CN1622800A - 可食用pga涂层组合物 - Google Patents
可食用pga涂层组合物 Download PDFInfo
- Publication number
- CN1622800A CN1622800A CNA028286014A CN02828601A CN1622800A CN 1622800 A CN1622800 A CN 1622800A CN A028286014 A CNA028286014 A CN A028286014A CN 02828601 A CN02828601 A CN 02828601A CN 1622800 A CN1622800 A CN 1622800A
- Authority
- CN
- China
- Prior art keywords
- composition
- coating composition
- coating
- propylene glycol
- glycol alginate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008199 coating composition Substances 0.000 title claims abstract description 67
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims abstract description 45
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims abstract description 45
- 239000000770 propane-1,2-diol alginate Substances 0.000 claims abstract description 45
- 239000004094 surface-active agent Substances 0.000 claims abstract description 18
- 239000000945 filler Substances 0.000 claims abstract description 16
- 239000000049 pigment Substances 0.000 claims abstract description 15
- 229920000642 polymer Polymers 0.000 claims abstract description 14
- 239000007909 solid dosage form Substances 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 73
- 239000006185 dispersion Substances 0.000 claims description 17
- 239000004014 plasticizer Substances 0.000 claims description 10
- 239000005913 Maltodextrin Substances 0.000 claims description 8
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 7
- 229920002774 Maltodextrin Polymers 0.000 claims description 7
- 235000010445 lecithin Nutrition 0.000 claims description 7
- 239000000787 lecithin Substances 0.000 claims description 7
- 229940067606 lecithin Drugs 0.000 claims description 7
- 229940035034 maltodextrin Drugs 0.000 claims description 7
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 235000010418 carrageenan Nutrition 0.000 claims description 5
- 229920001525 carrageenan Polymers 0.000 claims description 5
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
- 238000000576 coating method Methods 0.000 abstract description 85
- 239000011248 coating agent Substances 0.000 abstract description 82
- 239000000758 substrate Substances 0.000 abstract description 10
- 235000009508 confectionery Nutrition 0.000 abstract description 8
- 235000013305 food Nutrition 0.000 abstract description 8
- 239000003337 fertilizer Substances 0.000 abstract description 6
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000575 pesticide Substances 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- 239000002775 capsule Substances 0.000 description 28
- 239000000463 material Substances 0.000 description 22
- 230000036571 hydration Effects 0.000 description 19
- 238000006703 hydration reaction Methods 0.000 description 19
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 16
- 238000009472 formulation Methods 0.000 description 14
- 238000012856 packing Methods 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 239000003814 drug Substances 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 238000003756 stirring Methods 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 8
- 239000003086 colorant Substances 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- 239000003643 water by type Substances 0.000 description 7
- 208000029618 autoimmune pulmonary alveolar proteinosis Diseases 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 239000000273 veterinary drug Substances 0.000 description 6
- 229960005489 paracetamol Drugs 0.000 description 5
- 230000000704 physical effect Effects 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 230000002421 anti-septic effect Effects 0.000 description 4
- 239000012736 aqueous medium Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 244000045947 parasite Species 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 3
- 239000004353 Polyethylene glycol 8000 Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 229960001680 ibuprofen Drugs 0.000 description 3
- 239000002917 insecticide Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000000452 restraining effect Effects 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- -1 and spheroid Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000035784 germination Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229940085678 polyethylene glycol 8000 Drugs 0.000 description 2
- 235000019446 polyethylene glycol 8000 Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 238000009492 tablet coating Methods 0.000 description 2
- 239000002700 tablet coating Substances 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000001055 blue pigment Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 230000000640 hydroxylating effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/343—Products for covering, coating, finishing, decorating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
- A23P20/105—Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
- C09D105/04—Alginic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
- C09D105/06—Pectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
- C08L1/284—Alkyl ethers with hydroxylated hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
- C08L3/02—Starch; Degradation products thereof, e.g. dextrin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
公开了一种可食用可硬化的涂层组合物,其包含高含量的低粘度丙二醇藻酸酯,另外还可以包含表面活性剂,填料,颜料,和任选的少量次要成膜剂和/或增强聚合物。本发明的涂层组合物可以涂覆于药物和兽药固体剂型,糖果,种子,动物饲料,肥料,杀虫药片,和食品,形成迅速释放的完美涂层,不会延迟活性组分从该涂覆基片中释放。
Description
发明领域
本发明涉及可食用可硬化的迅速释放涂层组合物,包含成膜量的低粘度丙二醇藻酸酯,该组分作为涂层组合物中基本,主要或唯一的成膜剂。本发明的涂料能涂覆药物,包括类药剂营养品(neutraceutical),和兽药固体剂型,固体底物,比如种子,动物饲料,肥料,杀虫药片和颗粒,还可以涂覆糖果和食品。它们能很容易地分散于水相介质中,而且,作为涂料涂覆时,能形成高光泽涂层,不会延迟或延长活性组分从涂覆基片中释放。
发明背景
通常对药物和兽药药片进行涂覆以获得若干益处。其中包括改善片剂的表面特性,使其容易吞咽,减轻对水或潮气的吸收,吸潮可能会使活性组分降解或促使片剂结构中发生其他不需要的变化,和仅是提供外观更完美的片剂。
药物或兽药药片涂层的另一个非常重要的功能是,加强药片本身的整体性。未经涂覆的药片经常会受到磨损或发生破裂,导致在处理过程中损失活性组分。更显著的情况是,会破裂成两片或更多片。对有用涂层的一种评估是其防止片剂结构发生这些物理降解的能力。通过易碎性测试对涂层物质防止片剂磨损,破损,或断裂的效果进行测定。
可以用一种配制物涂覆糖果和食品,从而防止糖果或食品因为接触大气中的氧和潮气而变质。涂层还能改善食品的外观和提供理想的感官特性,还能防止香味的损失。
可以对种子进行涂覆,防止潮气从而保持种子的生存能力。它们还能通过涂覆,增加粒度便于机械种植。涂料配方中可以包含染料,以识别种子的品质,种类,或一些其他名称。涂料配方中通常掺合杀虫剂,比如杀真菌剂,以保护种子本身,还保护种子发芽后长成的子苗。在所有情况下,在将种子种入土壤中时,该涂层必须不会降低种子的生存能力或影响其发芽。
可以对动物饲料进行涂覆,增加其流动性,外观和抗粉末或粉尘的能力。在这些应用中,涂料配方中可以包含维生素,荷尔蒙,抗生素,或类似物质,以有利于食用这种饲料的牲畜。
可以对颗粒状或片状的肥料进行涂覆,保持其形状整体性,特别是保护肥料防止其受潮,在储存期间受潮会形成结块,导致将其迅速,均匀地施用于土壤中变得困难或不方便。
对药片状杀虫配制物进行涂覆,保持该片或颗粒的整体性直到其被置于水中,并迅速分解,形成能被施用于土壤或植物的溶液或浆料。含杀虫剂药片上涂层的另一个同样重要的作用是,防止人接触杀虫剂,从而提高处理和施用该杀虫剂的安全性。
在制备要喷涂的涂料配制物时,成膜剂和配方中的其他组分通常被溶解或分散在如水等溶剂中。在水体系中,由于许多聚合物需要较长时间才能完全水合,所以该涂料配制物必须在涂覆片剂之前提前制备。常用的方法是在涂覆操作的前一天制备涂料配制物,从而保证所用聚合物的充分水合。
主要基于HPMC的涂层的一个具体缺点是,该涂层会随时间的推移而硬化,从而增加片剂的崩解时间。崩解时间的增加对该活性组分生物利用度的延迟影响至少正比于崩解时间的增加。已知许多常用于涂层组合物中的其他试剂也会延迟药剂的释放,比如使用了不溶于水或胃液的聚合成膜材料的肠溶性涂层,特别选择部分材料能避开胃和小肠,产生结肠释放。
本发明的涂层符合关于活性组分从涂有它们的药片或其他固体剂型中迅速或立即溶解(U.S.P.专题23)的美国药典标准。它们所提供的迅速释放或溶解与未经涂覆药片或其他基片所产生的释放速率是一致的。因此,它们不会严重影响或延迟活性组分从涂有它们的基片中的释放。另外,本发明的涂层能很容易地在应用于涂覆基片的水介质中分散或迅速水合,提供外观完美的涂层,该涂层具有目前商用涂层的所有优点,而没有涂层常见缺点。
发明概述
通过本发明的涂层组合物能提供这些和其他优点,该涂层组合物包含低粘度的丙二醇藻酸酯作为涂层组合物中的基本或唯一的成膜组分,任选地含有表面活性剂。本发明涂层组合物利用低粘度的丙二醇藻酸酯(PGA)作为主要成膜剂,其1%水溶液在25℃下具有约1到500mPa·s范围的粘度。在本发明的一些实例中,该PGA是与表面活性剂组合使用的。在本发明的其他实例中,该涂层组合物中含有小于2%干重的表面活性剂。该涂层组合物任选含有其他组分,比如填料,增塑剂,着色剂,或其混合物,还可以包含少量次要成膜剂和/或增强聚合物作为附加组分。更具体地说,本发明提供了迅速释放,可食用,可硬化的PGA涂层组合物,及其干涂层,水分散体和被其涂覆的固体剂型。
发明的详细说明
在本申请中,术语“可食用”表示由管理机构批准的可用于药物或食物中的食品级或药物级物质。用术语“可硬化”说明本发明的涂层组合物,其只包括能由其水溶液或分散体干燥成抗磨损力的固体涂层的涂层组合物,该涂层硬化涂层,用以区别糖果上的“浸挂”涂层,“浸挂”涂层是一种软涂层,能处理和包装,但是明显不耐磨损力。术语“立刻”,“快速”,或“迅速”用于描述本发明涂层组合物或者涂覆有本发明组合物的片剂的溶解速度或时间,表示本发明的涂层符合关于涂覆有该涂层的片剂或其他固体剂型中活性组分快速或立刻溶解的美国药典标准(U.S.P.专题23)。因此,这些涂层所提供的迅速释放或溶解与未经涂覆的片剂或其他基片通常所得的释放速度是一致的。置于水中或服用之后,这些涂层不会严重影响或延迟具有这种涂层的片剂或其他剂型的释放或溶解。本发明制造的涂层被服用或置于水介质中之后,在小于10分钟之内就基本或完全崩解和/或溶解。除非清楚指明相反含义之外,这些定义适用于本申请全文。
丙二醇藻酸酯能提供形成完美涂层所需要的重要成膜特性,这种涂层特别适用于,比如涂覆药物和兽药药片,胶囊片,颗粒,和球体,药物和药片等包含要求在置于水介质中或服用之后能迅速释放的活性组分。
已知在将丙二醇藻酸酯的水分散体涂布在表面上并使之干燥时,丙二醇藻酸酯本身是一种成膜水胶体。但是,认为至今这种膜对形成令人满意的涂层而言其强度太小。不过,如果将低粘度丙二醇藻酸酯以高浓度与合适的表面活性剂混合,就能提供一种完美的,高性能的涂层配方,能很容易地作为水悬浮液分来涂覆基片。还可以在不含表面活性剂的情况下,使用高浓度的低粘度丙二醇藻酸酯,提供完美的,高性能的涂层配方。本发明所用丙二醇藻酸酯是低粘度丙二醇藻酸酯,当其在水中浓度为1%时,能形成25℃时的粘度在约1到500mPa·s范围的水溶液。已经发现,粘度基本大于约500mPa·s的PGA很难被配制成合适的涂料层,需要许多添加剂才能形成令人满意的涂料,而且对待涂覆材料的实际涂覆而言,往往是过于粘稠。低粘度丙二醇藻酸酯可以从Pronova以商品名Profoam和从Kibun以商品名Duckloid SLF-3购得。在本发明的一些实例中,在涂层组合物中所用的低粘度丙二醇藻酸酯占涂层组合物干重的约91%到约100%。在本发明的其他实例中,在涂层组合物中所用的低粘度丙二醇藻酸酯占该组合物干重的约55%到约100%,而且组合物中还包含小于其干重2%的表面活性剂。
本发明可食用,可硬化涂层组合物中优选使用阴离子型或非离子型表面活性剂。有用表面活性剂是,比如,月桂基硫酸钠,羟基化大豆卵磷脂(卵磷脂),聚山梨酸酯,和环氧丙烷与环氧乙烷的嵌段共聚物。这些表面活性剂用量最高可以占该组合物干重的约9%。卵磷脂等表面活性剂能帮助干组合物的再分散,并提高该涂料组合物涂覆时的流动性,保证形成平滑均匀的涂层。
除了PGA和任选的表面活性剂之外,该组合物其余部分可以包含某些常用于涂料组合物的助剂,包括填料和/或用于有色涂层的颜料,还可以包含少量次要成膜剂,比如角叉菜胶或HPMC和/或增强聚合物,比如羟乙基纤维素。
适用于本发明组合物的填料包括,比如碳酸钙,磷酸二钙和碳水化合物,比如淀粉,麦芽糖糊精,乳糖,甘露醇和其他糖,交联羧甲基纤维素钠,或微晶纤维素。其中,麦芽糖糊精的用量最好最高约为该组合物干重的9%,其他填料的用量也可以是这样。
可以在这些涂层组合物中使用着色剂和遮光剂或者将它们加入其悬浮液中合,该着色剂包括铝色淀,不溶性颜料,水溶性染料,二氧化钛,和滑石。这些着色剂的适用量是该组合物干重的约5%到约9%。总的来说,这些着色剂可以与填料同时使用或者用来代替填料。在以下实施例中将进一步说明,填料和着色剂的总含量优选在最高约为该组合物干重的9%的范围内。
还可以预期本发明组合物中包括或添加有某些其他添加剂。根据特定配方中PGA的量,可能最好包括次要成膜剂,比如角叉菜胶和/或增强聚合物,比如羟乙基纤维素。虽然通常并不需要这些附加添加剂,但是如果需要的话,其用量占该组合物干重的约3%到约9%。还可以包含这些含量的少量硬脂酸或其盐或酯,和/或常用增塑剂,用来增加涂层的光泽弹性,但是其含量也可以是其他数值。适用增塑剂包括,比如聚乙二醇,三醋精,癸二酸二丁酯,丙二醇,山梨糖醇,甘油,和柠檬酸三乙酯。
本发明的涂料配制物可以干粉配制物或现成的水中分散体出售。优选的水分散体是在无菌条件下制备的。在制备分散体前将水加热至升高温度,比如85℃,表明能在至少48小时内防止琼脂注皿上生长细菌,霉菌,和酵母。因此,如果正确消毒分散体容器,并在装满之后直到使用分散体为止保持封闭,就能使分散体中几乎不可能生长细菌,霉菌,或酵母。或者,如果该配制物是作为一种需要储存一段时间的水分散体出售,则可以添加防腐剂。关于这方面,可以使用对羟基苯甲酸甲酯和对羟基苯甲酸丙酯的混合物。
以干重百分比计,本发明一个实例的组合物包含91%到100%的所述丙二醇藻酸酯,2%到9%的卵磷脂,和1%到9%的麦芽糖糊精。第二个实例包含大约91%到100%的丙二醇藻酸酯,2%到9%的卵磷脂,和5%到9%的颜料。任何一个实例还可以包含占该组合物干重3%到约9%的次要成膜聚合物,比如角叉菜胶,或者增强聚合物,比如羟乙基纤维素。配方中还可以包含防腐剂,比如0.75%到1.50%的对羟基苯甲酸甲酯和/或0.075%到0.15%的对羟基苯甲酸丙酯。其他实例包含占该组合物干重约55%到约100%的丙二醇藻酸酯和小于2%干重的表面活性剂,还可以包含次要成膜聚合物,增强聚合物,增塑剂,一种或多种填料,一种或多种颜料,和一种或多种防腐剂。比如,本发明一个具体实例包含60%到75%的丙二醇藻酸酯和30%到45%的增塑剂,更优选是65%的丙二醇藻酸酯和35%的增塑剂。
水合配制物的粘度是很重要的。理想值应低到足以被连续泵入喷涂器中,然后以一种有用的方式被均匀喷涂至待涂覆基片上。因此,水中干组分的重量百分比计可以是约6%到约15%,宜是6.5%到11%,优选是约8%到约11%。为了保证涂料组合物的均匀性,优选在将其喷涂至药物或兽药固体剂型,糖果,种子,动物饲料,肥料,杀虫药片,或食品上的整个阶段中,持续搅拌该水分散体。
本发明优选的可食用,可硬化,迅速释放的涂层配制物可以采用简单过程进行制备和应用。所需组合物中的丙二醇藻酸酯和其他干组分,包括表面活性剂,填料,增塑剂,次要聚合物,和/或防腐剂被一起干混成干涂层组合物。可以在制备最终涂层配制物所要求的水合步骤之前,加入可食用的着色剂,比如,水溶性染料或颜料。然后缓慢地将该干混合物加入搅拌的纯水涡流中。持续搅拌该混合物足够长的时间,使所有组分完全水合。如果需要有色涂料物质时,还可以加入水溶性染料或颜料,优选作为分散体或溶液,加入水合的涂层组合物中。也可以在该方法的这个阶段加入任选的表面活性剂,和/或增塑剂。
在水合步骤中,使用简单的螺旋桨混合器就能为迅速水合提供足够的搅动。水合时间可以短至0.5小时。水合时间最好长一些,但是据信超过3小时是不必要的。水合可以在室温或在升高至65.6℃(150°F)的温度下发生,优选温度是约48.9℃(120°F)。当分散体是在升高温度下制备而成时,完全水合需要的时间和该分散体的粘度都会显著降低,但是对于在室温下制备而成的涂料分散体而言,只需要增加水合时间和略微降低固体含量,就能产生完全令人满意的效果。如上所述,如果更方便的话,这些配制物可以在进行涂覆操作的前一天制备;但是,需要一定的混合时间,克服配制物在储存过夜期间产生的触变性。与主要基于纤维素的羟烷基醚,比如HPMC的涂料配方不同,不必在整个涂覆过程中对本发明基于丙二醇藻酸酯配制物进行持续恒定搅拌,但是优选进行连续搅拌。
可以使用任何商用喷涂机进行涂覆。适用涂布机的实例是由VectorCorporation制造的Vector High Coaters和由Thomas Engineering制造的Accela-Coat。本领域技术人员能够控制并形成基于丙二醇藻酸酯的完美涂层的设备变量包括入口温度,出口温度,空气流速,涂布盘旋转速度,和涂料配制物被泵入涂布机中的速度。重要的是,要控制入口和出口温度,使其高到足以有效干燥涂层,防止已涂覆片剂发生翻滚,以避免在对该药片作进一步涂覆之前破坏刚涂覆的涂层。
涂覆于药物或兽药剂型上的涂层含量优选占未经涂覆剂型重量的约0.5%到约4%之间,更优选占未经涂剂型重量的约2%到约3.5%。这种含量的涂层能为各种剂型提供完美耐用的涂层。在药片上涂覆较厚的涂层是不经济的,会严重影响药片的崩解或其他特性。涂层太薄则不能由涂层提供所需要的最佳特性。
对糖果而言,涂层含量占未经涂覆糖果重量的约5%到约10%。种子涂层应占未经涂覆种子重量的约3%到约6%。肥料和杀虫药片及颗粒的涂层含量最好占未经涂覆颗粒或药片重量的1%到约3%。
本发明的涂层可以被成功涂覆于掺有各种活性组分的片剂上。比如,据报道,因为多种维生素片剂具有亲脂表面,很难对其进行涂覆。类似地,布洛芬也是一种很难涂覆的活性组分。可以使用本发明的涂层组合物很容易地对含有这些难覆的活性组分的片剂进行涂覆,制成外观完美的片剂。另外,该涂层还能被涂覆于刻有字母或标志的片剂上,不会形成导致遮盖或甚至湮设压印图案的桥连现象。
在环境温度和湿度条件以及40℃和75%相对湿度条件下,储存涂覆片剂一到三个月,证明不会发生明显的降解。这些药片发生崩解的时间长度与同批新涂覆片剂的时间长度相同,而且在每种情况下,其注解速度和时间基本上等于作为涂覆用基片的未经涂覆片剂的溶解速度和时间。这是基于丙二醇藻酸酯的涂层的另一个意想不到的优点。
配方中的所有组分一般是药物可接受的,可食用级别的物质。
在以下实施例中,百分比都是重量百分比,用实施例对这些完美涂层的制备方法和涂覆进行说明,但这些实施例不是对所述片剂涂层的任选组分含量和种类或者其特定涂覆方法的限制。
实施例1
在尺寸合适的V型混料机中装入95.0克PGA SLF-3(Kibun),2克蔗糖(Domino)和3克Red#40混合料(Warner Jenkinson),将这些物质混合15分钟。排出混好的物料,经#40目筛网过筛。在室温下将混好的物料储存在干净的多衬里容器中。
在配备有带叶片(#3)高速混合器的尺寸合适的不锈钢容器中装入1011.0克去离子水。将上述混好的物料加入去离子水的涡流中,以中-高速混合1.0到1.5小时。
在Vector LDCS 15″涂布机中装入2.0千克APAP 500毫克胶囊片,按照以下参数对胶囊片进行涂覆。
表1
目标 | ||
入口温度 | 65-75℃ | 70℃ |
排气温度 | 32-38℃ | 35℃ |
产物温度 | 32-38℃ | 35℃ |
喷涂速度 | 9-11克/分 | 10克/分 |
RPM | 13-16转/分 | 15转/分 |
对APAP胶囊片床进行喷涂,直到获得3%重量增量或者良好的颜色均匀性。
将涂膜胶囊片排入干净的多衬里容器中。
实施例2
在尺寸合适的V型混料机中装入98.0克PGA SLF-3(Kibun),1克蔗糖(Domino)和1克Red #40混合料(Warner Jenkinson),将这些物质混合15分钟。排出混好的物料,经#40目筛网过筛。在室温下将混好的物料储存在干净的多衬里容器中。
在配备有带叶片(#3)高速混合器的尺寸合适的不锈钢容器中装入1011.0克去离子水。将上述混好的物料加入去离子水的涡流中,以中-高速混合1.0到1.5小时。
在Vector LDCS 15″涂布机中装入2.0千克APAP 500毫克胶囊片,按照以下参数对胶囊片进行涂覆。
表2
目标 | ||
入口温度 | 65-75℃ | 70℃ |
排气温度 | 32-38℃ | 35℃ |
产物温度 | 32-38℃ | 35℃ |
喷涂速度 | 9-11克/分 | 10克/分 |
RPM | 13-16转/分 | 15转/分 |
对APAP胶囊片床进行喷涂,直到获得3%重量示呈或者良好的颜色均匀性。
鼗涂膜胶囊片排入干净的多衬里容器中。
实施例3
在尺寸合适的V型混料机中装入98.0克PGA SLF-3(Kibun)和2克Red#40混合料(Warner Jenkinson),将这些物质混合15分钟。排出混好的物料,经#40目筛网过筛。在室温下将混好的物料储存在干净的多衬里容器中。
在配备有带叶片(#3)高速混合器的尺寸合适的不锈钢容器中装入1011.0克去离子水。将上述混好的物料加入去离子水的涡流中,以中-高速混合1.0到1.5小时。
在Vector LDCS 15″涂布机中装入2.0千克APAP 500毫克胶囊片,按照以下参数对胶囊片进行涂覆。
表3
目标 | ||
入口温度 | 65-75℃ | 70℃ |
尾气温度 | 32-38℃ | 35℃ |
产物温度 | 32-38℃ | 35℃ |
喷射速度 | 9-11克/分 | 10克/分 |
RPM | 13-16转/分 | 15转/分 |
对APAP胶囊片床进行喷涂,直到获得3%重量增量或者良好的颜色均匀性。
将涂膜胶囊片排入干净的多衬里容器中。
实施例4
在Patterson-Kelly双壳混料机中装入90克低粘度丙二醇藻酸酯(Duckloid SLF-3,Kibun)和10.00克亲水氧化铁红(WCD)。对干组分进行充分混合之后,用Lightnin混合器对混合料进行搅拌。在室温下搅拌悬浮液4.5小时,使该组合物完全水合。在15″Vector LDCS装料器中装入1.9千克醋氨酚500毫克胶囊片。涂布机工作时的入口温度是74-75℃。出口温度是34-35℃,速度是14-16转/分。喷涂过程需要55分钟,涂覆占胶囊片重量3%的涂层。涂层组成和涂覆胶囊片的物理性质如下表4中实施例4所示。
实施例5
在Patterson-Kelly双壳混料机中装入80克低粘度丙二醇藻酸酯(Duckloid SLF-3,Kibun),17克聚乙二醇8000(PEG 8000,Union Carbide)和3.00克麦芽糖糊精-180(Maltrin-M-180,Grain Processing Corporation)。对干组分进行充分混合之后,将混合料缓慢加入用Lightnin混合器进行搅拌的900.0克去离子水的涡流中。在室温下搅拌悬浮液1小时,使该组合物完全水合。在15″Vector LDCS涂布机中装入2.0千克醋氨酚500毫克胶囊片。涂布机工作时的入口温度是73-78℃,出口温度是34-39℃,速度是13转/分。喷涂过程需要57分钟,涂覆占胶囊片重量3%的涂层。涂层组成和涂覆胶囊片的物理性质如下表4中实施例5所示。
实施例6
在Patterson-Kelly双壳混料机中装入80.82克低粘度丙二醇藻酸酯(Duckloid SLF-3,Kibun),10.1克无水乳糖(Sheffield Corporation)和9.1克蓝色颜料混合物(Chromatone,Warner Jenkinson)。对干组分进行充分混合之后,将混合料缓慢加入用Lightnin混合器进行搅拌的1011.0克去离子水的涡流中。搅拌悬浮液1小时45分钟,使该组合物完全水合。在15″VectorLDCD中装入2.0千克布洛芬200毫克胶片。涂布机工作时的入口温度是66-72℃,出口温度是32-35℃,速度是12-16转/分。喷涂过程需要1小时2分钟,涂覆占胶囊片重量3%的涂层。涂层组成和涂覆胶囊片的物理性质如下表4中
实施例6所示。
实施例7
在Patterson-Kelly双壳混料机中装入65.0克低粘度丙二醇藻酸酯(Duckloid SLF-3,Kibun)和35.0克聚乙二醇8000(PEG 8000,Union Carbide)。对组分进行充分混合之后,将混合料缓慢加入用Lightnin混合器进行搅拌的1011.0克去离子水的涡流中。在室温下搅拌悬浮液1小时,使该组合物完全水合。在15″Vector LDCD涂布机中装入1.9千克醋氨酚500毫克胶囊片。涂布机工作时的入口温度是73-78℃,出口温度是32-35℃,速度是12-17转/分。喷涂过程需要54分钟,涂覆占胶囊片重量3%的涂层。涂层组成和涂覆胶囊片的物理性质如下表4中实施例7所示。
实施例8
在Patterson-Kelly双壳混料机中装入85.0克低粘度丙二醇藻酸酯(Duckloid SLF-3,Kibun),5.00克无水乳糖(Sheffield Corporation)和10.0克黄色色淀混合物(Warner Jenkinson)。对干组分进行充分混合之后,将混合料缓慢加入用Lightnin混合器进行搅拌的1011.0克去离子水的涡流中。搅拌悬浮液1小时,使该组合物完全水合。在15″Vector LDCD中装入1.9千克醋氨酚500毫克胶囊片。涂布机工作时的入口温度是77-80℃,出口温度是33-36℃,速度是13-17转/分。喷涂过程需要53分钟,涂覆占胶囊片重量3%的涂层。涂层组成和涂覆胶囊片的物理性质如下表4中实施例8所示。
表4
实施例 | 4 | 5 | 6 | 7 | 8 |
组分 | (干重%) | ||||
PGA1 | 90.0 | 80 | 80.82 | 65.0 | 85 |
麦芽糖糊精2 | -- | 3.0 | -- | -- | -- |
颜料3 | 10.0 | -- | 9.1 | -- | 10.0 |
PEG 80004 | -- | 17.0 | -- | 35.0 | -- |
无水乳糖5 | -- | -- | 10.1 | -- | 5.0 |
胶囊片组分 | |||||
醋氨酚 | X | X | X | X | |
布洛芬 | X | ||||
涂层重量(%) | 3 | 3 | 3 | 3 | 3 |
易碎性(10分钟) | 0% | 0% | 0% | 0% | 0% |
外观(光泽)6 | 5 | 5 | 5 | 5 | 5 |
初始溶解 | (一定时间的百分比) | ||||
10分钟 | 87.0% | 86% | N/A | N/A | N/A |
15分钟 | N/A | N/A | 50.0% | N/A | N/A |
20分钟 | 99.0% | 97.0% | N/A | N/A | N/A |
30分钟 | 101.0% | 99.0% | 84.0% | N/A | N/A |
45分钟 | N/A | N/A | 96.0% | N/A | N/A |
60分钟 | N/A | N/A | 99.0% | N/A | N/A |
1聚丙二醇藻酸酯(Duckloid SLF-3,Kibun)(Spectrum Chem,USP/NF)
2麦芽糖糊精,Maltrin M180
3颜料(Whittaker Clarke & Daniels,Warner Jenkinson)
4聚乙二醇8000(Union Carbide)
5无水乳糖(Sheffield)
65=优良;4=可以接受的;3=勉强合格;2=差;1=不可接受的
Claims (28)
1.一种可食用,可硬化,迅速释放的涂层组合物,包含91%到100%的丙二醇藻酸酯和最高9%的表面活性剂,其特征在于该丙二醇藻酸酯是该组合物的主要成膜剂,其1%水溶液在25℃下具有约1到500mPa·s范围的粘度。
2.如权利要求1所述的涂层组合物,其特征在于所述表面活性剂是卵磷脂。
3.如权利要求2所述的涂层组合物,其特征在于该组合物还包括填料和颜料中的至少一种。
4.如权利要求3所述的涂层组合物,其特征在于该组合物包含作为填料的麦芽糖糊精。
5.如权利要求3所述的涂层组合物,其特征在于该组合物包含5%到9%的一种颜料。
6.如权利要求3所述的组合物,其特征在于颜料和填料的混合物占该组合物干重的1%到9%。
7.如权利要求1所述的涂层组合物,其特征在于所述组合物包含2%到9%的卵磷脂,和1%到9%的麦芽糖糊精。
8.如权利要求1所述的涂层组合物,其特征在于所述组合物包含2%到9%的卵磷脂,和5%到9%的颜料。
9.如权利要求7或权利要求8所述的涂层组合物,其特征在于该组合物还包含3%到9%的次要成膜剂或增强聚合物。
10.如权利要求9所述的涂层组合物,其特征在于角叉菜胶占该组合物干重的5%到9%。
11.如权利要求9所述的涂层组合物,其特征在于羟乙基纤维素占该组合物干重的5%到9%。
12.一种干涂层组合物,包含权利要求1所述的涂层组合物的干混合料。
13.一种湿涂料组合物,包含权利要求1所述的涂层组合物的水分散体。
14.一种固体剂型,其涂覆有如权利要求1所述的组合物。
15.如权利要求1所述的组合物,其特征在于该成膜聚合物由丙二醇藻酸酯组成。
16.一种可食用,可硬化,迅速释放的涂层组合物,包含55%到100%的丙二醇藻酸酯,其特征在于该丙二醇藻酸酯是该组合物的主要成膜剂,其1%的水溶液在25℃下具有约1到500mPa·s范围的粘度,其条件是该涂层组合物包含小于2%的表面活性剂。
17.如权利要求16所述的涂层组合物,其特征在于该组合物不含表面活性剂。
18.如权利要求16所述的涂层组合物,其特征在于该组合物还包含填料和颜料中的至少一种。
19.如权利要求18所述的涂层组合物,其特征在于该组合物包含作为填料的麦芽糖糊精。
20.如权利要求18所述的涂层组合物,其特征在于该组合物包含5%到15%的颜料。
21.如权利要求18所述的涂层组合物,其特征在于颜料和填料的混合物占该组合物干重的10%到40%。
22.如权利要求21所述的涂层组合物,其特征在于该组合物还包含3%到12%的次要成膜剂或增强聚合物。
23.如权利要求22所述的涂层组合物,其特征在于角叉菜胶占该组合物干重的5%到10%。
24.如权利要求22所述的涂层组合物,其特征在于羟乙基纤维素占该组合物干重的5%到10%。
25.一种湿涂料组合物,包含如权利要求16所述的涂层组合物的水分散体。
26.一种固体剂型,其涂覆有如权利要求16所述的组合物。
27.如权利要求16所述的涂层组合物,其特征在于该组合物还包含增塑剂。
28.如权利要求16所述的涂层组合物,该组合物还包含占该组合物干重30%到45%的增塑剂,其特征在于所述丙二醇藻酸酯占该组合物干重的60%到75%。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/077,338 US6932861B2 (en) | 2000-11-28 | 2002-02-15 | Edible PGA coating composition |
US10/077,338 | 2002-02-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1622800A true CN1622800A (zh) | 2005-06-01 |
CN1330379C CN1330379C (zh) | 2007-08-08 |
Family
ID=27752691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB028286014A Expired - Fee Related CN1330379C (zh) | 2002-02-15 | 2002-04-22 | 可食用pga涂层组合物 |
Country Status (7)
Country | Link |
---|---|
US (2) | US6932861B2 (zh) |
EP (1) | EP1474113A4 (zh) |
JP (1) | JP2005526039A (zh) |
CN (1) | CN1330379C (zh) |
AU (1) | AU2002367695A1 (zh) |
IL (1) | IL163507A0 (zh) |
WO (1) | WO2003070226A1 (zh) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US7910641B2 (en) * | 2001-10-12 | 2011-03-22 | Monosol Rx, Llc | PH modulated films for delivery of actives |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
US8518471B2 (en) * | 2003-01-21 | 2013-08-27 | Lw Global, Llc | Pan spray formulation and delivery system |
US20050075432A1 (en) * | 2003-10-07 | 2005-04-07 | Verrall Andrew P. | Acidulent film and method of making same |
BRPI0415741B1 (pt) | 2003-11-07 | 2013-07-23 | composições de tabaco e métodos de fabricação de uma composição de tabaco | |
US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
EP1799050A1 (en) * | 2004-10-14 | 2007-06-27 | Givaudan SA | Formulations for liquid coatings to deliver flavor to food products |
CN1331771C (zh) * | 2004-11-15 | 2007-08-15 | 抚顺华美水处理制剂有限公司 | 水处理除氯片及其制备方法 |
WO2007063553A1 (en) * | 2005-11-29 | 2007-06-07 | Ideal Cures Pvt. Ltd. | Aqueous film coating composition containing sodium alginate and preparation thereof |
SE530184C2 (sv) * | 2005-12-23 | 2008-03-18 | Kjell Stenberg | Bioadhesiv farmaceutisk filmkomposition innehållande lågviskösa alginater |
AU2006329819A1 (en) * | 2005-12-27 | 2007-07-05 | Monosol Rx Llc | pH modulated films for delivery of actives |
WO2007124093A2 (en) * | 2006-04-21 | 2007-11-01 | Cadbury Adams Usa Llc | Coating compositions, confectionery and chewing gum compositions and methods |
US8148377B2 (en) | 2007-02-11 | 2012-04-03 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile |
GB2456212B (en) * | 2008-01-09 | 2012-04-25 | Lrc Products | Lubricant mousse |
US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
US11191737B2 (en) | 2016-05-05 | 2021-12-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
Family Cites Families (145)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2134714A (en) | 1936-11-25 | 1938-11-01 | Jacob A Glassman | Saccharine-aspirin tablet |
US2494912A (en) * | 1947-01-20 | 1950-01-17 | Kelco Co | Higher alkylene glycol esters of alginic acid |
US2881085A (en) | 1953-11-09 | 1959-04-07 | Abbott Lab | Thin film coating for tablets and the like |
US3251824A (en) * | 1961-08-22 | 1966-05-17 | Fmc Corp | Method of preparing stable aqueous dispersion-forming cellulosic aggregates |
US3149039A (en) | 1961-10-03 | 1964-09-15 | Dow Chemical Co | Thin film coating for tablets and the like and method of coating |
US3149040A (en) | 1962-04-09 | 1964-09-15 | Dow Chemical Co | Thin film coating for tablets and the like and method of coating |
US3297535A (en) | 1963-02-28 | 1967-01-10 | Hoffmann La Roche | Shellac tablet coating compositions and methods of preparation |
US3407157A (en) | 1965-05-19 | 1968-10-22 | Hoffmann La Roche | Tablet coating compositions comprising methyl vinyl ethermaleic anhydride copolymer,plasticizer and surface active agent |
US3438797A (en) | 1965-10-21 | 1969-04-15 | Jerry Allen Biddle Sr | Method of preparing pharmaceutical tablets |
GB1135856A (en) | 1966-09-08 | 1968-12-04 | Alginate Ind Ltd | A method of modifying alkylene glycol alginates |
US3573058A (en) | 1967-01-30 | 1971-03-30 | Swift & Co | Microcrystalline cellulose compositions co-dried with hydrocolloids |
US3576663A (en) | 1967-05-29 | 1971-04-27 | Colorcon | Coated tablet |
US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
US3935326A (en) | 1967-06-28 | 1976-01-27 | Boehringer Mannheim G.M.B.H. | Process for coating tablets with aqueous resin dispersions |
US3981984A (en) | 1968-04-01 | 1976-09-21 | Colorcon Incorporated | Color film coating of tablets and the like |
US3649302A (en) | 1969-11-10 | 1972-03-14 | Cpc International Inc | Process of producing a ready-to-spread frosting |
DE2010416B2 (de) | 1970-03-05 | 1979-03-29 | Hoechst Ag, 6000 Frankfurt | Oral anwendbare Arzneiform mit Retardwirkung |
US3751277A (en) | 1971-03-24 | 1973-08-07 | Dow Chemical Co | Tablet coating process and composition |
US3906086A (en) | 1971-07-19 | 1975-09-16 | Richard G Powers | Timed-release aspirin |
US4009131A (en) | 1972-01-17 | 1977-02-22 | The Lubrizol Corporation | Powder coating compositions and metal objects coated therewith |
US3957966A (en) | 1972-05-19 | 1976-05-18 | Gaf Corporation | Stabilized vitamin food coatings |
BE791458A (fr) | 1972-07-31 | 1973-05-16 | Merck & Co Inc | Produit microencapsule |
FR2211213B1 (zh) | 1972-12-26 | 1976-04-23 | Montagne Noire Prod Chim | |
US3851574A (en) | 1972-12-26 | 1974-12-03 | Pillsbury Co | Heat and moisture activated savory coating system for popcorn |
DE2305023A1 (de) | 1973-02-02 | 1974-08-08 | Basf Ag | Mattierungsmittel fuer lacke |
US3873694A (en) | 1973-09-27 | 1975-03-25 | Cpc International Inc | Direct compression tabletting composition and pharmaceutical tablets produced therefrom |
DK152371C (da) | 1975-01-08 | 1988-07-25 | Ciba Geigy Ag | Organisk pigmentpraeparat |
US4112215A (en) | 1975-03-20 | 1978-09-05 | Rohm Gmbh | Copolymeric resin binder powders |
US4011392A (en) | 1975-09-02 | 1977-03-08 | The Sherwin-Williams Company | Mixed starch esters and the use thereof |
US4143163A (en) | 1976-06-30 | 1979-03-06 | Maxfibe, Inc. | Coated fibrous cellulose product and process |
DE2656408C2 (de) | 1976-12-13 | 1983-12-15 | CIBA-GEIGY AG, 4002 Basel | Verfahren zur Herstellung von staubarmen Präparaten und deren Verwendung |
US4274830A (en) | 1977-09-27 | 1981-06-23 | Colorcon, Inc. | Colored medicinal tablet, natural color pigment and method for using the pigment in coloring food, drug and cosmetic products |
US4336244A (en) | 1977-09-27 | 1982-06-22 | Colorcon, Inc. | Colored medicinal tablet, natural color pigment and method for using the pigment in coloring food, drug and cosmetic products |
US4263334A (en) * | 1978-05-31 | 1981-04-21 | Fmc Corporation | Water dispersible cellulosic powder and method of making the same |
US4330338A (en) | 1978-10-02 | 1982-05-18 | Purdue Research Foundation | Pharmaceutical coating composition, and preparation and dosages so coated |
JPS5562012A (en) | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
US4324554A (en) | 1978-11-09 | 1982-04-13 | Merck & Co., Inc. | Use of TKP as an antimigrant |
US4341563A (en) | 1978-11-17 | 1982-07-27 | Sankyo Company Limited | Protective coating compositions |
JPS5598120A (en) | 1979-01-16 | 1980-07-25 | Shin Etsu Chem Co Ltd | Preparation of drug having enteric coating |
US4316884A (en) | 1979-01-25 | 1982-02-23 | Adria Laboratories, Inc. | Sustained release pharmaceutical formulation |
JPS5620513A (en) | 1979-07-31 | 1981-02-26 | Eisai Co Ltd | Sugar-coated tablet containing fat-soluble drug |
US4257816A (en) | 1979-09-17 | 1981-03-24 | Merck & Co., Inc. | Novel blend of algin, TKP, and guar gum |
US4250195A (en) | 1979-09-24 | 1981-02-10 | Life Savers, Inc. | Method for applying soft flexible sugar coating to fresh chewing gum and coated chewing gum product |
US4252786A (en) | 1979-11-16 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Controlled release tablet |
US4543370A (en) | 1979-11-29 | 1985-09-24 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
FR2471186A1 (fr) | 1979-12-10 | 1981-06-19 | Roussel Uclaf | Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation |
US4307117A (en) | 1980-03-27 | 1981-12-22 | General Foods Corporation | Stabilized curcumin colorant |
US4475919A (en) | 1980-04-28 | 1984-10-09 | Colorcon, Inc. | Colored medicinal tablet, natural color pigment and method for using the pigment in coloring food, drug and cosmetic products |
US4311717A (en) * | 1980-05-19 | 1982-01-19 | Fmc Corporation | Stabilizing agent for dry mix food products |
US4302440B1 (en) | 1980-07-31 | 1986-08-05 | Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof | |
US4683256A (en) | 1980-11-06 | 1987-07-28 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
US4340582A (en) | 1981-01-15 | 1982-07-20 | Abbott Laboratories | Erythromycin base tablets |
IN158328B (zh) | 1981-03-09 | 1986-10-18 | Ici Plc | |
JPS57171428A (en) | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
ZA822995B (en) | 1981-05-21 | 1983-12-28 | Wyeth John & Brother Ltd | Slow release pharmaceutical composition |
US4375468A (en) | 1981-07-13 | 1983-03-01 | Verex Laboratories, Inc. | Constant order release aspirin composition and method of treating arthritis |
US4790881A (en) | 1982-03-26 | 1988-12-13 | Warner-Lambert Company | Molded hydrophilic polymer |
US4514384A (en) | 1983-03-14 | 1985-04-30 | Gallina Damian J | Hemorrhoid treatment method |
JPS59193831A (ja) | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | 腸溶性製剤の製造法 |
US4505890A (en) | 1983-06-30 | 1985-03-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation and method |
FR2548675B1 (fr) | 1983-07-06 | 1987-01-09 | Seppic Sa | Compositions filmogenes pour enrobage des formes solides de produits pharmaceutiques ou alimentaires et produits obtenus revetus desdites compositions |
US4576646A (en) | 1983-07-06 | 1986-03-18 | Seppic | Film-forming compositions for enveloping solid forms, particularly pharmaceutical or food products or seeds, and products obtained, coated with said compositions |
US4704295A (en) | 1983-09-19 | 1987-11-03 | Colorcon, Inc. | Enteric film-coating compositions |
US4556552A (en) | 1983-09-19 | 1985-12-03 | Colorcon, Inc. | Enteric film-coating compositions |
CH658188A5 (de) | 1984-03-23 | 1986-10-31 | Ciba Geigy Ag | Lagerstabile schnellzerfallende pharmazeutische presslinge. |
US4643894A (en) | 1984-07-24 | 1987-02-17 | Colorcon, Inc. | Maltodextrin coating |
US4828841A (en) | 1984-07-24 | 1989-05-09 | Colorcon, Inc. | Maltodextrin coating |
JPH0742219B2 (ja) | 1984-07-26 | 1995-05-10 | ライオン株式会社 | 口腔用組成物 |
US4693751A (en) | 1984-08-23 | 1987-09-15 | Crompton & Knowles Corporation | Titanium dioxide suspension for use in film coating |
DE3431861A1 (de) | 1984-08-30 | 1986-03-13 | Troponwerke GmbH & Co KG, 5000 Köln | Pellet-zubereitung |
US4652313A (en) | 1984-10-24 | 1987-03-24 | Crompton And Knowles Corporation | Aqueous lake pigment suspension |
US4636261A (en) | 1984-10-24 | 1987-01-13 | Heinze Richard F | Dry lake system |
US4596602A (en) | 1984-11-08 | 1986-06-24 | General Foods Corporation | Method of preparing an aqueous maltodextrin solution having microbial stability and decreased haze |
DE3506276C1 (de) | 1985-02-22 | 1986-04-24 | Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring | Direkttablettiermittel |
US4910028A (en) | 1985-03-06 | 1990-03-20 | Griffith Laboratories U.S.A., Inc. | Honey coated and honey glazed roasted nuts and method for producing same |
IT1183574B (it) | 1985-05-08 | 1987-10-22 | Eurand Spa | Metodo per ottenere una sospensione estemporanea omogenea di microcapsule |
GB8521494D0 (en) | 1985-08-29 | 1985-10-02 | Zyma Sa | Controlled release tablet |
US4786511A (en) | 1986-01-07 | 1988-11-22 | Warner-Lambert Company | Coatings for chewing gums containing gum arabic and a soluble calcium salt |
US4802924A (en) | 1986-06-19 | 1989-02-07 | Colorcon, Inc. | Coatings based on polydextrose for aqueous film coating of pharmaceutical food and confectionary products |
US4859462A (en) | 1986-07-30 | 1989-08-22 | Fisons Corporation | Polymer-treated ion exchange resins |
US4750938A (en) | 1986-11-12 | 1988-06-14 | Crompton & Knowles Corporation | Aqueous phosphate pigment dispersions |
US4913919A (en) | 1986-11-18 | 1990-04-03 | Frito-Lay, Inc. | Coating composition for comestible products |
US4981698A (en) | 1986-12-23 | 1991-01-01 | Warner-Lambert Co. | Multiple encapsulated sweetener delivery system and method of preparation |
CA1308357C (en) | 1987-01-28 | 1992-10-06 | Tohru Chiba | Method for the preparation of a coated solid medicament |
US5310572A (en) * | 1987-02-03 | 1994-05-10 | Dow Corning Corporation | Process for forming a coated active agent-containing article |
US4959227A (en) | 1987-02-17 | 1990-09-25 | Amer Moh S | High dietary fiber low lactose liquid food and a method of producing same |
US4981707A (en) | 1987-03-24 | 1991-01-01 | Ogilvie Mills, Inc. | Dextrin-based food-grade adhesive including xanthan or carboxymethylcellulose or mixtures thereof |
DE3720757A1 (de) | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
GB8716111D0 (en) | 1987-07-08 | 1987-08-12 | Unilever Plc | Edible plastic dispersion |
US4792452A (en) | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
US4915954A (en) | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering a drug at two different rates |
US4814181A (en) | 1987-09-03 | 1989-03-21 | Alza Corporation | Dosage form comprising fast agent delivery followed by slow agent delivery |
US4994276A (en) | 1988-09-19 | 1991-02-19 | Edward Mendell Co., Inc. | Directly compressible sustained release excipient |
US5023083A (en) | 1987-09-23 | 1991-06-11 | William Drell | Azarbine composition |
US5006513A (en) | 1987-11-09 | 1991-04-09 | Miles Inc. | Antimycotic compositions of nikkomycin compounds and azole antimycotica |
US4816298A (en) | 1987-11-27 | 1989-03-28 | The Dow Chemical Company | Method of making a granular, cold water dispersible coating composition |
US5024842A (en) | 1988-04-28 | 1991-06-18 | Alza Corporation | Annealed coats |
US4857337A (en) | 1988-05-24 | 1989-08-15 | American Home Products Corp. (Del) | Enteric coated aspirin tablets |
US4877629A (en) | 1988-06-10 | 1989-10-31 | International Flavors & Fragrances Inc. | Process for preparing a coated food product |
US5009897A (en) | 1988-06-24 | 1991-04-23 | Abbott Laboratories | Pharmaceutical granules and tablets made therefrom |
US5194464A (en) * | 1988-09-27 | 1993-03-16 | Takeda Chemical Industries, Ltd. | Enteric film and preparatoin thereof |
DE68914428T2 (de) * | 1988-12-29 | 1995-01-12 | Deknatel Tech Corp | Absorbierbare Beschichtung und Mischung. |
US5011701A (en) * | 1988-12-30 | 1991-04-30 | Kraft General Foods, Inc. | Low calorie food products having smooth, creamy, organoleptic characteristics |
EP0458484A3 (en) * | 1989-05-26 | 1992-12-09 | The Kendall Company | Rubber-based adhesive tapes |
US5047258A (en) | 1989-07-14 | 1991-09-10 | Sterling Drug Inc. | Aqueous spray-coating process |
JP2642486B2 (ja) * | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
US5059248A (en) | 1989-08-11 | 1991-10-22 | Warner-Jenkinson Company, Inc. | Stable, fluid, aqueous pigment dispersions for use in film coating tablets and the like |
US4983399A (en) | 1989-10-18 | 1991-01-08 | Eastman Kodak Company | Direct compression carrier composition |
US5082684A (en) * | 1990-02-05 | 1992-01-21 | Pfizer Inc. | Low-calorie fat substitute |
FR2660317B1 (fr) * | 1990-03-27 | 1994-01-14 | Seppic | Produit filmogene destine a l'enrobage des formes solides; son procede de fabrication et produits revetus de ce produit. |
US5089270A (en) * | 1990-05-15 | 1992-02-18 | L. Perrigo Company | Capsule-shaped tablet |
US5213738A (en) * | 1990-05-15 | 1993-05-25 | L. Perrigo Company | Method for making a capsule-shaped tablet |
US5202137A (en) * | 1990-06-29 | 1993-04-13 | Berwind Pharmaceutical Services, Inc. | Method of inhibiting fat and oil migration from an oily substrate of a food product into a coating layer of a food product |
IT1246350B (it) * | 1990-07-11 | 1994-11-17 | Eurand Int | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
US5591455A (en) * | 1990-12-20 | 1997-01-07 | Warner-Jenkinson Company, Inc. | Wet powder film-forming compositions |
ATE192335T1 (de) * | 1990-12-20 | 2000-05-15 | Warner Jenkinson Co Inc | Filmbildende zusammensetzungen aus feuchtem pulver |
US5098715A (en) * | 1990-12-20 | 1992-03-24 | Burroughs Wellcome Co. | Flavored film-coated tablet |
US5332595A (en) * | 1991-03-18 | 1994-07-26 | Kraft General Foods, Inc. | Stable multiple emulsions comprising interfacial gelatinous layer, flavor-encapsulating multiple emulsions and low/no-fat food products comprising the same |
GB2256648B (en) * | 1991-05-29 | 1995-08-30 | Colorcon Ltd | Wax polish composition |
AU664561B2 (en) * | 1991-06-21 | 1995-11-23 | University Of Cincinnati, The | Orally administrable therapeutic proteins and method of making |
DE4122217C2 (de) * | 1991-07-04 | 1997-02-13 | Merz & Co Gmbh & Co | Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern |
US5209942A (en) * | 1991-11-27 | 1993-05-11 | Thomas J. Lipton, Co., Division Of Conopco, Inc. | Low fat/no fat salad dressing having mimetic functional properties fat and a process therefor |
JP3703481B2 (ja) * | 1992-01-17 | 2005-10-05 | バーウィンド・ファーマスーティカル・サーヴィスィーズ・インコーポレーテッド | セルロース重合体およびラクトースに基づくフィルム被覆および被覆組成物 |
US5286502A (en) * | 1992-04-21 | 1994-02-15 | Wm. Wrigley Jr. Company | Use of edible film to prolong chewing gum shelf life |
US5286510A (en) * | 1992-10-07 | 1994-02-15 | Thomas J. Lipton Co., Division Of Conopco, Inc. | Fat mimetic containing salad dressing and process therefor |
FR2698560B1 (fr) * | 1992-11-30 | 1995-02-03 | Virbac Laboratoires | Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications. |
US5411746A (en) * | 1993-02-24 | 1995-05-02 | Warner-Jenkinson Company, Inc. | Dye compositions and methods for film coating tablets and the like |
US5718969A (en) * | 1993-08-25 | 1998-02-17 | Fmc Corporation | Nonaggregating hydrocolloid microparticulates, intermediates therefor, and processes for their preparation |
JP3492787B2 (ja) * | 1994-04-15 | 2004-02-03 | 信越化学工業株式会社 | 固形製剤のコーティング用水性エマルジョンの濃縮方法 |
GB9414045D0 (en) * | 1994-07-12 | 1994-08-31 | Berwind Pharma Service | Moisture barrier film coating composition, method, and coated form |
US5733575A (en) * | 1994-10-07 | 1998-03-31 | Bpsi Holdings, Inc. | Enteric film coating compositions, method of coating therewith, and coated forms |
US5709896A (en) * | 1996-06-18 | 1998-01-20 | Fmc Corporation | Reduced-fat food dispersions and method of preparing |
US5882707A (en) * | 1996-01-05 | 1999-03-16 | Bpsi Holdings, Inc. | Method of coating an edible substrate with sugar/syrup or sugarless solutions containing dry color concentrate |
US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
US5876739A (en) * | 1996-06-13 | 1999-03-02 | Novartis Ag | Insecticidal seed coating |
US6183808B1 (en) * | 1997-01-06 | 2001-02-06 | Bpsi Holdings, Inc. | Film coatings and film coating compositions based on dextrin |
EP0996508B1 (en) * | 1997-01-06 | 2004-08-11 | BPSI Holdings, Inc. | Film coatings and film coating compositions based on dextrin |
US6030641A (en) * | 1997-06-03 | 2000-02-29 | Uni Colloid Kabushiki Kaisha | Sustained release capsule and method for preparing the same |
US6248391B1 (en) * | 1997-07-16 | 2001-06-19 | Bpsi Holdings, Inc. | Bright white film coatings and film coating compositions therefor |
US5904937A (en) * | 1997-10-03 | 1999-05-18 | Fmc Corporation | Taste masked pharmaceutical compositions |
US6391368B1 (en) * | 1998-09-25 | 2002-05-21 | Fmc Corporation | Rapidly peptizable microcrystalline cellulose-based stabilizing agents |
US6723342B1 (en) * | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
US6432448B1 (en) * | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
US6500462B1 (en) * | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
JP2004531467A (ja) * | 2000-11-28 | 2004-10-14 | エフ エム シー コーポレーション | 可食性pga被覆組成物 |
-
2002
- 2002-02-15 US US10/077,338 patent/US6932861B2/en not_active Expired - Fee Related
- 2002-04-22 EP EP02806866A patent/EP1474113A4/en not_active Withdrawn
- 2002-04-22 CN CNB028286014A patent/CN1330379C/zh not_active Expired - Fee Related
- 2002-04-22 WO PCT/US2002/013668 patent/WO2003070226A1/en active Application Filing
- 2002-04-22 JP JP2003569184A patent/JP2005526039A/ja active Pending
- 2002-04-22 AU AU2002367695A patent/AU2002367695A1/en not_active Abandoned
- 2002-04-22 IL IL16350702A patent/IL163507A0/xx unknown
-
2004
- 2004-12-02 US US11/002,025 patent/US20050095272A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1330379C (zh) | 2007-08-08 |
EP1474113A1 (en) | 2004-11-10 |
WO2003070226A1 (en) | 2003-08-28 |
US20050095272A1 (en) | 2005-05-05 |
IL163507A0 (en) | 2005-12-18 |
EP1474113A4 (en) | 2008-02-27 |
AU2002367695A1 (en) | 2003-09-09 |
US20020121225A1 (en) | 2002-09-05 |
JP2005526039A (ja) | 2005-09-02 |
US6932861B2 (en) | 2005-08-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1330379C (zh) | 可食用pga涂层组合物 | |
CN100381117C (zh) | 可食用的包衣组合物 | |
EP1208143B1 (en) | Film coatings and film coating compositions based on polyvinyl alcohol | |
CN1198600C (zh) | 可食用的mcc/pga包衣组合物 | |
RU2528095C2 (ru) | Системы пленочного покрытия для препаратов с немедленным высвобождением, создающие усиленный барьер от влаги, и субстраты с таким покрытием | |
US6881449B2 (en) | Edible PGA coating composition | |
HU225964B1 (en) | Moisture barrier film coating composition, method, and coated form | |
EP1954770A1 (en) | Aqueous film coating composition containing sodium alginate and preparation thereof | |
JP2003527335A (ja) | 食用コーティング組成物 | |
US20050196445A1 (en) | Edible microcrystalline cellulose and carrageenan coating composition | |
CA2362356A1 (en) | Elegant film coating system | |
CN1708289A (zh) | 可食pga包衣组合物 | |
MXPA01007782A (en) | Edible coating composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |