UA77728C2 - Pharmaceutical composition of platinum compound (variants) - Google Patents
Pharmaceutical composition of platinum compound (variants) Download PDFInfo
- Publication number
- UA77728C2 UA77728C2 UA20040705324A UA20040705324A UA77728C2 UA 77728 C2 UA77728 C2 UA 77728C2 UA 20040705324 A UA20040705324 A UA 20040705324A UA 20040705324 A UA20040705324 A UA 20040705324A UA 77728 C2 UA77728 C2 UA 77728C2
- Authority
- UA
- Ukraine
- Prior art keywords
- composition according
- oxaliplatin
- lactic acid
- range
- pharmaceutically acceptable
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 150000003058 platinum compounds Chemical group 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims abstract description 83
- 229960001756 oxaliplatin Drugs 0.000 claims abstract description 82
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims abstract description 82
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 64
- 239000004310 lactic acid Substances 0.000 claims abstract description 32
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 32
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 20
- 239000003937 drug carrier Substances 0.000 claims abstract description 16
- -1 alkali metal salt Chemical class 0.000 claims description 18
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 230000003287 optical effect Effects 0.000 claims description 9
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 7
- 229910052697 platinum Inorganic materials 0.000 claims description 7
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000002844 melting Methods 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 6
- 239000001540 sodium lactate Substances 0.000 claims description 6
- 229940005581 sodium lactate Drugs 0.000 claims description 6
- 235000011088 sodium lactate Nutrition 0.000 claims description 6
- 239000008365 aqueous carrier Substances 0.000 claims description 5
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- FTDZDYKQOAOCRU-UHFFFAOYSA-N platinum(3+) Chemical compound [Pt+3] FTDZDYKQOAOCRU-UHFFFAOYSA-N 0.000 claims 2
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- 238000002560 therapeutic procedure Methods 0.000 abstract description 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000243 solution Substances 0.000 description 23
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
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- MUBZPKHOEPUJKR-UHFFFAOYSA-N oxalic acid group Chemical group C(C(=O)O)(=O)O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/010,122 US6476068B1 (en) | 2001-12-06 | 2001-12-06 | Platinum derivative pharmaceutical formulations |
| PCT/EP2002/013146 WO2003047587A1 (en) | 2001-12-06 | 2002-11-22 | Platinum derivative pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77728C2 true UA77728C2 (en) | 2007-01-15 |
Family
ID=21744006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040705324A UA77728C2 (en) | 2001-12-06 | 2002-11-22 | Pharmaceutical composition of platinum compound (variants) |
Country Status (42)
Families Citing this family (38)
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| WO2003004505A1 (en) * | 2001-07-02 | 2003-01-16 | Debiopharm S.A. | Oxaliplatin active substance with a very low content of oxalic acid |
| CA2388352A1 (en) * | 2002-05-31 | 2003-11-30 | Voiceage Corporation | A method and device for frequency-selective pitch enhancement of synthesized speed |
| US20040022842A1 (en) * | 2002-06-03 | 2004-02-05 | Mebiopharm Co., Ltd. | Liposome preparations containing oxaliplatin |
| DE10314377A1 (de) * | 2003-03-28 | 2004-10-07 | Stada Arzneimittel Ag | Gebrauchsfertige Oxaliplatin-Lösungen |
| JP2007504098A (ja) * | 2003-08-28 | 2007-03-01 | メイン・ファーマ・リミテッド | 酸を含むオキサリプラチン製剤 |
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| DK1757283T3 (da) * | 2004-06-09 | 2012-11-12 | Taiho Pharmaceutical Co Ltd | Antitumorvirkningsforstærker, antitumor middel og fremgangsmåde til cancerterrapi |
| KR20070048706A (ko) * | 2004-07-12 | 2007-05-09 | 시코르, 인크. | ｃｉｓ-디요오도-(ｔｒａｎｓ-Ｌ-1,2-시클로헥산디아민)백금(Ⅱ) 착물 및 고순도 옥살리플라틴의 제조 방법 |
| US20060063833A1 (en) * | 2004-09-22 | 2006-03-23 | Edgar Schridde | Ready-to-use oxaliplatin solutions |
| US20060063720A1 (en) * | 2004-09-22 | 2006-03-23 | Edgar Schridde | Oxaliplatin solution concentrate |
| DE102004052877B4 (de) * | 2004-11-02 | 2008-06-19 | Ebewe Pharma Ges.M.B.H. Nfg.Kg | Stabile wässrige Formulierungen eines Platin-Derivats |
| CN1311818C (zh) * | 2004-11-22 | 2007-04-25 | 山东蓝金生物工程有限公司 | 一种抗实体肿瘤的药物组合物 |
| DE102004063764A1 (de) * | 2004-12-29 | 2006-07-13 | Hexal Ag | Kunststoff-Flasche für Oxaliplatin |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| WO2006103691A1 (en) * | 2005-03-28 | 2006-10-05 | Dabur Pharma Ltd. | Stable pharmaceutical compositions of platinum (ii) antitumour agents |
| PL1885187T3 (pl) * | 2005-05-13 | 2014-03-31 | Novartis Ag | Sposoby leczenia lekoopornego raka |
| DE102005038347A1 (de) * | 2005-08-11 | 2007-02-15 | Hexal Ag | Herstellung einer Oxaliplatin-Lösung und Behälter sowie Behälter-Set mit der Lösung |
| WO2007029268A2 (en) * | 2005-09-05 | 2007-03-15 | Dabur Pharma Limited | Stable oxaliplatin formulation |
| MY148529A (en) * | 2005-11-29 | 2013-04-30 | Novartis Ag | Formulations of quinolinones |
| US20090076139A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched oxalplatin |
| EP2152239A1 (en) | 2007-11-12 | 2010-02-17 | Intas Pharmaceuticals Limited | Stable oxaliplatin composition for parenteral administration |
| CA2715832A1 (en) * | 2008-02-29 | 2009-09-11 | Eagle Pharmaceuticals, Inc. | Topotecan ready to use solutions |
| TW201021855A (en) * | 2008-11-13 | 2010-06-16 | Taigen Biotechnology Co Ltd | Lyophilization formulation |
| EP2481396A4 (en) | 2009-09-21 | 2014-03-05 | Jw Pharmaceutical Corp | OXALIPLATIN NANOPARTICLES AND MANUFACTURING METHOD THEREFOR |
| US9387152B2 (en) | 2010-06-28 | 2016-07-12 | The General Hospital Corporation | Blood substitutes and uses thereof |
| CN102274171A (zh) * | 2011-08-04 | 2011-12-14 | 上海希迪制药有限公司 | 一种奥沙利铂注射剂 |
| AU2013292647B2 (en) | 2012-07-18 | 2018-03-15 | Onyx Therapeutics, Inc. | Liposomal compositions of epoxyketone-based proteasome inhibitors |
| JP5929607B2 (ja) * | 2012-08-06 | 2016-06-08 | ニプロ株式会社 | オキサリプラチン製剤 |
| CN102885765B (zh) * | 2012-10-25 | 2013-11-06 | 哈药集团生物工程有限公司 | 一种盐酸伊立替康注射液及其制备方法 |
| US10098813B2 (en) * | 2014-09-03 | 2018-10-16 | Sun Pharmaceutical Industries Limited | Perfusion dosage form |
| KR101683635B1 (ko) * | 2014-12-29 | 2016-12-09 | 가천대학교 산학협력단 | 락테이트 금속염을 포함하는 암 치료용 약학 조성물 |
| KR102293907B1 (ko) * | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
| WO2017138023A1 (en) | 2016-02-09 | 2017-08-17 | Sun Pharmaceutical Industries Ltd. | Perfusion system |
| EP3538546A1 (en) | 2016-11-14 | 2019-09-18 | Novartis AG | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| CA3087953A1 (en) | 2018-01-12 | 2019-07-18 | Metimedi Pharmaceuticals Co., Ltd. | Methods of treating chronic inflammatory diseases |
| KR101998246B1 (ko) | 2018-08-22 | 2019-07-10 | 주식회사 메타파인즈 | 금속이온에 결합된 이온화합물을 포함하는 암 치료용 약학 조성물 |
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2001
- 2001-12-06 US US10/010,122 patent/US6476068B1/en not_active Expired - Fee Related
-
2002
- 2002-08-22 US US10/225,607 patent/US6673805B2/en not_active Expired - Fee Related
- 2002-11-15 US US10/295,799 patent/US20030109515A1/en not_active Abandoned
- 2002-11-22 KR KR1020047008709A patent/KR100941210B1/ko not_active IP Right Cessation
- 2002-11-22 NZ NZ533383A patent/NZ533383A/en not_active IP Right Cessation
- 2002-11-22 CA CA002468916A patent/CA2468916C/en not_active Expired - Fee Related
- 2002-11-22 HU HU0402217A patent/HUP0402217A3/hu unknown
- 2002-11-22 AU AU2002352105A patent/AU2002352105B2/en not_active Ceased
- 2002-11-22 EP EP02787779A patent/EP1453517B1/en not_active Expired - Lifetime
- 2002-11-22 RO ROA200400514A patent/RO121509B1/ro unknown
- 2002-11-22 WO PCT/EP2002/013146 patent/WO2003047587A1/en active IP Right Grant
- 2002-11-22 UA UA20040705324A patent/UA77728C2/uk unknown
- 2002-11-22 BR BR0214757-2A patent/BR0214757A/pt not_active IP Right Cessation
- 2002-11-22 AP APAP/P/2004/003055A patent/AP1760A/en active
- 2002-11-22 GE GE5607A patent/GEP20063895B/en unknown
- 2002-11-22 MX MXPA04005423A patent/MXPA04005423A/es active IP Right Grant
- 2002-11-22 PL PL370254A patent/PL206755B1/pl not_active IP Right Cessation
- 2002-11-22 DE DE60209145T patent/DE60209145T2/de not_active Expired - Lifetime
- 2002-11-22 IL IL16234802A patent/IL162348A0/xx unknown
- 2002-11-22 CN CNB028268431A patent/CN100540006C/zh not_active Expired - Fee Related
- 2002-11-22 ES ES02787779T patent/ES2258661T3/es not_active Expired - Lifetime
- 2002-11-22 RS YUP-597/04A patent/RS50360B/sr unknown
- 2002-11-22 AT AT02787779T patent/ATE317260T1/de active
- 2002-11-22 ME MEP-104/08A patent/MEP10408A/hr unknown
- 2002-11-22 OA OA1200400165A patent/OA12739A/en unknown
- 2002-11-22 SI SI200220035A patent/SI21493A/sl not_active IP Right Cessation
- 2002-11-22 JP JP2003548842A patent/JP2005515202A/ja not_active Withdrawn
- 2002-11-22 PT PT02787779T patent/PT1453517E/pt unknown
- 2002-11-22 DK DK02787779T patent/DK1453517T3/da active
- 2002-11-22 EA EA200400777A patent/EA008090B1/ru not_active IP Right Cessation
- 2002-12-04 MY MYPI20024553A patent/MY134422A/en unknown
- 2002-12-04 AR ARP020104679A patent/AR037629A1/es unknown
- 2002-12-05 TW TW091135278A patent/TW200409640A/zh unknown
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2004
- 2004-06-03 IL IL162348A patent/IL162348A/en not_active IP Right Cessation
- 2004-06-03 IS IS7298A patent/IS2580B/is unknown
- 2004-06-04 MA MA27715A patent/MA27153A1/fr unknown
- 2004-06-04 CR CR7362A patent/CR7362A/es not_active Application Discontinuation
- 2004-06-04 EC EC2004005140A patent/ECSP045140A/es unknown
- 2004-06-04 TN TNP2004000104A patent/TNSN04104A1/fr unknown
- 2004-06-07 HR HR20040514A patent/HRP20040514A2/hr not_active Application Discontinuation
- 2004-06-07 CO CO04053199A patent/CO5580776A2/es not_active Application Discontinuation
- 2004-06-08 ZA ZA200404525A patent/ZA200404525B/en unknown
- 2004-07-05 NO NO20042842A patent/NO330159B1/no not_active IP Right Cessation
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2005
- 2005-06-08 HK HK05104822.1A patent/HK1072002A1/xx not_active IP Right Cessation
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2006
- 2006-05-04 CY CY20061100574T patent/CY1105608T1/el unknown
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