AR034757A1 - Formulacion farmaceutica que comprende un inhibidor de bomba de protones y antiacidos - Google Patents

Formulacion farmaceutica que comprende un inhibidor de bomba de protones y antiacidos

Info

Publication number
AR034757A1
AR034757A1 ARP020102572A ARP020102572A AR034757A1 AR 034757 A1 AR034757 A1 AR 034757A1 AR P020102572 A ARP020102572 A AR P020102572A AR P020102572 A ARP020102572 A AR P020102572A AR 034757 A1 AR034757 A1 AR 034757A1
Authority
AR
Argentina
Prior art keywords
agent
pump
proton
pharmaceutical formulation
formulation including
Prior art date
Application number
ARP020102572A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR034757A1 publication Critical patent/AR034757A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Tableta multiparticulada, que se desintegra en la boca que contiene: i) un agente para inhibir la bomba de protones, en particular del tipo benzimidazol, en la forma de microgránulos con capas de revestimiento entérico y que están sobre-revestidos con, al menos, un revestimiento de barrera como por ejemplo, una película protectora basada en un polímero metacrílico; ii) al menos un antiácido en la forma de gránulos por ejemplo, basado en CaCO3, y/o Mg(OH)2 y/o Al(OH)3; y iii) una mezcla de excipientes que comprenden al menos un agente desintegrante, un agente diluyente, un lubricante y, opcionalmente, un agente para la dilatación, un agente permeabilizante, endulzantes, saborizantes y colores. Procesos para la fabricación de la tableta y su utilización en el tratamiento de los trastornos gastrointestinales.
ARP020102572A 2001-07-16 2002-07-10 Formulacion farmaceutica que comprende un inhibidor de bomba de protones y antiacidos AR034757A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01401896 2001-07-16

Publications (1)

Publication Number Publication Date
AR034757A1 true AR034757A1 (es) 2004-03-17

Family

ID=8182807

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020102572A AR034757A1 (es) 2001-07-16 2002-07-10 Formulacion farmaceutica que comprende un inhibidor de bomba de protones y antiacidos

Country Status (24)

Country Link
US (2) US20040219211A1 (es)
EP (1) EP1416922A1 (es)
JP (1) JP2004536855A (es)
KR (1) KR20040018463A (es)
CN (1) CN100469366C (es)
AR (1) AR034757A1 (es)
AU (1) AU2002316020B2 (es)
BG (1) BG108515A (es)
BR (1) BR0211117A (es)
CA (1) CA2453290A1 (es)
CO (1) CO5550417A2 (es)
HU (1) HUP0401941A3 (es)
IL (1) IL159584A0 (es)
IS (1) IS7111A (es)
MX (1) MXPA04000385A (es)
MY (1) MY136137A (es)
NO (1) NO20040178L (es)
NZ (1) NZ530511A (es)
PL (1) PL367686A1 (es)
RU (1) RU2301662C2 (es)
UA (1) UA75673C2 (es)
UY (1) UY27385A1 (es)
WO (1) WO2003007917A1 (es)
ZA (1) ZA200400285B (es)

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JP3841804B2 (ja) * 2003-10-15 2006-11-08 富士化学工業株式会社 口腔内速崩壊性錠剤用の組成物
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DE102005024614A1 (de) * 2005-05-25 2006-11-30 Röhm Gmbh Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug
US20080166407A1 (en) * 2005-07-29 2008-07-10 Shalaby Shalaby W Solid oral formulations for combination therapy
CN100431526C (zh) * 2005-11-07 2008-11-12 上海艾力斯医药科技有限公司 一种酸敏感型药物的快速崩解片剂
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WO2009086942A1 (en) * 2008-01-10 2009-07-16 Evonik Röhm Gmbh Coated pharmaceutical or nutraceutical preparation with accelerated controlled active substance release
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RU2497503C9 (ru) * 2008-03-10 2014-09-20 Байер Конзюмер Кер АГ Приятная на вкус твердая композиция, включающая нейтрализатор кислотности и стимулятор слюноотделения
GEP20135845B (en) 2008-03-11 2013-06-10 Takeda Pharmaceutical Orally-disintegrating solid formulation
MX2011004744A (es) * 2008-11-17 2011-05-30 Nycomed Pharma As Estabilidad mejorada de disolucion de tabletas de carbonato de calcio.
KR101908748B1 (ko) * 2010-12-03 2018-10-16 다케다 야쿠힌 고교 가부시키가이샤 구강내 붕괴정
CN102085188B (zh) * 2011-01-14 2013-01-02 寿光富康制药有限公司 一种兰索拉唑肠溶微丸的制备方法
CN102078616A (zh) * 2011-01-28 2011-06-01 北京虹湾医药技术有限公司 埃索美拉唑碳酸氢钠组合物
US8277842B1 (en) * 2012-01-20 2012-10-02 Dart Neuroscience (Cayman) Ltd. Enteric-coated HT-2157 compositions and methods of their use
CN102631327B (zh) * 2012-05-14 2013-08-28 海南葫芦娃制药有限公司 一种奥美拉唑肠溶微丸及其制备方法
CN103479593B (zh) * 2013-05-10 2014-10-08 青岛双鲸药业有限公司 一种奥美拉唑肠溶片的制备方法
JP6156037B2 (ja) * 2013-10-03 2017-07-05 ライオン株式会社 固形医薬製剤組成物
CN103784414B (zh) * 2013-12-18 2018-01-30 北京华禧联合科技发展有限公司 一种埃索美拉唑肠溶片及其制备方法
CA2910865C (en) 2014-07-15 2016-11-29 Isa Odidi Compositions and methods for reducing overdose
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
CA3010778C (en) * 2016-02-03 2024-02-27 Novartis Ag Galenic formulations of organic compounds
US20190151297A1 (en) * 2016-04-29 2019-05-23 Nauts Equine Brand Pty Ltd Veterinary Composition
US10076494B2 (en) * 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN108434117A (zh) * 2018-03-29 2018-08-24 成都通德药业有限公司 一种奥美拉唑肠溶胶囊的制备方法
RU2727506C1 (ru) * 2019-09-09 2020-07-22 Пивипи Лабс Пте. Лтд. Средство для лечения эректильной дисфункции
CN114980867B (zh) * 2020-01-23 2024-03-15 韩美药品株式会社 包含质子泵抑制剂和抗酸剂的药物复合制剂
KR20220065997A (ko) * 2020-11-13 2022-05-23 (주)휴온스 라베프라졸 및 제산제를 포함하는 약제학적 복합제제 및 이의 제조방법
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
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Also Published As

Publication number Publication date
MY136137A (en) 2008-08-29
UY27385A1 (es) 2003-02-28
ZA200400285B (en) 2005-06-29
UA75673C2 (en) 2006-05-15
WO2003007917A1 (en) 2003-01-30
CN100469366C (zh) 2009-03-18
PL367686A1 (en) 2005-03-07
KR20040018463A (ko) 2004-03-03
AU2002316020B2 (en) 2007-03-15
BR0211117A (pt) 2004-06-22
CA2453290A1 (en) 2003-01-30
RU2004101061A (ru) 2005-04-20
NO20040178L (no) 2004-03-16
HUP0401941A3 (en) 2008-04-28
IL159584A0 (en) 2004-06-01
CN1555256A (zh) 2004-12-15
HUP0401941A2 (hu) 2005-01-28
CO5550417A2 (es) 2005-08-31
RU2301662C2 (ru) 2007-06-27
EP1416922A1 (en) 2004-05-12
US20110135722A1 (en) 2011-06-09
IS7111A (is) 2004-01-15
NZ530511A (en) 2005-06-24
BG108515A (en) 2005-02-28
US20040219211A1 (en) 2004-11-04
JP2004536855A (ja) 2004-12-09
MXPA04000385A (es) 2004-05-04

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