UA72520C2 - Ендопаразитицидний засіб - Google Patents
Ендопаразитицидний засіб Download PDFInfo
- Publication number
- UA72520C2 UA72520C2 UA2001128532A UA2001128532A UA72520C2 UA 72520 C2 UA72520 C2 UA 72520C2 UA 2001128532 A UA2001128532 A UA 2001128532A UA 2001128532 A UA2001128532 A UA 2001128532A UA 72520 C2 UA72520 C2 UA 72520C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- substituted
- independently
- formula
- hydrogen
- Prior art date
Links
- 108010002156 Depsipeptides Proteins 0.000 claims abstract 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- -1 C1-C-- alkyl Chemical group 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000001041 indolyl group Chemical group 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- SOWBFZRMHSNYGE-UHFFFAOYSA-N Monoamide-Oxalic acid Chemical group NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19921887A DE19921887A1 (de) | 1999-05-12 | 1999-05-12 | Endoparasitizide Mittel |
| PCT/EP2000/004014 WO2000069425A2 (de) | 1999-05-12 | 2000-05-04 | Endoparasitizide synergistische kombination enthaltend cyclischen depsipeptiden und piperazinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA72520C2 true UA72520C2 (uk) | 2005-03-15 |
Family
ID=7907825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2001128532A UA72520C2 (uk) | 1999-05-12 | 2000-04-05 | Ендопаразитицидний засіб |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1189615B1 (enExample) |
| JP (1) | JP2002544224A (enExample) |
| KR (1) | KR100704717B1 (enExample) |
| CN (1) | CN1224391C (enExample) |
| AT (1) | ATE258795T1 (enExample) |
| AU (1) | AU768910B2 (enExample) |
| BR (1) | BR0010499A (enExample) |
| CA (1) | CA2373827C (enExample) |
| CZ (1) | CZ300782B6 (enExample) |
| DE (2) | DE19921887A1 (enExample) |
| DK (1) | DK1189615T3 (enExample) |
| ES (1) | ES2211558T3 (enExample) |
| HK (1) | HK1047228B (enExample) |
| HR (1) | HRP20010918B1 (enExample) |
| HU (1) | HUP0201201A3 (enExample) |
| MX (1) | MXPA01011455A (enExample) |
| NO (1) | NO328870B1 (enExample) |
| PL (1) | PL200951B1 (enExample) |
| PT (1) | PT1189615E (enExample) |
| RS (1) | RS50169B (enExample) |
| RU (1) | RU2250779C2 (enExample) |
| SK (1) | SK285494B6 (enExample) |
| TR (2) | TR200401875T2 (enExample) |
| UA (1) | UA72520C2 (enExample) |
| WO (1) | WO2000069425A2 (enExample) |
| ZA (1) | ZA200108238B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10008128A1 (de) * | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
| DE10358525A1 (de) * | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
| KR101671325B1 (ko) * | 2015-01-09 | 2016-11-02 | 한국생명공학연구원 | 신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물 |
| RS62130B1 (sr) | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| EP3397638B1 (en) | 2015-12-28 | 2023-08-23 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| US20230339874A1 (en) * | 2020-09-11 | 2023-10-26 | The Governing Council Of The University Of Toronto | Piperazinyl compounds and methods for treating nematode infections |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA842571B (en) * | 1983-04-07 | 1985-11-27 | Merck & Co Inc | Novel synergistic antiparasitic combinations |
| JPS6471865A (en) * | 1987-09-11 | 1989-03-16 | Nichibai Boeki Kk | 1-alkylcarbamoyl-4-methylpiperazine derivative |
| NO176766C (no) * | 1989-02-07 | 1995-05-24 | Meiji Seika Kaisha | Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet |
| EP0718293B1 (en) * | 1993-09-06 | 2002-03-13 | Fujisawa Pharmaceutical Co., Ltd. | Cyclodepsipeptide compound |
| DE4400464A1 (de) * | 1994-01-11 | 1995-07-13 | Bayer Ag | Endoparasitizide Mittel |
| DE19520275A1 (de) * | 1995-06-02 | 1996-12-05 | Bayer Ag | Endoparasitizide Mittel |
| KR19990044489A (ko) * | 1995-09-07 | 1999-06-25 | 로렌스 티. 마이젠헬더 | 환식 구충제 |
| WO1998037088A1 (en) * | 1997-02-19 | 1998-08-27 | Meiji Seika Kaisha Ltd. | Derivatives of cyclodepsipeptide, pf1022 substance |
| US6355615B1 (en) * | 1997-06-04 | 2002-03-12 | Bayer Aktiengesellschaft | Desoxycyclodepsipeptides and their use for combatting endoparasites |
| WO2000008047A1 (en) * | 1998-08-04 | 2000-02-17 | Nisshin Flour Milling Co., Ltd. | Depsipeptide derivatives bearing piperazinone rings |
-
1999
- 1999-05-12 DE DE19921887A patent/DE19921887A1/de not_active Withdrawn
-
2000
- 2000-04-05 UA UA2001128532A patent/UA72520C2/uk unknown
- 2000-05-04 PL PL351376A patent/PL200951B1/pl not_active IP Right Cessation
- 2000-05-04 RU RU2001133380/15A patent/RU2250779C2/ru not_active IP Right Cessation
- 2000-05-04 HR HR20010918A patent/HRP20010918B1/xx not_active IP Right Cessation
- 2000-05-04 BR BR0010499-0A patent/BR0010499A/pt not_active Application Discontinuation
- 2000-05-04 CA CA002373827A patent/CA2373827C/en not_active Expired - Fee Related
- 2000-05-04 DE DE50005213T patent/DE50005213D1/de not_active Expired - Lifetime
- 2000-05-04 CN CNB00807450XA patent/CN1224391C/zh not_active Expired - Fee Related
- 2000-05-04 HK HK02108544.2A patent/HK1047228B/zh not_active IP Right Cessation
- 2000-05-04 SK SK1626-2001A patent/SK285494B6/sk not_active IP Right Cessation
- 2000-05-04 PT PT00940235T patent/PT1189615E/pt unknown
- 2000-05-04 TR TR2004/01875T patent/TR200401875T2/xx unknown
- 2000-05-04 MX MXPA01011455A patent/MXPA01011455A/es active IP Right Grant
- 2000-05-04 AT AT00940235T patent/ATE258795T1/de active
- 2000-05-04 ES ES00940235T patent/ES2211558T3/es not_active Expired - Lifetime
- 2000-05-04 TR TR2001/03240T patent/TR200103240T2/xx unknown
- 2000-05-04 HU HU0201201A patent/HUP0201201A3/hu unknown
- 2000-05-04 AU AU55237/00A patent/AU768910B2/en not_active Ceased
- 2000-05-04 CZ CZ20014060A patent/CZ300782B6/cs not_active IP Right Cessation
- 2000-05-04 WO PCT/EP2000/004014 patent/WO2000069425A2/de not_active Ceased
- 2000-05-04 JP JP2000617884A patent/JP2002544224A/ja active Pending
- 2000-05-04 EP EP00940235A patent/EP1189615B1/de not_active Expired - Lifetime
- 2000-05-04 RS YUP-805/01A patent/RS50169B/sr unknown
- 2000-05-04 KR KR1020017013555A patent/KR100704717B1/ko not_active Expired - Fee Related
- 2000-05-04 DK DK00940235T patent/DK1189615T3/da active
-
2001
- 2001-10-08 ZA ZA200108238A patent/ZA200108238B/xx unknown
- 2001-11-05 NO NO20015398A patent/NO328870B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4163746B2 (ja) | 内部寄生虫を駆除するためのジオキソモルホリンの使用、新規ジオキソモルホリンおよびそれらの製造方法 | |
| CN1142790C (zh) | 杀内寄生虫组合物 | |
| RU2124364C1 (ru) | Эндопаразитицидное средство | |
| JPH07508723A (ja) | 内寄生性生物を駆除するための１８の環原子を有する環状デプシペプチドの利用，１８の環原子を有する新規環状デプシペプチド、ならびにそれらの製造のための方法 | |
| JP3626233B2 (ja) | １２の環原子を有する環状デプシペプチドの内部寄生虫の防除のための利用、１２の環原子を有する新規環状デプシペプチド及びそれらの製造法 | |
| CN1100537C (zh) | 用作杀体内寄生虫剂的昆虫烟碱能乙酰胆碱受体兴奋剂或拮抗剂 | |
| EP2310017B1 (de) | Nifurtimox zur behandlung von durch trichomonadida hervorgerufenen krankheiten | |
| JP5078619B2 (ja) | 垂直内部寄生虫感染の予防 | |
| CN1224391C (zh) | 杀内寄生虫组合物 | |
| CN1278735C (zh) | 具有改进活性的环缩酚肽的晶型 | |
| JP3798826B2 (ja) | 開鎖オクタデプシペプチドに基づく殺内部寄生虫性組成物 | |
| DE4412492A1 (de) | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen | |
| JP3798825B2 (ja) | 開鎖テトラデプシペプチドに基づく殺内部寄生虫性組成物 | |
| DE10314976A1 (de) | Verbesserte Penetration von Wirkstoffen in Zellen und Organe | |
| EP1835912B1 (de) | Substituierte benzimidazole zur behandlung der histomiasis | |
| JPH07196486A (ja) | 開鎖ヘキサデプシペプチドに基づく殺内部寄生虫性組成物 | |
| HUT72664A (en) | Thiazolo-pyrido-quinoline derivatives pharmaceutical compositions containing them and process for preparing said compounds | |
| HK1117041B (en) | Prevention of vertical endoparasite infections | |
| HK1075013B (en) | Crystal modification of a cyclic depsipeptide having improved strength | |
| WO2005041974A1 (de) | Mittel zur gewichtsreduktion | |
| HK1038932A (en) | Substituted cyclooctadepsipeptides |