WO2002016339A1 - Aminoalkylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant - Google Patents

Aminoalkylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant Download PDF

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Publication number
WO2002016339A1
WO2002016339A1 PCT/FR2001/002640 FR0102640W WO0216339A1 WO 2002016339 A1 WO2002016339 A1 WO 2002016339A1 FR 0102640 W FR0102640 W FR 0102640W WO 0216339 A1 WO0216339 A1 WO 0216339A1
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WO
WIPO (PCT)
Prior art keywords
group
benzofuran
general formula
branched
linear
Prior art date
Application number
PCT/FR2001/002640
Other languages
English (en)
French (fr)
Inventor
Jean-Louis Assens
Claude Bernhart
Frédérique Cabanel-Haudricourt
Patrick Gautier
Dino Nisato
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/362,324 priority Critical patent/US6949583B2/en
Priority to DK01963113.4T priority patent/DK1315709T3/da
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to IL15363201A priority patent/IL153632A0/xx
Priority to MEP-2008-230A priority patent/ME00106B/me
Priority to AU2001284149A priority patent/AU2001284149B2/en
Priority to EA200300062A priority patent/EA006237B1/ru
Priority to DE60142240T priority patent/DE60142240D1/de
Priority to CA2415847A priority patent/CA2415847C/fr
Priority to YU12903A priority patent/RS51603B/sr
Priority to AU8414901A priority patent/AU8414901A/xx
Priority to HU0302968A priority patent/HU229456B1/hu
Priority to JP2002521440A priority patent/JP5081363B2/ja
Priority to EP01963113A priority patent/EP1315709B1/fr
Priority to MXPA03001463A priority patent/MXPA03001463A/es
Priority to KR1020037002618A priority patent/KR100911280B1/ko
Priority to SI200130974T priority patent/SI1315709T1/sl
Priority to BRPI0113425-6A priority patent/BR0113425B1/pt
Priority to MEP-230/08A priority patent/MEP23008A/xx
Priority to SK216-2003A priority patent/SK288126B6/sk
Priority to AT01963113T priority patent/ATE469138T1/de
Priority to PL362119A priority patent/PL219848B1/pl
Priority to NZ523446A priority patent/NZ523446A/xx
Publication of WO2002016339A1 publication Critical patent/WO2002016339A1/fr
Priority to IL153632A priority patent/IL153632A/en
Priority to IS6677A priority patent/IS2821B/is
Priority to BG107527A priority patent/BG66240B1/bg
Priority to NO20030800A priority patent/NO328138B1/no
Priority to HK03105391.1A priority patent/HK1053113A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PCT/FR2001/002640 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant WO2002016339A1 (fr)

Priority Applications (27)

Application Number Priority Date Filing Date Title
KR1020037002618A KR100911280B1 (ko) 2000-08-23 2001-08-21 아미노알킬벤조일-벤조푸란 또는 벤조티오펜 유도체, 그의제조방법 및 그를 포함하는 조성물
MXPA03001463A MXPA03001463A (es) 2000-08-23 2001-08-21 Derivados de benzofurano o benzotiofeno de aminoalquilbenzoil, metodo para preparar los mismos y composiciones que los contienen.
IL15363201A IL153632A0 (en) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
DK01963113.4T DK1315709T3 (da) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuraner eller benzothiophener, fremgangsmåde til fremstilling deraf og sammensætninger indeholdende samme
AU2001284149A AU2001284149B2 (en) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
EA200300062A EA006237B1 (ru) 2000-08-23 2001-08-21 Производные аминоалкилбензоилбензофурана, способ их получения и содержащие их композиции
DE60142240T DE60142240D1 (de) 2000-08-23 2001-08-21 Aminoalkykbenzoyl-benzofurane oder benzothiophene, verfahren zu ihrer herstellung und die enthaltende zusammensetzungen
CA2415847A CA2415847C (fr) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
YU12903A RS51603B (sr) 2000-08-23 2001-08-21 Derivati aminoalkilbenzoil-benzofurana ili benzotiofena, postupak za njihovo pripremanje i farmaceutski oblici koji ih sadrže
AU8414901A AU8414901A (en) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparingsame and compositions containing same
SI200130974T SI1315709T1 (sl) 2000-08-23 2001-08-21 Aminoalkilbenzoil benzofurani ali benzoziofeni postopek za njihovo pripravo in sestavki ki jih vsebujejo
JP2002521440A JP5081363B2 (ja) 2000-08-23 2001-08-21 アミノアルキルベンゾイル−ベンゾフランまたはベンゾチオフェン誘導体、その製造方法およびそれを含む組成物
EP01963113A EP1315709B1 (fr) 2000-08-23 2001-08-21 Aminoalkykbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
US10/362,324 US6949583B2 (en) 2000-08-23 2001-08-21 Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method of preparing same and compositions containing same
MEP-2008-230A ME00106B (me) 2000-08-23 2001-08-21 Derivati aminoalkenilbenzoil-benzofurana ili benzotiopena, postupak za njihovo pripremanje i kompozicije koje ih sadrže
HU0302968A HU229456B1 (en) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
BRPI0113425-6A BR0113425B1 (pt) 2000-08-23 2001-08-21 Derivados de benzofurano ou de benzotiofeno, processo de preparação destes, medicamento, composição farmacêutica ou veterinária e utilização dos mesmos
MEP-230/08A MEP23008A (en) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
SK216-2003A SK288126B6 (sk) 2000-08-23 2001-08-21 Benzofuran and benzothiophene derivatives, process for their preparation and pharmaceutical or veterinary preparations containing them.
AT01963113T ATE469138T1 (de) 2000-08-23 2001-08-21 Aminoalkykbenzoyl-benzofurane oder benzothiophene,verfahren zu ihrer herstellung und die enthaltende zusammensetzungen
PL362119A PL219848B1 (pl) 2000-08-23 2001-08-21 Pochodne benzofuranu lub benzotiofenu, sposób wytwarzania pochodnych benzofuranu lub benzotiofenu, lek, środek farmaceutyczny lub weterynaryjny i zastosowanie pochodnych benzofuranu lub benzotiofenu
NZ523446A NZ523446A (en) 2000-08-23 2001-08-21 (Aminoalkylbenzoyl) benzofuran or benzothiophene, their process of prepation and the compositions comprising them
IL153632A IL153632A (en) 2000-08-23 2002-12-24 Derivatives of benzoporen and their salts suitable for medicinal use
IS6677A IS2821B (is) 2000-08-23 2003-01-13 Amínóalkýlbensóýl-bensófúran eða bensóþíófenafleiður, aðferð til framleiðslu þeirra og samsetningar sem innihalda þær
BG107527A BG66240B1 (bg) 2000-08-23 2003-02-05 Аминоалкилбензоил - бензофурани или бензотиофени, метод за получаването им и състави, които ги съдържат
NO20030800A NO328138B1 (no) 2000-08-23 2003-02-20 Benzofuran- eller benzotiofenderivater, fremgangsmate for deres fremstilling, preparater inneholdende de samme samt deres anvendelse
HK03105391.1A HK1053113A1 (en) 2000-08-23 2003-07-25 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR00/10834 2000-08-23
FR0010834A FR2813306B1 (fr) 2000-08-23 2000-08-23 Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Publications (1)

Publication Number Publication Date
WO2002016339A1 true WO2002016339A1 (fr) 2002-02-28

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PCT/FR2001/002640 WO2002016339A1 (fr) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Country Status (36)

Country Link
US (1) US6949583B2 (US06949583-20050927-C00005.png)
EP (1) EP1315709B1 (US06949583-20050927-C00005.png)
JP (2) JP5081363B2 (US06949583-20050927-C00005.png)
KR (1) KR100911280B1 (US06949583-20050927-C00005.png)
CN (1) CN1246315C (US06949583-20050927-C00005.png)
AR (1) AR032892A1 (US06949583-20050927-C00005.png)
AT (1) ATE469138T1 (US06949583-20050927-C00005.png)
AU (2) AU8414901A (US06949583-20050927-C00005.png)
BG (1) BG66240B1 (US06949583-20050927-C00005.png)
BR (1) BR0113425B1 (US06949583-20050927-C00005.png)
CA (1) CA2415847C (US06949583-20050927-C00005.png)
CY (1) CY1110738T1 (US06949583-20050927-C00005.png)
CZ (1) CZ304003B6 (US06949583-20050927-C00005.png)
DE (1) DE60142240D1 (US06949583-20050927-C00005.png)
DK (1) DK1315709T3 (US06949583-20050927-C00005.png)
EA (1) EA006237B1 (US06949583-20050927-C00005.png)
ES (1) ES2346291T3 (US06949583-20050927-C00005.png)
FR (1) FR2813306B1 (US06949583-20050927-C00005.png)
HK (1) HK1053113A1 (US06949583-20050927-C00005.png)
HU (1) HU229456B1 (US06949583-20050927-C00005.png)
IL (2) IL153632A0 (US06949583-20050927-C00005.png)
IS (1) IS2821B (US06949583-20050927-C00005.png)
MA (1) MA26943A1 (US06949583-20050927-C00005.png)
ME (2) MEP23008A (US06949583-20050927-C00005.png)
MX (1) MXPA03001463A (US06949583-20050927-C00005.png)
NO (1) NO328138B1 (US06949583-20050927-C00005.png)
NZ (1) NZ523446A (US06949583-20050927-C00005.png)
OA (1) OA12359A (US06949583-20050927-C00005.png)
PL (1) PL219848B1 (US06949583-20050927-C00005.png)
PT (1) PT1315709E (US06949583-20050927-C00005.png)
RS (1) RS51603B (US06949583-20050927-C00005.png)
SI (1) SI1315709T1 (US06949583-20050927-C00005.png)
SK (1) SK288126B6 (US06949583-20050927-C00005.png)
TW (1) TWI290920B (US06949583-20050927-C00005.png)
WO (1) WO2002016339A1 (US06949583-20050927-C00005.png)
ZA (1) ZA200300744B (US06949583-20050927-C00005.png)

Cited By (1)

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WO2011042877A1 (en) 2009-10-09 2011-04-14 Sanofi-Aventis Use of celivarone for the preparation of a medicament for use in the prevention of implantable cardioverter defibrillator interventions or death

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US7401072B2 (en) * 2003-06-10 2008-07-15 Google Inc. Named URL entry
KR20080015077A (ko) * 2005-05-05 2008-02-18 사노피-아벤티스 유.에스. 엘엘씨 안정한 나노입자 제형
FR2893616B1 (fr) * 2005-11-23 2008-01-04 Sanofi Aventis Sa Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
US20110207811A1 (en) * 2010-02-19 2011-08-25 Sanofi-Aventis Use of celivarone for reducing occurrences of cardiovascular hospitalization
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
FR2967067A1 (fr) 2010-11-10 2012-05-11 Sanofi Aventis Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
CN102757444B (zh) * 2011-04-29 2016-02-10 南京信诺泰医药有限公司 具有一氧化氮供体性质的苯并呋喃类化合物
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
CN105315245B (zh) * 2014-06-16 2018-10-12 华润赛科药业有限责任公司 苯并呋喃类衍生物、其制备方法和应用

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