IL152325A0 - Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents - Google Patents

Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Info

Publication number
IL152325A0
IL152325A0 IL15232501A IL15232501A IL152325A0 IL 152325 A0 IL152325 A0 IL 152325A0 IL 15232501 A IL15232501 A IL 15232501A IL 15232501 A IL15232501 A IL 15232501A IL 152325 A0 IL152325 A0 IL 152325A0
Authority
IL
Israel
Prior art keywords
bis
haloethyl
phosphoramidates
amino
antitumor agents
Prior art date
Application number
IL15232501A
Other languages
English (en)
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Publication of IL152325A0 publication Critical patent/IL152325A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2454Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2404Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL15232501A 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents IL152325A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56318100A 2000-05-02 2000-05-02
PCT/US2001/014290 WO2001083496A1 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents

Publications (1)

Publication Number Publication Date
IL152325A0 true IL152325A0 (en) 2003-05-29

Family

ID=24249433

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15232501A IL152325A0 (en) 2000-05-02 2001-05-02 Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidates as antitumor agents
IL152325A IL152325A (en) 2000-05-02 2002-10-16 Bite– (N, N'– Bite– (2-haloethyl) amino) phosphoramidates as antifungal agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL152325A IL152325A (en) 2000-05-02 2002-10-16 Bite– (N, N'– Bite– (2-haloethyl) amino) phosphoramidates as antifungal agents

Country Status (26)

Country Link
EP (2) EP1278759B1 (hu)
JP (1) JP4249928B2 (hu)
KR (1) KR100729980B1 (hu)
CN (1) CN1182143C (hu)
AR (1) AR029072A1 (hu)
AT (2) ATE313549T1 (hu)
AU (2) AU6115301A (hu)
BR (1) BR0110553A (hu)
CA (1) CA2407606C (hu)
CZ (1) CZ20023615A3 (hu)
DE (2) DE60116081T2 (hu)
DK (2) DK1607399T3 (hu)
EA (1) EA006852B1 (hu)
ES (2) ES2253380T3 (hu)
HK (2) HK1050368A1 (hu)
HU (1) HUP0300688A3 (hu)
IL (2) IL152325A0 (hu)
MX (1) MXPA02010813A (hu)
NO (2) NO328854B1 (hu)
NZ (1) NZ522189A (hu)
PL (1) PL207005B1 (hu)
PT (1) PT1607399E (hu)
TW (1) TWI308569B (hu)
UA (1) UA74574C2 (hu)
WO (1) WO2001083496A1 (hu)
ZA (1) ZA200208591B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
US7655799B2 (en) 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
JP2011517555A (ja) * 2008-03-14 2011-06-16 ジェネンテック, インコーポレイテッド 薬剤耐性に関連する遺伝的変異

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556942A (en) * 1991-04-29 1996-09-17 Terrapin Technologies, Inc. Glutathione S-transferase-activated compounds

Also Published As

Publication number Publication date
AU6115301A (en) 2001-11-12
TWI308569B (en) 2009-04-11
NO328854B1 (no) 2010-05-31
NO20093371L (no) 2002-12-04
ES2253380T3 (es) 2006-06-01
KR20020094000A (ko) 2002-12-16
EA006852B1 (ru) 2006-04-28
NO20025240D0 (no) 2002-11-01
CZ20023615A3 (cs) 2003-04-16
CN1427844A (zh) 2003-07-02
ES2337154T3 (es) 2010-04-21
NO331833B1 (no) 2012-04-16
NZ522189A (en) 2004-04-30
PL207005B1 (pl) 2010-10-29
EP1607399A3 (en) 2006-01-04
CA2407606C (en) 2008-07-15
ATE313549T1 (de) 2006-01-15
NO20025240L (no) 2002-12-04
CA2407606A1 (en) 2001-11-08
EP1607399B1 (en) 2010-01-20
DE60116081T2 (de) 2006-08-03
HK1084119A1 (en) 2006-07-21
JP2003531913A (ja) 2003-10-28
BR0110553A (pt) 2003-04-01
KR100729980B1 (ko) 2007-06-20
HK1050368A1 (en) 2003-06-20
AR029072A1 (es) 2003-06-04
IL152325A (en) 2011-04-28
AU2001261153B2 (en) 2005-04-07
DK1607399T3 (da) 2010-05-10
EP1278759A1 (en) 2003-01-29
UA74574C2 (en) 2006-01-16
EA200201154A1 (ru) 2003-04-24
DE60141181D1 (de) 2010-03-11
EP1607399A2 (en) 2005-12-21
ZA200208591B (en) 2004-03-04
CN1182143C (zh) 2004-12-29
HUP0300688A3 (en) 2005-02-28
HUP0300688A2 (hu) 2003-07-28
EP1278759B1 (en) 2005-12-21
ATE455779T1 (de) 2010-02-15
MXPA02010813A (es) 2004-02-26
DE60116081D1 (en) 2006-01-26
JP4249928B2 (ja) 2009-04-08
DK1278759T3 (da) 2006-02-13
PL358155A1 (en) 2004-08-09
WO2001083496A1 (en) 2001-11-08
PT1607399E (pt) 2010-02-02

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