UA78686C2 - Fused heterocyclic succinamide compounds and their analogs as modulators of functions of nuclear receptors for hormones - Google Patents

Info

Publication number

UA78686C2

UA78686C2 UA2003043564A UA2003043564A UA78686C2 UA 78686 C2 UA78686 C2 UA 78686C2 UA 2003043564 A UA2003043564 A UA 2003043564A UA 2003043564 A UA2003043564 A UA 2003043564A UA 78686 C2 UA78686 C2 UA 78686C2

Authority

UA

Ukraine

Prior art keywords

epoxy

isoindole

methyl

substituted

dione

Prior art date

2000-09-19

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• 108020005497 Nuclear hormone receptor Proteins 0.000 title claims abstract description 17
• -1 heterocyclic succinamide compounds Chemical class 0.000 title claims description 94
• 230000006870 function Effects 0.000 title claims description 15
• 229940088597 hormone Drugs 0.000 title description 17
• 239000005556 hormone Substances 0.000 title description 17
• 108020004017 nuclear receptors Proteins 0.000 title description 6
• 102000006255 nuclear receptors Human genes 0.000 title 1
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• 102000007399 Nuclear hormone receptor Human genes 0.000 claims abstract description 16
• 201000011510 cancer Diseases 0.000 claims abstract description 13
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
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• 125000000217 alkyl group Chemical group 0.000 claims description 130
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 105
• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 99
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 97
• 125000003118 aryl group Chemical group 0.000 claims description 86
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 80
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 79
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 78
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• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 54
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• 125000001424 substituent group Chemical group 0.000 claims description 47
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• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 43
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 38
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• LDECUSDQMXVUMP-UHFFFAOYSA-N benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]-hexylamino]-6-oxohexyl]-4-methyl-2-oxo-6-(4-phenylphenyl)-1,6-dihydropyrimidine-5-carboxylate Chemical compound O=C1NC(C=2C=CC(=CC=2)C=2C=CC=CC=2)C(C(=O)OCC=2C=CC=CC=2)=C(C)N1CCCCCC(=O)N(CCCCCC)C(C(=O)NCCCC)C1=CC=C(OCC(=O)OC)C(C(=O)OC)=C1 LDECUSDQMXVUMP-UHFFFAOYSA-N 0.000 claims description 11
• 229910052799 carbon Inorganic materials 0.000 claims description 11
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• 150000002009 diols Chemical class 0.000 claims description 8
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 8
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• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 7
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