UA74813C2 - Azapolycyclic compounds condensated with aryl - Google Patents
Azapolycyclic compounds condensated with aryl Download PDFInfo
- Publication number
- UA74813C2 UA74813C2 UA2002075792A UA2002075792A UA74813C2 UA 74813 C2 UA74813 C2 UA 74813C2 UA 2002075792 A UA2002075792 A UA 2002075792A UA 2002075792 A UA2002075792 A UA 2002075792A UA 74813 C2 UA74813 C2 UA 74813C2
- Authority
- UA
- Ukraine
- Prior art keywords
- dodeca
- diazatetracyclo
- triene
- azatricyclo
- tetraene
- Prior art date
Links
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- 125000003118 aryl group Chemical group 0.000 title description 15
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Classifications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Anesthesiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/514,002 US6605610B1 (en) | 1997-12-31 | 2000-02-25 | Aryl fused azapolycyclic compounds |
PCT/IB2001/000153 WO2001062736A1 (en) | 2000-02-25 | 2001-02-08 | Aryl fused azapolycyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
UA74813C2 true UA74813C2 (en) | 2006-02-15 |
Family
ID=24045406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2002075792A UA74813C2 (en) | 2000-02-25 | 2001-08-02 | Azapolycyclic compounds condensated with aryl |
Country Status (40)
Country | Link |
---|---|
US (3) | US6605610B1 (es) |
EP (2) | EP1619192B1 (es) |
JP (1) | JP2003524002A (es) |
KR (1) | KR100537976B1 (es) |
CN (1) | CN1263745C (es) |
AP (1) | AP1860A (es) |
AT (2) | ATE453643T1 (es) |
AU (2) | AU784081B2 (es) |
BG (1) | BG65891B1 (es) |
BR (1) | BR0108610A (es) |
CA (1) | CA2401229C (es) |
CR (1) | CR6726A (es) |
CU (1) | CU23148A3 (es) |
CY (1) | CY1105301T1 (es) |
CZ (1) | CZ303203B6 (es) |
DE (2) | DE60120366T2 (es) |
DK (2) | DK1259489T3 (es) |
DZ (1) | DZ3328A1 (es) |
EA (1) | EA005316B1 (es) |
EE (1) | EE200200475A (es) |
ES (2) | ES2336800T3 (es) |
GE (1) | GEP20053454B (es) |
HK (1) | HK1050894A1 (es) |
HR (1) | HRP20020700A2 (es) |
HU (1) | HU229482B1 (es) |
IL (2) | IL150639A0 (es) |
IS (1) | IS2293B (es) |
MA (1) | MA26875A1 (es) |
MX (1) | MXPA02008311A (es) |
NO (1) | NO323608B1 (es) |
NZ (1) | NZ519973A (es) |
OA (1) | OA12181A (es) |
PL (1) | PL365163A1 (es) |
PT (1) | PT1259489E (es) |
RS (1) | RS51123B (es) |
SI (1) | SI1259489T1 (es) |
SK (1) | SK12042002A3 (es) |
UA (1) | UA74813C2 (es) |
WO (1) | WO2001062736A1 (es) |
ZA (1) | ZA200206768B (es) |
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PT1448235E (pt) * | 2001-11-30 | 2007-05-31 | Pfizer Prod Inc | Composições farmacêuticas orais de libertação controlada de 5,8,14-triazatetraciclo ( 10.3.1.0(2,11).0(4,9) ) - hexadeca-2(11),3,5,7,9-pentaeno. |
AU2002365314A1 (en) * | 2001-11-30 | 2003-06-10 | Pfizer Products Inc. | Aryl fused azapolycyclic compounds |
BR0312297A (pt) | 2002-07-18 | 2005-04-12 | Cytos Biotechnology Ag | Conjugados veìculos de hapteno e seu uso |
WO2004037850A2 (en) * | 2002-10-22 | 2004-05-06 | Millipore Corporation | Multi-sided immersion formation of composite structures and method |
RU2284319C2 (ru) * | 2002-11-25 | 2006-09-27 | Пфайзер Продактс Инк. | Усовершенствованный способ получения 1,3-замещенных инденов |
MXPA05007565A (es) * | 2003-01-15 | 2005-09-21 | Pfizer Prod Inc | Procedimiento mejorado de preparacion de lactamas policiclicas fusionadas con arilos. |
BRPI0410219A (pt) * | 2003-05-20 | 2006-05-09 | Pfizer Prod Inc | composições farmacêuticas de vareniclina |
PL378491A1 (pl) * | 2003-06-04 | 2006-05-02 | Pfizer Products Inc. | Sposób wytwarzania podstawionych chinoksalin z dianiliny i z 2,3-dihydroksy-1,4-dioksanu |
WO2005007630A2 (en) * | 2003-07-21 | 2005-01-27 | Pfizer Products Inc. | Aryl fused azapolycyclic compounds |
US8580842B2 (en) * | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
JP4308263B2 (ja) | 2003-10-14 | 2009-08-05 | ゼノポート,インコーポレイティド | γ−アミノ酪酸アナログの結晶形 |
JP2007516275A (ja) * | 2003-12-23 | 2007-06-21 | ファイザー・プロダクツ・インク | 認知増強および精神病性障害のための治療的組合せ |
WO2006006071A1 (en) * | 2004-07-07 | 2006-01-19 | Pfizer Products Inc. | Resolution of an aryl-fused azapolycyclic compound |
EP1866308B1 (en) * | 2005-02-24 | 2008-10-22 | Pfizer Products Incorporated | Preparation of a high purity substituted quinoxaline |
RU2403016C2 (ru) * | 2006-04-24 | 2010-11-10 | Пфайзер Продактс Инк. | Асимметричные мембраны для устройств доставки лекарственного препарата |
WO2008060487A2 (en) * | 2006-11-09 | 2008-05-22 | Pfizer Products Inc. | Polymorphs of nicotinic intermediates |
US8486979B2 (en) * | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
UY30846A1 (es) * | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
US20090062257A1 (en) * | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched varenicline |
WO2009034431A2 (en) | 2007-09-10 | 2009-03-19 | Pfizer Inc. | Controlled-release dosage forms for varenicline |
WO2009065872A2 (en) * | 2007-11-20 | 2009-05-28 | Medichem, S.A. | Improved processes for the synthesis of varenicline l-tartrate |
US8703774B2 (en) * | 2007-12-07 | 2014-04-22 | AbbVie Deutschland GmbH & Co. KG | Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases |
CN101952276B (zh) * | 2007-12-07 | 2014-10-22 | Abbvie德国有限责任两合公司 | 5-卤素取代的羟吲哚衍生物和其用于治疗加压素依赖性疾病的用途 |
JP5645217B2 (ja) | 2007-12-07 | 2014-12-24 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | 5,6−二置換オキシンドール誘導体およびバソプレッシン依存性疾患を治療するためのこれらの使用 |
JP5701607B2 (ja) * | 2007-12-07 | 2015-04-15 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミドメチル置換オキシインドール誘導体およびバソプレッシン依存性疾患の治療へのこれらの使用 |
US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
JP2011516489A (ja) | 2008-03-31 | 2011-05-26 | ユニバーシティ・オブ・サウス・フロリダ | 疾患誘発性運動失調症および非運動失調性平衡異常の治療法 |
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US20090318695A1 (en) * | 2008-06-19 | 2009-12-24 | Vinod Kumar Kansal | Processes for the preparation of varenicline and intermediates thereof |
WO2010005643A1 (en) * | 2008-07-10 | 2010-01-14 | Teva Pharmaceutical Industries Ltd. | Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt |
US8314235B2 (en) * | 2008-09-01 | 2012-11-20 | Actavis Group Ptc Ehf | Process for preparing varenicline, varenicline intermediates, pharmaceutically acceptable salts thereof |
KR20110132564A (ko) | 2009-02-11 | 2011-12-08 | 선오비온 파마슈티컬스 인코포레이티드 | 히스타민 h3 역 작용제 및 길항제, 및 이의 사용 방법 |
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WO2010151524A1 (en) * | 2009-06-22 | 2010-12-29 | Teva Pharmaceutical Industries Ltd | Solid states forms of varenicline salts and processes for preparation thereof |
CN110381919A (zh) | 2017-03-03 | 2019-10-25 | 西梯茜生命工学股份有限公司 | 含有伐尼克兰或其药学上可接受的盐的包合复合物的口服施用制剂 |
JP2023509453A (ja) * | 2020-01-03 | 2023-03-08 | ブルー オーク ファーマシューティカルズ インコーポレイテッド | Cns障害を処置するための化合物および組成物 |
CN115322105A (zh) * | 2021-05-11 | 2022-11-11 | 江苏润安制药有限公司 | 一种合成艾拉莫德关键中间体的方法 |
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EP0955301A3 (en) | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors |
EA003669B1 (ru) | 1998-04-29 | 2003-08-28 | Пфайзер Продактс Инк. | Конденсированные с арилом азаполициклические соединения |
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FR2788982B1 (fr) * | 1999-02-02 | 2002-08-02 | Synthelabo | Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique |
IL137937A0 (en) * | 1999-08-27 | 2001-10-31 | Pfizer Prod Inc | A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal |
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US8123947B2 (en) | 2007-10-22 | 2012-02-28 | Baxter International Inc. | Priming and air removal systems and methods for dialysis |
-
2000
- 2000-02-25 US US09/514,002 patent/US6605610B1/en not_active Expired - Fee Related
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2001
- 2001-02-08 RS YUP-596/02A patent/RS51123B/sr unknown
- 2001-02-08 AT AT05106835T patent/ATE453643T1/de not_active IP Right Cessation
- 2001-02-08 OA OA1200200256A patent/OA12181A/en unknown
- 2001-02-08 DE DE60120366T patent/DE60120366T2/de not_active Expired - Lifetime
- 2001-02-08 HU HU0204580A patent/HU229482B1/hu not_active IP Right Cessation
- 2001-02-08 SK SK1204-2002A patent/SK12042002A3/sk not_active Application Discontinuation
- 2001-02-08 DK DK01953630T patent/DK1259489T3/da active
- 2001-02-08 EE EEP200200475A patent/EE200200475A/xx unknown
- 2001-02-08 GE GE4911A patent/GEP20053454B/en unknown
- 2001-02-08 DZ DZ013328A patent/DZ3328A1/fr active
- 2001-02-08 BR BR0108610-3A patent/BR0108610A/pt not_active Application Discontinuation
- 2001-02-08 EA EA200200716A patent/EA005316B1/ru not_active IP Right Cessation
- 2001-02-08 ES ES05106835T patent/ES2336800T3/es not_active Expired - Lifetime
- 2001-02-08 PT PT01953630T patent/PT1259489E/pt unknown
- 2001-02-08 SI SI200130584T patent/SI1259489T1/sl unknown
- 2001-02-08 AU AU28748/01A patent/AU784081B2/en not_active Ceased
- 2001-02-08 PL PL01365163A patent/PL365163A1/xx not_active Application Discontinuation
- 2001-02-08 NZ NZ519973A patent/NZ519973A/en not_active IP Right Cessation
- 2001-02-08 WO PCT/IB2001/000153 patent/WO2001062736A1/en active IP Right Grant
- 2001-02-08 MX MXPA02008311A patent/MXPA02008311A/es active IP Right Grant
- 2001-02-08 EP EP05106835A patent/EP1619192B1/en not_active Expired - Lifetime
- 2001-02-08 CZ CZ20022778A patent/CZ303203B6/cs not_active IP Right Cessation
- 2001-02-08 ES ES01953630T patent/ES2263640T3/es not_active Expired - Lifetime
- 2001-02-08 EP EP01953630A patent/EP1259489B1/en not_active Expired - Lifetime
- 2001-02-08 AT AT01953630T patent/ATE328872T1/de active
- 2001-02-08 DK DK05106835.1T patent/DK1619192T3/da active
- 2001-02-08 CN CNB018055737A patent/CN1263745C/zh not_active Expired - Fee Related
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- 2001-02-08 CA CA002401229A patent/CA2401229C/en not_active Expired - Fee Related
- 2001-02-08 JP JP2001562518A patent/JP2003524002A/ja active Pending
- 2001-02-08 DE DE60140965T patent/DE60140965D1/de not_active Expired - Lifetime
- 2001-02-08 AP APAP/P/2002/002604A patent/AP1860A/en active
- 2001-02-08 KR KR10-2002-7011140A patent/KR100537976B1/ko not_active IP Right Cessation
- 2001-08-02 UA UA2002075792A patent/UA74813C2/uk unknown
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- 2002-07-05 BG BG106908A patent/BG65891B1/bg unknown
- 2002-07-05 IS IS6459A patent/IS2293B/is unknown
- 2002-07-08 IL IL150639A patent/IL150639A/en not_active IP Right Cessation
- 2002-08-09 CR CR6726A patent/CR6726A/es unknown
- 2002-08-13 MA MA26775A patent/MA26875A1/fr unknown
- 2002-08-21 CU CU177A patent/CU23148A3/es not_active IP Right Cessation
- 2002-08-22 ZA ZA200206768A patent/ZA200206768B/xx unknown
- 2002-08-23 NO NO20024042A patent/NO323608B1/no not_active IP Right Cessation
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2003
- 2003-01-03 US US10/336,508 patent/US7205300B2/en not_active Expired - Fee Related
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- 2003-04-29 HK HK03103024A patent/HK1050894A1/xx not_active IP Right Cessation
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2005
- 2005-11-18 AU AU2005234671A patent/AU2005234671B2/en not_active Ceased
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