WO1996025956B1 - Conjugue pour le dosage individuel de medicaments - Google Patents
Conjugue pour le dosage individuel de medicamentsInfo
- Publication number
- WO1996025956B1 WO1996025956B1 PCT/DE1996/000267 DE9600267W WO9625956B1 WO 1996025956 B1 WO1996025956 B1 WO 1996025956B1 DE 9600267 W DE9600267 W DE 9600267W WO 9625956 B1 WO9625956 B1 WO 9625956B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- conjugate according
- metal
- conjugate
- derivative
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims abstract 10
- 239000000126 substance Substances 0.000 claims abstract 3
- 150000002736 metal compounds Chemical class 0.000 claims 9
- RGCKGOZRHPZPFP-UHFFFAOYSA-N Alizarin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC=C3C(=O)C2=C1 RGCKGOZRHPZPFP-UHFFFAOYSA-N 0.000 claims 6
- 239000000969 carrier Substances 0.000 claims 6
- 239000002184 metal Substances 0.000 claims 4
- 102100001249 ALB Human genes 0.000 claims 3
- 101710027066 ALB Proteins 0.000 claims 3
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- -1 TTHE Chemical compound 0.000 claims 3
- 229940050528 albumin Drugs 0.000 claims 3
- 230000001809 detectable Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 150000002500 ions Chemical class 0.000 claims 2
- 238000009206 nuclear medicine Methods 0.000 claims 2
- 210000000987 Immune System Anatomy 0.000 claims 1
- 208000001179 Infectious Skin Disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002285 radioactive Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Abstract
L'invention concerne un conjugué contenant un principe actif et un composé présentant un site de liaison pour des composés métalliques. L'invention concerne en outre un procédé de fabrication de ce conjugué et son utilisation.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/913,217 US6410695B1 (en) | 1995-02-21 | 1996-02-21 | Individual medicament dosing conjugate |
DK96903881T DK0810883T3 (da) | 1995-02-21 | 1996-02-21 | Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler |
JP8525299A JPH11500134A (ja) | 1995-02-21 | 1996-02-21 | 個体に投与する薬学製剤のためのコンジュゲート |
EP96903881A EP0810883B1 (fr) | 1995-02-21 | 1996-02-21 | Conjugue contenant dtpa et albumine pour le dosage individuel de medicaments |
AT96903881T ATE221391T1 (de) | 1995-02-21 | 1996-02-21 | Konjugat enthaltend dtpa und albumin zur individuellen dosierung von arzneimitteln |
DE59609508T DE59609508D1 (de) | 1995-02-21 | 1996-02-21 | Konjugat enthaltend dtpa und albumin zur individuellen dosierung von arzneimitteln |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19505960A DE19505960A1 (de) | 1995-02-21 | 1995-02-21 | Konjugat zur individuellen Dosierung von Arzneimitteln |
DE19505960.3 | 1995-02-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1996025956A2 WO1996025956A2 (fr) | 1996-08-29 |
WO1996025956A3 WO1996025956A3 (fr) | 1996-12-27 |
WO1996025956B1 true WO1996025956B1 (fr) | 1997-02-13 |
Family
ID=7754621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1996/000267 WO1996025956A2 (fr) | 1995-02-21 | 1996-02-21 | Conjugue pour le dosage individuel de medicaments |
Country Status (8)
Country | Link |
---|---|
US (1) | US6410695B1 (fr) |
EP (1) | EP0810883B1 (fr) |
JP (1) | JPH11500134A (fr) |
AT (1) | ATE221391T1 (fr) |
DE (2) | DE19505960A1 (fr) |
DK (1) | DK0810883T3 (fr) |
ES (1) | ES2180737T3 (fr) |
WO (1) | WO1996025956A2 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1042003A1 (fr) * | 1998-03-23 | 2000-10-11 | Conjuchem, Inc. | Apport local d'agents therapeutiques a action prolongee |
US6740756B1 (en) | 1998-07-07 | 2004-05-25 | Smithkline Beecham Corporation | Fluorescent lanthanide chelates |
JP2002519404A (ja) * | 1998-07-07 | 2002-07-02 | スミスクライン・ビーチャム・コーポレイション | 新規蛍光ランタニドキレート |
DE19847362A1 (de) * | 1998-10-14 | 2000-04-20 | Deutsches Krebsforsch | Makromolekulare Wirkstoffkonjugate und Verfahren zu ihrer Herstellung |
AUPP856399A0 (en) * | 1999-02-08 | 1999-03-04 | Australian Membrane And Biotechnology Research Institute | Improved compounds for protein binding |
GB9929801D0 (en) * | 1999-12-16 | 2000-02-09 | Btg Int Ltd | Anti-cancer agents iii |
JP2008513533A (ja) * | 2004-09-23 | 2008-05-01 | ゲルベ | Cestイメージング用の造影剤封入システム |
US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
US8926945B2 (en) * | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
FR2942227B1 (fr) | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
FR2980364B1 (fr) | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
FR3061713B1 (fr) * | 2017-01-11 | 2020-02-14 | Universite D'orleans | Complexes de lanthanides a base de derives d'acide triethylenetetramine-n,n,n',n'',n''',n'''-hexaacetique |
WO2020007822A1 (fr) | 2018-07-02 | 2020-01-09 | Conservatoire National Des Arts Et Metiers (Cnam) | Nanoparticules de bismuth métallique (0), procédé de fabrication et utilisations de celles-ci |
Family Cites Families (37)
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DE2551480C3 (de) | 1975-11-15 | 1982-04-22 | Hoechst Ag, 6000 Frankfurt | Technetium-99m-markiertes Nierendiagnostikum und Verfahren zu seiner Herstellung |
US4339426A (en) | 1980-03-18 | 1982-07-13 | Regents Of The University Of California | Bleomycin analog |
NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
US4663277A (en) * | 1983-05-20 | 1987-05-05 | Profile Diagnostic Sciences Inc. | Virus detection method and materials |
DE3404443A1 (de) * | 1984-02-08 | 1985-08-08 | Hartmut Prof. Dr. 1000 Berlin Köpf | Metallicenium-salze und deren verwendung als cytostatica bei der krebsbekaempfung |
US4634586A (en) * | 1984-05-21 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Reagent and method for radioimaging leukocytes |
US4837003A (en) * | 1984-09-13 | 1989-06-06 | Mallinckrodt, Inc. | Radiolabeled antibody fragments |
US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
EP0188256B1 (fr) * | 1985-01-14 | 1991-08-21 | NeoRx | Protéines marquées par un radionuclide d'un métal pour diagnostic et thérapie |
CA1282069C (fr) | 1985-09-12 | 1991-03-26 | Damon L. Meyer | Complexes d'anticorps comprenant des agents therapeutiques ou de diagnostic modifies par des haptenes |
GB8610551D0 (en) * | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
EP0274343A1 (fr) * | 1987-01-06 | 1988-07-13 | IntraCel Corporation | Système de réactifs avec une apo-enzyme, utilisé dans les analyses immunologiques et un procédé pour exécuter les essais immunologiques avec ce système |
WO1989000062A1 (fr) | 1987-07-07 | 1989-01-12 | The Cancer Institute Board | Radiotherapie |
WO1989005853A1 (fr) | 1987-12-15 | 1989-06-29 | Synthetic Genetics | Conjugue de chelate d'acide nucleique utilise comme agent therapeutique et de diagnostic |
IL89222A (en) * | 1988-02-09 | 1995-03-30 | Mallinckrodt Inc | Preparation of metal-radionuclide-labelled proteins, certain novel compounds used therein and radiopharmaceutical compositions containing the labelled proteins |
CA1340527C (fr) * | 1988-05-31 | 1999-05-04 | Lidia Vallarino | Complexes macrocycliques d'ions d'yttrium, de lanthanides et d'actinides, renfermant des fonctions de couplage peripherique |
US5094950A (en) * | 1988-06-07 | 1992-03-10 | Nihon Medi-Physics Co., Ltd. | Diethylenetriamine pentaacetic acid derivatives |
HU219485B (hu) * | 1988-06-24 | 2001-04-28 | Dow Chemical Co. | Eljárás 1,4,7,10-tetraaza-ciklododekán-származékok, ezek komplexei, valamint antitestekkel képzett konjugátumai, és ilyeneket tartalmazó gyógyszerkészítmények előállítására és a komplexeket, illetve konjugátumokat tartalmazó diagnosztikai készítmények |
US5101041A (en) * | 1989-04-26 | 1992-03-31 | The Curators Of The University Of Missouri | Triamines and their derivatives as bifunctional chelating agents |
ES2070329T3 (es) | 1989-07-20 | 1995-06-01 | Sandoz Ltd | Derivados de polipeptidos. |
US5124471A (en) | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
US5367080A (en) * | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
US5439829A (en) * | 1991-01-30 | 1995-08-08 | Eli Lilly And Company | Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion |
US5310539A (en) * | 1991-04-15 | 1994-05-10 | Board Of Regents, The University Of Texas System | Melanin-based agents for image enhancement |
JPH0616561A (ja) * | 1991-07-09 | 1994-01-25 | Tsumura & Co | 抗レトロウイルス剤 |
EP0594749A1 (fr) * | 1991-07-15 | 1994-05-04 | Repligen Corporation | Compositions pf4 et procedes d'utilisation desdites compositions |
CA2113578A1 (fr) * | 1991-07-19 | 1993-02-04 | Ann E. Huang | Composes trifonctionnels specifiques de cellules multiresistantes |
DE4134158C2 (de) * | 1991-10-11 | 1997-02-13 | Max Delbrueck Centrum | Verwendung von Carboplatin in lyotrophen Mesophasen zur Überwindung einer durch Zytostatika ausgelösten Leukopenie |
US5326778A (en) * | 1992-03-03 | 1994-07-05 | Research Corporation Technologies, Inc. | Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy |
EP0630407B1 (fr) | 1992-03-11 | 2000-08-02 | PRENDERGAST, Kenneth, Francis | Peptides de fusion anti-viraux |
US5292938A (en) * | 1992-04-13 | 1994-03-08 | Associated Universities, Inc. | Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging |
JP3358141B2 (ja) * | 1992-05-07 | 2002-12-16 | アメルシャム ヘルス アクスイェ セルスカプ | 錯化剤と金属放射性核種イオンとの錯体及びそれを含む診断用組成物 |
GB2268494B (en) * | 1992-07-08 | 1996-08-21 | Kenneth Francis Prendergast | Imaging compositions |
JPH08502300A (ja) * | 1992-10-14 | 1996-03-12 | スターリング ウィンスロップ アイエヌシー. | 治療および診断像形成組成物および方法 |
WO1995019791A1 (fr) * | 1994-01-24 | 1995-07-27 | Neorx Corporation | Annexines marquees isotopiquement |
CA2189051C (fr) | 1994-04-29 | 2008-06-17 | M. Jules Mattes | Composition destinee a l'apport de radio-isotopes toxiques au noyau de la cellule, et son utilisation |
DE4435087A1 (de) | 1994-09-30 | 1996-04-04 | Deutsches Krebsforsch | Konjugat zur Behandlung von Infektions-, Autoimmun- und Hauterkrankungen |
-
1995
- 1995-02-21 DE DE19505960A patent/DE19505960A1/de not_active Withdrawn
-
1996
- 1996-02-21 DE DE59609508T patent/DE59609508D1/de not_active Expired - Fee Related
- 1996-02-21 US US08/913,217 patent/US6410695B1/en not_active Expired - Fee Related
- 1996-02-21 AT AT96903881T patent/ATE221391T1/de not_active IP Right Cessation
- 1996-02-21 ES ES96903881T patent/ES2180737T3/es not_active Expired - Lifetime
- 1996-02-21 EP EP96903881A patent/EP0810883B1/fr not_active Expired - Lifetime
- 1996-02-21 JP JP8525299A patent/JPH11500134A/ja active Pending
- 1996-02-21 WO PCT/DE1996/000267 patent/WO1996025956A2/fr active IP Right Grant
- 1996-02-21 DK DK96903881T patent/DK0810883T3/da active
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