UA95641C2 - Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы - Google Patents

Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы

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Publication number
UA95641C2
UA95641C2 UAA200900764A UAA200900764A UA95641C2 UA 95641 C2 UA95641 C2 UA 95641C2 UA A200900764 A UAA200900764 A UA A200900764A UA A200900764 A UAA200900764 A UA A200900764A UA 95641 C2 UA95641 C2 UA 95641C2
Authority
UA
Ukraine
Prior art keywords
protein kinase
kinase inhibitors
akt protein
cyclopentane
hydroxylated
Prior art date
Application number
UAA200900764A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Ян С. МИТЧЕЛЛ
Джеймс Ф. Блейк
Руи КСУ
Николас С. Каллан
Денгминг КСИАО
Кейт Ли Спенсер
Джозеф Р. Бенсик
Джун Лианг
Браян Сафина
Биронг Жанг
Кристин Шабо
Стивен ДО
Эли М. Веллес
Анна Л. БАНКА
Стивен Шлахтер
Original Assignee
Эррей Биофарма Инк.
Дженентек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA95641(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эррей Биофарма Инк., Дженентек, Инк. filed Critical Эррей Биофарма Инк.
Publication of UA95641C2 publication Critical patent/UA95641C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical Kinetics & Catalysis (AREA)
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  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Virology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
UAA200900764A 2006-07-06 2007-05-07 Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы UA95641C2 (xx)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06

Publications (1)

Publication Number Publication Date
UA95641C2 true UA95641C2 (xx) 2011-08-25

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ID=38686743

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UAA200900764A UA95641C2 (xx) 2006-07-06 2007-05-07 Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы

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EP (4) EP2402325B1 (instruction)
JP (4) JP5266216B2 (instruction)
KR (5) KR20140093291A (instruction)
CN (2) CN102816124A (instruction)
AR (3) AR061842A1 (instruction)
AT (1) ATE524447T1 (instruction)
AU (1) AU2007269060B2 (instruction)
BR (3) BRPI0713923B8 (instruction)
CA (2) CA2836316A1 (instruction)
CL (1) CL2007001993A1 (instruction)
CO (1) CO6150161A2 (instruction)
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DK (2) DK2402325T3 (instruction)
ES (3) ES2372774T3 (instruction)
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MX (4) MX377920B (instruction)
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PL (2) PL2049501T3 (instruction)
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RS (1) RS52212B (instruction)
RU (2) RU2478632C2 (instruction)
SG (4) SG188905A1 (instruction)
SI (2) SI2049501T1 (instruction)
TW (2) TWI402266B (instruction)
UA (1) UA95641C2 (instruction)
WO (1) WO2008006040A1 (instruction)
ZA (1) ZA200900070B (instruction)

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US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101516891B (zh) * 2006-07-06 2013-06-05 阵列生物制药公司 作为akt蛋白激酶抑制剂的二氢噻吩并嘧啶
CN103288753A (zh) 2006-07-06 2013-09-11 阵列生物制药公司 作为akt蛋白激酶抑制剂的环戊二烯并[d]嘧啶
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
US20110135569A1 (en) 2007-03-20 2011-06-09 Peak Biosciences Inc. Method for therapeutic administration of radionucleosides
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