CN1142790C - 杀内寄生虫组合物 - Google Patents
杀内寄生虫组合物 Download PDFInfo
- Publication number
- CN1142790C CN1142790C CNB961956615A CN96195661A CN1142790C CN 1142790 C CN1142790 C CN 1142790C CN B961956615 A CNB961956615 A CN B961956615A CN 96195661 A CN96195661 A CN 96195661A CN 1142790 C CN1142790 C CN 1142790C
- Authority
- CN
- China
- Prior art keywords
- ivermectin
- avermectins
- cyclodepsipeptide
- spp
- macrolide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
大环内酯 | -C22R1-X-C23R2- | R3 | R4 |
阿凡曼菌素A1a | -CH=CH- | -sec-Bu | -Me |
阿凡曼菌素A1b | -CH=CH- | -iso-Pr | -Me |
阿凡曼菌素A2a | -CH2-CHOH- | -sec-Bu | -Me |
阿凡曼菌素A2b | -CH2-CHOH- | -iso-Pr | -Me |
阿凡曼菌素B1a | -CH=CH- | -sec-Bu | -H |
阿凡曼菌素B1b | -CH=CH- | -iso-Pr | -H |
阿凡曼菌素B2a | -CH2-CHOH- | -sec-Bu | -H |
阿凡曼菌素B2b | -CH2-CHOH- | -iso-Pr | -H |
22,23-二氢阿凡曼菌素B1a | -CH2-CH2- | -sec-Bu | -H |
22,23-二氢阿凡曼菌素B1b | -CH2-CH2- | -iso-Pr | -H |
多拉霉素(多拉克汀) | -CH=CH- | -Chx | -H |
活性物质及用量[mg/kg] | 降低率[%] | |
PF 1022 A | 50.0 | 0 |
异阿凡曼菌素B1a/B1b | 0.1 | 0 |
PF 1022 A+异阿凡曼菌素B1a/B1b | 50.00.1 | 100 |
PF 1022 A | 25.0 | 0 |
PF 1022 A+异阿凡曼菌素B1a/B1b | 25.00.1 | >80 |
活性物质及用量 | 降低率[%] | |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 50.00.110.0 | 100 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 50.00.15.0 | 100 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 50.00.11.0 | 100 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 25.00.110.0 | >80 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 25.00.15.0 | >80 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 25.00.11.0 | >80 |
活性物质及用量[mg/kg] | 降低率[%] | |
PF1022A | 50.0 | 0 |
异阿凡曼菌素B1a/B1b | 0.1 | <50 |
PF1022A+异阿凡曼菌素B1a/B1b | 50.00.1 | 100 |
PF1022A | 25.0 | 0 |
PF1022A+异阿凡曼菌素B1a/B1b | 25.00.1 | 100 |
PF1022A | 10.0 | 0 |
PF1022A+异阿凡曼菌素B1a/B1b | 10.00.1 | >80 |
PF1022A | 5.0 | 0 |
PF1022A+异阿凡曼菌素B1a/B1b | 5.00.1 | >80 |
活性物质及用量[mg/kg] | 降低率[%] | |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 50.00.110.0 | 100 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 50.00.15.0 | 100 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 50.00.11.0 | 100 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 25.00.110.0 | 100 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 25.00.15.0 | 100 |
PF1022A+异阿凡曼菌素B1a/B1b+环吡异喹酮 | 25.00.11.0 | 100 |
活性物质及用量[mg/kg] | 降低率[%] | |
FP1022A | 1.0 | 100 |
0.5 | 0 | |
异阿凡曼菌素B1a/B1b | 0.01 | 100 |
0.001 | 0 | |
FP 1022 A+异阿凡曼菌素B1a/B1b | 0.50.001 | >80 |
Claims (2)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19520275A DE19520275A1 (de) | 1995-06-02 | 1995-06-02 | Endoparasitizide Mittel |
DE19520275.9 | 1995-06-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1191489A CN1191489A (zh) | 1998-08-26 |
CN1142790C true CN1142790C (zh) | 2004-03-24 |
Family
ID=7763518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB961956615A Expired - Lifetime CN1142790C (zh) | 1995-06-02 | 1996-05-20 | 杀内寄生虫组合物 |
Country Status (25)
Country | Link |
---|---|
US (1) | US6159932A (zh) |
EP (1) | EP0828506B1 (zh) |
JP (1) | JP4104653B2 (zh) |
KR (1) | KR100434388B1 (zh) |
CN (1) | CN1142790C (zh) |
AR (1) | AR005640A1 (zh) |
AT (1) | ATE213645T1 (zh) |
AU (1) | AU703048B2 (zh) |
BR (1) | BR9608961A (zh) |
CA (1) | CA2222680C (zh) |
CZ (1) | CZ287290B6 (zh) |
DE (2) | DE19520275A1 (zh) |
DK (1) | DK0828506T3 (zh) |
ES (1) | ES2173284T3 (zh) |
HU (1) | HU224961B1 (zh) |
IL (1) | IL118518A (zh) |
NO (1) | NO316608B1 (zh) |
NZ (1) | NZ309073A (zh) |
PL (1) | PL184848B1 (zh) |
PT (1) | PT828506E (zh) |
SK (1) | SK283884B6 (zh) |
TR (1) | TR199701484T1 (zh) |
TW (1) | TW469133B (zh) |
WO (1) | WO1996038165A2 (zh) |
ZA (1) | ZA964473B (zh) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19545044A1 (de) * | 1995-12-02 | 1997-06-05 | Bayer Ag | Endoparasitizide Mittel |
CA2260143C (en) * | 1996-07-30 | 2004-07-13 | Ashmont Holdings Limited | Anthelmintic formulations |
DE19654079A1 (de) * | 1996-12-23 | 1998-06-25 | Bayer Ag | Endo-ekto-parasitizide Mittel |
GB9825402D0 (en) † | 1998-11-19 | 1999-01-13 | Pfizer Ltd | Antiparasitic formulations |
DE19921887A1 (de) * | 1999-05-12 | 2000-11-16 | Bayer Ag | Endoparasitizide Mittel |
DE19962147A1 (de) * | 1999-12-22 | 2001-06-28 | Bayer Ag | Schädlingsbekämpfungsmittel / PF 1022-221 |
DE19962145A1 (de) * | 1999-12-22 | 2001-06-28 | Bayer Ag | Schädlingsbekämpfungsmittel/Depsipeptide |
DE10008128A1 (de) * | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
DE60118132T2 (de) * | 2000-10-10 | 2006-10-19 | Wyeth | Anthelmintika |
US6893652B2 (en) * | 2001-08-27 | 2005-05-17 | Wyeth | Endoparasiticidal gel composition |
US20040254125A1 (en) * | 2001-10-25 | 2004-12-16 | Akio Saito | Anthelmintic composition |
US7001889B2 (en) * | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
ITMI20031015A1 (it) * | 2003-05-20 | 2004-11-21 | Naxospharma S R L | Poli-(amminopirrolcarbossammidi) per uso nella profilassi e nel trattamento delle endoparassitosi animali e loro composizioni con ciclodestrine. |
DE10358525A1 (de) * | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
DE10359798A1 (de) * | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Cyclohexadepsipeptide zur Bekämpfung von Endoparasiten und ein Verfahren zu ihrer Herstellung |
EP1734954A4 (en) * | 2004-04-07 | 2007-05-30 | Intervet Int Bv | EFFECTIVE COMPOSITION OF A BENZIMIDAZOLE, AVERMECTIN AND PRAZIQUANTEL AND RELEVANT APPLICATION METHOD |
US20060147485A1 (en) * | 2005-01-04 | 2006-07-06 | Morten Pedersen | Oil-in-water formulation of avermectins |
WO2006069580A1 (en) * | 2004-12-30 | 2006-07-06 | Cheminova A/S | Oil-in-water formulation of avermectins |
DE102005011779A1 (de) * | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasitizide Mittel |
US20080027011A1 (en) * | 2005-12-20 | 2008-01-31 | Hassan Nached | Homogeneous paste and gel formulations |
WO2012028556A1 (en) * | 2010-08-31 | 2012-03-08 | Bayer Animal Health Gmbh | Macrocyclic lactones and their use and their combinations with other active substances |
BR112013008834B1 (pt) | 2010-10-12 | 2021-08-03 | Bayer Intellectual Property Gmbh | Produto mastigável macio e seu processo de preparação |
ES2549045T3 (es) | 2010-10-20 | 2015-10-22 | Galderma S.A. | Método para tratar una infección por el virus del herpes usando un compuesto de lactona macrocíclica |
MX354966B (es) | 2012-03-13 | 2018-03-27 | Bayer New Zealand Ltd | Composiciones de accion prolongada. |
ES2848394T3 (es) | 2012-12-19 | 2021-08-09 | Bayer Animal Health Gmbh | Comprimidos que tienen aceptación mejorada y buena estabilidad durante el almacenamiento |
BR112017020975A2 (pt) * | 2015-04-02 | 2018-07-10 | Merial Inc | combinações antelmínticas e seus usos |
UY36683A (es) | 2015-05-20 | 2016-12-30 | Merial Inc | Compuestos depsipeptídicos como anthelmínticos |
RU2715556C2 (ru) | 2015-12-28 | 2020-03-02 | Мериал, Инк. | Противогельминтные депсипептидные соединения |
CN107318861A (zh) * | 2016-04-28 | 2017-11-07 | 江苏龙灯化学有限公司 | 一种杀虫组合物 |
AU2017361099A1 (en) | 2016-11-16 | 2019-06-06 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
KR102601629B1 (ko) * | 2017-03-17 | 2023-11-10 | 텔루리스 바이오테크 인디아 프라이빗 리미티드 | 선충구제제의 상승작용적 조성물 |
US10857151B1 (en) * | 2020-02-21 | 2020-12-08 | Villya LLC | Treatment of female genital schistosomiasis |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
JPS57139012A (en) * | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
ZA842571B (en) * | 1983-04-07 | 1985-11-27 | Merck & Co Inc | Novel synergistic antiparasitic combinations |
NO176766C (no) * | 1989-02-07 | 1995-05-24 | Meiji Seika Kaisha | Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet |
GB9024924D0 (en) * | 1990-11-16 | 1991-01-02 | Beecham Group Plc | Novel compositions |
NZ247278A (en) * | 1991-02-12 | 1995-03-28 | Ancare Distributors | Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier |
JPH0570366A (ja) * | 1991-03-08 | 1993-03-23 | Meiji Seika Kaisha Ltd | 薬用組成物 |
DE69331414T2 (de) * | 1992-03-17 | 2002-08-08 | Fujisawa Pharmaceutical Co., Ltd. | Depsipeptide, herstellung und anwendung |
DE4317458A1 (de) * | 1992-06-11 | 1993-12-16 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung |
US5747448A (en) * | 1993-02-19 | 1998-05-05 | Meiji Seika Kaisha, Ltd. | Derivatives of cyclodepsipeptide PF 1022 |
BG61064B1 (bg) * | 1993-08-12 | 1996-10-31 | Илия Илиев | Лекарствено средство за обезпаразитяване на животни |
DE4400464A1 (de) * | 1994-01-11 | 1995-07-13 | Bayer Ag | Endoparasitizide Mittel |
DE4401389A1 (de) * | 1994-01-19 | 1995-07-20 | Bayer Ag | Verwendung von cyclischen Depsipeptiden mit 12 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 12 Ringatomen und Verfahren zu ihrer Herstellung |
-
1995
- 1995-06-02 DE DE19520275A patent/DE19520275A1/de not_active Withdrawn
-
1996
- 1996-05-10 TW TW085105513A patent/TW469133B/zh not_active IP Right Cessation
- 1996-05-20 EP EP96916137A patent/EP0828506B1/de not_active Expired - Lifetime
- 1996-05-20 PT PT96916137T patent/PT828506E/pt unknown
- 1996-05-20 NZ NZ309073A patent/NZ309073A/xx not_active IP Right Cessation
- 1996-05-20 CZ CZ19973825A patent/CZ287290B6/cs not_active IP Right Cessation
- 1996-05-20 AU AU59004/96A patent/AU703048B2/en not_active Expired
- 1996-05-20 BR BR9608961A patent/BR9608961A/pt active IP Right Grant
- 1996-05-20 SK SK1599-97A patent/SK283884B6/sk not_active IP Right Cessation
- 1996-05-20 ES ES96916137T patent/ES2173284T3/es not_active Expired - Lifetime
- 1996-05-20 AT AT96916137T patent/ATE213645T1/de active
- 1996-05-20 HU HU9900346A patent/HU224961B1/hu unknown
- 1996-05-20 DK DK96916137T patent/DK0828506T3/da active
- 1996-05-20 PL PL96323595A patent/PL184848B1/pl unknown
- 1996-05-20 US US08/952,356 patent/US6159932A/en not_active Expired - Lifetime
- 1996-05-20 WO PCT/EP1996/002170 patent/WO1996038165A2/de active IP Right Grant
- 1996-05-20 KR KR1019970708573A patent/KR100434388B1/ko not_active IP Right Cessation
- 1996-05-20 DE DE59608798T patent/DE59608798D1/de not_active Expired - Lifetime
- 1996-05-20 CN CNB961956615A patent/CN1142790C/zh not_active Expired - Lifetime
- 1996-05-20 TR TR97/01484T patent/TR199701484T1/xx unknown
- 1996-05-20 CA CA002222680A patent/CA2222680C/en not_active Expired - Lifetime
- 1996-05-20 JP JP53614696A patent/JP4104653B2/ja not_active Expired - Lifetime
- 1996-05-31 AR ARP960102860A patent/AR005640A1/es not_active Application Discontinuation
- 1996-05-31 IL IL11851896A patent/IL118518A/en not_active IP Right Cessation
- 1996-05-31 ZA ZA9604473A patent/ZA964473B/xx unknown
-
1997
- 1997-12-01 NO NO19975516A patent/NO316608B1/no not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: BAYER ANIMAL HEALTH PROMOTION CO.,LTD. Free format text: FORMER OWNER: BAYER AG Effective date: 20091106 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20091106 Address after: Germany Leverkusen Patentee after: Bayer Animal Health GmbH Address before: Germany Leverkusen Patentee before: Bayer Aktiengesellschaft |
|
ASS | Succession or assignment of patent right |
Owner name: BAYER INTELLECTUAL PROPERTY GMBH Free format text: FORMER OWNER: BAYER ANIMAL HEALTH GMBH Effective date: 20130124 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20130124 Address after: German Monheim Patentee after: Bayer Pharma Aktiengesellschaft Address before: Germany Leverkusen Patentee before: Bayer Animal Health GmbH |
|
CX01 | Expiry of patent term |
Granted publication date: 20040324 |
|
EXPY | Termination of patent right or utility model |