WO2003040146A1 - Nouveaux composes carbapenem - Google Patents

Nouveaux composes carbapenem Download PDF

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Publication number
WO2003040146A1
WO2003040146A1 PCT/JP2002/011477 JP0211477W WO03040146A1 WO 2003040146 A1 WO2003040146 A1 WO 2003040146A1 JP 0211477 W JP0211477 W JP 0211477W WO 03040146 A1 WO03040146 A1 WO 03040146A1
Authority
WO
WIPO (PCT)
Prior art keywords
represents hydrogen
gram
ring
alkyl
carbapenem compounds
Prior art date
Application number
PCT/JP2002/011477
Other languages
English (en)
French (fr)
Inventor
Makoto Sunagawa
Akira Sasaki
Original Assignee
Sumitomo Pharmaceuticals Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co., Ltd. filed Critical Sumitomo Pharmaceuticals Co., Ltd.
Priority to EP02775484A priority Critical patent/EP1443047A4/en
Priority to JP2003542192A priority patent/JP4377231B2/ja
Priority to CNB028267907A priority patent/CN1330652C/zh
Priority to CA002465336A priority patent/CA2465336C/en
Priority to US10/494,603 priority patent/US7205291B2/en
Priority to KR1020047006747A priority patent/KR100945706B1/ko
Publication of WO2003040146A1 publication Critical patent/WO2003040146A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PCT/JP2002/011477 2001-11-05 2002-11-01 Nouveaux composes carbapenem WO2003040146A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP02775484A EP1443047A4 (en) 2001-11-05 2002-11-01 NEW CARBAPENE COMPOUNDS
JP2003542192A JP4377231B2 (ja) 2001-11-05 2002-11-01 新規なカルバペネム化合物
CNB028267907A CN1330652C (zh) 2001-11-05 2002-11-01 新的卡巴培南化合物
CA002465336A CA2465336C (en) 2001-11-05 2002-11-01 Novel carbapenem compounds
US10/494,603 US7205291B2 (en) 2001-11-05 2002-11-01 Carbapenem compounds
KR1020047006747A KR100945706B1 (ko) 2001-11-05 2002-11-01 신규 카르바페넴 화합물

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001339195 2001-11-05
JP2001-339195 2001-11-05
JP2002-145485 2002-05-20
JP2002145485 2002-05-20

Publications (1)

Publication Number Publication Date
WO2003040146A1 true WO2003040146A1 (fr) 2003-05-15

Family

ID=26624344

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/011477 WO2003040146A1 (fr) 2001-11-05 2002-11-01 Nouveaux composes carbapenem

Country Status (7)

Country Link
US (1) US7205291B2 (ja)
EP (1) EP1443047A4 (ja)
JP (1) JP4377231B2 (ja)
KR (1) KR100945706B1 (ja)
CN (1) CN1330652C (ja)
CA (1) CA2465336C (ja)
WO (1) WO2003040146A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089954A1 (ja) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. 新規なカルバペネム化合物
WO2006103999A1 (ja) * 2005-03-25 2006-10-05 Dainippon Sumitomo Pharma Co., Ltd. 新規なカルバペネム化合物
JP2007039383A (ja) * 2005-08-03 2007-02-15 Dainippon Sumitomo Pharma Co Ltd アリールカルバペネム化合物の製造方法
JP2007039382A (ja) * 2005-08-03 2007-02-15 Dainippon Sumitomo Pharma Co Ltd カルバペネム化合物の製造方法
US10519161B2 (en) 2012-10-29 2019-12-31 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds
JP2020523311A (ja) * 2017-06-09 2020-08-06 フオブ・シンセシス・インコーポレーテツド 細菌感染治療のためのカルバペネム化合物及び組成物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2577924A1 (en) * 2004-09-03 2006-03-09 Dainippon Sumitomo Pharma Co., Ltd. Novel carbapenem compound
KR100930586B1 (ko) * 2007-11-23 2009-12-09 한국화학연구원 2-아릴메틸아제티딘-카바페넴-3-카복실산 에스테르 유도체,이의 제조방법 및 이를 포함하는 약학 조성물
CN101868460A (zh) * 2007-11-23 2010-10-20 国际药品工业株式会社 2-芳基甲基吖丁啶-碳青霉烯-3-羧酸酯衍生物或其盐、其制备方法以及包含上述的药物组合物
WO2013157583A1 (ja) * 2012-04-18 2013-10-24 大日本住友製薬株式会社 新規カルバペネム化合物
WO2021071832A1 (en) * 2019-10-07 2021-04-15 D.E. Shaw Research, Llc Aryl heterobicyclic compounds as kv1.3 potassium shaker channel blockers

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
US4775669A (en) 1976-11-19 1988-10-04 Merck & Co., Inc. 1-carba-2-penem-3-carboxylic acid
JPH0249783A (ja) 1988-05-10 1990-02-20 Sankyo Co Ltd １―メチルカルバペネム誘導体
JPH02223587A (ja) 1988-11-08 1990-09-05 Dai Ichi Seiyaku Co Ltd カルバペネム誘導体
US5034385A (en) * 1990-06-26 1991-07-23 Merck & Co., Inc. 2-(heteroarylsubstituted)phenyl carbapenem antibacterial agents
EP0444889A1 (en) * 1990-02-26 1991-09-04 Merck & Co. Inc. Novel synthesis of carbapenem intermediates
WO1992003437A1 (en) 1990-08-21 1992-03-05 Glaxo S.P.A. 10(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3.8]undec-2-ene-2-carboxylic acid esters and a process for preparing thereof
JPH04279588A (ja) 1990-09-07 1992-10-05 Tanabe Seiyaku Co Ltd １−メチルカルバペネム誘導体及びその製法
US5256777A (en) * 1991-10-17 1993-10-26 Merck & Co., Inc. 2-phenyl-carbapenems
US5258509A (en) 1989-11-21 1993-11-02 Banyu Pharmaceutical Co., Ltd. Process for producing 2-carbon-substituted carbapenem derivatives
US5338875A (en) * 1992-11-19 1994-08-16 Merck & Co., Inc. Boron containing intermediates useful in the preparation of carbapenems
JPH0853453A (ja) 1993-07-01 1996-02-27 Lederle Japan Ltd ２−［１−（１，３−チアゾリン−２−イル）アゼチジン−３−イル］チオ−カルバペネム化合物
WO1998034936A1 (fr) 1997-02-07 1998-08-13 Kyoto Pharmaceutical Industries, Ltd. Composes de carbapenem, leur utilisation et composes intermediaires de celui-ci
US5821362A (en) * 1993-02-12 1998-10-13 Suntory Limited Method of desilylating silylether compounds
WO1999057121A1 (fr) 1998-05-01 1999-11-11 Kyoto Pharmaceutical Industries, Ltd. Derives de carbapenem, son utilisation et composes intermediaires a base de carbapenem

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68916908T2 (de) 1988-11-08 1994-12-01 Daiichi Seiyaku Co Carbapenemderivate.
US5034358A (en) * 1989-05-05 1991-07-23 Kaman Sciences Corporation Ceramic material and method for producing the same
US5208348A (en) 1990-09-07 1993-05-04 Tanabe Seiyaku Co., Ltd. Mercaptan compound
US5783703A (en) 1993-07-01 1998-07-21 Lederle (Japan), Ltd. Sulfur-containing compounds method for their use and prodction
JP3557989B2 (ja) * 2000-02-28 2004-08-25 株式会社日立製作所 化学物質総合管理システム
ES2254324T3 (es) 2000-12-27 2006-06-16 Dainippon Sumitomo Pharma Co., Ltd. Compuestos de carbapenemo, medicamento y antibacteriano que los comprende y sus usos.

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775669A (en) 1976-11-19 1988-10-04 Merck & Co., Inc. 1-carba-2-penem-3-carboxylic acid
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
JPH0249783A (ja) 1988-05-10 1990-02-20 Sankyo Co Ltd １―メチルカルバペネム誘導体
JPH02223587A (ja) 1988-11-08 1990-09-05 Dai Ichi Seiyaku Co Ltd カルバペネム誘導体
US5258509A (en) 1989-11-21 1993-11-02 Banyu Pharmaceutical Co., Ltd. Process for producing 2-carbon-substituted carbapenem derivatives
EP0444889A1 (en) * 1990-02-26 1991-09-04 Merck & Co. Inc. Novel synthesis of carbapenem intermediates
US5034385A (en) * 1990-06-26 1991-07-23 Merck & Co., Inc. 2-(heteroarylsubstituted)phenyl carbapenem antibacterial agents
WO1992003437A1 (en) 1990-08-21 1992-03-05 Glaxo S.P.A. 10(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3.8]undec-2-ene-2-carboxylic acid esters and a process for preparing thereof
JPH04279588A (ja) 1990-09-07 1992-10-05 Tanabe Seiyaku Co Ltd １−メチルカルバペネム誘導体及びその製法
US5256777A (en) * 1991-10-17 1993-10-26 Merck & Co., Inc. 2-phenyl-carbapenems
US5338875A (en) * 1992-11-19 1994-08-16 Merck & Co., Inc. Boron containing intermediates useful in the preparation of carbapenems
US5821362A (en) * 1993-02-12 1998-10-13 Suntory Limited Method of desilylating silylether compounds
JPH0853453A (ja) 1993-07-01 1996-02-27 Lederle Japan Ltd ２−［１−（１，３−チアゾリン−２−イル）アゼチジン−３−イル］チオ−カルバペネム化合物
WO1998034936A1 (fr) 1997-02-07 1998-08-13 Kyoto Pharmaceutical Industries, Ltd. Composes de carbapenem, leur utilisation et composes intermediaires de celui-ci
WO1999057121A1 (fr) 1998-05-01 1999-11-11 Kyoto Pharmaceutical Industries, Ltd. Derives de carbapenem, son utilisation et composes intermediaires a base de carbapenem

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, March 1999 (1999-03-01), pages 460 - 464
JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, 1987, pages 871 - 880
See also references of EP1443047A4
TETRAHEDRON, vol. 39, 1983, pages 2531 - 2549

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089954A1 (ja) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. 新規なカルバペネム化合物
US7468364B2 (en) 2003-04-08 2008-12-23 Dainippon Sumitomo Pharma Co., Ltd. Carbapenem compounds
WO2006103999A1 (ja) * 2005-03-25 2006-10-05 Dainippon Sumitomo Pharma Co., Ltd. 新規なカルバペネム化合物
JP2007039383A (ja) * 2005-08-03 2007-02-15 Dainippon Sumitomo Pharma Co Ltd アリールカルバペネム化合物の製造方法
JP2007039382A (ja) * 2005-08-03 2007-02-15 Dainippon Sumitomo Pharma Co Ltd カルバペネム化合物の製造方法
US10519161B2 (en) 2012-10-29 2019-12-31 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds
JP2020523311A (ja) * 2017-06-09 2020-08-06 フオブ・シンセシス・インコーポレーテツド 細菌感染治療のためのカルバペネム化合物及び組成物
JP7326164B2 (ja) 2017-06-09 2023-08-15 フオブ・シンセシス・インコーポレーテツド 細菌感染治療のためのカルバペネム化合物及び組成物

Also Published As

Publication number Publication date
JPWO2003040146A1 (ja) 2005-03-03
US20050020566A1 (en) 2005-01-27
EP1443047A1 (en) 2004-08-04
CN1612879A (zh) 2005-05-04
EP1443047A4 (en) 2005-04-27
US7205291B2 (en) 2007-04-17
KR100945706B1 (ko) 2010-03-05
CA2465336C (en) 2009-04-28
CN1330652C (zh) 2007-08-08
JP4377231B2 (ja) 2009-12-02
CA2465336A1 (en) 2003-05-15
KR20040062615A (ko) 2004-07-07

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