UA75673C2 - Pharmaceutical composition containing proton pump inhibitor and antacids, processes for manufacture of tablets and method for treatment - Google Patents
Pharmaceutical composition containing proton pump inhibitor and antacids, processes for manufacture of tablets and method for treatment Download PDFInfo
- Publication number
- UA75673C2 UA75673C2 UA2004010288A UA2004010288A UA75673C2 UA 75673 C2 UA75673 C2 UA 75673C2 UA 2004010288 A UA2004010288 A UA 2004010288A UA 2004010288 A UA2004010288 A UA 2004010288A UA 75673 C2 UA75673 C2 UA 75673C2
- Authority
- UA
- Ukraine
- Prior art keywords
- tablet according
- items
- omeprazole
- tablet
- differs
- Prior art date
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- 239000003159 antacid agent Substances 0.000 title claims abstract description 63
- 229940069428 antacid Drugs 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000011282 treatment Methods 0.000 title claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- 229940126409 proton pump inhibitor Drugs 0.000 title claims description 34
- 239000000612 proton pump inhibitor Substances 0.000 title claims description 34
- 239000008194 pharmaceutical composition Substances 0.000 title 1
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- 238000000576 coating method Methods 0.000 claims abstract description 100
- 230000004888 barrier function Effects 0.000 claims abstract description 59
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 53
- 239000000203 mixture Substances 0.000 claims abstract description 50
- 230000001458 anti-acid effect Effects 0.000 claims abstract description 42
- 229920001577 copolymer Polymers 0.000 claims abstract description 25
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
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- 239000003765 sweetening agent Substances 0.000 claims abstract description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 5
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims abstract description 4
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- 102100021904 Potassium-transporting ATPase alpha chain 1 Human genes 0.000 claims abstract 2
- 108010083204 Proton Pumps Proteins 0.000 claims abstract 2
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- 239000003826 tablet Substances 0.000 claims description 91
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 58
- 229960000381 omeprazole Drugs 0.000 claims description 54
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 50
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 13
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- KWORUUGOSLYAGD-UHFFFAOYSA-N magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide Chemical compound [Mg+2].N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C.N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C KWORUUGOSLYAGD-UHFFFAOYSA-N 0.000 claims description 12
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- MQEUGMWHWPYFDD-UHFFFAOYSA-N magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical compound [Mg].N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C MQEUGMWHWPYFDD-UHFFFAOYSA-N 0.000 claims description 6
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- 239000001506 calcium phosphate Substances 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
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- MPRVXUYAJZZBHG-UHFFFAOYSA-K dicarbonoperoxoyloxyalumanyl hydroxy carbonate Chemical compound [Al+3].OOC([O-])=O.OOC([O-])=O.OOC([O-])=O MPRVXUYAJZZBHG-UHFFFAOYSA-K 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
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- 229940015826 dihydroxyaluminum aminoacetate Drugs 0.000 description 1
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- 239000003623 enhancer Substances 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 208000028299 esophageal disease Diseases 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
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- 210000004051 gastric juice Anatomy 0.000 description 1
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
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- 229960001708 magnesium carbonate Drugs 0.000 description 1
- 229960000816 magnesium hydroxide Drugs 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 229960000869 magnesium oxide Drugs 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- AACACXATQSKRQG-UHFFFAOYSA-L magnesium;2-aminoacetate Chemical compound [Mg+2].NCC([O-])=O.NCC([O-])=O AACACXATQSKRQG-UHFFFAOYSA-L 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 239000011325 microbead Substances 0.000 description 1
- 239000013081 microcrystal Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 description 1
- 235000010434 neohesperidine DC Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000008183 oral pharmaceutical preparation Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
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- 230000000704 physical effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
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- 238000012545 processing Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
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- 229960001407 sodium bicarbonate Drugs 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- 229960002920 sorbitol Drugs 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 description 1
- 229960004291 sucralfate Drugs 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01401896 | 2001-07-16 | ||
PCT/SE2002/001370 WO2003007917A1 (en) | 2001-07-16 | 2002-07-10 | Pharmaceutical formulation comprising a proton pump inhibitor and antacids |
Publications (1)
Publication Number | Publication Date |
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UA75673C2 true UA75673C2 (en) | 2006-05-15 |
Family
ID=8182807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2004010288A UA75673C2 (en) | 2001-07-16 | 2002-10-07 | Pharmaceutical composition containing proton pump inhibitor and antacids, processes for manufacture of tablets and method for treatment |
Country Status (24)
Country | Link |
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US (2) | US20040219211A1 (is) |
EP (1) | EP1416922A1 (is) |
JP (1) | JP2004536855A (is) |
KR (1) | KR20040018463A (is) |
CN (1) | CN100469366C (is) |
AR (1) | AR034757A1 (is) |
AU (1) | AU2002316020B2 (is) |
BG (1) | BG108515A (is) |
BR (1) | BR0211117A (is) |
CA (1) | CA2453290A1 (is) |
CO (1) | CO5550417A2 (is) |
HU (1) | HUP0401941A3 (is) |
IL (1) | IL159584A0 (is) |
IS (1) | IS7111A (is) |
MX (1) | MXPA04000385A (is) |
MY (1) | MY136137A (is) |
NO (1) | NO20040178L (is) |
NZ (1) | NZ530511A (is) |
PL (1) | PL367686A1 (is) |
RU (1) | RU2301662C2 (is) |
UA (1) | UA75673C2 (is) |
UY (1) | UY27385A1 (is) |
WO (1) | WO2003007917A1 (is) |
ZA (1) | ZA200400285B (is) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
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BR0212951A (pt) | 2001-09-28 | 2004-10-26 | Mcneil Ppc Inc | Formas de dosagens compósitas |
DE10304403A1 (de) | 2003-01-28 | 2004-08-05 | Röhm GmbH & Co. KG | Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung |
AR045068A1 (es) * | 2003-07-23 | 2005-10-12 | Univ Missouri | Formulacion de liberacion inmediata de composiciones farmaceuticas |
TWI372066B (en) * | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
CN100438914C (zh) * | 2003-10-15 | 2008-12-03 | 富士化学工业株式会社 | 用于口腔内快速崩解的片剂的组合物 |
US8349361B2 (en) | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
JP3841804B2 (ja) | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤用の組成物 |
WO2005044223A1 (en) * | 2003-11-07 | 2005-05-19 | Takeda Pharmaceutical Company Limited | Chewable tablet |
US20050281876A1 (en) | 2004-06-18 | 2005-12-22 | Shun-Por Li | Solid dosage form for acid-labile active ingredient |
EP1621187A1 (en) * | 2004-07-26 | 2006-02-01 | AstraZeneca AB | Pharmaceutical multiparticulate tablet formulations and process for their preparation |
US8758814B2 (en) | 2004-10-08 | 2014-06-24 | Mcneil-Ppc, Inc. | Chewable enteric coated aspirin tablets |
US8057820B2 (en) | 2004-10-08 | 2011-11-15 | Mcneil-Ppc, Inc. | Enteric coated aspirin granules comingled with binder |
US8673352B2 (en) | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
DE102005024614A1 (de) * | 2005-05-25 | 2006-11-30 | Röhm Gmbh | Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug |
US20080166407A1 (en) * | 2005-07-29 | 2008-07-10 | Shalaby Shalaby W | Solid oral formulations for combination therapy |
CN100431526C (zh) * | 2005-11-07 | 2008-11-12 | 上海艾力斯医药科技有限公司 | 一种酸敏感型药物的快速崩解片剂 |
CN101120930B (zh) * | 2006-08-11 | 2010-09-29 | 石药集团中奇制药技术(石家庄)有限公司 | 一种奥美拉唑组合物及其制备方法 |
KR20100103565A (ko) * | 2008-01-10 | 2010-09-27 | 에보니크 룀 게엠베하 | 촉진되고 조절된 활성 물질 방출을 갖는 코팅된 제약학적 또는 건강기능성 제제 |
US9011907B2 (en) * | 2008-01-10 | 2015-04-21 | Evonik Röhm Gmbh | Coated pharmaceutical or nutraceutical preparation with enhanced pulsed active substance release |
RU2497503C9 (ru) * | 2008-03-10 | 2014-09-20 | Байер Конзюмер Кер АГ | Приятная на вкус твердая композиция, включающая нейтрализатор кислотности и стимулятор слюноотделения |
US9241910B2 (en) * | 2008-03-11 | 2016-01-26 | Takeda Pharmaceutical Company Limited | Orally-disintegrating solid preparation |
JP5523467B2 (ja) * | 2008-11-17 | 2014-06-18 | タケダ ニコメド エイエス | 炭酸カルシウム錠剤の改善された溶解安定性 |
PE20140005A1 (es) * | 2010-12-03 | 2014-01-23 | Takeda Pharmaceutical | Tableta oralmente desintegradora |
CN102085188B (zh) * | 2011-01-14 | 2013-01-02 | 寿光富康制药有限公司 | 一种兰索拉唑肠溶微丸的制备方法 |
CN102078616A (zh) * | 2011-01-28 | 2011-06-01 | 北京虹湾医药技术有限公司 | 埃索美拉唑碳酸氢钠组合物 |
US8277842B1 (en) * | 2012-01-20 | 2012-10-02 | Dart Neuroscience (Cayman) Ltd. | Enteric-coated HT-2157 compositions and methods of their use |
CN102631327B (zh) * | 2012-05-14 | 2013-08-28 | 海南葫芦娃制药有限公司 | 一种奥美拉唑肠溶微丸及其制备方法 |
CN103479593B (zh) * | 2013-05-10 | 2014-10-08 | 青岛双鲸药业有限公司 | 一种奥美拉唑肠溶片的制备方法 |
JP6156037B2 (ja) * | 2013-10-03 | 2017-07-05 | ライオン株式会社 | 固形医薬製剤組成物 |
CN103784414B (zh) * | 2013-12-18 | 2018-01-30 | 北京华禧联合科技发展有限公司 | 一种埃索美拉唑肠溶片及其制备方法 |
CA2910865C (en) | 2014-07-15 | 2016-11-29 | Isa Odidi | Compositions and methods for reducing overdose |
EP3288556A4 (en) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
JP7156945B2 (ja) * | 2016-02-03 | 2022-10-19 | ノバルティス アーゲー | 有機化合物のガレヌス製剤 |
WO2017185123A1 (en) * | 2016-04-29 | 2017-11-02 | Alan Thompson | Veterinary composition |
US10076494B2 (en) * | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
CN108434117A (zh) * | 2018-03-29 | 2018-08-24 | 成都通德药业有限公司 | 一种奥美拉唑肠溶胶囊的制备方法 |
RU2727506C1 (ru) * | 2019-09-09 | 2020-07-22 | Пивипи Лабс Пте. Лтд. | Средство для лечения эректильной дисфункции |
CN114980867B (zh) * | 2020-01-23 | 2024-03-15 | 韩美药品株式会社 | 包含质子泵抑制剂和抗酸剂的药物复合制剂 |
WO2022103233A1 (ko) * | 2020-11-13 | 2022-05-19 | (주)휴온스 | 라베프라졸 및 제산제를 포함하는 약제학적 복합제제 및 이의 제조방법 |
CN114617852B (zh) * | 2020-12-10 | 2023-06-27 | 昆药集团股份有限公司 | 一种奥美拉唑肠溶制剂及其制备方法 |
CA3216359A1 (en) | 2021-04-07 | 2022-10-13 | Battelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
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JP2516408B2 (ja) * | 1988-08-18 | 1996-07-24 | エスエス製薬株式会社 | 被覆顆粒を含む錠剤 |
DE4122217C2 (de) * | 1991-07-04 | 1997-02-13 | Merz & Co Gmbh & Co | Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern |
US5464632C1 (en) * | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
CZ289804B6 (cs) * | 1994-07-08 | 2002-04-17 | Astrazeneca Ab | Multijednotková tabletovaná dávková forma I |
SE9600071D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
DE19617487A1 (de) * | 1996-05-02 | 1997-11-06 | Merck Patent Gmbh | Geschmacksverbesserung von Arzneimittelwirkstoffen |
JP3961596B2 (ja) * | 1996-10-15 | 2007-08-22 | 富士化学工業株式会社 | 無機制酸剤含有速分散性造粒物、その製造方法及び用時懸濁内服制酸剤 |
US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
CN1256085C (zh) * | 1997-07-01 | 2006-05-17 | 美国辉瑞有限公司 | 舍曲林盐和舍曲林的缓释剂型 |
FR2766089B1 (fr) * | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
CA2323680C (en) * | 1998-05-18 | 2007-05-22 | Takeda Chemical Industries, Ltd. | Orally disintegrable tablets |
CA2374760A1 (en) * | 1999-06-18 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Quickly disintegrating solid preparations |
DE19954653B4 (de) * | 1999-11-13 | 2006-01-19 | Contitech Profile Gmbh | Extruder zur Aufbereitung von Kautschukmischungen |
US6656492B2 (en) * | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
US6749867B2 (en) * | 2000-11-29 | 2004-06-15 | Joseph R. Robinson | Delivery system for omeprazole and its salts |
DK1341528T3 (da) * | 2000-12-07 | 2012-03-26 | Nycomed Gmbh | Hurtigtopløsende tablet omfattende en syrelabil aktiv bestanddel |
-
2002
- 2002-07-10 IL IL15958402A patent/IL159584A0/xx unknown
- 2002-07-10 KR KR10-2004-7000606A patent/KR20040018463A/ko not_active Application Discontinuation
- 2002-07-10 AU AU2002316020A patent/AU2002316020B2/en not_active Ceased
- 2002-07-10 HU HU0401941A patent/HUP0401941A3/hu unknown
- 2002-07-10 CN CNB028180135A patent/CN100469366C/zh not_active Expired - Fee Related
- 2002-07-10 NZ NZ530511A patent/NZ530511A/en unknown
- 2002-07-10 CA CA002453290A patent/CA2453290A1/en not_active Abandoned
- 2002-07-10 BR BR0211117-9A patent/BR0211117A/pt not_active IP Right Cessation
- 2002-07-10 WO PCT/SE2002/001370 patent/WO2003007917A1/en active IP Right Grant
- 2002-07-10 PL PL02367686A patent/PL367686A1/xx not_active Application Discontinuation
- 2002-07-10 JP JP2003513526A patent/JP2004536855A/ja active Pending
- 2002-07-10 EP EP02746288A patent/EP1416922A1/en not_active Withdrawn
- 2002-07-10 US US10/484,064 patent/US20040219211A1/en not_active Abandoned
- 2002-07-10 RU RU2004101061/15A patent/RU2301662C2/ru not_active IP Right Cessation
- 2002-07-10 MX MXPA04000385A patent/MXPA04000385A/es active IP Right Grant
- 2002-07-10 AR ARP020102572A patent/AR034757A1/es unknown
- 2002-07-15 MY MYPI20022672A patent/MY136137A/en unknown
- 2002-07-16 UY UY27385A patent/UY27385A1/es unknown
- 2002-10-07 UA UA2004010288A patent/UA75673C2/uk unknown
-
2004
- 2004-01-06 BG BG108515A patent/BG108515A/xx unknown
- 2004-01-14 ZA ZA2004/00285A patent/ZA200400285B/en unknown
- 2004-01-15 NO NO20040178A patent/NO20040178L/no not_active Application Discontinuation
- 2004-01-15 IS IS7111A patent/IS7111A/is unknown
- 2004-01-16 CO CO04002774A patent/CO5550417A2/es not_active Application Discontinuation
-
2010
- 2010-06-10 US US12/813,018 patent/US20110135722A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20040018463A (ko) | 2004-03-03 |
UY27385A1 (es) | 2003-02-28 |
US20040219211A1 (en) | 2004-11-04 |
CO5550417A2 (es) | 2005-08-31 |
MXPA04000385A (es) | 2004-05-04 |
MY136137A (en) | 2008-08-29 |
RU2004101061A (ru) | 2005-04-20 |
CN100469366C (zh) | 2009-03-18 |
BG108515A (en) | 2005-02-28 |
AU2002316020B2 (en) | 2007-03-15 |
IS7111A (is) | 2004-01-15 |
AR034757A1 (es) | 2004-03-17 |
RU2301662C2 (ru) | 2007-06-27 |
US20110135722A1 (en) | 2011-06-09 |
ZA200400285B (en) | 2005-06-29 |
EP1416922A1 (en) | 2004-05-12 |
CN1555256A (zh) | 2004-12-15 |
WO2003007917A1 (en) | 2003-01-30 |
PL367686A1 (en) | 2005-03-07 |
BR0211117A (pt) | 2004-06-22 |
CA2453290A1 (en) | 2003-01-30 |
IL159584A0 (en) | 2004-06-01 |
HUP0401941A2 (hu) | 2005-01-28 |
JP2004536855A (ja) | 2004-12-09 |
NZ530511A (en) | 2005-06-24 |
HUP0401941A3 (en) | 2008-04-28 |
NO20040178L (no) | 2004-03-16 |
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