UA65518C2 - Peptide derivatives - Google Patents
Peptide derivatives Download PDFInfo
- Publication number
- UA65518C2 UA65518C2 UA95115078A UA95115078A UA65518C2 UA 65518 C2 UA65518 C2 UA 65518C2 UA 95115078 A UA95115078 A UA 95115078A UA 95115078 A UA95115078 A UA 95115078A UA 65518 C2 UA65518 C2 UA 65518C2
- Authority
- UA
- Ukraine
- Prior art keywords
- group
- spa
- rab
- rho
- age
- Prior art date
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 40
- 150000001875 compounds Chemical class 0.000 claims abstract description 385
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 54
- 239000012634 fragment Substances 0.000 claims abstract description 54
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- 239000003868 thrombin inhibitor Substances 0.000 claims abstract description 18
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 6
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 305
- 125000000217 alkyl group Chemical group 0.000 claims description 179
- 125000004432 carbon atom Chemical group C* 0.000 claims description 172
- 238000000034 method Methods 0.000 claims description 127
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 100
- 238000002360 preparation method Methods 0.000 claims description 91
- 229910052799 carbon Inorganic materials 0.000 claims description 83
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims description 56
- 238000006243 chemical reaction Methods 0.000 claims description 43
- -1 p-toluenesulfonyl group Chemical group 0.000 claims description 37
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 36
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 34
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 32
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- 150000001413 amino acids Chemical class 0.000 claims description 26
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 25
- 125000006239 protecting group Chemical group 0.000 claims description 25
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- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims description 21
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims description 21
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 17
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 17
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 9
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- 125000004429 atom Chemical group 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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Applications Claiming Priority (2)
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| SE19939301916A SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | New peptides derivatives |
| PCT/SE1994/000535 WO1994029336A1 (en) | 1993-06-03 | 1994-06-02 | New peptide derivatives |
Publications (1)
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| UA65518C2 true UA65518C2 (en) | 2004-04-15 |
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| US6984627B1 (en) * | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
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| CN1077886C (zh) * | 1993-10-21 | 2002-01-16 | G·D·瑟尔公司 | 用作一氧化一氮合酶抑制剂的脒基衍生物 |
| JP4561696B2 (ja) * | 1994-01-27 | 2010-10-13 | 三菱化学株式会社 | プロリンアミド誘導体 |
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| CA2143533A1 (en) * | 1994-03-04 | 1995-09-05 | Kenneth D. Kurz | Antithrombotic agents |
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| AU2790895A (en) * | 1994-06-10 | 1996-01-05 | Universitaire Instelling Antwerpen | Purification of serine protease and synthetic inhibitors thereof |
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| US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| US5629324A (en) * | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
| US5610308A (en) * | 1995-05-18 | 1997-03-11 | Bristol-Myers Squibb Company | Process for preparing intermediates for thrombin inhibitors |
| SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| CA2227607C (en) * | 1995-07-26 | 2008-06-10 | Mitsubishi Chemical Corporation | Penicillaminamide derivatives |
| JP2008024720A (ja) * | 1995-07-26 | 2008-02-07 | Mitsubishi Chemicals Corp | ペニシラミンアミド誘導体 |
| TW455580B (en) * | 1995-12-09 | 2001-09-21 | Roche Diagnostics Gmbh | 3-aminoethyl-N-amidino-2,5-dihyropyrrole-derivatives having arginine mimentic properties and pharmaceutical compositions containing these compounds |
| GB9526273D0 (en) * | 1995-12-21 | 1996-02-21 | Astra Ab | New prodrugs |
| TWI238827B (en) * | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| SE9600216D0 (sv) * | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
| EP1007544A1 (en) * | 1996-02-13 | 2000-06-14 | Akzo Nobel N.V. | Serine protease inhibitors |
| TW523513B (en) * | 1996-03-01 | 2003-03-11 | Akzo Nobel Nv | Serine protease inhibitors |
| IL120310A (en) * | 1996-03-01 | 2002-02-10 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
| US5811402A (en) * | 1996-03-22 | 1998-09-22 | Eli Lilly And Company | Antithrombotic diamides |
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| US6756389B2 (en) * | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| US5792761A (en) * | 1996-08-12 | 1998-08-11 | Merck & Co., Inc. | Thrombin inhibitors |
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| US5869487A (en) * | 1996-10-24 | 1999-02-09 | Merck & Co., Inc. | Pyrido 3,4-B!pyrazines for use as thrombin inhibitors |
| AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
| US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| DE69830410T2 (de) * | 1997-08-29 | 2006-01-26 | Tularik Ltd. | Meta-benzamidinderivate als serinprotease-inhibitoren |
| US6087373A (en) * | 1997-09-23 | 2000-07-11 | Merck & Co., Inc. | Thrombin inhibitors |
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| WO1999037611A1 (de) * | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Heterocyclische amidine als kallikrein protease inhibitoren |
| CA2317761A1 (en) | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Thrombin inhibitors |
| US6417161B1 (en) | 1998-04-24 | 2002-07-09 | 3-Dimensional Pharmaceuticals, Inc. | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors |
| SE9802939D0 (sv) | 1998-09-01 | 1998-09-01 | Astra Ab | New process |
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| EP0987274A1 (en) * | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Factor VIIa Inhibitors |
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| AR023510A1 (es) * | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| US6239132B1 (en) | 1999-04-23 | 2001-05-29 | Merck & Co., Inc. | Thrombin inhibitors |
| AR023819A1 (es) * | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
| DE50008187D1 (de) * | 1999-05-10 | 2004-11-18 | Abbott Gmbh & Co Kg | Salze von Thrombininhibitoren |
| JP2003501389A (ja) | 1999-06-04 | 2003-01-14 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害物質 |
| EP1059302A1 (en) * | 1999-06-08 | 2000-12-13 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitors |
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| CA2383358A1 (en) * | 1999-08-31 | 2001-03-08 | Board Of Regents, The University Of Texas System | Methods and compositions of a novel serine protease inhibitor |
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| DE10029014A1 (de) | 2000-06-15 | 2001-12-20 | Univ Schiller Jena | Urokinase-Hemmstoffe |
| DE10029015A1 (de) * | 2000-06-15 | 2001-12-20 | Curacyte Ag | Hemmstoffe für den Gerinnungsfaktor Xa |
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1993
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1994
- 1994-02-06 UA UA95115078A patent/UA65518C2/uk unknown
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- 1994-06-02 WO PCT/SE1994/000535 patent/WO1994029336A1/en active IP Right Grant
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- 1994-06-02 DE DE0701568T patent/DE701568T1/de active Pending
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