UA66787C2 - A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds - Google Patents

A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds

Info

Publication number
UA66787C2
UA66787C2 UA99105491A UA99105491A UA66787C2 UA 66787 C2 UA66787 C2 UA 66787C2 UA 99105491 A UA99105491 A UA 99105491A UA 99105491 A UA99105491 A UA 99105491A UA 66787 C2 UA66787 C2 UA 66787C2
Authority
UA
Ukraine
Prior art keywords
preparation
methylpiperazine
ethoxyphenyl
pyrazolo
pyrimidine
Prior art date
Application number
UA99105491A
Other languages
English (en)
Inventor
Peter James Dann
Philippe Charles Levett
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA66787(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of UA66787C2 publication Critical patent/UA66787C2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
UA99105491A 1998-10-12 1999-10-08 A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds UA66787C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (1)

Publication Number Publication Date
UA66787C2 true UA66787C2 (en) 2004-06-15

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99105491A UA66787C2 (en) 1998-10-12 1999-10-08 A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds

Country Status (49)

Country Link
US (3) US6207829B1 (es)
EP (1) EP0994115B1 (es)
JP (1) JP3721021B2 (es)
KR (1) KR100380954B1 (es)
CN (2) CN1473831A (es)
AP (1) AP1233A (es)
AR (1) AR019244A1 (es)
AT (1) ATE290003T1 (es)
AU (1) AU756463B2 (es)
BG (1) BG63205B1 (es)
BR (1) BR9905092A (es)
CA (1) CA2285733C (es)
CO (1) CO5150214A1 (es)
CR (1) CR6118A (es)
CU (1) CU22928A3 (es)
CZ (1) CZ296816B6 (es)
DE (1) DE69923906T2 (es)
DK (1) DK0994115T3 (es)
DZ (1) DZ2912A1 (es)
EA (1) EA003774B1 (es)
EE (1) EE04192B1 (es)
EG (1) EG22630A (es)
ES (1) ES2237049T3 (es)
GB (1) GB9822238D0 (es)
GE (1) GEP20022700B (es)
GT (1) GT199900172A (es)
HK (1) HK1027559A1 (es)
HR (1) HRP990318B1 (es)
HU (1) HU226162B1 (es)
ID (1) ID23351A (es)
IL (11) IL152924A (es)
IS (1) IS1951B (es)
MA (1) MA25007A1 (es)
MY (1) MY124620A (es)
NO (1) NO313700B1 (es)
OA (1) OA11165A (es)
PE (1) PE20001086A1 (es)
PL (1) PL198150B1 (es)
PT (1) PT994115E (es)
RS (1) RS49762B (es)
SG (1) SG118060A1 (es)
SI (1) SI0994115T1 (es)
SK (1) SK285215B6 (es)
TN (1) TNSN99189A1 (es)
TR (1) TR199902541A2 (es)
TW (1) TW589314B (es)
UA (1) UA66787C2 (es)
UY (1) UY25750A1 (es)
ZA (1) ZA996412B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078760A1 (fr) * 1999-06-21 2000-12-28 The Biochemical Pharmaceutical Factory Of Zhuhai Sez Procede de preparation de sildenafil, agent et procede d'obtention d'un comprime mixte a base de sildenafil et de chlorhydrate d'apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
ES2223863T3 (es) * 2000-06-22 2005-03-01 Pfizer Inc. Procedimiento para la preparacion de pirazolopirimidinonas.
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
US7335680B2 (en) 2001-12-20 2008-02-26 Laboratoires Serono Sa Pyrrolidine derivatives as prostaglandin modulators
JP4361800B2 (ja) * 2001-12-21 2009-11-11 サイトキネティックス， インコーポレイテッド 心不全を処置するための組成物および方法
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
ES2378620T3 (es) * 2003-03-27 2012-04-16 Cytokinetics, Inc. Sulfonamidas para el tratamiento de insuficiencia cardiaca congestiva, sus composiciones y usos.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP2024369A4 (en) * 2006-06-05 2010-10-27 Matrix Lab Ltd NEW PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
KR100390612B1 (ko) * 1997-04-25 2003-07-07 화이자 인코포레이티드 타입 5 시클릭 구아노신 3',5'-모노포스페이트포스포디에스테라제를 억제하는 성기능 장애 치료용피라졸로피리미디논 제조용 중간체의 제조 방법

Also Published As

Publication number Publication date
IL132273A0 (en) 2001-03-19
HUP9903469A3 (en) 2000-10-30
ATE290003T1 (de) 2005-03-15
CA2285733A1 (en) 2000-04-12
KR20000028987A (ko) 2000-05-25
GB9822238D0 (en) 1998-12-09
US20030069422A1 (en) 2003-04-10
CZ353299A3 (cs) 2000-05-17
SI0994115T1 (es) 2005-08-31
SK138599A3 (en) 2000-05-16
IL152928A (en) 2007-07-04
HRP990318A2 (en) 2000-06-30
SK285215B6 (sk) 2006-09-07
BG63205B1 (bg) 2001-06-29
AU5358199A (en) 2000-04-13
IL152927A0 (en) 2003-06-24
CU22928A3 (es) 2004-02-20
IL152926A0 (en) 2003-06-24
HU9903469D0 (en) 1999-12-28
US20010009962A1 (en) 2001-07-26
CA2285733C (en) 2004-08-24
CR6118A (es) 2005-09-16
EG22630A (en) 2003-05-31
EE9900507A (et) 2000-06-15
PL198150B1 (pl) 2008-05-30
US6207829B1 (en) 2001-03-27
PE20001086A1 (es) 2000-10-18
IL132273A (en) 2004-06-20
HRP990318B1 (en) 2004-06-30
GEP20022700B (en) 2002-05-27
TR199902541A2 (xx) 2000-07-21
ID23351A (id) 2000-04-13
YU48999A (sh) 2002-06-19
CO5150214A1 (es) 2002-04-29
DE69923906T2 (de) 2006-04-06
DZ2912A1 (fr) 2004-03-01
CN1207295C (zh) 2005-06-22
EP0994115A3 (en) 2000-05-24
AR019244A1 (es) 2001-12-26
JP3721021B2 (ja) 2005-11-30
NO994943D0 (no) 1999-10-11
EE04192B1 (et) 2003-12-15
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
CN1255497A (zh) 2000-06-07
AU756463B2 (en) 2003-01-16
IS5209A (is) 2000-04-13
TNSN99189A1 (fr) 2005-11-10
IL152927A (en) 2004-06-01
DK0994115T3 (da) 2005-06-20
UY25750A1 (es) 2001-08-27
EP0994115A2 (en) 2000-04-19
BG103794A (en) 2000-09-29
EA199900822A3 (ru) 2000-08-28
TW589314B (en) 2004-06-01
IL152923A (en) 2004-02-08
IL152928A0 (en) 2003-06-24
MY124620A (en) 2006-06-30
NO994943L (no) 2000-04-13
EA003774B1 (ru) 2003-08-28
PL335959A1 (en) 2000-04-25
AP1233A (en) 2003-12-18
AP9901672A0 (en) 1999-12-31
NO313700B1 (no) 2002-11-18
IS1951B (is) 2004-10-13
GT199900172A (es) 2001-03-28
CZ296816B6 (cs) 2006-06-14
IL152924A (en) 2004-02-19
ES2237049T3 (es) 2005-07-16
EP0994115B1 (en) 2005-03-02
HUP9903469A2 (hu) 2000-08-28
CN1473831A (zh) 2004-02-11
IL152923A0 (en) 2003-06-24
KR100380954B1 (ko) 2003-04-21
EA199900822A2 (ru) 2000-04-24
HK1027559A1 (en) 2001-01-19
JP2000119273A (ja) 2000-04-25
SG118060A1 (en) 2006-01-27
OA11165A (en) 2003-04-22
BR9905092A (pt) 2000-08-08
HU226162B1 (en) 2008-05-28
RS49762B (sr) 2008-04-04
IL152924A0 (en) 2003-06-24
IL152926A (en) 2004-02-19
PT994115E (pt) 2005-06-30
DE69923906D1 (de) 2005-04-07

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