DK0810883T3 - Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler - Google Patents

Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler

Info

Publication number
DK0810883T3
DK0810883T3 DK96903881T DK96903881T DK0810883T3 DK 0810883 T3 DK0810883 T3 DK 0810883T3 DK 96903881 T DK96903881 T DK 96903881T DK 96903881 T DK96903881 T DK 96903881T DK 0810883 T3 DK0810883 T3 DK 0810883T3
Authority
DK
Denmark
Prior art keywords
albumin
drugs
conjugate containing
individual dosing
containing dtpa
Prior art date
Application number
DK96903881T
Other languages
English (en)
Inventor
Hans-Hermann Schrenk
Wolfgang Maier-Borst
Hannsjoerg Sinn
Gerd Stehle
Original Assignee
Deutsches Krebsforsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch
Application granted granted Critical
Publication of DK0810883T3 publication Critical patent/DK0810883T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DK96903881T 1995-02-21 1996-02-21 Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler DK0810883T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19505960A DE19505960A1 (de) 1995-02-21 1995-02-21 Konjugat zur individuellen Dosierung von Arzneimitteln
PCT/DE1996/000267 WO1996025956A2 (de) 1995-02-21 1996-02-21 Konjugat zur individuellen dosierung von arzneimitteln

Publications (1)

Publication Number Publication Date
DK0810883T3 true DK0810883T3 (da) 2002-11-11

Family

ID=7754621

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96903881T DK0810883T3 (da) 1995-02-21 1996-02-21 Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler

Country Status (8)

Country Link
US (1) US6410695B1 (da)
EP (1) EP0810883B1 (da)
JP (1) JPH11500134A (da)
AT (1) ATE221391T1 (da)
DE (2) DE19505960A1 (da)
DK (1) DK0810883T3 (da)
ES (1) ES2180737T3 (da)
WO (1) WO1996025956A2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002512640A (ja) * 1998-03-23 2002-04-23 コンジュケム，インコーポレーテッド 持続性治療薬の局所送達
WO2000001663A1 (en) * 1998-07-07 2000-01-13 Smithkline Beecham Corporation Novel fluorescent lanthanide chelates
US6740756B1 (en) 1998-07-07 2004-05-25 Smithkline Beecham Corporation Fluorescent lanthanide chelates
DE19847362A1 (de) * 1998-10-14 2000-04-20 Deutsches Krebsforsch Makromolekulare Wirkstoffkonjugate und Verfahren zu ihrer Herstellung
AUPP856399A0 (en) * 1999-02-08 1999-03-04 Australian Membrane And Biotechnology Research Institute Improved compounds for protein binding
GB9929801D0 (en) * 1999-12-16 2000-02-09 Btg Int Ltd Anti-cancer agents iii
ATE493152T1 (de) * 2004-09-23 2011-01-15 Guerbet Sa Liposomale kontrastmittel für die cest-bildgebung
EP1940841B9 (fr) * 2005-10-07 2017-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
FR2968999B1 (fr) 2010-12-20 2013-01-04 Guerbet Sa Nanoemulsion de chelate pour irm
FR2980364B1 (fr) 2011-09-26 2018-08-31 Guerbet Nanoemulsions et leur utilisation comme agents de contraste
FR3001154B1 (fr) 2013-01-23 2015-06-26 Guerbet Sa Magneto-emulsion vectorisee
FR3061713B1 (fr) 2017-01-11 2020-02-14 Universite D'orleans Complexes de lanthanides a base de derives d'acide triethylenetetramine-n,n,n',n'',n''',n'''-hexaacetique
WO2020007822A1 (en) 2018-07-02 2020-01-09 Conservatoire National Des Arts Et Metiers (Cnam) Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2551480C3 (de) * 1975-11-15 1982-04-22 Hoechst Ag, 6000 Frankfurt Technetium-99m-markiertes Nierendiagnostikum und Verfahren zu seiner Herstellung
US4339426A (en) 1980-03-18 1982-07-13 Regents Of The University Of California Bleomycin analog
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4663277A (en) * 1983-05-20 1987-05-05 Profile Diagnostic Sciences Inc. Virus detection method and materials
DE3404443A1 (de) * 1984-02-08 1985-08-08 Hartmut Prof. Dr. 1000 Berlin Köpf Metallicenium-salze und deren verwendung als cytostatica bei der krebsbekaempfung
US4634586A (en) * 1984-05-21 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Reagent and method for radioimaging leukocytes
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
DE3680924D1 (de) * 1985-01-14 1991-09-26 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
CA1282069C (en) * 1985-09-12 1991-03-26 Damon L. Meyer Antibody complexes of hapten-modified diagnostic or therapeutic agents
GB8610551D0 (en) * 1986-04-30 1986-06-04 Hoffmann La Roche Polypeptide & protein derivatives
EP0274343A1 (en) * 1987-01-06 1988-07-13 IntraCel Corporation A system of reactants involving an apo-enzyme useful in immunological analysis and a method for carrying out immunoassays with this system
WO1989000062A1 (en) * 1987-07-07 1989-01-12 The Cancer Institute Board Radiotherapy
WO1989005853A1 (en) * 1987-12-15 1989-06-29 Synthetic Genetics Nucleic acid chelate conjugate as therapeutic and diagnostic agents
EP0401302B1 (en) * 1988-02-09 1995-06-28 Mallinckrodt, Inc. Method of preparing a metal-radionuclide-labelled protein
CA1340527C (en) * 1988-05-31 1999-05-04 Lidia Vallarino Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities
US5094950A (en) * 1988-06-07 1992-03-10 Nihon Medi-Physics Co., Ltd. Diethylenetriamine pentaacetic acid derivatives
WO1989012631A1 (en) * 1988-06-24 1989-12-28 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
US5101041A (en) * 1989-04-26 1992-03-31 The Curators Of The University Of Missouri Triamines and their derivatives as bifunctional chelating agents
WO1991001144A1 (en) * 1989-07-20 1991-02-07 Sandoz Ltd Labeled polypeptide derivatives
US5124471A (en) * 1990-03-26 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Bifunctional dtpa-type ligand
US5367080A (en) * 1990-11-08 1994-11-22 Sterling Winthrop Inc. Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods
US5439829A (en) * 1991-01-30 1995-08-08 Eli Lilly And Company Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion
US5310539A (en) * 1991-04-15 1994-05-10 Board Of Regents, The University Of Texas System Melanin-based agents for image enhancement
JPH0616561A (ja) * 1991-07-09 1994-01-25 Tsumura & Co 抗レトロウイルス剤
CA2113206A1 (en) * 1991-07-15 1993-02-04 Theodore E. Maione Modified pf4 compositions and methods of use
AU2400692A (en) 1991-07-19 1993-02-23 Hybritech Incorporated Trifunctional compounds having specificity for multi-drug resistant cells
DE4134158C2 (de) * 1991-10-11 1997-02-13 Max Delbrueck Centrum Verwendung von Carboplatin in lyotrophen Mesophasen zur Überwindung einer durch Zytostatika ausgelösten Leukopenie
US5326778A (en) * 1992-03-03 1994-07-05 Research Corporation Technologies, Inc. Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy
EP0630407B1 (en) 1992-03-11 2000-08-02 PRENDERGAST, Kenneth, Francis Anti-viral fusion peptides
US5292938A (en) * 1992-04-13 1994-03-08 Associated Universities, Inc. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
DE69231952T2 (de) * 1992-05-07 2002-04-04 Nycomed Imaging As Komplexbildnermittel und zielimmunoreagenzien
GB2268494B (en) * 1992-07-08 1996-08-21 Kenneth Francis Prendergast Imaging compositions
EP0664713B1 (en) * 1992-10-14 2000-01-19 Nycomed Imaging As Therapeutic and diagnostic imaging compositions and methods
DE69530375T2 (de) * 1994-01-24 2004-02-05 Neorx Corp., Seattle Radioaktiv-markierte annexine
CA2189051C (en) * 1994-04-29 2008-06-17 M. Jules Mattes Composition for delivery of toxic radioisotopes to the cell nucleus and use
DE4435087A1 (de) * 1994-09-30 1996-04-04 Deutsches Krebsforsch Konjugat zur Behandlung von Infektions-, Autoimmun- und Hauterkrankungen

Also Published As

Publication number Publication date
US6410695B1 (en) 2002-06-25
EP0810883A2 (de) 1997-12-10
DE19505960A1 (de) 1996-08-22
DE59609508D1 (de) 2002-09-05
ES2180737T3 (es) 2003-02-16
EP0810883B1 (de) 2002-07-31
JPH11500134A (ja) 1999-01-06
WO1996025956A3 (de) 1996-12-27
ATE221391T1 (de) 2002-08-15
WO1996025956A2 (de) 1996-08-29

Similar Documents

Publication Publication Date Title
DK0810883T3 (da) Konjugat indeholdende DTPA og albumin til individuel dosering af lægemidler
DK1011632T3 (da) Farmaceutisk præparat til behandling af dysmenoré og præmature fødselsveer
SE9704546D0 (sv) Novel compounds
TR199802423T2 (xx) Konsantre antikor terkibi.
DK1156049T3 (da) Substituerede heterocykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
SE9704545D0 (sv) Novel compounds
SE9704544D0 (sv) Novel compounds
DK0812195T3 (da) Farmaceutisk sammensætning til piperidinoalkanolforbindelser
DE69710095T2 (de) Pharmazeutische zubereitung zur behandlung von diabetes
EE9700241A (et) Farmatseutiline kompositsioon transdermaalseks manustamiseks
DK1093819T3 (da) Forbindelse og præparat til tilförsel af aktive midler
DK0994710T4 (da) Farmaceutiske præparater til oral indgivelse omfattende en benzylhydrylpiperazin og en cyclodextrin
YU50695A (sh) Obložena pesticidna sredstva, postupci za njihovo dobijanje i smese koje ih sadrže
DK1063995T3 (da) Kombination til behandling af alkoholafhængighed indeholdende en opiod-antagonist og en NMDA-receptorkompleks-modulator
DK1003494T3 (da) (d)-metadon, et ikke-opioidt analgetikum
SE9802937D0 (sv) Novel compounds
MX9708394A (es) Composicion farmaceutica que contiene clorhidrato de tiagabina y el proceso para su preparacion.
DK0862545T3 (da) Pesticide forbindelser, sammensætninger og fremgangsmåde til fremstilling deraf
DK0806949T3 (da) Ny farmaceutisk komposition, der indeholder trimebutin, og fremgangsmåde til fremstilling deraf
IT1290910B1 (it) 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
PT1001942E (pt) Poli-hidroxibutilpirazinas sua preparacao e medicamentos que as contem
DK1100775T3 (da) 2,5-Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til fremstilling deraf, anvendelse deraf og farmaceutiske præparater indeholdende disse
NO305959B1 (no) Tiosubstituerte cykliske fosfonatforbindelser, anvendelser derav, og farmasoeytiske preparater inneholdende slike forbindelser
MY116275A (en) A pharmaceutical composition for treating dysmenorrhea and premature labor
BR1100937A (pt) Composto, processos para sua preparação e obtenção, e, composições farmacêuticas