ATE493152T1 - Liposomale kontrastmittel für die cest-bildgebung - Google Patents
Liposomale kontrastmittel für die cest-bildgebungInfo
- Publication number
- ATE493152T1 ATE493152T1 AT05801399T AT05801399T ATE493152T1 AT E493152 T1 ATE493152 T1 AT E493152T1 AT 05801399 T AT05801399 T AT 05801399T AT 05801399 T AT05801399 T AT 05801399T AT E493152 T1 ATE493152 T1 AT E493152T1
- Authority
- AT
- Austria
- Prior art keywords
- contrast agents
- cest imaging
- liposomal contrast
- liposomal
- contrast agent
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 3
- 238000003384 imaging method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61217304P | 2004-09-23 | 2004-09-23 | |
| PCT/EP2005/054798 WO2006032705A2 (en) | 2004-09-23 | 2005-09-23 | Contrast agents encapsulating systems for cest imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE493152T1 true ATE493152T1 (de) | 2011-01-15 |
Family
ID=35871207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05801399T ATE493152T1 (de) | 2004-09-23 | 2005-09-23 | Liposomale kontrastmittel für die cest-bildgebung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070292354A1 (de) |
| EP (1) | EP1793868B1 (de) |
| JP (1) | JP2008513533A (de) |
| AT (1) | ATE493152T1 (de) |
| DE (1) | DE602005025659D1 (de) |
| WO (1) | WO2006032705A2 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006116451A2 (en) | 2005-04-22 | 2006-11-02 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in endosialin-positive cells |
| CN101166547B (zh) * | 2005-04-26 | 2013-02-06 | 皇家飞利浦电子股份有限公司 | 包含cest活性的顺磁性配合物的mri造影剂 |
| US7610077B2 (en) * | 2005-12-08 | 2009-10-27 | General Electric Compnay | Quantitation of sample properties using contrast enhancement from saturation transfer |
| US20090142273A1 (en) * | 2006-06-08 | 2009-06-04 | Case Western Reserve University | Activatable cest MRI agent |
| WO2007141767A2 (en) * | 2006-06-09 | 2007-12-13 | Koninklijke Philips Electronics N.V. | Elimination of contrast agent concentration dependency in mri |
| NO20064315L (no) | 2006-09-22 | 2008-03-24 | Epitarget As | T1 MRI-sporbare medikamentavleveringspartikler and anvendelse derav |
| ES2804801T3 (es) | 2006-12-26 | 2021-02-09 | Lantheus Medical Imaging Inc | Ligandos para la formación de imágenes de la inervación cardíaca |
| FR2914304B1 (fr) | 2007-03-28 | 2012-11-16 | Guerbet Sa | Composes pour le diagnostic de maladies liees a l'expression de vcam. |
| FR2914303A1 (fr) * | 2007-03-28 | 2008-10-03 | Guerbet Sa | Composes pour le diagnostic de l'apoptose. |
| CA2682726C (en) | 2007-04-05 | 2017-05-09 | Morphotek, Inc. | Methods for inhibiting the binding of endosialin to ligands |
| EP2065058A1 (de) * | 2007-11-28 | 2009-06-03 | Koninklijke Philips Electronics N.V. | Nicht kugelförmige Kontrastmittel für CEST-MRI auf der Basis des magnetischen Bulk-Suszeptibilitätseffekts |
| EP2067490A1 (de) * | 2007-12-07 | 2009-06-10 | Koninklijke Philips Electronics N.V. | Chelatbildnerderivate und diese enthaltende Zusammensetzungen zur Verwendung bei Bildgebungsverfahren |
| EP2067485A1 (de) * | 2007-12-07 | 2009-06-10 | Koninklijke Philips Electronics N.V. | Wirkstoffträger zur Verbesserung des MRI-Kontrastes |
| CN101888857A (zh) * | 2007-12-07 | 2010-11-17 | 皇家飞利浦电子股份有限公司 | 用于图像引导的递送的聚合物药物载体 |
| JP5604432B2 (ja) * | 2008-09-10 | 2014-10-08 | コーニンクレッカ フィリップス エヌ ヴェ | Mriコントラスト強化薬物キャリア |
| FR2939318B1 (fr) * | 2008-12-10 | 2012-07-13 | Guerbet Sa | Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2 |
| KR20170042373A (ko) * | 2010-05-11 | 2017-04-18 | 랜티우스 메디컬 이메징, 인크. | 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 |
| US12097269B2 (en) * | 2010-10-27 | 2024-09-24 | Vikas Kundra | Dual mode gadolinium nanoparticle contrast agents |
| EP2457594A1 (de) * | 2010-11-05 | 2012-05-30 | Bracco Imaging S.p.A | CEST-Systeme mit konzentrationsunabhängiger Ansprechempfindlichkeit |
| PL2694116T3 (pl) * | 2011-04-06 | 2018-12-31 | Board Of Regents Of The University Of Texas System | Nanocząstki na bazie lipidów |
| US11246949B2 (en) * | 2011-05-11 | 2022-02-15 | The Research Foundation For The State University Of New York | Imaging contrast agents and uses thereof |
| EP3567029A1 (de) | 2011-09-09 | 2019-11-13 | Lantheus Medical Imaging, Inc. | Zusammensetzungen, verfahren und systeme zur synthese und verwendung von kontrastmitteln |
| JP6130401B2 (ja) | 2012-01-20 | 2017-05-17 | アンナプラガダ,アナンス | 医学画像を客観的に特徴付けるための方法および組成物 |
| US20150038435A1 (en) * | 2012-03-01 | 2015-02-05 | Novo Nordisk A/S | N-terminally modified oligopeptides and uses thereof |
| PT2825156T (pt) | 2012-03-16 | 2017-11-02 | Merck Patent Gmbh | Aminoácidos lipídicos de direcionamento |
| US20160022842A1 (en) | 2013-03-11 | 2016-01-28 | Wayne State University | Formation and uses of europium |
| CA2951260C (en) * | 2014-06-06 | 2023-02-28 | Archer Daniels Midland Company | Microemulsions and uses thereof |
| US9744251B2 (en) | 2014-10-08 | 2017-08-29 | Texas Children's Hospital | MRI imaging of amyloid plaque using liposomes |
| NZ733669A (en) * | 2015-01-23 | 2019-03-29 | Helix Biopharma Corp | Antibody-urease conjugates for therapeutic purposes |
| IL264363B2 (en) * | 2016-07-25 | 2024-05-01 | Wisconsin Alumni Res Found | Radioactive phospholipid metal chelates for cancer imaging and therapy |
| CN109789207B (zh) * | 2016-07-25 | 2022-11-18 | 威斯康星校友研究基金会 | 用于原位免疫调节的癌症疫苗接种的靶向放射治疗螯合物 |
| DK3568205T3 (da) * | 2017-01-12 | 2023-10-09 | Radiomedix Inc | Behandling af cancerceller, der overeksprimerer somatostatinreceptorer ved at anvende radioisotop-chelaterede ocreotid-derivater |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| US11327000B2 (en) * | 2018-05-21 | 2022-05-10 | Saudi Arabian Oil Company | Detecting saturation levels of a core sample using magnetic fields |
| CA3212963A1 (en) | 2021-04-23 | 2022-10-27 | Reinier HERNANDEZ | Psma-targeting ligands with optimal properties for imaging and therapy |
| CN119424688B (zh) * | 2025-01-10 | 2025-03-21 | 上海交通大学医学院附属仁济医院 | 一种基于叶酸的核磁共振成像对比剂的制备方法及其应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0442962B1 (de) * | 1988-11-09 | 1994-01-05 | UNGER, Evan C | Liposomale radiologische kontrastmittel |
| US5242681A (en) * | 1990-03-12 | 1993-09-07 | Research Corporation Technologies, Inc. | Lipophilic contrast agents for diagnostic image analysis |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5534241A (en) * | 1993-07-23 | 1996-07-09 | Torchilin; Vladimir P. | Amphipathic polychelating compounds and methods of use |
| US6132764A (en) * | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| GB9420390D0 (en) * | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
| DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
| DE69616453T2 (de) * | 1995-02-24 | 2002-07-11 | Bracco Research S.A., Plan-Les-Quates | Liposomensuspensionen als blut-pool-kontrastmittel |
| US5707605A (en) * | 1995-06-02 | 1998-01-13 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US5804164A (en) * | 1996-03-13 | 1998-09-08 | Research Corporation Technologies, Inc. | Water-soluble lipophilic contrast agents |
| US6045774A (en) * | 1997-01-10 | 2000-04-04 | Epicyte Pharmaceutical Inc. | J chain polypeptide targeting molecule linked to an imaging agent |
| CN1256634A (zh) * | 1997-03-18 | 2000-06-14 | 赤池敏宏 | 识别微小环境变化的mri造影剂 |
| CA2333927A1 (en) * | 1998-04-01 | 1999-10-07 | Dupont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| AU3119199A (en) * | 1998-04-03 | 1999-10-25 | Du Pont Pharmaceuticals Company | Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer |
| CA2727746A1 (en) * | 1998-12-18 | 2000-06-22 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
| ES2321054T3 (es) * | 1999-01-19 | 2009-06-02 | Molecular Insight Pharmaceuticals, Inc. | Conjugados de factores estimulantes de colonias de granulocitos para direccionamiento y formacion de imagenes de infeccion e inflamacion. |
| US6534038B2 (en) * | 2000-04-07 | 2003-03-18 | Bristol-Myers Squibb Pharma Company | Ternary ligand complexes useful as radiopharmaceuticals |
| US6676963B1 (en) * | 2000-10-27 | 2004-01-13 | Barnes-Jewish Hospital | Ligand-targeted emulsions carrying bioactive agents |
| EP1390079A2 (de) * | 2000-11-20 | 2004-02-25 | Board of Regents University of Texas System | Paramagnetischen metallion-basierte makrozyklische kontrastmitteln |
| EP1337278A2 (de) * | 2000-11-27 | 2003-08-27 | Bristol-Myers Squibb Medical Imaging, Inc. | Gleichzeitiges imaging der kardialen perfusion und eines auf den vitronektin rezeptor zielgerichteten agens |
| US6517814B2 (en) * | 2001-01-09 | 2003-02-11 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants useful for metallopharmaceuticals |
| US6562319B2 (en) * | 2001-03-12 | 2003-05-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy |
| EP1331012A1 (de) * | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung |
| US6869591B2 (en) * | 2002-03-26 | 2005-03-22 | Barnes-Jewish Hospital | Paramagnetic particles that provide improved relaxivity |
| US7672704B2 (en) * | 2002-09-11 | 2010-03-02 | Duke University | Methods and compositions for blood pool identification, drug distribution quantification and drug release verification |
| EP1466629A1 (de) * | 2003-04-11 | 2004-10-13 | BRACCO IMAGING S.p.A. | Adducte zwischen NMR Vershibungsreagenzen und Substraten mit austauschbaren Protonen für die "CEST" Anwendung |
| FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| CN101166547B (zh) * | 2005-04-26 | 2013-02-06 | 皇家飞利浦电子股份有限公司 | 包含cest活性的顺磁性配合物的mri造影剂 |
-
2005
- 2005-09-23 DE DE602005025659T patent/DE602005025659D1/de not_active Expired - Lifetime
- 2005-09-23 AT AT05801399T patent/ATE493152T1/de not_active IP Right Cessation
- 2005-09-23 JP JP2007532901A patent/JP2008513533A/ja not_active Ceased
- 2005-09-23 WO PCT/EP2005/054798 patent/WO2006032705A2/en not_active Ceased
- 2005-09-23 US US11/663,583 patent/US20070292354A1/en not_active Abandoned
- 2005-09-23 EP EP05801399A patent/EP1793868B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008513533A (ja) | 2008-05-01 |
| DE602005025659D1 (de) | 2011-02-10 |
| US20070292354A1 (en) | 2007-12-20 |
| WO2006032705A2 (en) | 2006-03-30 |
| EP1793868A2 (de) | 2007-06-13 |
| WO2006032705A3 (en) | 2006-12-21 |
| EP1793868B1 (de) | 2010-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |