US7803634B2 - Fluorescent nanoscopy method - Google Patents

Fluorescent nanoscopy method Download PDF

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Publication number
US7803634B2
US7803634B2 US11/920,661 US92066106A US7803634B2 US 7803634 B2 US7803634 B2 US 7803634B2 US 92066106 A US92066106 A US 92066106A US 7803634 B2 US7803634 B2 US 7803634B2
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molecules
fluorescing
frames
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US20090045353A1 (en
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Andrey Alexeevich Klimov
Dmitry Andreevich Klimov
Evgeniy Andreevich Klimov
Tatiana Vitalyevna Klimova
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Super Resolution Technologies LLC
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Assigned to Stereonic International, Inc. reassignment Stereonic International, Inc. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KLIMOV, ANDREY ALEXEEVICH, KLIMOV, DMITRY ANDREEVICH, KLIMOV, EVGENIY ANDREEVICH, KLIMOVA, TATIANA VITALYEVNA
Assigned to SUPER RESOLUTION TECHNOLOGIES LLC reassignment SUPER RESOLUTION TECHNOLOGIES LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: Stereonic International, Inc.
Priority to US14/155,979 priority Critical patent/US9028757B2/en
Priority to US14/710,214 priority patent/US20150316478A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N13/00—Stereoscopic video systems; Multi-view video systems; Details thereof
    • H04N13/20—Image signal generators
    • H04N13/275—Image signal generators from 3D object models, e.g. computer-generated stereoscopic image signals
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N7/00—Television systems
    • H04N7/18—Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
    • Y10S977/86—Scanning probe structure
    • Y10S977/868—Scanning probe structure with optical means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
    • Y10S977/86—Scanning probe structure
    • Y10S977/868—Scanning probe structure with optical means
    • Y10S977/869—Optical microscope
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/88—Manufacture, treatment, or detection of nanostructure with arrangement, process, or apparatus for testing
    • Y10S977/881—Microscopy or spectroscopy, e.g. sem, tem
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Multimedia (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
US11/920,661 2005-05-18 2006-05-05 Fluorescent nanoscopy method Active 2027-04-12 US7803634B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/155,979 US9028757B2 (en) 2005-05-18 2014-01-15 Fluorescent nanoscopy device and method
US14/710,214 US20150316478A1 (en) 2005-05-18 2015-05-12 Fluorescent nanoscopy device and method

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2005115052/28A RU2305270C2 (ru) 2005-05-18 2005-05-18 Способ флуоресцентной наноскопии (варианты)
RU2005115052 2005-05-18
PCT/RU2006/000231 WO2006123967A2 (fr) 2005-05-18 2006-05-05 Procede de nanoscopie par fluorescence

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2006/000231 A-371-Of-International WO2006123967A2 (fr) 2005-05-18 2006-05-05 Procede de nanoscopie par fluorescence

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/891,420 Continuation US8110405B2 (en) 2005-05-18 2010-09-27 Fluorescent nanoscopy method

Publications (2)

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US20090045353A1 US20090045353A1 (en) 2009-02-19
US7803634B2 true US7803634B2 (en) 2010-09-28

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ID=37431689

Family Applications (6)

Application Number Title Priority Date Filing Date
US11/920,661 Active 2027-04-12 US7803634B2 (en) 2005-05-18 2006-05-05 Fluorescent nanoscopy method
US12/891,420 Expired - Fee Related US8110405B2 (en) 2005-05-18 2010-09-27 Fluorescent nanoscopy method
US13/366,813 Expired - Fee Related US8334143B2 (en) 2005-05-18 2012-02-06 Fluorescent nanoscopy method
US13/714,609 Active - Reinstated US8668872B2 (en) 2005-05-18 2012-12-14 Fluorescent nanoscopy device and method
US14/155,979 Expired - Fee Related US9028757B2 (en) 2005-05-18 2014-01-15 Fluorescent nanoscopy device and method
US14/710,214 Abandoned US20150316478A1 (en) 2005-05-18 2015-05-12 Fluorescent nanoscopy device and method

Family Applications After (5)

Application Number Title Priority Date Filing Date
US12/891,420 Expired - Fee Related US8110405B2 (en) 2005-05-18 2010-09-27 Fluorescent nanoscopy method
US13/366,813 Expired - Fee Related US8334143B2 (en) 2005-05-18 2012-02-06 Fluorescent nanoscopy method
US13/714,609 Active - Reinstated US8668872B2 (en) 2005-05-18 2012-12-14 Fluorescent nanoscopy device and method
US14/155,979 Expired - Fee Related US9028757B2 (en) 2005-05-18 2014-01-15 Fluorescent nanoscopy device and method
US14/710,214 Abandoned US20150316478A1 (en) 2005-05-18 2015-05-12 Fluorescent nanoscopy device and method

Country Status (7)

Country Link
US (6) US7803634B2 (ru)
EP (1) EP1892517A4 (ru)
JP (2) JP5065256B2 (ru)
CN (2) CN102023148B (ru)
CA (1) CA2648777A1 (ru)
RU (1) RU2305270C2 (ru)
WO (1) WO2006123967A2 (ru)

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US20100019170A1 (en) * 2008-07-24 2010-01-28 Hart Douglas P Three-dimensional imaging using a fluorescent medium
US20110102787A1 (en) * 2005-05-23 2011-05-05 Hestzig Llc Optical microscopy with phototransformable optical labels
US8568991B2 (en) 2011-12-23 2013-10-29 General Electric Company Photoactivated chemical bleaching of dyes
US8845526B2 (en) 2008-07-24 2014-09-30 Massachusetts Institute Of Technology Integrated otoscope and three dimensional scanning system
US9077975B2 (en) 2007-12-21 2015-07-07 President And Fellows Of Harvard College Sub-diffraction limit image resolution in three dimensions
US9140649B2 (en) 2008-07-24 2015-09-22 Massachusetts Institute Of Technology Inflatable membrane having non-uniform inflation characteristic
US9170199B2 (en) 2008-07-24 2015-10-27 Massachusetts Institute Of Technology Enhanced sensors in three dimensional scanning system
US9170200B2 (en) 2008-07-24 2015-10-27 Massachusetts Institute Of Technology Inflatable membrane with hazard mitigation
US9176032B2 (en) 2011-12-23 2015-11-03 General Electric Company Methods of analyzing an H and E stained biological sample
US9291565B2 (en) 2008-07-24 2016-03-22 Massachusetts Institute Of Technology Three dimensional scanning using membrane with optical features
US9915592B2 (en) 2013-03-06 2018-03-13 General Electric Company Methods of analyzing an H and E stained biological sample
US10073035B2 (en) 2006-08-07 2018-09-11 President And Fellows Of Harvard College Sub-diffraction limit image resolution and other imaging techniques
US10783697B2 (en) 2016-02-26 2020-09-22 Yale University Systems, methods, and computer-readable media for ultra-high resolution 3D imaging of whole cells
US10866170B2 (en) 2011-01-24 2020-12-15 Roche Molecular Systems, Inc Devices, systems, and methods for extracting a material from a material sample
US10871425B2 (en) 2015-01-31 2020-12-22 Roche Molecular Systems Inc. Systems and methods for meso-dissection
US10876933B2 (en) 2016-11-09 2020-12-29 Ventana Medical Systems, Inc. Automated tissue dissection instrument and methods of using the same
US11125660B2 (en) 2015-01-31 2021-09-21 Roche Molecular Systems, Inc. Systems and methods for meso-dissection
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RU2305270C2 (ru) * 2005-05-18 2007-08-27 Андрей Алексеевич Климов Способ флуоресцентной наноскопии (варианты)
RU2319948C2 (ru) * 2006-04-07 2008-03-20 Юрий Владимирович Микляев Способ получения изображения повышенной разрешающей способности
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WO2009002225A2 (ru) * 2007-06-25 2008-12-31 Closed Company 'molecular-Medicine Technologies' Многофункциональное устройство для диагностики и способ тестирования биологических объектов
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