ES2094694A1 - Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. - Google Patents

Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.

Info

Publication number
ES2094694A1
ES2094694A1 ES09500181A ES9500181A ES2094694A1 ES 2094694 A1 ES2094694 A1 ES 2094694A1 ES 09500181 A ES09500181 A ES 09500181A ES 9500181 A ES9500181 A ES 9500181A ES 2094694 A1 ES2094694 A1 ES 2094694A1
Authority
ES
Spain
Prior art keywords
labile
acid
production process
formulations containing
new stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09500181A
Other languages
English (en)
Other versions
ES2094694B1 (es
Inventor
Rodes Montserrat Ballester
Boven Marinus Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8289322&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2094694(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Priority to ES09500181A priority Critical patent/ES2094694B1/es
Priority to US08/429,689 priority patent/US5626875A/en
Priority to IL11667396A priority patent/IL116673A/xx
Priority to AR10105196A priority patent/AR002702A1/es
Priority to IN104CA1996 priority patent/IN186596B/en
Priority to AU45403/96A priority patent/AU4540396A/en
Priority to DE29623938U priority patent/DE29623938U1/de
Priority to ES96901349T priority patent/ES2148725T3/es
Priority to PCT/ES1996/000013 priority patent/WO1996023500A1/es
Priority to KR1019960704702A priority patent/KR100331290B1/ko
Priority to HU9603014A priority patent/HU229219B1/hu
Priority to EP96901349A priority patent/EP0773025B1/en
Priority to EP99116334A priority patent/EP0993830B1/en
Priority to DK99116334T priority patent/DK0993830T3/da
Priority to DE69634613T priority patent/DE69634613T2/de
Priority to ES99116334T priority patent/ES2238796T3/es
Priority to SI9630226T priority patent/SI0773025T1/xx
Priority to PT99116334T priority patent/PT993830E/pt
Priority to TW085100946A priority patent/TW503115B/zh
Priority to DK96901349T priority patent/DK0773025T3/da
Priority to JP52327896A priority patent/JP4183746B2/ja
Priority to CA002184842A priority patent/CA2184842C/en
Priority to SI9630710T priority patent/SI0993830T1/xx
Priority to AT96901349T priority patent/ATE193649T1/de
Priority to DE69608767T priority patent/DE69608767D1/de
Priority to AT99116334T priority patent/ATE292967T1/de
Priority to PT96901349T priority patent/PT773025E/pt
Priority to ZA96683A priority patent/ZA96683B/xx
Priority to FI963916A priority patent/FI121730B/fi
Publication of ES2094694A1 publication Critical patent/ES2094694A1/es
Publication of ES2094694B1 publication Critical patent/ES2094694B1/es
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NUEVA FORMULACION FARMACEUTICAMENTE ESTABLE DE UN COMPUESTO DE BENCIMIDAZOL Y SU PROCESO DE OBTENCION. DICHA FORMULACION COMPRENDE UN NUCLEO NEUTRO SOBRE EL QUE SE APLICA UNA CAPA CON EL INGREDIENTE ACTIVO CONSTITUIDA POR EL COMPUESTO DE BENCIMIDAZOL DE FORMULA I, UN POLIMERO SOLUBLE EN AGUA Y EXCIPIENTES DE REACCION NO ALCALINA, SOBRE LA QUE SE APLICA UNA SEGUNDA CAPA AISLANTE QUE COMPRENDE UN POLIMERO SOLUBLE EN AGUA, UN PIGMENTO Y TALCO, Y UNA ULTIMA CAPA ENTERICA QUE CONTIENE UN POLIMERO, UN PLASTIFICANTE Y TALCO.
ES09500181A 1995-02-01 1995-02-01 Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. Expired - Fee Related ES2094694B1 (es)

Priority Applications (29)

Application Number Priority Date Filing Date Title
ES09500181A ES2094694B1 (es) 1995-02-01 1995-02-01 Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
US08/429,689 US5626875A (en) 1995-02-01 1995-04-27 Stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation
IL11667396A IL116673A (en) 1995-02-01 1996-01-04 Stable oral pharmaceutical composition containing an acid labile benzimidazole
AR10105196A AR002702A1 (es) 1995-02-01 1996-01-17 Formulación farmacéutica oral estable conteniendo un compuesto de bencimidazol labil en medio ácido su procedimiento de obtención y sus formulaciones galenicas
IN104CA1996 IN186596B (es) 1995-02-01 1996-01-22
SI9630226T SI0773025T1 (en) 1995-02-01 1996-01-26 New stable galenic formulations containing an acid-labile benzimidazol compound, and production process
JP52327896A JP4183746B2 (ja) 1995-02-01 1996-01-26 酸不安定性ベンズイミダゾールを含有する新規安定型ガレニック製剤、及びその製造方法
ES96901349T ES2148725T3 (es) 1995-02-01 1996-01-26 Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion.
PCT/ES1996/000013 WO1996023500A1 (es) 1995-02-01 1996-01-26 Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion
KR1019960704702A KR100331290B1 (ko) 1995-02-01 1996-01-26 산에불안정한벤즈이미다졸화합물을포함하는신규의안정화된갈레닉(Galenic)제제및그의제조방법
HU9603014A HU229219B1 (en) 1995-02-01 1996-01-26 Stabilized galenic compositions containing benzimidazol derivatives decomposing in acidic medium, and process for producing them
EP96901349A EP0773025B1 (en) 1995-02-01 1996-01-26 New stable galenic formulations containing an acid-labile benzimidazol compound, and production process
EP99116334A EP0993830B1 (en) 1995-02-01 1996-01-26 New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation
DK99116334T DK0993830T3 (da) 1995-02-01 1996-01-26 Nye stabiliserede galeniske formuleringer indeholdende en syrelabil benzimidazolforbindselse og fremgangsmåde til fremstilling heraf
DE69634613T DE69634613T2 (de) 1995-02-01 1996-01-26 Neue stabilisierte galenische Formulierungen enthaltend ein säureempfindliches Benzimidazol und Verfahren zu ihrer Herstellung
ES99116334T ES2238796T3 (es) 1995-02-01 1996-01-26 Nuevas formulaciones galenicas estabilizadas que comprenden un compuesto de bencimidazol labil en medio acido y su preparacion.
AU45403/96A AU4540396A (en) 1995-02-01 1996-01-26 New stable ganelic formulations containing an acid-labile benzimidazol compound, and production process
PT99116334T PT993830E (pt) 1995-02-01 1996-01-26 Novas formulacoes galenicas estabilizadas compreendendo um composto acido labil de benzimidazole e a sua preparacao
TW085100946A TW503115B (en) 1995-02-01 1996-01-26 New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation
DK96901349T DK0773025T3 (da) 1995-02-01 1996-01-26 Nye stabile galeniske formuleringer indeholdende en syrelabil benzimidazolforbindelser, og fremgangsmåde til fremstilling
DE29623938U DE29623938U1 (de) 1995-02-01 1996-01-26 Neue stabile galenische Formulierungen, enthaltend eine säureempfindliche Benzimidazolverbindung
CA002184842A CA2184842C (en) 1995-02-01 1996-01-26 New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation
SI9630710T SI0993830T1 (en) 1995-02-01 1996-01-26 New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation
AT96901349T ATE193649T1 (de) 1995-02-01 1996-01-26 Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren
DE69608767T DE69608767D1 (de) 1995-02-01 1996-01-26 Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren
AT99116334T ATE292967T1 (de) 1995-02-01 1996-01-26 Neue stabilisierte galenische formulierungen enthaltend ein säureempfindliches benzimidazol und verfahren zu ihrer herstellung
PT96901349T PT773025E (pt) 1995-02-01 1996-01-26 Novas formulacoes galenicas estaveis que contem um composto de benzimidazol acido-labil e processo de preparacao.
ZA96683A ZA96683B (en) 1995-02-01 1996-01-30 New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation
FI963916A FI121730B (fi) 1995-02-01 1996-09-30 Uudet stabiloidut galeeniset formulaatiot, jotka sisältävät happolabiilia bentsimidatsoliyhdistettä, ja niiden valmistus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09500181A ES2094694B1 (es) 1995-02-01 1995-02-01 Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.

Publications (2)

Publication Number Publication Date
ES2094694A1 true ES2094694A1 (es) 1997-01-16
ES2094694B1 ES2094694B1 (es) 1997-12-16

Family

ID=8289322

Family Applications (3)

Application Number Title Priority Date Filing Date
ES09500181A Expired - Fee Related ES2094694B1 (es) 1995-02-01 1995-02-01 Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
ES96901349T Expired - Lifetime ES2148725T3 (es) 1995-02-01 1996-01-26 Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion.
ES99116334T Expired - Lifetime ES2238796T3 (es) 1995-02-01 1996-01-26 Nuevas formulaciones galenicas estabilizadas que comprenden un compuesto de bencimidazol labil en medio acido y su preparacion.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES96901349T Expired - Lifetime ES2148725T3 (es) 1995-02-01 1996-01-26 Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion.
ES99116334T Expired - Lifetime ES2238796T3 (es) 1995-02-01 1996-01-26 Nuevas formulaciones galenicas estabilizadas que comprenden un compuesto de bencimidazol labil en medio acido y su preparacion.

Country Status (20)

Country Link
US (1) US5626875A (es)
EP (2) EP0773025B1 (es)
JP (1) JP4183746B2 (es)
KR (1) KR100331290B1 (es)
AR (1) AR002702A1 (es)
AT (2) ATE292967T1 (es)
AU (1) AU4540396A (es)
CA (1) CA2184842C (es)
DE (3) DE69634613T2 (es)
DK (2) DK0773025T3 (es)
ES (3) ES2094694B1 (es)
FI (1) FI121730B (es)
HU (1) HU229219B1 (es)
IL (1) IL116673A (es)
IN (1) IN186596B (es)
PT (2) PT993830E (es)
SI (2) SI0773025T1 (es)
TW (1) TW503115B (es)
WO (1) WO1996023500A1 (es)
ZA (1) ZA96683B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2168043A1 (es) * 1999-09-13 2002-05-16 Esteve Labor Dr Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
ATE262332T1 (de) * 1995-09-21 2004-04-15 Pharma Pass Ii Llc Lansoprazolhaltige arzneizusammensetzung und herstellungsverfahren
SI9700186B (sl) 1997-07-14 2006-10-31 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
ES2137862B1 (es) * 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
US6559158B1 (en) 1997-11-03 2003-05-06 Ur Labs, Inc. Use of methylnaltrexone and related compounds to treat chronic opioid use side affects
US6274591B1 (en) 1997-11-03 2001-08-14 Joseph F. Foss Use of methylnaltrexone and related compounds
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
FR2774288B1 (fr) † 1998-01-30 2001-09-07 Ethypharm Sa Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques
DK173431B1 (da) 1998-03-20 2000-10-23 Gea Farmaceutisk Fabrik As Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs
WO1999053918A1 (fr) 1998-04-20 1999-10-28 Eisai Co., Ltd. Compositions stabilisees contenant des composes du type benzimidazole
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
SI1105105T1 (sl) * 1998-08-12 2006-08-31 Altana Pharma Ag Oralna dajalna oblika za piridin-2-ilmetilsulfinil-1J-benzimidazole
FR2793688B1 (fr) * 1999-05-21 2003-06-13 Ethypharm Lab Prod Ethiques Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
WO2001028559A1 (fr) 1999-10-20 2001-04-26 Eisai Co., Ltd. Procede de stabilisation de composes benzimidazoles
DE19959419A1 (de) * 1999-12-09 2001-06-21 Ratiopharm Gmbh Stabile galenische Zubereitungen umfassend ein Benzimidazol und Verfahren zu ihrer Herstellung
ATE297194T1 (de) * 1999-12-16 2005-06-15 Medinfar Produtos Farmaceutico Neue stabile mehreinheitliche substituierte benzimidazole enthaltende pharmazeutische präparate
US6419956B1 (en) 1999-12-30 2002-07-16 Ancile Pharmaceuticals Odor-masking coating for a pharmaceutical preparation
US20020064555A1 (en) * 2000-09-29 2002-05-30 Dan Cullen Proton pump inhibitor formulation
EP1341529A2 (en) * 2000-11-10 2003-09-10 F. Hoffman-la Roche AG Hydrolytically unstable compositions
AU2002314967B2 (en) * 2001-06-05 2007-09-20 University Of Chicago Use of methylnaltrexone to treat immune suppression
IL159854A0 (en) 2001-07-16 2004-06-20 Janssen Pharmaceutica Nv Improved process for preparing benzimidazole-type compounds
CN1596101A (zh) * 2001-09-28 2005-03-16 麦克内尔-Ppc股份有限公司 含有糖果组分的剂型
US20040170689A1 (en) * 2001-11-09 2004-09-02 Odink Debra Alida Stabilized formulations comprising hydrolytically unstable compositions
ES2198195B1 (es) 2001-12-18 2004-10-01 Laboratorios Del Dr. Esteve, S.A. Forma de dosificacion farmaceutica oral comprimida, con recubrimiento enterico, que contiene un compuesto de bencimidazol labil en medio acido.
EP1524967B1 (en) * 2002-08-02 2008-03-12 Ratiopharm GmbH Pharmaceutical preparation containing a benzimidazole compound mixed with microcrystalline cellulose and a method for its preparation
US20040028737A1 (en) * 2002-08-12 2004-02-12 Kopran Research Laboratories Limited Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same
EP1594479A1 (en) * 2003-01-31 2005-11-16 Ranbaxy Laboratories Limited Stable oral benzimidazole compositions and processes for their preparation
CA2521420A1 (en) * 2003-04-08 2004-10-28 Progenics Pharmaceuticals, Inc. Combination therapy for constipation comprising a laxative and a peripheral opioid antagonist
WO2004091622A1 (en) * 2003-04-08 2004-10-28 Progenics Pharmaceuticals, Inc. The use of peripheral opiois antagonists, especially methylnaltrexone to treat irritable bowel syndrome
DK2368553T3 (en) 2003-04-08 2015-02-09 Progenics Pharm Inc Pharmaceutical preparation comprising methylnaltrexone
ES2234393B2 (es) * 2003-04-29 2006-09-01 Laboratorios Belmac, S.A. "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido".
WO2004098573A1 (en) * 2003-05-08 2004-11-18 Natco Pharma Limited An improved and stable pharmaceutical composition containing substituted benzimidazoles and a process for its preparation
WO2005011637A1 (ja) * 2003-08-04 2005-02-10 Eisai Co., Ltd. 用時分散型製剤
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
WO2005034924A1 (en) * 2003-10-14 2005-04-21 Natco Pharma Limited Enteric coated pellets comprising esomeprazole, hard gelatin capsule containing them, and method of preparation
GB0400781D0 (en) * 2004-01-14 2004-02-18 Novartis Ag Organic compounds
US20050214372A1 (en) * 2004-03-03 2005-09-29 Simona Di Capua Stable pharmaceutical composition comprising an acid labile drug
ATE531361T1 (de) 2004-05-07 2011-11-15 Nycomed Gmbh Neue pharmazeutische dosierform und herstellungsverfahren
US20050281876A1 (en) 2004-06-18 2005-12-22 Shun-Por Li Solid dosage form for acid-labile active ingredient
CN101111233A (zh) 2004-12-23 2008-01-23 兰贝克赛实验室有限公司 稳定的口服苯并咪唑组合物及其制备方法
WO2006066932A1 (en) * 2004-12-24 2006-06-29 Lek Pharmaceuticals D.D. Stable pharmaceutical composition comprising an active substance in the form of solid solution
MX2007008141A (es) * 2005-01-03 2007-12-10 Lupin Ltd Composicion farmaceutica de sustancias labiles en medio acido.
MX2007008756A (es) * 2005-01-20 2007-09-27 Progenics Pharm Inc Uso de metilnaltrexona y compuestos relacionados para el tratamiento de disfuncion gastrointestinal postoperatoria.
US20080279951A1 (en) * 2005-02-02 2008-11-13 Rajesh Gandhi Stable Oral Benzimidazole Compositions Prepared by Non-Aqueous Layering Process
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
CN101171010B (zh) 2005-03-07 2014-09-17 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8673352B2 (en) * 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
US7981908B2 (en) * 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) * 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
US20080194611A1 (en) * 2005-06-03 2008-08-14 Alverdy John C Modulation of Cell Barrier Dysfunction
EP1785135A1 (en) 2005-11-10 2007-05-16 Laboratorios Del Dr. Esteve, S.A. New stabilized galenic formulations comprising lansoprazole and their preparation
EP1813275A1 (en) * 2005-12-20 2007-08-01 Teva Pharmaceutical Industries Ltd Lansoprazole orally disintegrating tablets
EP1962844A2 (en) * 2005-12-20 2008-09-03 Teva Pharmaceutical Industries Ltd Lansoprazole orally disintegrating tablets
US7579476B2 (en) * 2006-02-24 2009-08-25 Praktikatalyst Pharma, Llc Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals
ITMI20061024A1 (it) * 2006-05-25 2007-11-26 Eurand Pharmaceuticals Ltd Pellet a base di acido lipoico
RU2467747C2 (ru) * 2006-07-25 2012-11-27 Векта Лтд. Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
EP2134718A2 (en) 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
PL2137191T3 (pl) 2007-03-29 2016-12-30 Antagoniści obwodowego receptora opioidowego i ich zastosowania
AU2008349873B2 (en) 2008-02-06 2014-02-13 Progenics Pharmaceuticals, Inc. Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
US8911787B2 (en) 2008-02-26 2014-12-16 Ranbaxy Laboratories Limited Stable oral benzimidazole compositions and process of preparation thereof
AU2009225434B2 (en) * 2008-03-21 2014-05-22 The University Of Chicago Treatment with opioid antagonists and mTOR inhibitors
ES2620373T3 (es) 2008-07-01 2017-06-28 University Of Chicago Partículas que contienen un antagonista del receptor de opioides periférico
CH699302B1 (de) * 2008-08-11 2012-03-15 Mepha Gmbh Orale pharmazeutische Formulierung für Omeprazol, enthaltend eine spezifische Trennschicht.
JP2011530569A (ja) * 2008-08-11 2011-12-22 メファ・ゲーエムベーハー 特定の分離層を含むオメプラゾールの経口医薬製剤
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
WO2010117756A2 (en) * 2009-03-31 2010-10-14 Dr. Reddy's Laboratories Ltd Substituted benzimidazole pharmaceutical formulations
WO2011138797A2 (en) 2010-05-04 2011-11-10 Cadila Healthcare Limited Delayed release oral disintegrating pharmaceutical compositions of lansoprazole
EP2773348B1 (en) * 2011-11-02 2018-02-21 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical composition of omeprazole
GB2513172A (en) * 2013-04-18 2014-10-22 Nupharm Lab Ltd Liquid dosage form and delivery system
EP3718404A1 (en) 2014-10-17 2020-10-07 Salix Pharmaceuticals, Inc. Use of methylnaltrexone to attenuate tumor progession
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
EP3292862A1 (en) 2016-09-07 2018-03-14 Sandoz Ag Omeprazole formulations

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366621A1 (en) * 1988-10-20 1990-05-02 BOEHRINGER INGELHEIM ITALIA S.p.A. Orally pharmaceutical preparations with colon selective delivery
EP0466566A2 (en) * 1990-07-10 1992-01-15 Shin-Etsu Chemical Co., Ltd. Coated solid medicament form having releasebility in large intestine
WO1992011001A1 (en) * 1990-12-19 1992-07-09 Solvay (Societe Anonyme) Oral pharmaceutical composition
EP0519365A1 (de) * 1991-06-17 1992-12-23 Byk Gulden Lomberg Chemische Fabrik GmbH Pantoprazol enthaltende orale Darreichungsformen
EP0519144A1 (en) * 1991-06-21 1992-12-23 Ilsan Ilac Ve Hammaddeleri Sanayi A.S. New galenic process for omeprazole containing pellets
ES2051919T3 (es) * 1988-05-18 1994-07-01 Eisai Co Ltd Preparado para via oral de un compuesto de un acido inestable.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB829055A (en) * 1958-02-07 1960-02-24 Charles E Frosst And Company Improvements in or relating to pharmaceutical preparations
US4150111A (en) * 1974-05-28 1979-04-17 Allister Warren Enteric coated magnesium chloride
JPS5837285B2 (ja) * 1975-05-29 1983-08-15 カブシキガイシヤ ミドリジユウジ チヨウナイカンセンシヨウチリヨウザイノセイゾウホウホウ
JPS5598120A (en) * 1979-01-16 1980-07-25 Shin Etsu Chem Co Ltd Preparation of drug having enteric coating
US4470980A (en) * 1980-03-07 1984-09-11 Interx Research Corp. Method of increasing oral absorption of β-lactam antibiotics
US4377568A (en) * 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same
JPS58208155A (ja) * 1982-05-28 1983-12-03 Sumitomo Electric Ind Ltd 光伝送用ガラスフアイバの製造方法
JPS59193831A (ja) * 1983-04-18 1984-11-02 Sankyo Co Ltd 腸溶性製剤の製造法
CA1327010C (en) * 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US5395611A (en) * 1990-04-24 1995-03-07 The Governors Of The University Of Alberta Phenolic amine depigmenting and antimelanoma agents
IT1241740B (it) * 1990-06-22 1994-02-01 Edi Bondioli Protezione per una forcella di estremita' di un albero cardanico
US5232706A (en) * 1990-12-31 1993-08-03 Esteve Quimica, S.A. Oral pharmaceutical preparation containing omeprazol
FR2692146B1 (fr) * 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
WO1994002140A1 (en) * 1992-07-17 1994-02-03 Astra Aktiebolag Pharmaceutical composition containing antiulcer agent
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9500478D0 (sv) 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2051919T3 (es) * 1988-05-18 1994-07-01 Eisai Co Ltd Preparado para via oral de un compuesto de un acido inestable.
EP0366621A1 (en) * 1988-10-20 1990-05-02 BOEHRINGER INGELHEIM ITALIA S.p.A. Orally pharmaceutical preparations with colon selective delivery
EP0466566A2 (en) * 1990-07-10 1992-01-15 Shin-Etsu Chemical Co., Ltd. Coated solid medicament form having releasebility in large intestine
WO1992011001A1 (en) * 1990-12-19 1992-07-09 Solvay (Societe Anonyme) Oral pharmaceutical composition
EP0519365A1 (de) * 1991-06-17 1992-12-23 Byk Gulden Lomberg Chemische Fabrik GmbH Pantoprazol enthaltende orale Darreichungsformen
EP0519144A1 (en) * 1991-06-21 1992-12-23 Ilsan Ilac Ve Hammaddeleri Sanayi A.S. New galenic process for omeprazole containing pellets

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2168043A1 (es) * 1999-09-13 2002-05-16 Esteve Labor Dr Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.

Also Published As

Publication number Publication date
FI963916A (fi) 1996-09-30
PT773025E (pt) 2000-10-31
EP0773025B1 (en) 2000-06-07
WO1996023500A1 (es) 1996-08-08
EP0993830B1 (en) 2005-04-13
ES2238796T3 (es) 2005-09-01
CA2184842C (en) 2007-08-07
IN186596B (es) 2001-10-06
KR100331290B1 (ko) 2002-11-22
ZA96683B (en) 1997-09-23
HUP9603014A3 (en) 2000-12-28
JPH09511257A (ja) 1997-11-11
AR002702A1 (es) 1998-04-29
AU4540396A (en) 1996-08-21
FI121730B (fi) 2011-03-31
ATE193649T1 (de) 2000-06-15
US5626875A (en) 1997-05-06
PT993830E (pt) 2005-06-30
ATE292967T1 (de) 2005-04-15
TW503115B (en) 2002-09-21
DK0993830T3 (da) 2005-08-08
DE29623938U1 (de) 2000-10-05
IL116673A0 (en) 1996-05-14
SI0993830T1 (en) 2005-10-31
ES2148725T3 (es) 2000-10-16
EP0773025A1 (en) 1997-05-14
EP0993830A3 (en) 2001-10-04
JP4183746B2 (ja) 2008-11-19
EP0993830A2 (en) 2000-04-19
HU229219B1 (en) 2013-09-30
HUP9603014A2 (hu) 1998-03-30
FI963916A0 (fi) 1996-09-30
DE69608767D1 (de) 2000-07-13
CA2184842A1 (en) 1996-08-08
DE69634613T2 (de) 2006-03-09
IL116673A (en) 2000-10-31
DE69634613D1 (de) 2005-05-19
DK0773025T3 (da) 2000-10-09
ES2094694B1 (es) 1997-12-16
SI0773025T1 (en) 2000-10-31

Similar Documents

Publication Publication Date Title
ES2094694A1 (es) Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
WO2002098869A3 (en) 1,4-disubstituted benzo-fused cycloalkyl urea compounds
AU1924699A (en) Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
CA2284468A1 (en) Anti-inflammatory compounds
MX9605023A (es) Compuestos substituidos de imidazolidin-2,4-diona como substancias farmaceuticamente activas.
CA2217333A1 (fr) Compositions pour la teinture des fibres keratiniques contenant des diamino pyrazoles, procede de teinture, nouveaux diamino pyrazoles et leur procede de preparation
AU6392899A (en) Dynamic matching TM of users for group communication
EP1134224A3 (en) Cyclosilane compound, and solution composition and process for forming a silicon film
AU5313496A (en) Nodulisporic acid derivatives
AU1994499A (en) Process for production of hydrogen peroxide
NO974504L (no) Fremgangsmåte for fremstilling av 1,1'-£1,4-fenylenbis(metylen)|-bis-1,4,8,11-tetraazacyklotetradecan
EP0648752A4 (en) TRIAZOLE DERIVATIVE, INSECTICIDE / ACARICIDE AGENT, AND PROCESS FOR PRODUCING THE SAME.
AU9313198A (en) Gas generant compositions, methods of production of the same and devices made therefrom
MX9709611A (es) Composicion de revestimiento acuosa.
CA2219656A1 (en) Antibacterial cephalosporins
WO2002044194A1 (fr) Derives d'acide l-nucleique et procedes de synthese correspondants
CA2219359A1 (en) Hydantoin derivatives as intermediates for pharmaceutical active compounds
AU5627296A (en) Process for the manufacture of difluoromethane
WO1998017230A3 (en) New 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivatives
AU6339000A (en) Serotonergic benzothiophenes
AU2001289659A1 (en) Tocotrienolquinone cyclisation product with an anti-hypercholesterol effect
PL343316A1 (en) Process for producing 5-hydroxybenzo[b]thiophene-3-carboxylic acid derivatives
AU7517694A (en) Synthesis of 4,10-dinitro-2,6,8,12-tetraoxa-4,10-diazatetracyclo(5.5.0.05 ,9-03,11-)dodecane
AU8631698A (en) A process for the preparation of tetraazamacrocycles
AU4498799A (en) Method of preparing 5- or 8-bromoisoquinoline derivatives

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19970116

Kind code of ref document: A1

Effective date: 19970116

PC2A Transfer of patent
GC2A Exploitation certificate registered application with search report

Effective date: 19990506

GD2A Contractual licences

Effective date: 20000120

FD2A Announcement of lapse in spain

Effective date: 20180806