WO1998003510B1 - - Google Patents
Info
- Publication number
- WO1998003510B1 WO1998003510B1 PCT/US1997/013072 US9713072W WO9803510B1 WO 1998003510 B1 WO1998003510 B1 WO 1998003510B1 US 9713072 W US9713072 W US 9713072W WO 9803510 B1 WO9803510 B1 WO 9803510B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- stereoisomeric forms
- ome
- isomers
- dimethyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- -1 2-methyl-4-methoxyphenyl Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000000651 prodrug Chemical group 0.000 claims 2
- 229940002612 prodrugs Drugs 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
Priority Applications (26)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RO99-00078A RO121272B1 (ro) | 1996-07-24 | 1997-07-23 | Azolotriazine şi pirimidine |
AU38942/97A AU747708B2 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
IL15016397A IL150163A0 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
SI9720045A SI9720045B (sl) | 1996-07-24 | 1997-07-23 | Azolo triazini in pirimidini |
DK97936222T DK0915880T3 (da) | 1996-07-24 | 1997-07-23 | Azolotriaziner og pyrimidiner |
JP50723398A JP4704521B2 (ja) | 1996-07-24 | 1997-07-23 | アゾロトリアジン類およびアゾロピリミジン類 |
BR9710544A BR9710544A (pt) | 1996-07-24 | 1997-07-23 | M-todo de tratamento composto e composi-Æo farmac-utica |
DE69738197T DE69738197T2 (de) | 1996-07-24 | 1997-07-23 | Azolotriazine und pyrimidine |
IL12787197A IL127871A0 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
UA99010100A UA73913C2 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
PL97331523A PL195762B1 (pl) | 1996-07-24 | 1997-07-23 | Związki [1,5-a]pirazolo-1,3,5-triazynowe, środek farmaceutyczny i zastosowanie związków [1,5-a]pirazolo-1,3,5-triazynowych do wytwarzania leku |
KR1019997000568A KR100548853B1 (ko) | 1996-07-24 | 1997-07-23 | 아졸로 트리아진 및 피리미딘 |
CA002259583A CA2259583C (fr) | 1996-07-24 | 1997-07-23 | Azolo triazines et pyrimidines |
HU0102187A HU228962B1 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines, pharmaceutical compositions containing them and use of the compounds |
EP97936222A EP0915880B1 (fr) | 1996-07-24 | 1997-07-23 | Azolo triazines et pyrimidines |
HU0500549A HU229024B1 (en) | 1996-07-24 | 1997-07-23 | Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof |
SK97-99A SK286461B6 (sk) | 1996-07-24 | 1997-07-23 | [1,5-a]-Pyrazolo-1,3,5-triazíny, ich použitie a farmaceutické kompozície na ich báze |
EEP199900019A EE04316B1 (et) | 1996-07-24 | 1997-07-23 | Asolotriasiinid ja -pürimidiinid, neid sisaldavadfarmatseutilised kompositsioonid ning nende kasutamine ravimite valmistamiseks |
EA199900158A EA004403B1 (ru) | 1996-07-24 | 1997-07-23 | Производные пиразолотриазинов, фармацевтические композиции, содержащие их, способы лечения |
NZ333777A NZ333777A (en) | 1996-07-24 | 1997-07-23 | (1,5-a) pyrazolo and triazole triazines and pyrimidines |
IL127871A IL127871A (en) | 1996-07-24 | 1998-12-30 | PHARMACEUTICAL COMPOSITIONS CONTAINING CRF ANTAGONIST 3-ARYL-PYRAZOLO (AND 1,2,3-TRIAZOLO) [1,5-a]-1,3,5-TRIAZINE DERIVATIVES AND SOME NEW SUCH DERIVATIVES |
LVP-99-13A LV12292B (en) | 1996-07-24 | 1999-01-20 | TRIANGLE AND PYRIMIDINES AZOL-DERIVATIVES |
NO19990264A NO315610B3 (no) | 1996-07-24 | 1999-01-21 | Azolotriaziner og -pyrimidiner |
AU23236/02A AU773039C (en) | 1996-07-24 | 2002-03-12 | Azolo triazines and pyrimidines |
IL150163A IL150163A (en) | 1996-07-24 | 2002-06-11 | PHARMACEUTICAL COMPOSITIONS COMPRISING PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND SOME NOVEL SUCH COMPOUNDS |
IL164513A IL164513A (en) | 1996-07-24 | 2004-10-12 | Pyrazolopyrimidines, pharmaceutical compositions containing them and their use in the preparation of medicaments |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68604796A | 1996-07-24 | 1996-07-24 | |
US2329096P | 1996-07-24 | 1996-07-24 | |
US08/686,047 | 1997-07-23 | ||
US60/023,290 | 1997-07-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998003510A1 WO1998003510A1 (fr) | 1998-01-29 |
WO1998003510B1 true WO1998003510B1 (fr) | 1998-04-02 |
Family
ID=26696934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/013072 WO1998003510A1 (fr) | 1996-07-24 | 1997-07-23 | Azolo triazines et pyrimidines |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP0915880B1 (fr) |
KR (1) | KR100548853B1 (fr) |
AR (1) | AR007994A1 (fr) |
AT (1) | ATE375344T1 (fr) |
AU (1) | AU747708B2 (fr) |
CZ (1) | CZ2005613A3 (fr) |
DE (1) | DE69738197T2 (fr) |
DK (1) | DK0915880T3 (fr) |
EA (1) | EA006626B1 (fr) |
ES (1) | ES2294800T3 (fr) |
HK (1) | HK1052693A1 (fr) |
HU (2) | HU229024B1 (fr) |
LV (1) | LV12292B (fr) |
PT (1) | PT915880E (fr) |
RO (1) | RO121272B1 (fr) |
TW (2) | TWI238164B (fr) |
WO (1) | WO1998003510A1 (fr) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
EP0970082A2 (fr) * | 1997-02-18 | 2000-01-12 | Neurocrine Biosciences, Inc. | Antagonistes crf biazacycliques |
NZ505079A (en) * | 1998-01-28 | 2003-08-29 | Du Pont Pharm Co | Pyrazolotriazines and pyrazolopyrimidines useful as corticotropin releasing factor antagonists |
US6613777B1 (en) | 1998-03-06 | 2003-09-02 | Chen Chen | CRF antagonistic pyrazolo[4,3-b]pyridines |
US6509338B1 (en) * | 1998-06-22 | 2003-01-21 | Bristol-Myers Squibb Company | Pyrazolo[1,5-A]triazine corticotropin releasing factor antagonists |
US6348466B1 (en) | 1998-11-12 | 2002-02-19 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
ES2180338T3 (es) | 1998-11-12 | 2003-02-01 | Neurocrine Biosciences Inc | Antagonistas del receptor de crf y metodos relacionados. |
WO2000059908A2 (fr) * | 1999-04-06 | 2000-10-12 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines antagonistes de corticoliberine (crf) |
AU4331500A (en) | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
US6372743B1 (en) | 1999-09-30 | 2002-04-16 | Neurogen Corporation | Certain alkylene diamine-substituted pyrazlo (1,5-a)-1,5-pyrimidines and pyrazolo (1,5-a) 1,3,5-triazines |
ES2277855T3 (es) * | 1999-09-30 | 2007-08-01 | Neurogen Corporation | Pirazolo-(1,5-a)-1,5-pirimidinas y pirazolo-(1,5-a)-1,3,5-triazinas amino sustituidas. |
US6506762B1 (en) | 1999-09-30 | 2003-01-14 | Neurogen Corporation | Certain alkylene diamine-substituted heterocycles |
AU2001232271A1 (en) * | 2000-02-14 | 2001-08-20 | Japan Tobacco Inc. | Preventives/remedies for postoperative stress |
WO2002006286A2 (fr) * | 2000-07-14 | 2002-01-24 | Bristol-Myers Squibb Pharma Company | Imidazo[1,2-a]pyrazines destinees au traitement d'affections neurologiques |
CN1446316A (zh) * | 2000-08-02 | 2003-10-01 | 玛洛普有限公司 | 基于下丘脑-垂体-肾上腺轴异常的非溃疡性消化不良的诊断和处置 |
RU2292347C2 (ru) | 2001-03-13 | 2007-01-27 | Бристоль-Мейерз Сквибб Фарма Компани | 4-(2-БУТИЛАМИНО)-2,7-ДИМЕТИЛ-8-(2-МЕТИЛ-6-МЕТОКСИПИРИД-3-ИЛ)ПИРАЗОЛО-[1,5-а]-1,3,5-ТРИАЗИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЕГО СОДЕРЖАЩАЯ, И ЕГО ПРИМЕНЕНИЕ |
CA2446980A1 (fr) | 2001-05-14 | 2002-11-21 | Argyrios G. Arvanitis | Pyrazinones, pyridines et pyrimidines substitues en tant que ligands de la corticoliberine |
WO2003005969A2 (fr) | 2001-07-12 | 2003-01-23 | Bristol-Myers Squibb Pharma Company | Tetrahydropurinones et leurs derives en tant que ligands du recepteur du facteur de liberation de corticotropine |
US7276526B2 (en) | 2001-07-13 | 2007-10-02 | Bristol-Myers Squibb Pharma Company | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands |
US20030119831A1 (en) | 2001-11-20 | 2003-06-26 | Hartz Richard A. | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands |
DE60301339T2 (de) | 2002-03-07 | 2006-03-09 | Smithkline Beecham Corp. | Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen |
ES2298513T3 (es) * | 2002-04-26 | 2008-05-16 | Eli Lilly And Company | Derivados de tiazol como antagonistas del receptor de taquicinina. |
FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
FR2850653A1 (fr) * | 2003-02-04 | 2004-08-06 | Univ Pasteur | Derives de pyrazolotriazine, procede de preparation et utilisations |
US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
US7112585B2 (en) | 2003-04-18 | 2006-09-26 | Bristol-Myers Squibb Company | Pyrimidine derivatives as corticotropin releasing factor inhibitors |
US7030145B2 (en) | 2003-04-18 | 2006-04-18 | Bristol-Myers Squibb Company | Pyridinyl derivatives for the treatment of depression |
US7208596B2 (en) | 2003-11-25 | 2007-04-24 | Bristol-Myers Squibb Pharma Company | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof |
US7153961B2 (en) | 2003-11-25 | 2006-12-26 | Bristol-Myers Squibb Pharma Co. | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist |
WO2005063755A1 (fr) | 2003-12-22 | 2005-07-14 | Sb Pharmco Puerto Rico Inc | Antagonistes du recepteur de crf et procedes correspondants |
GB0519957D0 (en) | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
US20100216798A1 (en) * | 2005-07-29 | 2010-08-26 | Astellas Pharma Inc | Fused heterocycles as lck inhibitors |
CN101516886B (zh) | 2006-09-20 | 2012-02-29 | 伊莱利利公司 | 噻吩吡唑并嘧啶化合物 |
PL2094709T3 (pl) * | 2006-09-20 | 2011-02-28 | Lilly Co Eli | Tiazolopirazolopirymidyny jako antagoniści receptora crf1 |
JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
AR064491A1 (es) | 2006-12-22 | 2009-04-08 | Astex Therapeutics Ltd | Derivados de imidazo[1, 2-a]pirimidina, un proceso para su preparacion, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por las quinasas fgfr. |
EP2522351B1 (fr) * | 2007-06-13 | 2017-09-06 | Research Development Foundation | Traitement et prévention de tauopathies et de l'amyloïdose de bêta-amyloïde en modulant la signalisation de récepteur CRF |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
WO2010118207A1 (fr) | 2009-04-09 | 2010-10-14 | Schering Corporation | Dérivés pyrazolo[1, 5-a]pyrimidine en tant qu'inhibiteurs de mtor |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
EP2264035A1 (fr) * | 2009-06-04 | 2010-12-22 | Merz Pharma GmbH & Co. KGaA | B antagonistes de la glycine |
EP2723746A1 (fr) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Composés inhibiteurs de la kinase atr |
PL2760453T3 (pl) | 2011-09-30 | 2016-11-30 | Makrocykliczne Inhibitory kinazy LRRK2 | |
GB201210686D0 (en) | 2012-06-15 | 2012-08-01 | Holsboermaschmeyer Neurochemie Gmbh | V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level |
CA2891122C (fr) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methodes et compositions pour le traitement de la schizophrenie |
US8871754B2 (en) | 2012-11-19 | 2014-10-28 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
CN105164124B (zh) | 2012-11-19 | 2017-03-15 | 诺华股份有限公司 | 用于治疗寄生虫疾病的化合物和组合物 |
CN107501275B (zh) | 2012-12-07 | 2019-11-22 | 沃泰克斯药物股份有限公司 | 可用作atr激酶抑制剂的化合物 |
WO2014144801A1 (fr) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Procédés et compositions pour améliorer la fonction cognitive |
WO2014144663A1 (fr) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Procédés et compositions pour améliorer la fonction cognitive |
GB201310782D0 (en) | 2013-06-17 | 2013-07-31 | Max Planck Innovation Gmbh | Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms |
RU2720408C2 (ru) | 2013-12-06 | 2020-04-29 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения ингибиторов atr киназы (варианты) |
AU2015271030B2 (en) | 2014-06-05 | 2019-05-16 | Vertex Pharmaceuticals Incorporated | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof |
ES2733847T3 (es) | 2014-06-17 | 2019-12-03 | Vertex Pharma | Método para tratar cáncer usando una combinación de inhibidores de CHK1 y ATR |
WO2016042089A1 (fr) | 2014-09-17 | 2016-03-24 | Oncodesign S.A. | Inhibiteurs macrocycliques de kinases lrrk2 |
AU2015342021B2 (en) | 2014-11-03 | 2020-02-27 | Bayer Pharma Aktiengesellschaft | Piperidinylpyrazolopyrimidinones and their use |
EA034167B8 (ru) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Фармацевтические композиции леветирацетама пролонгированного высвобождения |
WO2017059357A1 (fr) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Méthode de traitement du cancer utilisant une association d'agents endommageant l'adn et d'inhibiteurs de l'atr |
US20210032253A1 (en) * | 2018-02-06 | 2021-02-04 | Jiangsu Hengrui Medicine Co., Ltd. | Pyrazolo[1,5-a][1,3,5]triazine-2-amine derivative, preparation method therefor and medical use thereof |
MX2021004769A (es) | 2018-10-30 | 2021-08-24 | Kronos Bio Inc | Compuestos, composiciones, y metodos para modular la actividad cdk9. |
WO2022036123A1 (fr) | 2020-08-12 | 2022-02-17 | Spruce Biosciences, Inc. | Procédés et compositions pour traiter le syndrome des ovaires polykystiques |
US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE786611A (fr) * | 1971-08-16 | 1973-01-22 | Int Chem & Nuclear Corp | Nouveaux inhibiteurs de xanthine-oxydase et leur procede de preparatio |
US3910907A (en) * | 1973-07-09 | 1975-10-07 | Icn Pharmaceuticals | Pyrazolo(1,5-a)-1,3,5-triazines |
US3995039A (en) * | 1975-05-27 | 1976-11-30 | Merck & Co., Inc. | Pyrazolo [1,5-a] [1,3,5] triazines |
JPS6157587A (ja) * | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
US4824834A (en) * | 1986-10-31 | 1989-04-25 | Otsuka Pharmaceutical Company, Limited | Pyrazolotriazine compounds |
DE3722072A1 (de) * | 1987-07-01 | 1989-01-12 | Schering Ag | 6,7-dihydro-pyrazolo(1,5-a)(1,3,5) triazin-2-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider und pflanzenwuchsregulierender wirkung |
JP2585462B2 (ja) * | 1989-10-25 | 1997-02-26 | 株式会社大塚製薬工場 | ピラゾロ[1,5―a]ピリミジン誘導体 |
US5420128A (en) * | 1990-10-09 | 1995-05-30 | Otsuka Pharmaceutical Co., Ltd. | Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor |
US5484760A (en) * | 1990-12-31 | 1996-01-16 | Monsanto Company | Herbicide antidotes as safeners for reducing phytotoxicity resulting from synergistic interaction between herbicides and other pesticides |
DE69130683T2 (de) * | 1991-04-22 | 1999-05-06 | Otsuka Pharma Co Ltd | PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL |
US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
US6765008B1 (en) * | 1992-12-17 | 2004-07-20 | Pfizer Inc | Pyrrolopyrimidines as CRF antagonists |
KR100315837B1 (ko) * | 1994-06-21 | 2002-02-28 | 고리 히데아끼 | 피라졸로[1,5-a]피리미딘유도체 |
KR100256707B1 (ko) * | 1995-05-12 | 2000-05-15 | 해피 페너 | 데아자푸린 유도체; 새로운 부류의 crf1 특이 리간드 |
EP0880523B1 (fr) * | 1996-02-07 | 2006-08-16 | Neurocrine Biosciences, Inc. | Pyrazolopyrimidines en tant qu'antagonistes du recepteur de crf |
-
1997
- 1997-07-23 AT AT97936222T patent/ATE375344T1/de active
- 1997-07-23 DK DK97936222T patent/DK0915880T3/da active
- 1997-07-23 EP EP97936222A patent/EP0915880B1/fr not_active Expired - Lifetime
- 1997-07-23 RO RO99-00078A patent/RO121272B1/ro unknown
- 1997-07-23 EA EA200301042A patent/EA006626B1/ru not_active IP Right Cessation
- 1997-07-23 AU AU38942/97A patent/AU747708B2/en not_active Expired
- 1997-07-23 PT PT97936222T patent/PT915880E/pt unknown
- 1997-07-23 HU HU0500549A patent/HU229024B1/hu unknown
- 1997-07-23 CZ CZ2005-613A patent/CZ2005613A3/cs unknown
- 1997-07-23 DE DE69738197T patent/DE69738197T2/de not_active Expired - Lifetime
- 1997-07-23 EP EP07015514A patent/EP1908764A1/fr not_active Withdrawn
- 1997-07-23 WO PCT/US1997/013072 patent/WO1998003510A1/fr active IP Right Grant
- 1997-07-23 KR KR1019997000568A patent/KR100548853B1/ko not_active IP Right Cessation
- 1997-07-23 HU HU0102187A patent/HU228962B1/hu unknown
- 1997-07-23 ES ES97936222T patent/ES2294800T3/es not_active Expired - Lifetime
- 1997-07-24 AR ARP970103368A patent/AR007994A1/es unknown
- 1997-07-25 TW TW092105694A patent/TWI238164B/zh not_active IP Right Cessation
- 1997-07-25 TW TW086110640A patent/TW542827B/zh not_active IP Right Cessation
-
1999
- 1999-01-20 LV LVP-99-13A patent/LV12292B/en unknown
-
2003
- 2003-07-02 HK HK03104703.7A patent/HK1052693A1/zh unknown
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