UA74574C2 - Bis (n,n'-bis(2-halogenethyl)amino)phosphodiamates, a method for producing thereof (variants), a pharmaceutical composition containing them, and a method for the treatment of tumors - Google Patents

Bis (n,n'-bis(2-halogenethyl)amino)phosphodiamates, a method for producing thereof (variants), a pharmaceutical composition containing them, and a method for the treatment of tumors Download PDF

Info

Publication number
UA74574C2
UA74574C2 UA2002119554A UA2002119554A UA74574C2 UA 74574 C2 UA74574 C2 UA 74574C2 UA 2002119554 A UA2002119554 A UA 2002119554A UA 2002119554 A UA2002119554 A UA 2002119554A UA 74574 C2 UA74574 C2 UA 74574C2
Authority
UA
Ukraine
Prior art keywords
compound
substituted
formula
heteroaryl
aryl
Prior art date
Application number
UA2002119554A
Other languages
English (en)
Ukrainian (uk)
Inventor
Jason P Herr
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of UA74574C2 publication Critical patent/UA74574C2/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2454Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2404Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UA2002119554A 2000-05-02 2001-02-05 Bis (n,n'-bis(2-halogenethyl)amino)phosphodiamates, a method for producing thereof (variants), a pharmaceutical composition containing them, and a method for the treatment of tumors UA74574C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
PCT/US2001/014290 WO2001083496A1 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (1)

Publication Number Publication Date
UA74574C2 true UA74574C2 (en) 2006-01-16

Family

ID=24249433

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2002119554A UA74574C2 (en) 2000-05-02 2001-02-05 Bis (n,n'-bis(2-halogenethyl)amino)phosphodiamates, a method for producing thereof (variants), a pharmaceutical composition containing them, and a method for the treatment of tumors

Country Status (26)

Country Link
EP (2) EP1278759B1 (hu)
JP (1) JP4249928B2 (hu)
KR (1) KR100729980B1 (hu)
CN (1) CN1182143C (hu)
AR (1) AR029072A1 (hu)
AT (2) ATE313549T1 (hu)
AU (2) AU6115301A (hu)
BR (1) BR0110553A (hu)
CA (1) CA2407606C (hu)
CZ (1) CZ20023615A3 (hu)
DE (2) DE60116081T2 (hu)
DK (2) DK1607399T3 (hu)
EA (1) EA006852B1 (hu)
ES (2) ES2253380T3 (hu)
HK (2) HK1050368A1 (hu)
HU (1) HUP0300688A3 (hu)
IL (2) IL152325A0 (hu)
MX (1) MXPA02010813A (hu)
NO (2) NO328854B1 (hu)
NZ (1) NZ522189A (hu)
PL (1) PL207005B1 (hu)
PT (1) PT1607399E (hu)
TW (1) TWI308569B (hu)
UA (1) UA74574C2 (hu)
WO (1) WO2001083496A1 (hu)
ZA (1) ZA200208591B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
JP2011517555A (ja) * 2008-03-14 2011-06-16 ジェネンテック, インコーポレイテッド 薬剤耐性に関連する遺伝的変異

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
AU6115301A (en) 2001-11-12
TWI308569B (en) 2009-04-11
NO328854B1 (no) 2010-05-31
NO20093371L (no) 2002-12-04
ES2253380T3 (es) 2006-06-01
KR20020094000A (ko) 2002-12-16
EA006852B1 (ru) 2006-04-28
NO20025240D0 (no) 2002-11-01
CZ20023615A3 (cs) 2003-04-16
CN1427844A (zh) 2003-07-02
ES2337154T3 (es) 2010-04-21
NO331833B1 (no) 2012-04-16
NZ522189A (en) 2004-04-30
PL207005B1 (pl) 2010-10-29
EP1607399A3 (en) 2006-01-04
CA2407606C (en) 2008-07-15
ATE313549T1 (de) 2006-01-15
NO20025240L (no) 2002-12-04
CA2407606A1 (en) 2001-11-08
EP1607399B1 (en) 2010-01-20
DE60116081T2 (de) 2006-08-03
HK1084119A1 (en) 2006-07-21
JP2003531913A (ja) 2003-10-28
BR0110553A (pt) 2003-04-01
KR100729980B1 (ko) 2007-06-20
HK1050368A1 (en) 2003-06-20
AR029072A1 (es) 2003-06-04
IL152325A (en) 2011-04-28
AU2001261153B2 (en) 2005-04-07
DK1607399T3 (da) 2010-05-10
EP1278759A1 (en) 2003-01-29
EA200201154A1 (ru) 2003-04-24
DE60141181D1 (de) 2010-03-11
EP1607399A2 (en) 2005-12-21
ZA200208591B (en) 2004-03-04
CN1182143C (zh) 2004-12-29
HUP0300688A3 (en) 2005-02-28
HUP0300688A2 (hu) 2003-07-28
EP1278759B1 (en) 2005-12-21
ATE455779T1 (de) 2010-02-15
IL152325A0 (en) 2003-05-29
MXPA02010813A (es) 2004-02-26
DE60116081D1 (en) 2006-01-26
JP4249928B2 (ja) 2009-04-08
DK1278759T3 (da) 2006-02-13
PL358155A1 (en) 2004-08-09
WO2001083496A1 (en) 2001-11-08
PT1607399E (pt) 2010-02-02

Similar Documents

Publication Publication Date Title
AU2010237633B2 (en) Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof
US5041424A (en) Epipodophyllotoxin glucoside 4'-phosphate derivatives
EA027788B1 (ru) N-ацилсульфонамидные промоторы апоптоза
EP1916251A1 (en) Erianin salts, their preparation methods and pharmaceutical compositions containing the same
US6506739B1 (en) Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
NO331833B1 (no) Bis-(N'N'-bis-(2-halogenetyl)amino)-fosforamidat-forbindelser, farmasoytisk preparat omfattende slike forbindelser, anvendelse av forbindelsene som antitumormiddel, og fremgangsmate for fremstilling av forbindelsene
WO1998009668A2 (en) Use of amphiphiles as phosphatidyl choline synthesis inhibitors
US4544501A (en) Bis(2,2-dimethyl-1-aziridinyl)phosphinic amides for use in the treatment of tumors
AU2001261153A1 (en) Bis-(N,N'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents
EP0272330A1 (en) 1,1,2-triaryl-1-butene derivatives
Sosnovsky et al. In the Search for New Anticancer Drugs. 27. Synthesis and Comparison of Anticancer Activity in Vivo of Amino Acids, Carbohydrates, and Carbohydrate-Amino Acid Conjugates Containing the [N′‐(2‐chloroethyl)‐N′‐nitrosoamino] carbonyl group
NO178729B (no) Terapeutisk aktive sukkerderivater
CN102766165A (zh) 合成钼蝶呤前体z衍生物的方法
BR112020008542B1 (pt) Derivado de triptolídeo e método de preparação do mesmo e uso do mesmo
Hsu CHEMICAL SYNTHESES AND ANTITUMOR ACTIVITY OF SUBSTITUTED 1, 3, 2-OXAZAPHOSPHOLIDINE 2-OXIDES.