WO1996023500A1 - Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion - Google Patents
Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion Download PDFInfo
- Publication number
- WO1996023500A1 WO1996023500A1 PCT/ES1996/000013 ES9600013W WO9623500A1 WO 1996023500 A1 WO1996023500 A1 WO 1996023500A1 ES 9600013 W ES9600013 W ES 9600013W WO 9623500 A1 WO9623500 A1 WO 9623500A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inert
- acid
- polymer
- labile
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Definitions
- the present invention relates to novel pharmaceutical preparations for oral administration containing a 2 [(2-pyridyl) methylsulfinyl] -benzimidazole derivative (hereinafter referred to as "benzimidazole compound”) of formula I:
- R- ⁇ is hydrogen, methoxy or difluoromethoxy
- R.2 is methyl or methoxy
- R3 is methoxy, 2,2,2-trifluoroethoxy or 3- methoxypropoxy
- R4 is hydrogen or methyl
- the invention is also related to a method for the manufacture of said preparations, and the ways of administration to patients with gastrointestinal diseases.
- the referred benzimidazole compounds are very effective medications for the treatment of gastric and duodenal ulcers, gastroesophageal reflux, severe erosive esophagitis, and in the eradication of H-pylori.
- these compounds are little stable In solid state they are sensitive to heat, humidity and light, and in aqueous solution or suspension stability decreases with decreasing pH. The degradation of these compounds is catalyzed by acid reaction compounds.
- compositions containing acid-labile compounds should be undercoated to avoid a reaction between the active ingredient and the external acidic enteric coating. Such a reaction, if any, would cause degradation, destabilization and consequently alteration of the color of the active ingredient.
- an alkaline salt of the benzimidazole compound or by incorporating an alkaline reaction compound in the enteric coated preparation (oxide, hydroxide or magnesium carbonate, aluminum hydroxide, carbonate, phosphate or citrate Aluminum, calcium, sodium or potassium, aluminum / magnesium composite material, sodium lauryl sulfate, amino acids, N-methyl-D-glucam; .na, etc.) as described in US-A- 4,786,505, US-A-5,232,706, EP-A-237200, EP-A-124495, the alkaline reaction compound being present within or on the surface of the core together with the benzimidazole compound.
- solid pharmaceutical preparations of high stability are obtained containing a benzimidazole compound of Formula I.
- the new galenic formulations do not contain alkaline reaction compounds, therefore, an alkaline compound is not present within the preparations. enterically coated.
- the new preparations described have great stability during storage over long periods of time, far superior to that of known formulations, avoiding loss of color and richness, thus being more suitable for pharmaceutical use.
- the new preparation is characterized by an inert spherical core of sugar and starch, on which a first coating layer containing a mixture of the benzimidazolic compound of Formula I is applied as active ingredient, an inert water soluble polymer and reaction excipients non - alkaline pharmaceutical acceptable ⁇ ; a second inert insulating layer formed by water soluble polymers and compatible excipients; and finally a third layer consisting of an enteric coating.
- the core, the process conditions and the excipients have been selected in order to obtain an effective coating, required in each layer.
- the new preparation obtained is resistant to dissolution in acidic medium being stable during the passage through gastric juice, and quickly dissolves in a neutral or alkaline medium, conditions of the proximal part of the small intestine.
- the acid resistance evaluated according to Farri.acopea USA, demonstrates that after 2 hours the amount of benzimidazole remains unchanged, and that by changing the pH to 6.8, after 30 minutes all the benzimidazole dissolves (analyzed according to Pharmacopoeia USA).
- inert spherical cores are coated with a first layer containing the benzimidazole acid-labile compound, an inert water soluble polymer such as hydroxypropyl methylcellulose or hydroxypropyl cellulose, and talc. It is then coated with a second layer consisting of a water soluble inert polymer such as hydroxypropylmethylcellulose or hydroxypropylcellulose, talc and a pigment such as titanium dioxide.
- a third, enteric layer is applied, consisting of a polymer resistant to gastric juice such as methacrylic acid / methyl ester of copolymerized methacrylic acid, a plasticizer such as triethyl citrate or the like, and talc.
- the layers are applied by conventional fluid bed coating techniques using aqueous solutions or dispersions.
- the active ingredients can be administered in the same doses and according to the same protocol as the corresponding already commercial forms.
- the final dose may be administered in the form of capsules containing the pellets or pellets formulated as tablets.
- the dose for the benzimidazole compound is between 1 mg and 100 mg / kg / day, adjusted to the needs of each patient and for the clinically indicated time.
- a fluid bed apparatus 3010 g of uniform spherical inert sugar and starch nuclei (composition according to Pharmacopoeia USA) are introduced, onto which the previously obtained dispersion is sprayed. After spraying, and before applying the second layer, the spheres are dried.
- pellets thus obtained were stored in closed polyethylene bags inside a cardboard bottle as well as in closed glass jars, and were subjected to the so-called accelerated conditions, that is, 40 ⁇ C and 75% relative humidity.
- pellets extracted from Prilosec® capsules (trademark of Merck / Astra) were packed in identical containers and subjected to the same conditions.
- the test results in accelerated conditions are summarized in Tables 1, 2 and 3, demonstrating superior stability of the new pellets against the authorized products available in the market.
- Second layer 350 g of deionized water, 52 g of hydroxypropyl methylcellulose, 7 g of talc and 7 g of titanium dioxide.
- Enteric coating layer 280 g of deionized water, 290 g of methacrylic acid copolymer according to Pharmacopoeia USA - aqueous suspension type C-, 13 g of triethyl citrate and 13 g of talc.
- the pellets obtained were stable and showed a profile similar to those obtained in example 1.
- the purpose of the study was to investigate the bioavailability and pharmacokinetic profile of the new pharmaceutical formulation of omeprazole compared to the standard capsule formulation (Prilosec®; 20 mg).
- Hard gelatin capsules were filled with the new galenic form of omeprazole, prepared according to example 1, in an amount equivalent to 20 mg of omeprazole.
- the experimental design carried out in a single center, was an open, randomized, crossed study in 24 healthy volunteers, male and female.
- the medication was administered with 200 ml of tap water after fasting (solid and liquids), at least, during the previous 10 hours.
- the concentration of omeprazole in blood plasma was analyzed by a validated method of high pressure liquid chromatography with ultraviolet detector
- Teeth values for the geometric mean of the maximum plasma concentration C ma ⁇ were 249 (197) and 241 (174) ng / ml, and the AUC Q - ⁇ were 434 (440) and 486 (436) ng h / ml, respectively.
- the ratio of the geometric means (new / Prilo-sec®) of C ma ⁇ and AUC was 1.03 in both cases, and the 90% confidence intervals (CI) for these relationships were completely within the range 0 , 80 - 1.25. According to the CPMP directives for bioequivalence studies, the bioequivalence of the formulations (new formulation and Prilosec®) is accepted
- omeprazole capsules according to the present invention, a preparation is obtained with the same bioavailability as Prilosec® capsules containing the same amount of micronized active compound.
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK96901349T DK0773025T3 (da) | 1995-02-01 | 1996-01-26 | Nye stabile galeniske formuleringer indeholdende en syrelabil benzimidazolforbindelser, og fremgangsmåde til fremstilling |
HU9603014A HU229219B1 (en) | 1995-02-01 | 1996-01-26 | Stabilized galenic compositions containing benzimidazol derivatives decomposing in acidic medium, and process for producing them |
KR1019960704702A KR100331290B1 (ko) | 1995-02-01 | 1996-01-26 | 산에불안정한벤즈이미다졸화합물을포함하는신규의안정화된갈레닉(Galenic)제제및그의제조방법 |
AT96901349T ATE193649T1 (de) | 1995-02-01 | 1996-01-26 | Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren |
JP52327896A JP4183746B2 (ja) | 1995-02-01 | 1996-01-26 | 酸不安定性ベンズイミダゾールを含有する新規安定型ガレニック製剤、及びその製造方法 |
SI9630226T SI0773025T1 (en) | 1995-02-01 | 1996-01-26 | New stable galenic formulations containing an acid-labile benzimidazol compound, and production process |
DE69608767T DE69608767D1 (de) | 1995-02-01 | 1996-01-26 | Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren |
EP96901349A EP0773025B1 (en) | 1995-02-01 | 1996-01-26 | New stable galenic formulations containing an acid-labile benzimidazol compound, and production process |
ES96901349T ES2148725T3 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion. |
CA002184842A CA2184842C (en) | 1995-02-01 | 1996-01-26 | New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation |
AU45403/96A AU4540396A (en) | 1995-02-01 | 1996-01-26 | New stable ganelic formulations containing an acid-labile benzimidazol compound, and production process |
FI963916A FI121730B (fi) | 1995-02-01 | 1996-09-30 | Uudet stabiloidut galeeniset formulaatiot, jotka sisältävät happolabiilia bentsimidatsoliyhdistettä, ja niiden valmistus |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09500181A ES2094694B1 (es) | 1995-02-01 | 1995-02-01 | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
ESP9500181 | 1995-02-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996023500A1 true WO1996023500A1 (es) | 1996-08-08 |
Family
ID=8289322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES1996/000013 WO1996023500A1 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion |
Country Status (20)
Country | Link |
---|---|
US (1) | US5626875A (es) |
EP (2) | EP0773025B1 (es) |
JP (1) | JP4183746B2 (es) |
KR (1) | KR100331290B1 (es) |
AR (1) | AR002702A1 (es) |
AT (2) | ATE292967T1 (es) |
AU (1) | AU4540396A (es) |
CA (1) | CA2184842C (es) |
DE (3) | DE69634613T2 (es) |
DK (2) | DK0773025T3 (es) |
ES (3) | ES2094694B1 (es) |
FI (1) | FI121730B (es) |
HU (1) | HU229219B1 (es) |
IL (1) | IL116673A (es) |
IN (1) | IN186596B (es) |
PT (2) | PT773025E (es) |
SI (2) | SI0773025T1 (es) |
TW (1) | TW503115B (es) |
WO (1) | WO1996023500A1 (es) |
ZA (1) | ZA96683B (es) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999053918A1 (fr) | 1998-04-20 | 1999-10-28 | Eisai Co., Ltd. | Compositions stabilisees contenant des composes du type benzimidazole |
US6391342B1 (en) | 1998-03-20 | 2002-05-21 | A/S Gea Farmaceutisk Fabrik | Pharmaceutical formulation comprising a 2- [(2-pyridinyl) methyl] sulfinyl benzimidazole having anti-ulcer activity and a process for the preparation of such formulation |
US6576258B1 (en) | 1997-07-14 | 2003-06-10 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Pharmaceutical formulation with controlled release of active substances |
US7402321B2 (en) | 1998-08-12 | 2008-07-22 | Nycomed Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles |
US7838027B2 (en) | 2003-10-01 | 2010-11-23 | Wyeth Llc | Pantoprazole multiparticulate formulations |
EP3292862A1 (en) | 2016-09-07 | 2018-03-14 | Sandoz Ag | Omeprazole formulations |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
DE69631981T2 (de) | 1995-09-21 | 2005-04-14 | Pharma Pass Ii Llc, Irvine | Lansoprazolhaltige Arzneizusammensetzung und Herstellungsverfahren |
ES2137862B1 (es) * | 1997-07-31 | 2000-09-16 | Intexim S A | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
US6559158B1 (en) | 1997-11-03 | 2003-05-06 | Ur Labs, Inc. | Use of methylnaltrexone and related compounds to treat chronic opioid use side affects |
FR2774288B1 (fr) † | 1998-01-30 | 2001-09-07 | Ethypharm Sa | Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques |
ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. |
FR2793688B1 (fr) * | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
ES2168043B1 (es) * | 1999-09-13 | 2003-04-01 | Esteve Labor Dr | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. |
JP4081273B2 (ja) | 1999-10-20 | 2008-04-23 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ベンズイミダゾール系化合物安定化方法 |
DE19959419A1 (de) * | 1999-12-09 | 2001-06-21 | Ratiopharm Gmbh | Stabile galenische Zubereitungen umfassend ein Benzimidazol und Verfahren zu ihrer Herstellung |
DK1108425T3 (da) * | 1999-12-16 | 2005-09-26 | Medinfar Produtos Farmaceutico | Nye, stabile flerenhedspræparater, der indeholder substituerede benzimidazoler |
US6419956B1 (en) | 1999-12-30 | 2002-07-16 | Ancile Pharmaceuticals | Odor-masking coating for a pharmaceutical preparation |
AU2001296908A1 (en) * | 2000-09-29 | 2002-04-08 | Geneva Pharmaceuticals, Inc. | Proton pump inhibitor formulation |
CN1474686A (zh) * | 2000-11-10 | 2004-02-11 | 弗・哈夫曼-拉罗切有限公司 | 水解不稳定的组合物 |
ATE446751T1 (de) * | 2001-06-05 | 2009-11-15 | Univ Chicago | Verwendung von methylnaltrexon zur behandlung von immunsuppression |
IL159854A0 (en) | 2001-07-16 | 2004-06-20 | Janssen Pharmaceutica Nv | Improved process for preparing benzimidazole-type compounds |
CN1596100A (zh) * | 2001-09-28 | 2005-03-16 | 麦克内尔-Ppc股份有限公司 | 可食用组合物及含可食用外壳的制剂 |
US20040170689A1 (en) * | 2001-11-09 | 2004-09-02 | Odink Debra Alida | Stabilized formulations comprising hydrolytically unstable compositions |
ES2198195B1 (es) | 2001-12-18 | 2004-10-01 | Laboratorios Del Dr. Esteve, S.A. | Forma de dosificacion farmaceutica oral comprimida, con recubrimiento enterico, que contiene un compuesto de bencimidazol labil en medio acido. |
PT1524967E (pt) * | 2002-08-02 | 2008-04-03 | Ratiopharm Gmbh | Preparação farmacêutica contendo um composto de benzimidazole misturado com celulose microcristalina e método para a sua preparação. |
US20040028737A1 (en) * | 2002-08-12 | 2004-02-12 | Kopran Research Laboratories Limited | Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same |
WO2004066982A1 (en) * | 2003-01-31 | 2004-08-12 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and processes for their preparation |
CN104383542B (zh) | 2003-04-08 | 2017-09-26 | 普罗热尼奇制药公司 | 包含甲基纳曲酮的药物配方 |
MXPA05010819A (es) * | 2003-04-08 | 2006-03-30 | Progenics Pharm Inc | Uso de antagonistas de opioide perifericos, especialmente metilnaltrexona para tratar sindrome de intestino irritable. |
US20040259899A1 (en) * | 2003-04-08 | 2004-12-23 | Sanghvi Suketu P. | Combination therapy for constipation |
ES2234393B2 (es) * | 2003-04-29 | 2006-09-01 | Laboratorios Belmac, S.A. | "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido". |
WO2004098573A1 (en) * | 2003-05-08 | 2004-11-18 | Natco Pharma Limited | An improved and stable pharmaceutical composition containing substituted benzimidazoles and a process for its preparation |
WO2005011637A1 (ja) * | 2003-08-04 | 2005-02-10 | Eisai Co., Ltd. | 用時分散型製剤 |
WO2005034924A1 (en) * | 2003-10-14 | 2005-04-21 | Natco Pharma Limited | Enteric coated pellets comprising esomeprazole, hard gelatin capsule containing them, and method of preparation |
GB0400781D0 (en) * | 2004-01-14 | 2004-02-18 | Novartis Ag | Organic compounds |
CA2558535A1 (en) * | 2004-03-03 | 2005-10-06 | Teva Pharmaceutical Industries Ltd. | A stable pharmaceutical composition comprising an acid labile drug |
CA2565083C (en) | 2004-05-07 | 2014-07-08 | Altana Pharma Ag | Novel pharmaceutical dosage form and manufacturing process |
US20050281876A1 (en) * | 2004-06-18 | 2005-12-22 | Shun-Por Li | Solid dosage form for acid-labile active ingredient |
WO2006067599A2 (en) | 2004-12-23 | 2006-06-29 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and process of preparation thereof |
WO2006066932A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Stable pharmaceutical composition comprising an active substance in the form of solid solution |
US20090208575A1 (en) * | 2005-01-03 | 2009-08-20 | Lupin Limited | Pharmaceutical Composition Of Acid Labile Substances |
JP2008528497A (ja) * | 2005-01-20 | 2008-07-31 | プロジェニックス ファーマシューティカルズ,インコーポレーテッド | メチルナルトレキソンおよび関連化合物の術後性胃腸障害のための使用 |
EP1845982A2 (en) * | 2005-02-02 | 2007-10-24 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions prepared by non-aqueous layering process |
MX2007010833A (es) | 2005-03-07 | 2009-02-17 | Univ Chicago | Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales. |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8524731B2 (en) * | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
US8673352B2 (en) * | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
US20080194611A1 (en) * | 2005-06-03 | 2008-08-14 | Alverdy John C | Modulation of Cell Barrier Dysfunction |
EP1785135A1 (en) | 2005-11-10 | 2007-05-16 | Laboratorios Del Dr. Esteve, S.A. | New stabilized galenic formulations comprising lansoprazole and their preparation |
EP1813275A1 (en) * | 2005-12-20 | 2007-08-01 | Teva Pharmaceutical Industries Ltd | Lansoprazole orally disintegrating tablets |
JP2009524592A (ja) * | 2005-12-20 | 2009-07-02 | テバ ファーマシューティカル インダストリーズ リミティド | ランソプラゾール経口崩壊錠剤 |
US7579476B2 (en) * | 2006-02-24 | 2009-08-25 | Praktikatalyst Pharma, Llc | Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals |
ITMI20061024A1 (it) * | 2006-05-25 | 2007-11-26 | Eurand Pharmaceuticals Ltd | Pellet a base di acido lipoico |
PL2046334T3 (pl) * | 2006-07-25 | 2015-02-27 | Vecta Ltd | Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI |
TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
MX351611B (es) | 2007-03-29 | 2017-10-20 | Wyeth Llc | Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas. |
PA8774201A1 (es) | 2007-03-29 | 2009-06-23 | Progenics Pharm Inc | Antagonista del receptor |
SI2139890T1 (sl) * | 2007-03-29 | 2014-12-31 | Wyeth Llc | Antagonisti perifernih opioidnih receptorjev in njih uporaba |
EP2730578A1 (en) | 2008-02-06 | 2014-05-14 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnal trexone |
US8911787B2 (en) | 2008-02-26 | 2014-12-16 | Ranbaxy Laboratories Limited | Stable oral benzimidazole compositions and process of preparation thereof |
EP2278966B1 (en) * | 2008-03-21 | 2019-10-09 | The University of Chicago | Treatment with opioid antagonists and mtor inhibitors |
EP2306829B1 (en) | 2008-07-01 | 2017-01-04 | University of Chicago | Particles containing a peripheral opioid receptor antagonist |
CH699302B1 (de) * | 2008-08-11 | 2012-03-15 | Mepha Gmbh | Orale pharmazeutische Formulierung für Omeprazol, enthaltend eine spezifische Trennschicht. |
JP2011530569A (ja) * | 2008-08-11 | 2011-12-22 | メファ・ゲーエムベーハー | 特定の分離層を含むオメプラゾールの経口医薬製剤 |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
WO2010117756A2 (en) * | 2009-03-31 | 2010-10-14 | Dr. Reddy's Laboratories Ltd | Substituted benzimidazole pharmaceutical formulations |
US20130202688A1 (en) | 2010-05-04 | 2013-08-08 | Sunilendu Bhushan Roy | Delayed release oral disintegrating pharmaceutical compositions of lansoprazole |
RU2647472C2 (ru) * | 2011-11-02 | 2018-03-15 | Лабораторьос Дель Др. Эстеве, С.А. | Фармацевтическая композиция омепразола |
GB2513172A (en) * | 2013-04-18 | 2014-10-22 | Nupharm Lab Ltd | Liquid dosage form and delivery system |
EP3206491B1 (en) | 2014-10-17 | 2019-11-27 | Salix Pharmaceuticals, Inc. | Use of methylnaltrexone to attenuate tumor progression |
US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0519144A1 (en) * | 1991-06-21 | 1992-12-23 | Ilsan Ilac Ve Hammaddeleri Sanayi A.S. | New galenic process for omeprazole containing pellets |
EP0519365A1 (de) * | 1991-06-17 | 1992-12-23 | Byk Gulden Lomberg Chemische Fabrik GmbH | Pantoprazol enthaltende orale Darreichungsformen |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB829055A (en) * | 1958-02-07 | 1960-02-24 | Charles E Frosst And Company | Improvements in or relating to pharmaceutical preparations |
US4150111A (en) * | 1974-05-28 | 1979-04-17 | Allister Warren | Enteric coated magnesium chloride |
JPS5837285B2 (ja) * | 1975-05-29 | 1983-08-15 | カブシキガイシヤ ミドリジユウジ | チヨウナイカンセンシヨウチリヨウザイノセイゾウホウホウ |
JPS5598120A (en) * | 1979-01-16 | 1980-07-25 | Shin Etsu Chem Co Ltd | Preparation of drug having enteric coating |
US4470980A (en) * | 1980-03-07 | 1984-09-11 | Interx Research Corp. | Method of increasing oral absorption of β-lactam antibiotics |
US4377568A (en) * | 1981-08-12 | 1983-03-22 | Merck Sharp & Dohme (I.A.) Corp. | Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same |
JPS58208155A (ja) * | 1982-05-28 | 1983-12-03 | Sumitomo Electric Ind Ltd | 光伝送用ガラスフアイバの製造方法 |
JPS59193831A (ja) * | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | 腸溶性製剤の製造法 |
CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
US5026560A (en) * | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
JPH0768125B2 (ja) * | 1988-05-18 | 1995-07-26 | エーザイ株式会社 | 酸不安定化合物の内服用製剤 |
IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
US5395611A (en) * | 1990-04-24 | 1995-03-07 | The Governors Of The University Of Alberta | Phenolic amine depigmenting and antimelanoma agents |
IT1241740B (it) * | 1990-06-22 | 1994-02-01 | Edi Bondioli | Protezione per una forcella di estremita' di un albero cardanico |
JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
US5316772A (en) * | 1990-12-19 | 1994-05-31 | Solvay & Cie, S.A. (Societe Anonyme) | Bilayered oral pharmaceutical composition with pH dependent release |
US5232706A (en) * | 1990-12-31 | 1993-08-03 | Esteve Quimica, S.A. | Oral pharmaceutical preparation containing omeprazol |
FR2692146B1 (fr) | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
AU4513393A (en) * | 1992-07-17 | 1994-02-14 | Astra Aktiebolag | Pharmaceutical composition containing antiulcer agent |
SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
SE9500478D0 (sv) | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
-
1995
- 1995-02-01 ES ES09500181A patent/ES2094694B1/es not_active Expired - Fee Related
- 1995-04-27 US US08/429,689 patent/US5626875A/en not_active Expired - Lifetime
-
1996
- 1996-01-04 IL IL11667396A patent/IL116673A/xx not_active IP Right Cessation
- 1996-01-17 AR AR10105196A patent/AR002702A1/es not_active Application Discontinuation
- 1996-01-22 IN IN104CA1996 patent/IN186596B/en unknown
- 1996-01-26 ES ES99116334T patent/ES2238796T3/es not_active Expired - Lifetime
- 1996-01-26 DE DE69634613T patent/DE69634613T2/de not_active Revoked
- 1996-01-26 TW TW085100946A patent/TW503115B/zh not_active IP Right Cessation
- 1996-01-26 KR KR1019960704702A patent/KR100331290B1/ko not_active IP Right Cessation
- 1996-01-26 PT PT96901349T patent/PT773025E/pt unknown
- 1996-01-26 DK DK96901349T patent/DK0773025T3/da active
- 1996-01-26 PT PT99116334T patent/PT993830E/pt unknown
- 1996-01-26 ES ES96901349T patent/ES2148725T3/es not_active Expired - Lifetime
- 1996-01-26 DK DK99116334T patent/DK0993830T3/da active
- 1996-01-26 AT AT99116334T patent/ATE292967T1/de not_active IP Right Cessation
- 1996-01-26 DE DE29623938U patent/DE29623938U1/de not_active Expired - Lifetime
- 1996-01-26 WO PCT/ES1996/000013 patent/WO1996023500A1/es not_active Application Discontinuation
- 1996-01-26 EP EP96901349A patent/EP0773025B1/en not_active Revoked
- 1996-01-26 CA CA002184842A patent/CA2184842C/en not_active Expired - Fee Related
- 1996-01-26 SI SI9630226T patent/SI0773025T1/xx unknown
- 1996-01-26 AU AU45403/96A patent/AU4540396A/en not_active Abandoned
- 1996-01-26 EP EP99116334A patent/EP0993830B1/en not_active Revoked
- 1996-01-26 JP JP52327896A patent/JP4183746B2/ja not_active Expired - Fee Related
- 1996-01-26 SI SI9630710T patent/SI0993830T1/xx unknown
- 1996-01-26 HU HU9603014A patent/HU229219B1/hu not_active IP Right Cessation
- 1996-01-26 AT AT96901349T patent/ATE193649T1/de not_active IP Right Cessation
- 1996-01-26 DE DE69608767T patent/DE69608767D1/de not_active Revoked
- 1996-01-30 ZA ZA96683A patent/ZA96683B/xx unknown
- 1996-09-30 FI FI963916A patent/FI121730B/fi not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0519365A1 (de) * | 1991-06-17 | 1992-12-23 | Byk Gulden Lomberg Chemische Fabrik GmbH | Pantoprazol enthaltende orale Darreichungsformen |
EP0519144A1 (en) * | 1991-06-21 | 1992-12-23 | Ilsan Ilac Ve Hammaddeleri Sanayi A.S. | New galenic process for omeprazole containing pellets |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6576258B1 (en) | 1997-07-14 | 2003-06-10 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Pharmaceutical formulation with controlled release of active substances |
US6391342B1 (en) | 1998-03-20 | 2002-05-21 | A/S Gea Farmaceutisk Fabrik | Pharmaceutical formulation comprising a 2- [(2-pyridinyl) methyl] sulfinyl benzimidazole having anti-ulcer activity and a process for the preparation of such formulation |
WO1999053918A1 (fr) | 1998-04-20 | 1999-10-28 | Eisai Co., Ltd. | Compositions stabilisees contenant des composes du type benzimidazole |
US7402321B2 (en) | 1998-08-12 | 2008-07-22 | Nycomed Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles |
US8465767B2 (en) | 1998-08-12 | 2013-06-18 | Takeda Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1H benzimidazoles |
US7838027B2 (en) | 2003-10-01 | 2010-11-23 | Wyeth Llc | Pantoprazole multiparticulate formulations |
EP3292862A1 (en) | 2016-09-07 | 2018-03-14 | Sandoz Ag | Omeprazole formulations |
WO2018046498A1 (en) | 2016-09-07 | 2018-03-15 | Sandoz Ag | Omeprazole formulations |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1996023500A1 (es) | Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion | |
ES2218054T3 (es) | Nueva composicion que contiene lansoprazol, y procedimiento para su preparacion. | |
US4786505A (en) | Pharmaceutical preparation for oral use | |
EP0293885B1 (en) | Antibiotic-polymer compositions | |
ES2286119T3 (es) | Composicion de recubrimiento para enmascarar el sabor. | |
BR112018001859B1 (pt) | Comprimido, e, método para produzir um comprimido | |
ES2667402T3 (es) | Composición farmacéutica de omeprazol | |
ES2336757B1 (es) | Nuevas formulaciones galenicas estabilizadas que comprenden lansoprazol y su preparacion. | |
JPH0873345A (ja) | 医薬製剤 | |
EP2558079B1 (en) | Ciprofloxacin dry syrup composition | |
KR100523082B1 (ko) | 쓴 맛이 은폐된 세푸록심악세틸 제제의 제약조성물 및 그의 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AT AU AZ BB BG BR BY CA CH CN CZ CZ DE DE DK DK EE EE FI FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK TJ TM TR TT UA UG UZ VN AZ BY KG KZ RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2184842 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1996901349 Country of ref document: EP |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1996901349 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1996901349 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1996901349 Country of ref document: EP |