BR0211117A - Tablete multiparticulado, processo para a manufatura e uso do mesmo, e, método e tratamento de distúrbios gastrointestinais - Google Patents

Tablete multiparticulado, processo para a manufatura e uso do mesmo, e, método e tratamento de distúrbios gastrointestinais

Info

Publication number
BR0211117A
BR0211117A BR0211117-9A BR0211117A BR0211117A BR 0211117 A BR0211117 A BR 0211117A BR 0211117 A BR0211117 A BR 0211117A BR 0211117 A BR0211117 A BR 0211117A
Authority
BR
Brazil
Prior art keywords
agent
treatment
gastrointestinal disorders
tablet
manufacture
Prior art date
Application number
BR0211117-9A
Other languages
English (en)
Inventor
Bruno Criere
Nourredine Nouri
Ake Pilbrant
Pascal Suplie
Jean-Marc Zuccarelli
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0211117A publication Critical patent/BR0211117A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"TABLETE MULTIPARTICULADO, PROCESSO PARA A MANUFATURA E USO DO MESMO, E, MéTODO DE TRATAMENTO DE DISTúRBIOS GASTROINTESTINAIS". A presente invenção refere-se a um tablete multiparticulado, que se desintegra na boca, contendo: i) um agente de inibição de bomba de próton, em particular do tipo benzimidazol, sob a forma de microgrânulos revestidos entéricos, cujos grânulos revestidos entéricos são recobertos com pelo menos um revestimento de barreira, tal que, por exemplo, um filme protetor a base de copolímero metacrílico; ii) pelo menos um antiácido sob a forma de grânulos, por exemplo, baseado em CaCO~ 3~ e/ou Mg(OH)~ 2~ e/ou Al(OH)~ 3~; e iii) uma mistura de excipientes, que compreende pelo menos um agente de desintegração, um agente diluente, um lubrificante, e opcionalmente um agente de intumescência, um agente de permeabilização, adoçantes, flavorizantes e colorantes. Além disso, a presente invenção é dirigida a processos para a manufatura do tablete e a seu uso no tratamento de distúrbios gastrointestinais.
BR0211117-9A 2001-07-16 2002-07-10 Tablete multiparticulado, processo para a manufatura e uso do mesmo, e, método e tratamento de distúrbios gastrointestinais BR0211117A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01401896 2001-07-16
PCT/SE2002/001370 WO2003007917A1 (en) 2001-07-16 2002-07-10 Pharmaceutical formulation comprising a proton pump inhibitor and antacids

Publications (1)

Publication Number Publication Date
BR0211117A true BR0211117A (pt) 2004-06-22

Family

ID=8182807

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211117-9A BR0211117A (pt) 2001-07-16 2002-07-10 Tablete multiparticulado, processo para a manufatura e uso do mesmo, e, método e tratamento de distúrbios gastrointestinais

Country Status (24)

Country Link
US (2) US20040219211A1 (pt)
EP (1) EP1416922A1 (pt)
JP (1) JP2004536855A (pt)
KR (1) KR20040018463A (pt)
CN (1) CN100469366C (pt)
AR (1) AR034757A1 (pt)
AU (1) AU2002316020B2 (pt)
BG (1) BG108515A (pt)
BR (1) BR0211117A (pt)
CA (1) CA2453290A1 (pt)
CO (1) CO5550417A2 (pt)
HU (1) HUP0401941A3 (pt)
IL (1) IL159584A0 (pt)
IS (1) IS7111A (pt)
MX (1) MXPA04000385A (pt)
MY (1) MY136137A (pt)
NO (1) NO20040178L (pt)
NZ (1) NZ530511A (pt)
PL (1) PL367686A1 (pt)
RU (1) RU2301662C2 (pt)
UA (1) UA75673C2 (pt)
UY (1) UY27385A1 (pt)
WO (1) WO2003007917A1 (pt)
ZA (1) ZA200400285B (pt)

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US20080166407A1 (en) * 2005-07-29 2008-07-10 Shalaby Shalaby W Solid oral formulations for combination therapy
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CN102085188B (zh) * 2011-01-14 2013-01-02 寿光富康制药有限公司 一种兰索拉唑肠溶微丸的制备方法
CN102078616A (zh) * 2011-01-28 2011-06-01 北京虹湾医药技术有限公司 埃索美拉唑碳酸氢钠组合物
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CN102631327B (zh) * 2012-05-14 2013-08-28 海南葫芦娃制药有限公司 一种奥美拉唑肠溶微丸及其制备方法
CN103479593B (zh) * 2013-05-10 2014-10-08 青岛双鲸药业有限公司 一种奥美拉唑肠溶片的制备方法
JP6156037B2 (ja) * 2013-10-03 2017-07-05 ライオン株式会社 固形医薬製剤組成物
CN103784414B (zh) * 2013-12-18 2018-01-30 北京华禧联合科技发展有限公司 一种埃索美拉唑肠溶片及其制备方法
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CA3010778C (en) * 2016-02-03 2024-02-27 Novartis Ag Galenic formulations of organic compounds
US20190151297A1 (en) * 2016-04-29 2019-05-23 Nauts Equine Brand Pty Ltd Veterinary Composition
US10076494B2 (en) * 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN108434117A (zh) * 2018-03-29 2018-08-24 成都通德药业有限公司 一种奥美拉唑肠溶胶囊的制备方法
RU2727506C1 (ru) * 2019-09-09 2020-07-22 Пивипи Лабс Пте. Лтд. Средство для лечения эректильной дисфункции
CN114980867B (zh) * 2020-01-23 2024-03-15 韩美药品株式会社 包含质子泵抑制剂和抗酸剂的药物复合制剂
KR20220065997A (ko) * 2020-11-13 2022-05-23 (주)휴온스 라베프라졸 및 제산제를 포함하는 약제학적 복합제제 및 이의 제조방법
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Also Published As

Publication number Publication date
MY136137A (en) 2008-08-29
UY27385A1 (es) 2003-02-28
ZA200400285B (en) 2005-06-29
UA75673C2 (en) 2006-05-15
WO2003007917A1 (en) 2003-01-30
CN100469366C (zh) 2009-03-18
PL367686A1 (en) 2005-03-07
KR20040018463A (ko) 2004-03-03
AU2002316020B2 (en) 2007-03-15
CA2453290A1 (en) 2003-01-30
RU2004101061A (ru) 2005-04-20
NO20040178L (no) 2004-03-16
HUP0401941A3 (en) 2008-04-28
IL159584A0 (en) 2004-06-01
CN1555256A (zh) 2004-12-15
HUP0401941A2 (hu) 2005-01-28
CO5550417A2 (es) 2005-08-31
RU2301662C2 (ru) 2007-06-27
EP1416922A1 (en) 2004-05-12
US20110135722A1 (en) 2011-06-09
IS7111A (is) 2004-01-15
NZ530511A (en) 2005-06-24
AR034757A1 (es) 2004-03-17
BG108515A (en) 2005-02-28
US20040219211A1 (en) 2004-11-04
JP2004536855A (ja) 2004-12-09
MXPA04000385A (es) 2004-05-04

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