ES2094694A1 - Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. - Google Patents
Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.Info
- Publication number
- ES2094694A1 ES2094694A1 ES09500181A ES9500181A ES2094694A1 ES 2094694 A1 ES2094694 A1 ES 2094694A1 ES 09500181 A ES09500181 A ES 09500181A ES 9500181 A ES9500181 A ES 9500181A ES 2094694 A1 ES2094694 A1 ES 2094694A1
- Authority
- ES
- Spain
- Prior art keywords
- labile
- acid
- production process
- formulations containing
- new stable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NUEVA FORMULACION FARMACEUTICAMENTE ESTABLE DE UN COMPUESTO DE BENCIMIDAZOL Y SU PROCESO DE OBTENCION. DICHA FORMULACION COMPRENDE UN NUCLEO NEUTRO SOBRE EL QUE SE APLICA UNA CAPA CON EL INGREDIENTE ACTIVO CONSTITUIDA POR EL COMPUESTO DE BENCIMIDAZOL DE FORMULA I, UN POLIMERO SOLUBLE EN AGUA Y EXCIPIENTES DE REACCION NO ALCALINA, SOBRE LA QUE SE APLICA UNA SEGUNDA CAPA AISLANTE QUE COMPRENDE UN POLIMERO SOLUBLE EN AGUA, UN PIGMENTO Y TALCO, Y UNA ULTIMA CAPA ENTERICA QUE CONTIENE UN POLIMERO, UN PLASTIFICANTE Y TALCO.
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09500181A ES2094694B1 (es) | 1995-02-01 | 1995-02-01 | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
US08/429,689 US5626875A (en) | 1995-02-01 | 1995-04-27 | Stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation |
IL11667396A IL116673A (en) | 1995-02-01 | 1996-01-04 | Stable oral pharmaceutical composition containing an acid labile benzimidazole |
AR10105196A AR002702A1 (es) | 1995-02-01 | 1996-01-17 | Formulación farmacéutica oral estable conteniendo un compuesto de bencimidazol labil en medio ácido su procedimiento de obtención y sus formulaciones galenicas |
IN104CA1996 IN186596B (es) | 1995-02-01 | 1996-01-22 | |
AT96901349T ATE193649T1 (de) | 1995-02-01 | 1996-01-26 | Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren |
PT96901349T PT773025E (pt) | 1995-02-01 | 1996-01-26 | Novas formulacoes galenicas estaveis que contem um composto de benzimidazol acido-labil e processo de preparacao. |
AU45403/96A AU4540396A (en) | 1995-02-01 | 1996-01-26 | New stable ganelic formulations containing an acid-labile benzimidazol compound, and production process |
PCT/ES1996/000013 WO1996023500A1 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion |
DK99116334T DK0993830T3 (da) | 1995-02-01 | 1996-01-26 | Nye stabiliserede galeniske formuleringer indeholdende en syrelabil benzimidazolforbindselse og fremgangsmåde til fremstilling heraf |
DE69608767T DE69608767D1 (de) | 1995-02-01 | 1996-01-26 | Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren |
KR1019960704702A KR100331290B1 (ko) | 1995-02-01 | 1996-01-26 | 산에불안정한벤즈이미다졸화합물을포함하는신규의안정화된갈레닉(Galenic)제제및그의제조방법 |
DE29623938U DE29623938U1 (de) | 1995-02-01 | 1996-01-26 | Neue stabile galenische Formulierungen, enthaltend eine säureempfindliche Benzimidazolverbindung |
HU9603014A HU229219B1 (en) | 1995-02-01 | 1996-01-26 | Stabilized galenic compositions containing benzimidazol derivatives decomposing in acidic medium, and process for producing them |
EP99116334A EP0993830B1 (en) | 1995-02-01 | 1996-01-26 | New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation |
TW085100946A TW503115B (en) | 1995-02-01 | 1996-01-26 | New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation |
ES96901349T ES2148725T3 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion. |
PT99116334T PT993830E (pt) | 1995-02-01 | 1996-01-26 | Novas formulacoes galenicas estabilizadas compreendendo um composto acido labil de benzimidazole e a sua preparacao |
DE69634613T DE69634613T2 (de) | 1995-02-01 | 1996-01-26 | Neue stabilisierte galenische Formulierungen enthaltend ein säureempfindliches Benzimidazol und Verfahren zu ihrer Herstellung |
JP52327896A JP4183746B2 (ja) | 1995-02-01 | 1996-01-26 | 酸不安定性ベンズイミダゾールを含有する新規安定型ガレニック製剤、及びその製造方法 |
EP96901349A EP0773025B1 (en) | 1995-02-01 | 1996-01-26 | New stable galenic formulations containing an acid-labile benzimidazol compound, and production process |
ES99116334T ES2238796T3 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estabilizadas que comprenden un compuesto de bencimidazol labil en medio acido y su preparacion. |
AT99116334T ATE292967T1 (de) | 1995-02-01 | 1996-01-26 | Neue stabilisierte galenische formulierungen enthaltend ein säureempfindliches benzimidazol und verfahren zu ihrer herstellung |
DK96901349T DK0773025T3 (da) | 1995-02-01 | 1996-01-26 | Nye stabile galeniske formuleringer indeholdende en syrelabil benzimidazolforbindelser, og fremgangsmåde til fremstilling |
SI9630226T SI0773025T1 (en) | 1995-02-01 | 1996-01-26 | New stable galenic formulations containing an acid-labile benzimidazol compound, and production process |
SI9630710T SI0993830T1 (en) | 1995-02-01 | 1996-01-26 | New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation |
CA002184842A CA2184842C (en) | 1995-02-01 | 1996-01-26 | New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation |
ZA96683A ZA96683B (en) | 1995-02-01 | 1996-01-30 | New stabilized galenic formulations comprising an acid labile benzimidazole compound and its preparation |
FI963916A FI121730B (fi) | 1995-02-01 | 1996-09-30 | Uudet stabiloidut galeeniset formulaatiot, jotka sisältävät happolabiilia bentsimidatsoliyhdistettä, ja niiden valmistus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09500181A ES2094694B1 (es) | 1995-02-01 | 1995-02-01 | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2094694A1 true ES2094694A1 (es) | 1997-01-16 |
ES2094694B1 ES2094694B1 (es) | 1997-12-16 |
Family
ID=8289322
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09500181A Expired - Fee Related ES2094694B1 (es) | 1995-02-01 | 1995-02-01 | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
ES96901349T Expired - Lifetime ES2148725T3 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion. |
ES99116334T Expired - Lifetime ES2238796T3 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estabilizadas que comprenden un compuesto de bencimidazol labil en medio acido y su preparacion. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96901349T Expired - Lifetime ES2148725T3 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion. |
ES99116334T Expired - Lifetime ES2238796T3 (es) | 1995-02-01 | 1996-01-26 | Nuevas formulaciones galenicas estabilizadas que comprenden un compuesto de bencimidazol labil en medio acido y su preparacion. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5626875A (es) |
EP (2) | EP0773025B1 (es) |
JP (1) | JP4183746B2 (es) |
KR (1) | KR100331290B1 (es) |
AR (1) | AR002702A1 (es) |
AT (2) | ATE193649T1 (es) |
AU (1) | AU4540396A (es) |
CA (1) | CA2184842C (es) |
DE (3) | DE69608767D1 (es) |
DK (2) | DK0993830T3 (es) |
ES (3) | ES2094694B1 (es) |
FI (1) | FI121730B (es) |
HU (1) | HU229219B1 (es) |
IL (1) | IL116673A (es) |
IN (1) | IN186596B (es) |
PT (2) | PT993830E (es) |
SI (2) | SI0773025T1 (es) |
TW (1) | TW503115B (es) |
WO (1) | WO1996023500A1 (es) |
ZA (1) | ZA96683B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2168043A1 (es) * | 1999-09-13 | 2002-05-16 | Esteve Labor Dr | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. |
Families Citing this family (79)
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SI9700186B (sl) | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
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US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
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DK173431B1 (da) | 1998-03-20 | 2000-10-23 | Gea Farmaceutisk Fabrik As | Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs |
ATE526022T1 (de) * | 1998-04-20 | 2011-10-15 | Eisai R&D Man Co Ltd | Stabilisierte zusammenstellungen die benzimidazole enthalten |
ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. |
AU772726B2 (en) * | 1998-08-12 | 2004-05-06 | Takeda Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles |
FR2793688B1 (fr) * | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
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ATE297194T1 (de) * | 1999-12-16 | 2005-06-15 | Medinfar Produtos Farmaceutico | Neue stabile mehreinheitliche substituierte benzimidazole enthaltende pharmazeutische präparate |
US6419956B1 (en) | 1999-12-30 | 2002-07-16 | Ancile Pharmaceuticals | Odor-masking coating for a pharmaceutical preparation |
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- 1996-01-26 SI SI9630226T patent/SI0773025T1/xx unknown
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- 1996-01-26 DK DK96901349T patent/DK0773025T3/da active
- 1996-01-26 DE DE29623938U patent/DE29623938U1/de not_active Expired - Lifetime
- 1996-01-26 SI SI9630710T patent/SI0993830T1/xx unknown
- 1996-01-26 TW TW085100946A patent/TW503115B/zh not_active IP Right Cessation
- 1996-01-26 KR KR1019960704702A patent/KR100331290B1/ko not_active IP Right Cessation
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- 1996-01-26 CA CA002184842A patent/CA2184842C/en not_active Expired - Fee Related
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