03-18 1994-07-26 Kraft General Foods, Inc. Stable multiple emulsions comprising interfacial gelatinous layer, flavor-encapsulating multiple emulsions and low/no-fat food products comprising the same
GB2256648B (en) 1991-05-29 1995-08-30 Colorcon Ltd Wax polish composition
WO1993000077A1 (en) 1991-06-21 1993-01-07 University Of Cincinnati Orally administrable therapeutic proteins and method of making
DE4122217C2 (de) 1991-07-04 1997-02-13 Merz & Co Gmbh & Co Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern
KR100221695B1 (ko) 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
US5225202A (en) 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
US5209942A (en) 1991-11-27 1993-05-11 Thomas J. Lipton, Co., Division Of Conopco, Inc. Low fat/no fat salad dressing having mimetic functional properties fat and a process therefor
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
DE4200821A1 (de) 1992-01-15 1993-07-22 Bayer Ag Geschmacksmaskierte pharmazeutische mittel
WO1993014158A1 (en) 1992-01-17 1993-07-22 Berwind Pharmaceutical Services, Inc. Film coatings and film coating compositions based on cellulosic polymers and lactose
CA2129828A1 (en) 1992-02-12 1993-08-19 Giovanni Lucchetti Liposomal itraconazole formulations
US5262173A (en) 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
CA2117651C (en) 1992-03-18 2006-01-03 Jan Heeres Itraconazole and saperconazole stereoisomers
US5286502A (en) 1992-04-21 1994-02-15 Wm. Wrigley Jr. Company Use of edible film to prolong chewing gum shelf life
US5711954A (en) 1992-06-08 1998-01-27 Schering-Plough Healthcare Products, Inc. Stable imidazole anti-fungal powder compositions
EP0653935B1 (en) 1992-08-05 2002-05-08 F.H. FAULDING & CO. LIMITED Pelletised pharmaceutical composition
IT1255522B (it) 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
JP3116602B2 (ja) 1992-10-06 2000-12-11 シオノギクオリカプス株式会社 硬質カプセル
US5286510A (en) * 1992-10-07 1994-02-15 Thomas J. Lipton Co., Division Of Conopco, Inc. Fat mimetic containing salad dressing and process therefor
US6093391A (en) 1992-10-08 2000-07-25 Supratek Pharma, Inc. Peptide copolymer compositions
DE4236025A1 (de) 1992-10-24 1994-04-28 Merck Patent Gmbh Orale Arzneiformen
FR2698560B1 (fr) 1992-11-30 1995-02-03 Virbac Laboratoires Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications.
US5411746A (en) 1993-02-24 1995-05-02 Warner-Jenkinson Company, Inc. Dye compositions and methods for film coating tablets and the like
US5514435A (en) 1993-03-10 1996-05-07 New Oji Paper Co., Ltd. Adhesive sheet
IT1265092B1 (it) 1993-05-31 1996-10-30 Giuliani Spa Preparato per uso come integratore alimentare, o dietetico,a rilascio mirato nel colon
DK0707475T3 (da) 1993-06-14 1997-12-29 Janssen Pharmaceutica Nv Langsom frigørende, filmcoatet tablet af astemizol og pseudoephedrin
DE4323636A1 (de) 1993-07-15 1995-01-19 Hoechst Ag Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung
US5718969A (en) * 1993-08-25 1998-02-17 Fmc Corporation Nonaggregating hydrocolloid microparticulates, intermediates therefor, and processes for their preparation
PH31594A (en) 1993-09-30 1998-11-03 Janssen Pharmaceutica Nv Oral formulations on an antifungal.
JP3017906B2 (ja) 1993-10-08 2000-03-13 信越化学工業株式会社 腸溶性コーティング剤分散液
FR2711525B1 (fr) 1993-10-29 1996-01-12 Virbac Laboratoires Forme Galénique à administration orale pour animaux, son procédé de préparation et ses applications.
DE69423643T2 (de) 1993-10-29 2000-09-07 R.P. Scherer Corp., Troy Schäumende gelatinkapselfüllung
US5560930A (en) 1993-12-27 1996-10-01 Shin-Etsu Chemical Co., Ltd. Method for preparing aqueous emulsion for coating solid pharmaceutical preparations
EP0746310B1 (en) 1994-02-23 1998-11-18 BM Research A/S Controlled release composition
US5458887A (en) 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
SE502595C2 (sv) 1994-03-23 1995-11-20 Polysaccharide Ind Ab Polysackaridskyddsfilm samt sätt för dess applicering
JP3492787B2 (ja) 1994-04-15 2004-02-03 信越化学工業株式会社 固形製剤のコーティング用水性エマルジョンの濃縮方法
DK171127B1 (da) 1994-04-22 1996-06-24 Gea Farmaceutisk Fabrik As Ranitidintablet med et hydroxypropylmethylcelluloseholdigt overtræk samt fremgangsmåde til at tilvejebringe dette overtræk
HU212428B (en) 1994-05-13 1996-06-28 Egyt Gyogyszervegyeszeti Gyar Process to prepare pharmaceutical compositions containing gemfibrozyl
US5523293A (en) 1994-05-25 1996-06-04 Iowa State University Research Foundation, Inc. Soy protein-based thermoplastic composition for preparing molded articles
US5429830A (en) 1994-07-08 1995-07-04 Fmc Corporation Marshmallow-type confections
GB9414045D0 (en) 1994-07-12 1994-08-31 Berwind Pharma Service Moisture barrier film coating composition, method, and coated form
HU225964B1 (en) 1994-07-12 2008-01-28 Berwind Pharma Service Moisture barrier film coating composition, method, and coated form
US5733575A (en) 1994-10-07 1998-03-31 Bpsi Holdings, Inc. Enteric film coating compositions, method of coating therewith, and coated forms
CA2206511A1 (en) 1994-11-30 1996-06-06 The University Hospital Compositions for the treatment of parasitic and fungal infections
US5756123A (en) 1994-12-01 1998-05-26 Japan Elanco Co., Ltd. Capsule shell
JP2959423B2 (ja) 1994-12-01 1999-10-06 シオノギクオリカプス株式会社 カプセル用皮膜組成物
US5529783A (en) 1994-12-19 1996-06-25 Mcneil-Ppc, Inc. Rotor granulation and coating of acetaminophen, pseudoephedrine, chlorpheniramine, and, optionally dextromethorphan
US5759577A (en) 1995-01-17 1998-06-02 American Home Products Corporation Controlled release of steroids from sugar coatings
US5547948A (en) 1995-01-17 1996-08-20 American Home Products Corporation Controlled release of steroids from sugar coatings
KR100201352B1 (ko) 1995-03-16 1999-06-15 성재갑 단일주사 백신 제형
FI98343C (fi) 1995-03-21 1997-06-10 Orion Yhtymae Oy Peroraalinen formulaatio
WO1996030011A1 (en) 1995-03-30 1996-10-03 Bioplex, L.C. Topical antimycotic compositions
US5558879A (en) 1995-04-28 1996-09-24 Andrx Pharmaceuticals, Inc. Controlled release formulation for water soluble drugs in which a passageway is formed in situ
JP3149125B2 (ja) 1995-05-01 2001-03-26 信越化学工業株式会社 固形腸溶製剤のコーティング用基剤
TR199701323T1 (xx) 1995-05-09 1998-02-21 Colorcon Limited Farmas�tik alttabakalar�n elektrostatik olarak kaplanmas� i�in toz kaplama kompozisyonu.
US5709896A (en) 1996-06-18 1998-01-20 Fmc Corporation Reduced-fat food dispersions and method of preparing
EP0896541A1 (en) 1995-06-30 1999-02-17 CAPELLI, Christopher C. Silver-based pharmaceutical compositions
FR2738833B1 (fr) 1995-09-14 1997-12-05 Seppic Sa Composition filmogene pour le masquage de gout destinee a l'enrobage de formes solides ingerables telles qu'en particulier des comprimes pharmaceutiques
CA2234817A1 (en) 1995-10-27 1997-05-01 Mandana Asgharnejad Wet granulation formulation of a growth hormone secretagogue
CN1198655C (zh) 1995-11-23 2005-04-27 詹森药业有限公司 通过熔体挤出法制备的环糊精固体混合物
CA2240180C (en) 1995-12-21 2008-01-22 The Dow Chemical Company Compositions comprising hydroxy-functional polymers
US5882707A (en) 1996-01-05 1999-03-16 Bpsi Holdings, Inc. Method of coating an edible substrate with sugar/syrup or sugarless solutions containing dry color concentrate
US6231888B1 (en) 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
IT1282576B1 (it) 1996-02-06 1998-03-31 Jagotec Ag Compressa farmaceutica atta a cedere la sostanza attiva in tempi successivi e predeterminabili
IT1282650B1 (it) 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
WO1997034580A1 (en) 1996-03-21 1997-09-25 Dong Wha Pharmaceutical Industrial Co., Ltd. Suppository composition of the drug which has gastro-intestinal disturbances or undergoes the decomposition by gastric acid
DE59710349D1 (de) 1996-04-04 2003-07-31 Felix Specht Verfahren zur herstellung von gering dosierten freifliessenden und/oder direktkomprimierbaren pulversystemen
US5876739A (en) 1996-06-13 1999-03-02 Novartis Ag Insecticidal seed coating
US5849320A (en) 1996-06-13 1998-12-15 Novartis Corporation Insecticidal seed coating
US5820915A (en) 1996-06-27 1998-10-13 Bioavailability Systems, L.L.C. Method for the preparation of a first-pass effective citrus-derived substance and product thereof
FR2750864B1 (fr) 1996-07-10 1999-04-16 Oreal Utilisation d'un polyholoside dans une composition destinee a stimuler les defenses immunitaires, et composition le comprenant
EP0852141A1 (en) 1996-08-16 1998-07-08 J.B. Chemicals & Pharmaceuticals Ltd. Nifedipine containing pharmaceutical extended release composition and a process for the preparation thereof
US5662732A (en) 1996-08-09 1997-09-02 Bpsi Holdings, Inc. Polish composition
RU2102853C1 (ru) 1996-08-13 1998-01-27 Александр Владимирович Шафрановский Питательное устройство для растений
EP0829478A3 (en) 1996-09-09 1998-03-25 F. Hoffmann-La Roche Ag N-Benzylimidazolium and N-benzyltriazolium derivatives, their preparation and their use as antifungal and antimycotic agents
CA2269598A1 (en) 1996-10-21 1998-04-30 Asahi Kasei Kogyo Kabushiki Kaisha Stabilizer for meat products and meat product composition
US5851579A (en) 1996-10-28 1998-12-22 Eastman Chemical Company Aqueous enteric coating compositions
US5807580A (en) 1996-10-30 1998-09-15 Mcneil-Ppc, Inc. Film coated tablet compositions having enhanced disintegration characteristics
CN1237174A (zh) 1996-11-12 1999-12-01 塞普拉科公司 2r,4s,s,r－和2s,4r,s,r－羟基伊曲康唑
GB9623634D0 (en) 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
EP0996508B1 (en) * 1997-01-06 2004-08-11 BPSI Holdings, Inc. Film coatings and film coating compositions based on dextrin
US6183808B1 (en) * 1997-01-06 2001-02-06 Bpsi Holdings, Inc. Film coatings and film coating compositions based on dextrin
KR100693266B1 (ko) 1997-03-28 2007-03-27 에자이 가부시키가이샤 쓴맛 등을 은폐한 경구 약제
AU6677698A (en) 1997-03-31 1998-10-22 Johnson & Johnson Consumer Companies, Inc. Solvent system for enhanced penetration of pharmaceutical compounds
US6030641A (en) 1997-06-03 2000-02-29 Uni Colloid Kabushiki Kaisha Sustained release capsule and method for preparing the same
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
DE19728249C2 (de) 1997-07-02 2001-05-03 Georgios Pandalis Produkt aus einem Kern und mindestens einer ein Naturharz enthaltenden Umhüllung, Steckkapsel, Verfahren zur Herstellung einer Filmtablette, Weichkapsel, Steckkapsel und Verwendung von Naturharzen
IT1293088B1 (it) 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in
US6248391B1 (en) 1997-07-16 2001-06-19 Bpsi Holdings, Inc. Bright white film coatings and film coating compositions therefor
ES2137862B1 (es) 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
FR2767070B1 (fr) 1997-08-08 1999-09-17 Laurence Paris Composition visqueuses aqueuses, limpides ou non, pour la fabrication de capsules molles et de capsules dures, et procede de fabrication de films pour de telles capsules
US5869098A (en) 1997-08-20 1999-02-09 Fuisz Technologies Ltd. Fast-dissolving comestible units formed under high-speed/high-pressure conditions
EP1017427B1 (en) 1997-08-26 2006-04-26 Board of Regents, The University of Texas System Use of a composition comprising a chelating agent and an antimicrobial compound for the treatment of biofilms
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
JPH11116467A (ja) 1997-10-08 1999-04-27 Taisho Pharmaceut Co Ltd 糖衣錠
DE69814122T2 (de) 1997-10-09 2004-03-18 Dexcel Pharma Technologies Ltd. Darreichungsform zur verzögerten, vollständigen wirkstoffabgabe im verdauungstrakt
FR2769838B1 (fr) 1997-10-16 2000-04-07 Roc Sa Utilisation de derives d'azole pour la preparation d'une composition dermatologique ou cosmetologique
TR200001117T2 (tr) 1997-10-22 2000-09-21 Ponikau Jens Mukozal dokudaki enflomasyonu önlemek ve tedavi etmek için maddeler ve yöntemler.
US6326028B1 (en) 1997-10-31 2001-12-04 Monsanto Company Alginate and gellan gum as tablet coating
EP1028713A1 (en) 1997-11-12 2000-08-23 The Dow Chemical Company A process for making a free-flowing, dust-free, cold water dispersible, edible, film-coating composition
CA2317411C (en) 1998-01-30 2005-06-28 Scios Inc. Controlled release delivery of peptide or protein
KR19990072826A (ko) 1998-02-26 1999-09-27 우재영 판크레아틴장용코팅과립의제조방법
WO1999049895A2 (en) 1998-03-31 1999-10-07 Johnson And Johnson Consumer Companies, Inc. Method for increasing the permeability of horny human tissue
US6231875B1 (en) 1998-03-31 2001-05-15 Johnson & Johnson Consumer Companies, Inc. Acidified composition for topical treatment of nail and skin conditions
NL1008795C2 (nl) 1998-04-02 1999-10-05 Rene Werenfridus Lodewijk Vroo Samenstelling voor het behandelen van hoeven en werkwijze voor het vervaardigen van de samenstelling.
TWI243687B (en) 1998-04-21 2005-11-21 Teijin Ltd Pharmaceutical composition for application to mucosa
KR100258849B1 (ko) 1998-04-24 2000-08-01 박원배 약학적으로 유용한 프로토베르베린염 유도체 및프로토베르베린유도체와 이의 염
CN1308523A (zh) 1998-04-27 2001-08-15 詹森药业有限公司 含有用降脂剂和聚合物包衣的丸芯的微丸
US6673832B1 (en) 1998-05-04 2004-01-06 Gudarz Davar Methods for identifying compounds for treating pain
DE69924735T2 (de) 1998-07-28 2006-01-19 Tanabe Seiyaku Co., Ltd. Zur wirkstoffabgabe an zielorten im darm fähige zubereitung
US6214376B1 (en) 1998-08-25 2001-04-10 Banner Pharmacaps, Inc. Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture
US6391368B1 (en) * 1998-09-25 2002-05-21 Fmc Corporation Rapidly peptizable microcrystalline cellulose-based stabilizing agents
WO2000018374A1 (en) 1998-10-01 2000-04-06 Elan Pharma International, Ltd. Controlled release nanoparticulate compositions
EP1126826B3 (en) 1998-11-02 2019-05-15 Alkermes Pharma Ireland Limited Multiparticulate modified release composition of methylphenidate
US6723342B1 (en) * 1999-02-08 2004-04-20 Fmc Corporation Edible coating composition
US6432448B1 (en) 1999-02-08 2002-08-13 Fmc Corporation Edible coating composition
US6274162B1 (en) 2000-01-14 2001-08-14 Bpsi Holdings, Inc. Elegant film coating system
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
US6340473B1 (en) 1999-07-07 2002-01-22 R.P. Scherer Technologies, Inc. Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same
AU1195001A (en) 1999-10-11 2001-04-23 Monsanto Company Tablets coated with locust bean gum, guar gum or carrageenan gum
JP2003527335A (ja) 1999-10-29 2003-09-16 エフ エム シー コーポレーション 食用コーティング組成物
US6500462B1 (en) 1999-10-29 2002-12-31 Fmc Corporation Edible MCC/PGA coating composition
IL155959A0 (en) 2000-11-28 2003-12-23 Fmc Corp Edible pga (propylene glycol alginate) coating composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725441A (en) * 1984-07-24 1988-02-16 Colorcon, Inc. Maltodextrin coating
US5082684A (en) * 1990-02-05 1992-01-21 Pfizer Inc. Low-calorie fat substitute

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALGINATES FOR PHARMACEUTICAL APPLICATIONS, 20 October 2000 (2000-10-20), XP002951969, Retrieved from the Internet <URL:http://www.isp-pharma.com/library/algnpharm/algnpharm> *
See also references of EP1474113A4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1954770A4 (en) * 2005-11-29 2012-10-31 Ideal Cures Pvt Ltd AQUEOUS FILM COATING COMPOSITION WITH SODIUM ALGINATE AND ITS PRODUCTION
WO2007073346A1 (en) * 2005-12-23 2007-06-28 Kjell Stenberg Water-soluble films comprising low-viscosity alginates
US8759282B2 (en) 2005-12-23 2014-06-24 Uppsalagruppen Medical Ab Water-soluble films comprising low-viscosity alginates
US10172853B2 (en) 2007-02-11 2019-01-08 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile

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AU2002367695A1 (en) 2003-09-09
EP1474113A1 (en) 2004-11-10
US20020121225A1 (en) 2002-09-05
CN1330379C (zh) 2007-08-08
IL163507A0 (en) 2005-12-18
JP2005526039A (ja) 2005-09-02
CN1622800A (zh) 2005-06-01
US20050095272A1 (en) 2005-05-05
US6932861B2 (en) 2005-08-23

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