UY33476A - Estimuladores de sgc - Google Patents

Estimuladores de sgc

Info

Publication number
UY33476A
UY33476A UY0001033476A UY33476A UY33476A UY 33476 A UY33476 A UY 33476A UY 0001033476 A UY0001033476 A UY 0001033476A UY 33476 A UY33476 A UY 33476A UY 33476 A UY33476 A UY 33476A
Authority
UY
Uruguay
Prior art keywords
sgc stimulators
stimulators
compounds
useful
sgc
Prior art date
Application number
UY0001033476A
Other languages
English (en)
Inventor
Thomas Wai-Ho Lee
Kim Charles
Nakai Takashi
Moore Joel
Nicholas Robert Perl
Rajesh R Iyengar
Mermerian Ara
Rohde Jason
Original Assignee
Ironwood Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of UY33476A publication Critical patent/UY33476A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Se describen compuestos de Fórmula I. Los mismos son útiles como estimuladores de sGC, en particular estimuladores independientes de NO y dependientes de hemo. Estos compuestos pueden ser útiles para tratar, prevenir o manejar distintos trastornos que se divulgan en el presente.
UY0001033476A 2010-06-30 2011-06-30 Estimuladores de sgc UY33476A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36023610P 2010-06-30 2010-06-30
US40684510P 2010-10-26 2010-10-26
US201161474563P 2011-04-12 2011-04-12

Publications (1)

Publication Number Publication Date
UY33476A true UY33476A (es) 2012-02-29

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UY0001033476A UY33476A (es) 2010-06-30 2011-06-30 Estimuladores de sgc

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US (4) US8748442B2 (es)
EP (2) EP2588465B1 (es)
JP (1) JP5860459B2 (es)
KR (1) KR101813931B1 (es)
CN (2) CN107021951B (es)
AR (1) AR088020A1 (es)
AU (1) AU2011272800B2 (es)
BR (1) BR112012033341B1 (es)
CA (1) CA2803292C (es)
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CN103313976B (zh) 2016-11-23
AU2011272800A1 (en) 2013-01-10
BR112012033341A2 (pt) 2021-05-11
EP2588465B1 (en) 2017-01-25
JP5860459B2 (ja) 2016-02-16
CN103313976A (zh) 2013-09-18
KR20130124477A (ko) 2013-11-14
CN107021951A (zh) 2017-08-08
KR101813931B1 (ko) 2018-01-02
US20190345130A1 (en) 2019-11-14
BR112012033341B1 (pt) 2022-08-23
EA201201648A1 (ru) 2013-06-28
TW201206915A (en) 2012-02-16
CA2803292A1 (en) 2012-01-05
EP3173407A1 (en) 2017-05-31
AU2011272800B2 (en) 2016-11-03
EA026692B1 (ru) 2017-05-31
TW201623297A (zh) 2016-07-01
WO2012003405A1 (en) 2012-01-05
US8748442B2 (en) 2014-06-10
US20170305878A1 (en) 2017-10-26
ES2623491T3 (es) 2017-07-11
DK2588465T3 (en) 2017-05-01
TWI532737B (zh) 2016-05-11
AR088020A1 (es) 2014-05-07
US20140323448A1 (en) 2014-10-30
TWI582091B (zh) 2017-05-11
CA2803292C (en) 2016-06-14
MX2012015252A (es) 2013-05-30
EP2588465A1 (en) 2013-05-08
CN107021951B (zh) 2020-10-20
WO2012003405A4 (en) 2012-02-23
US10189809B2 (en) 2019-01-29
JP2013530241A (ja) 2013-07-25

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