DE69608767D1 - Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren - Google Patents

Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren

Info

Publication number
DE69608767D1
DE69608767D1 DE69608767T DE69608767T DE69608767D1 DE 69608767 D1 DE69608767 D1 DE 69608767D1 DE 69608767 T DE69608767 T DE 69608767T DE 69608767 T DE69608767 T DE 69608767T DE 69608767 D1 DE69608767 D1 DE 69608767D1
Authority
DE
Germany
Prior art keywords
production method
formulations containing
benzimidazole compound
new stable
acid labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69608767T
Other languages
English (en)
Inventor
Rodes Montserrat Ballester
Boven Marinus Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8289322&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69608767(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69608767D1 publication Critical patent/DE69608767D1/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69608767T 1995-02-01 1996-01-26 Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren Revoked DE69608767D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES09500181A ES2094694B1 (es) 1995-02-01 1995-02-01 Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
PCT/ES1996/000013 WO1996023500A1 (es) 1995-02-01 1996-01-26 Nuevas formulaciones galenicas estables conteniendo un compuesto de bencimidazol acido-labil, y su proceso de obtencion

Publications (1)

Publication Number Publication Date
DE69608767D1 true DE69608767D1 (de) 2000-07-13

Family

ID=8289322

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69634613T Revoked DE69634613T2 (de) 1995-02-01 1996-01-26 Neue stabilisierte galenische Formulierungen enthaltend ein säureempfindliches Benzimidazol und Verfahren zu ihrer Herstellung
DE29623938U Expired - Lifetime DE29623938U1 (de) 1995-02-01 1996-01-26 Neue stabile galenische Formulierungen, enthaltend eine säureempfindliche Benzimidazolverbindung
DE69608767T Revoked DE69608767D1 (de) 1995-02-01 1996-01-26 Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69634613T Revoked DE69634613T2 (de) 1995-02-01 1996-01-26 Neue stabilisierte galenische Formulierungen enthaltend ein säureempfindliches Benzimidazol und Verfahren zu ihrer Herstellung
DE29623938U Expired - Lifetime DE29623938U1 (de) 1995-02-01 1996-01-26 Neue stabile galenische Formulierungen, enthaltend eine säureempfindliche Benzimidazolverbindung

Country Status (20)

Country Link
US (1) US5626875A (de)
EP (2) EP0993830B1 (de)
JP (1) JP4183746B2 (de)
KR (1) KR100331290B1 (de)
AR (1) AR002702A1 (de)
AT (2) ATE292967T1 (de)
AU (1) AU4540396A (de)
CA (1) CA2184842C (de)
DE (3) DE69634613T2 (de)
DK (2) DK0773025T3 (de)
ES (3) ES2094694B1 (de)
FI (1) FI121730B (de)
HU (1) HU229219B1 (de)
IL (1) IL116673A (de)
IN (1) IN186596B (de)
PT (2) PT993830E (de)
SI (2) SI0993830T1 (de)
TW (1) TW503115B (de)
WO (1) WO1996023500A1 (de)
ZA (1) ZA96683B (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
PL186605B1 (pl) 1995-09-21 2004-01-30 Pharma Pass Llc Tabletka lub mikrotabletka zawierająca rdzeń posiadający jako kwasolabilny składnik aktywny omeprazol oraz sposób wytwarzania tabletek lub mikrotabletek zawierających rdzeń posiadający jako kwasolabilny składnik aktywny omeprazol
SI9700186B (sl) 1997-07-14 2006-10-31 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
ES2137862B1 (es) * 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
US6274591B1 (en) * 1997-11-03 2001-08-14 Joseph F. Foss Use of methylnaltrexone and related compounds
US6559158B1 (en) 1997-11-03 2003-05-06 Ur Labs, Inc. Use of methylnaltrexone and related compounds to treat chronic opioid use side affects
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
FR2774288B1 (fr) † 1998-01-30 2001-09-07 Ethypharm Sa Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques
DK173431B1 (da) 1998-03-20 2000-10-23 Gea Farmaceutisk Fabrik As Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs
US20020039597A1 (en) * 1998-04-20 2002-04-04 Koji Ukai Stabilized compositions containing benzimidazole-type compounds
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
SI1105105T1 (sl) * 1998-08-12 2006-08-31 Altana Pharma Ag Oralna dajalna oblika za piridin-2-ilmetilsulfinil-1J-benzimidazole
FR2793688B1 (fr) * 1999-05-21 2003-06-13 Ethypharm Lab Prod Ethiques Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
ES2168043B1 (es) 1999-09-13 2003-04-01 Esteve Labor Dr Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.
KR20020038759A (ko) 1999-10-20 2002-05-23 다니구치 미즈오 벤즈이미다졸계 화합물 안정화 방법
DE19959419A1 (de) * 1999-12-09 2001-06-21 Ratiopharm Gmbh Stabile galenische Zubereitungen umfassend ein Benzimidazol und Verfahren zu ihrer Herstellung
DK1108425T3 (da) * 1999-12-16 2005-09-26 Medinfar Produtos Farmaceutico Nye, stabile flerenhedspræparater, der indeholder substituerede benzimidazoler
US6419956B1 (en) 1999-12-30 2002-07-16 Ancile Pharmaceuticals Odor-masking coating for a pharmaceutical preparation
US20020064555A1 (en) * 2000-09-29 2002-05-30 Dan Cullen Proton pump inhibitor formulation
CN1474686A (zh) * 2000-11-10 2004-02-11 弗・哈夫曼-拉罗切有限公司 水解不稳定的组合物
DE60234183D1 (de) * 2001-06-05 2009-12-10 Univ Chicago Verwendung von methylnaltrexon zur behandlung von immunsuppression
DE60210292T2 (de) 2001-07-16 2006-12-07 Janssen Pharmaceutica N.V. Verbessertes verfahren zur herstellung von verbindungen des benzimidazoltyps
BR0212950A (pt) * 2001-09-28 2004-10-26 Mcneil Ppc Inc Formas de dosagens compósitas tendo uma porção inserida
US20040170689A1 (en) * 2001-11-09 2004-09-02 Odink Debra Alida Stabilized formulations comprising hydrolytically unstable compositions
ES2198195B1 (es) 2001-12-18 2004-10-01 Laboratorios Del Dr. Esteve, S.A. Forma de dosificacion farmaceutica oral comprimida, con recubrimiento enterico, que contiene un compuesto de bencimidazol labil en medio acido.
EP1524967B1 (de) * 2002-08-02 2008-03-12 Ratiopharm GmbH Pharmazeutische zusammensetzung enthaltend ein benzimidazol-derivat gemischt mit mikrokristalliner cellulose
US20040028737A1 (en) * 2002-08-12 2004-02-12 Kopran Research Laboratories Limited Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same
WO2004066982A1 (en) * 2003-01-31 2004-08-12 Ranbaxy Laboratories Limited Stable oral benzimidazole compositions and processes for their preparation
WO2004091665A1 (en) * 2003-04-08 2004-10-28 Progenics Pharmaceuticals, Inc. Combination therapy for constipation comprising a laxative and a peripheral opioid antagonist
EP1617846A1 (de) * 2003-04-08 2006-01-25 Progenics Pharmaceuticals, Inc. Verwendung von peripherern opioid-antagonisten, insbesondere methylnaltrexon zur behandlung des reizdarmsyndroms
EP2368554B1 (de) 2003-04-08 2014-12-24 Progenics Pharmaceuticals, Inc. Pharmazeutische Formulierungen enthaltend Methylnaltrexon
ES2234393B2 (es) * 2003-04-29 2006-09-01 Laboratorios Belmac, S.A. "formulaciones de pelets de compuestos bencimidazolicos antiulcerosos y labiles al acido".
WO2004098573A1 (en) * 2003-05-08 2004-11-18 Natco Pharma Limited An improved and stable pharmaceutical composition containing substituted benzimidazoles and a process for its preparation
WO2005011637A1 (ja) * 2003-08-04 2005-02-10 Eisai Co., Ltd. 用時分散型製剤
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
WO2005034924A1 (en) * 2003-10-14 2005-04-21 Natco Pharma Limited Enteric coated pellets comprising esomeprazole, hard gelatin capsule containing them, and method of preparation
GB0400781D0 (en) * 2004-01-14 2004-02-18 Novartis Ag Organic compounds
WO2005092297A2 (en) * 2004-03-03 2005-10-06 Teva Pharmaceutical Industries Ltd. A stable pharmaceutical composition comprising an acid labile drug
CA2565083C (en) 2004-05-07 2014-07-08 Altana Pharma Ag Novel pharmaceutical dosage form and manufacturing process
US20050281876A1 (en) 2004-06-18 2005-12-22 Shun-Por Li Solid dosage form for acid-labile active ingredient
CN101111233A (zh) 2004-12-23 2008-01-23 兰贝克赛实验室有限公司 稳定的口服苯并咪唑组合物及其制备方法
EP1830822A1 (de) * 2004-12-24 2007-09-12 LEK Pharmaceuticals D.D. Stabile pharmazeutische zusammensetzung mit einer wirksubstanz in form einer festen lösung
WO2006085335A2 (en) * 2005-01-03 2006-08-17 Lupin Limited Pharmaceutical composition of acid labile substances
MX2007008756A (es) * 2005-01-20 2007-09-27 Progenics Pharm Inc Uso de metilnaltrexona y compuestos relacionados para el tratamiento de disfuncion gastrointestinal postoperatoria.
EP1845982A2 (de) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Durch ein nichtwässriges schichtungsverfahren hergestellte stabile orale benzimidaziol-zusammensetzungen
US8524731B2 (en) * 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US9662390B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8673352B2 (en) * 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
US7981908B2 (en) * 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) * 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
US20080194611A1 (en) * 2005-06-03 2008-08-14 Alverdy John C Modulation of Cell Barrier Dysfunction
EP1785135A1 (de) * 2005-11-10 2007-05-16 Laboratorios Del Dr. Esteve, S.A. Neue Lanzoprazol enthaltende stabilisierte galenische Formulierungen und ihre Herstellung
CA2633825A1 (en) * 2005-12-20 2007-07-05 Teva Pharmaceutical Industries Ltd. Lansoprazole orally disintegrating tablets
EP1813275A1 (de) * 2005-12-20 2007-08-01 Teva Pharmaceutical Industries Ltd In der Mundhöle zerfallende Lansoprazol-Tabletten
US7579476B2 (en) * 2006-02-24 2009-08-25 Praktikatalyst Pharma, Llc Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals
ITMI20061024A1 (it) * 2006-05-25 2007-11-26 Eurand Pharmaceuticals Ltd Pellet a base di acido lipoico
EP2046334B1 (de) * 2006-07-25 2014-05-21 Vecta Ltd. Zusammensetzungen und verfahren zur hemmung von magensäuresekretion anhand von derivaten kleiner dicarbonsäuren in kombination mit ppi
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
PE20130480A1 (es) * 2007-03-29 2013-05-08 Progenics Pharm Inc Compuestos heterociclicos como antagonistas del receptor opioide periferico
EP3263571B2 (de) * 2007-03-29 2023-08-23 Progenics Pharmaceuticals, Inc. Kristallform von (r)-n-methylnaltrexonebromide und verwendungen davon
MX2009010515A (es) * 2007-03-29 2009-10-19 Wyeth Corp Antagonistas del receptor opioide periferico y usos de los mismos.
CA2713568C (en) * 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
US8911787B2 (en) 2008-02-26 2014-12-16 Ranbaxy Laboratories Limited Stable oral benzimidazole compositions and process of preparation thereof
EP2278966B1 (de) 2008-03-21 2019-10-09 The University of Chicago Behandlung mit opioid-antagonisten und mtor-inhibitoren
WO2010002576A1 (en) 2008-07-01 2010-01-07 University Of Chicago Particles containing an opioid receptor antagonist and methods of use
CH699302B1 (de) * 2008-08-11 2012-03-15 Mepha Gmbh Orale pharmazeutische Formulierung für Omeprazol, enthaltend eine spezifische Trennschicht.
US20110150945A1 (en) * 2008-08-11 2011-06-23 Mepha Gmbh Oral pharmaceutical formulation for omeprazole comprising a specific separation layer
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
WO2010117756A2 (en) * 2009-03-31 2010-10-14 Dr. Reddy's Laboratories Ltd Substituted benzimidazole pharmaceutical formulations
US20130202688A1 (en) 2010-05-04 2013-08-08 Sunilendu Bhushan Roy Delayed release oral disintegrating pharmaceutical compositions of lansoprazole
AU2012331182B2 (en) * 2011-11-02 2016-05-12 Towa Pharmaceutical Europe, S.L. Pharmaceutical composition of omeprazole
GB2513172A (en) * 2013-04-18 2014-10-22 Nupharm Lab Ltd Liquid dosage form and delivery system
CN107249327A (zh) 2014-10-17 2017-10-13 萨利克斯药品公司 使用甲基纳曲酮减缓肿瘤进展
EP3288556A4 (de) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Oral zerfallende zusammensetzungen
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
EP3292862A1 (de) 2016-09-07 2018-03-14 Sandoz Ag Omeprazolformulierungen

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB829055A (en) * 1958-02-07 1960-02-24 Charles E Frosst And Company Improvements in or relating to pharmaceutical preparations
US4150111A (en) * 1974-05-28 1979-04-17 Allister Warren Enteric coated magnesium chloride
JPS5837285B2 (ja) * 1975-05-29 1983-08-15 カブシキガイシヤ ミドリジユウジ チヨウナイカンセンシヨウチリヨウザイノセイゾウホウホウ
JPS5598120A (en) * 1979-01-16 1980-07-25 Shin Etsu Chem Co Ltd Preparation of drug having enteric coating
US4470980A (en) * 1980-03-07 1984-09-11 Interx Research Corp. Method of increasing oral absorption of β-lactam antibiotics
US4377568A (en) * 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same
JPS58208155A (ja) * 1982-05-28 1983-12-03 Sumitomo Electric Ind Ltd 光伝送用ガラスフアイバの製造方法
JPS59193831A (ja) * 1983-04-18 1984-11-02 Sankyo Co Ltd 腸溶性製剤の製造法
CA1327010C (en) * 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
JPH0768125B2 (ja) * 1988-05-18 1995-07-26 エーザイ株式会社 酸不安定化合物の内服用製剤
IT1230576B (it) * 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon
US5395611A (en) * 1990-04-24 1995-03-07 The Governors Of The University Of Alberta Phenolic amine depigmenting and antimelanoma agents
IT1241740B (it) * 1990-06-22 1994-02-01 Edi Bondioli Protezione per una forcella di estremita' di un albero cardanico
JP2773959B2 (ja) * 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
US5316772A (en) * 1990-12-19 1994-05-31 Solvay & Cie, S.A. (Societe Anonyme) Bilayered oral pharmaceutical composition with pH dependent release
US5232706A (en) * 1990-12-31 1993-08-03 Esteve Quimica, S.A. Oral pharmaceutical preparation containing omeprazol
YU48263B (sh) * 1991-06-17 1997-09-30 Byk Gulden Lomberg Chemische Fabrik Gmbh. Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola
DE69127275T2 (de) * 1991-06-21 1998-03-12 Ilsan Ilac Ve Hammaddeleri San Neues galenisches Verfahren für Omeprazol enthaltende Pellets
FR2692146B1 (fr) * 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
WO1994002140A1 (en) * 1992-07-17 1994-02-03 Astra Aktiebolag Pharmaceutical composition containing antiulcer agent
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9500478D0 (sv) 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process

Also Published As

Publication number Publication date
DE69634613D1 (de) 2005-05-19
DK0773025T3 (da) 2000-10-09
ATE193649T1 (de) 2000-06-15
CA2184842C (en) 2007-08-07
SI0773025T1 (en) 2000-10-31
SI0993830T1 (en) 2005-10-31
ZA96683B (en) 1997-09-23
DE29623938U1 (de) 2000-10-05
PT993830E (pt) 2005-06-30
FI121730B (fi) 2011-03-31
HU229219B1 (en) 2013-09-30
ES2094694B1 (es) 1997-12-16
ES2148725T3 (es) 2000-10-16
KR100331290B1 (ko) 2002-11-22
EP0993830B1 (de) 2005-04-13
EP0773025A1 (de) 1997-05-14
JPH09511257A (ja) 1997-11-11
IN186596B (de) 2001-10-06
CA2184842A1 (en) 1996-08-08
AU4540396A (en) 1996-08-21
ES2094694A1 (es) 1997-01-16
IL116673A0 (en) 1996-05-14
ES2238796T3 (es) 2005-09-01
IL116673A (en) 2000-10-31
WO1996023500A1 (es) 1996-08-08
FI963916A (fi) 1996-09-30
DE69634613T2 (de) 2006-03-09
EP0993830A2 (de) 2000-04-19
TW503115B (en) 2002-09-21
PT773025E (pt) 2000-10-31
FI963916A0 (fi) 1996-09-30
JP4183746B2 (ja) 2008-11-19
ATE292967T1 (de) 2005-04-15
EP0773025B1 (de) 2000-06-07
AR002702A1 (es) 1998-04-29
EP0993830A3 (de) 2001-10-04
US5626875A (en) 1997-05-06
DK0993830T3 (da) 2005-08-08
HUP9603014A3 (en) 2000-12-28
HUP9603014A2 (hu) 1998-03-30

Similar Documents

Publication Publication Date Title
DE69608767D1 (de) Neue stabile galenische formulierungen, die eine säurelabile benzimidazolverbindung enthalten, und herstellungsverfahren
DE59807213D1 (de) 11beta-halogen-7alpha-substituierte-estratriene, verfahren zur herstellung pharmazeutischer präparate, die diese 11beta-halogen-7alpha-substituierte-estratriene enthalten, sowie deren verwendung zur herstellung von arzneimitteln
DE69707650D1 (de) Reinigungsmittel die xanthangummi und vernetzte polyacylsäure enthalten
IT1313618B1 (it) Derivati di acidi 2-ammino-biciclo(3.1.0)-esan-2,6-bicarbossilici eprocedimento per la loro preparazione.
DE69605610D1 (de) Stabile Zusammensetzung, die Ascorbinsäure enthällt
CY2007005I1 (el) Υποκατεστημενες 3,5-διφαινυλ-1,2,4-τριαζολες και η χρηση τους ως φαρμακευτικων χηλικων σκευασματων για μεταλλα
ATA902196A (de) Neue kristalline form von 2-methyl-4-(4-methyl- 1-piperazinyl)-1oh-thieno (2,3-b) (1,5)-benzodiazepin, verfahren zu deren herstellung, pharmazeutische mittel und deren verwendung
DE69635410D1 (de) Halbleiterlaser und dessen herstellungsverfahren
GB2309695B (en) Asiatic acid derivative, it's manufacturing method and dermatological agent containing it
IT1293968B1 (it) Produzione ed utilizzo di composizioni comprendenti alte concentrazioni di attivita' di vitamina b12.
DK0700898T3 (da) L-carnitinsalt og kosmetiske og farmaceutiske præparater indeholdende samme, til behandling af dermatoser.
FR2763949B1 (fr) Compose stabilisant, composition le contenant et procede l'utilisant
IT1285009B1 (it) Procedimento ed apparecchiatura perfezionati per la fabbricazione di maniche.
IT8848259A0 (it) 1,4-diidropiridine, loro procedimento di preparazione e loro applicazione come medicamenti
TR28873A (tr) N-sübstitüe edilmis, N,N'-kaynasik heterosiklik benzoik asit üretmeye mahsus yöntem.
IT8720260A0 (it) Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti.
DE69818516D1 (de) Phenylaminoalkylcarbonsäure-derivate und medizinische zusammensetzungen, die diese enthalten
DE3681334D1 (de) Androstane-17-beta-carbonsaeureester, verfahren zu deren herstellung und pharmazeutische praeparate die diese enthalten.
DE3760617D1 (en) Aliphatic aldehydes, method for their production and their application as perfume agents
ATE254124T1 (de) Octahydro-2h-pyrido(1,2-a)pyrazinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ATE289595T1 (de) Neue pyrimidin-2,4,6-trion-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel die diese enthalten
KR970704417A (ko) 친유성 히드록시산, 그의 화장제 및 약제학적 용도 및 그의 제조 방법(lipophilic hydroxylated acid, cosmetic and pharmaceutical use thereof and method for preparing same)
ATE136299T1 (de) Verfahren zur herstellung der racemischen und optisch aktiven 1,2,3,4-tetrahydroisochinolin-3- carbonsäure sowie deren vorprodukte
GB2318789B (en) Carboxylic acid derivatives,method of manufacturing the same and therapeutic agents containing these compounds
DE69632338D1 (de) Neue aminosäurederivate, die eine n, n-dialkylaminophenylgruppe haben

Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation