UA42715C2 - Полінуклеотидна вакцина на основі плазмідної днк, імуногенна композиція(варіанти) - Google Patents

Полінуклеотидна вакцина на основі плазмідної днк, імуногенна композиція(варіанти)

Info

Publication number
UA42715C2
UA42715C2 UA95094152A UA95094152A UA42715C2 UA 42715 C2 UA42715 C2 UA 42715C2 UA 95094152 A UA95094152 A UA 95094152A UA 95094152 A UA95094152 A UA 95094152A UA 42715 C2 UA42715 C2 UA 42715C2
Authority
UA
Ukraine
Prior art keywords
plasmid dna
variants
polynucleotide vaccine
immunogenic composition
terminator
Prior art date
Application number
UA95094152A
Other languages
English (en)
Russian (ru)
Inventor
Джон Дж. Доннеллі
Джон Дж. ДОННЕЛЛИ
Варавані Дж. Дваркі
Варавани Дж. ДВАРКИ
Маргарет А. Ліу
Маргарет А. ЛИУ
Донна Л. Монтгомері
Донна Л. МОНТГОМЕРИ
С'юзанн Е. Паркер
Съюзанн Е. Паркер
Джон В. Шівер
Джон В. ШИВЕР
Джеффрі Б. Алмер
Джеффри Б. АЛМЕР
Original Assignee
Мерк Енд Ко., Інк.
Мерк Энд Ко., Инк.
Вікал Інкорпорейтед
Викал Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Енд Ко., Інк., Мерк Энд Ко., Инк., Вікал Інкорпорейтед, Викал Инкорпорейтед filed Critical Мерк Енд Ко., Інк.
Publication of UA42715C2 publication Critical patent/UA42715C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Полінуклеотидна вакцина на основі плазмідної ДНК містить регуляторну послідовність, яка являє собою промотор цитомегаловірусу з послідовністю інтрону А (1,63 т.п.н.), термінатор транскрипції, що являє собою термінатор транскрипції бичачого гормону росту (0,55 т.п.н.), бактеріальну область початку реплікації, що являє собою ori (0,64 т.п.н.) та маркер, що визначається, що являє собою ген стійкості до канаміцину (1,30 т.п.н.).
UA95094152A 1993-03-18 1994-03-14 Полінуклеотидна вакцина на основі плазмідної днк, імуногенна композиція(варіанти) UA42715C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3238393A 1993-03-18 1993-03-18
US8998593A 1993-07-08 1993-07-08
PCT/US1994/002751 WO1994021797A1 (en) 1993-03-18 1994-03-14 Nucleic acid pharmaceuticals

Publications (1)

Publication Number Publication Date
UA42715C2 true UA42715C2 (uk) 2001-11-15

Family

ID=26708344

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95094152A UA42715C2 (uk) 1993-03-18 1994-03-14 Полінуклеотидна вакцина на основі плазмідної днк, імуногенна композиція(варіанти)

Country Status (22)

Country Link
EP (1) EP0620277A1 (uk)
JP (2) JP2812352B2 (uk)
CN (1) CN1119458A (uk)
AU (1) AU676258B2 (uk)
BG (1) BG63126B1 (uk)
BR (1) BR9406007A (uk)
CA (1) CA2119175A1 (uk)
CZ (1) CZ290315B6 (uk)
DZ (1) DZ1759A1 (uk)
FI (1) FI954329A (uk)
HR (1) HRP940175A2 (uk)
HU (1) HUT73397A (uk)
IL (1) IL108915A0 (uk)
NO (1) NO953649L (uk)
NZ (1) NZ263680A (uk)
PL (1) PL178626B1 (uk)
RO (1) RO117710B1 (uk)
SI (1) SI9420014A (uk)
SK (1) SK114295A3 (uk)
UA (1) UA42715C2 (uk)
WO (1) WO1994021797A1 (uk)
YU (1) YU12894A (uk)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849719A (en) * 1993-08-26 1998-12-15 The Regents Of The University Of California Method for treating allergic lung disease
US6911216B1 (en) 1994-10-12 2005-06-28 Genzyme Corporation Targeted delivery via biodegradable polymers
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
DE19512142A1 (de) * 1995-03-31 1996-10-02 Immuno Ag Infektiöser cDNA-Klon des Tick-Borne Enzephalitis (TBE)-Virus, davon abgeleiteter rekombinanter Impfstoff und Herstellung desselben sowie ein pharmazeutisches Produkt, das eine replizierbare Nukleinsäure enthält
US6083925A (en) * 1995-06-07 2000-07-04 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US6017897A (en) * 1995-06-07 2000-01-25 Pasteur Merieux Connaught Canada Nucleic acid respiratory syncytial virus vaccines
US6019980A (en) 1995-06-07 2000-02-01 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
FR2751225B1 (fr) * 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique aviaire
US6204250B1 (en) 1996-11-22 2001-03-20 The Mount Sinai Medical Center Of The City Of New York Immunization of infants
ATE284613T1 (de) * 1997-02-14 2005-01-15 Merck & Co Inc Polynukleotid-impfstoff-formulierungen
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US6686339B1 (en) 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
EP1105490A1 (en) 1998-08-20 2001-06-13 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein c of chlamydia
US6693087B1 (en) 1998-08-20 2004-02-17 Aventis Pasteur Limited Nucleic acid molecules encoding POMP91A protein of Chlamydia
US6881723B1 (en) 1998-11-05 2005-04-19 Powderject Vaccines, Inc. Nucleic acid constructs
US7618797B2 (en) 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7691389B2 (en) 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
WO2000047227A2 (en) 1999-02-09 2000-08-17 Powderject Vaccines, Inc. Mycobacterium tuberculosis, immunization
US6943152B1 (en) 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
JP2001151698A (ja) * 1999-09-10 2001-06-05 Nichiko Pharmaceutical Co Ltd インフルエンザワクチン
CA2721011A1 (en) 1999-10-22 2001-05-03 Aventis Pasteur Limited Modified gp100 and uses thereof
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
US6852705B2 (en) 2000-01-21 2005-02-08 Merial DNA vaccines for farm animals, in particular bovines and porcines
US7078388B2 (en) 2000-01-21 2006-07-18 Merial DNA vaccines for farm animals, in particular bovines and porcines
EP1792995A3 (en) 2000-05-08 2007-06-13 Sanofi Pasteur Limited Chlamydia secretory locus orf and uses thereof
WO2001085932A2 (en) 2000-05-10 2001-11-15 Aventis Pasteur Limited Immunogenic polypeptides encoded by mage minigenes and uses thereof
US20060024670A1 (en) 2004-05-18 2006-02-02 Luke Catherine J Influenza virus vaccine composition and methods of use
US8202967B2 (en) 2006-10-27 2012-06-19 Boehringer Ingelheim Vetmedica, Inc. H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
EP2152871A4 (en) * 2007-05-31 2011-01-05 Becton Dickinson Co SEQUENCES AND METHOD FOR DETECTING INFLUENZA VIRUS A AND INFLUENZA VIRUS B
US8354230B2 (en) * 2007-12-21 2013-01-15 Quest Diagnostics Investments Inc. Multiplex detection assay for influenza and RSV viruses
WO2010012045A1 (en) 2008-08-01 2010-02-04 Gamma Vaccines Pty Limited Influenza vaccines
US8894997B2 (en) 2009-04-30 2014-11-25 Vanderbilt University Monoclonal antibodies to influenza H1N1 virus uses thereof
SG168423A1 (en) * 2009-07-13 2011-02-28 Agency Science Tech & Res Influenza detection method and kit therefor
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
AR083533A1 (es) 2010-10-22 2013-03-06 Boehringer Ingelheim Vetmed Proteinas de hemaglutinina 5 (h5) para el tratamiento y prevencion de las infecciones de gripe
AR088028A1 (es) 2011-08-15 2014-05-07 Boehringer Ingelheim Vetmed Proteinas h5, de h5n1 para un uso medicinal
WO2013033092A2 (en) 2011-09-03 2013-03-07 Boehringer Ingelheim Vetmedica Gmbh Streptococcus suis pilus antigens
US10383835B2 (en) 2012-03-14 2019-08-20 The Regents Of The University Of California Treatment of inflammatory disorders in non-human mammals
ES2689878T3 (es) 2013-02-21 2018-11-16 Boehringer Ingelheim Vetmedica Gmbh Proteínas H5 del virus de la gripe H5N1 para su uso como un medicamento
WO2014147087A1 (en) * 2013-03-18 2014-09-25 Imaxio Influenza nucleoprotein vaccines
MX2016003855A (es) 2013-09-25 2016-08-04 Zoetis Services Llc Composicion de vacuna de circovirus porcino tipo 2b divergente y procedimientos de uso.
AU2015241107B2 (en) 2014-04-03 2019-10-03 Boehringer Ingelheim Animal Health USA Inc. Porcine epidemic diarrhea virus vaccine
US9920302B2 (en) 2015-08-31 2018-03-20 Boehringer Ingelheim Vetmedica Gmbh Pestivirus vaccines for congenital tremors
AU2016323106A1 (en) 2015-09-16 2018-03-29 Boehringer Ingelheim Animal Health USA Inc. Salmonella Choleraesuis-Salmonella Typhimurium vaccines
CN109790550B (zh) 2016-09-20 2024-02-09 勃林格殷格翰动物保健有限公司 新颖的启动子
UY37405A (es) 2016-09-20 2018-03-23 Boehringer Ingelheim Vetmedica Gmbh Vectores de adenovirus canino
WO2018054822A1 (en) 2016-09-20 2018-03-29 Boehringer Ingelheim Vetmedica Gmbh New swine influenza vaccine
AU2017329669A1 (en) 2016-09-20 2019-03-21 Boehringer Ingelheim Vetmedica Gmbh New EHV insertion site ORF70
PL3534939T3 (pl) 2016-11-03 2023-06-12 Boehringer Ingelheim Vetmedica Gmbh Szczepionka przeciw parwowirusowi świń i wirusowi zespołu rozrodczo-oddechowego świń oraz sposoby ich wytwarzania
KR20240090735A (ko) 2016-11-03 2024-06-21 베링거잉겔하임베트메디카게엠베하 돼지 파보바이러스에 대한 백신
AU2018212843A1 (en) 2017-01-30 2019-06-27 Boehringer Ingelheim Animal Health USA Inc. Porcine coronavirus vaccines
CN110869047A (zh) 2017-07-12 2020-03-06 勃林格殷格翰动物保健美国有限公司 塞内卡病毒a免疫原性组合物及其方法
EP3675903A1 (en) 2017-09-23 2020-07-08 Boehringer Ingelheim Vetmedica GmbH Paramyxoviridae expression system
WO2019092027A1 (en) 2017-11-09 2019-05-16 Boehringer Ingelheim Vetmedica Gmbh Sapelovirus immunogenic compositions and uses thereof
CN111712575B (zh) 2018-02-23 2024-07-19 勃林格殷格翰动物保健有限公司 表达外源猫副粘病毒基因的重组病毒载体系统及由其制备的疫苗
EA202092164A1 (ru) 2018-03-19 2021-02-10 Бёрингер Ингельхайм Ветмедика Гмбх Новый ehv с инактивированным ul18 и/или ul8
JP7245260B2 (ja) 2018-03-19 2023-03-23 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー Ehv挿入部位ul43
US11957746B2 (en) 2018-03-26 2024-04-16 Boehringer Ingelheim Animal Health USA Inc. Method of producing an immunogenic composition
JP7284822B2 (ja) 2018-09-20 2023-05-31 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 改変pedvスパイクタンパク質
US10905758B2 (en) 2018-09-20 2021-02-02 Boehringer Ingelheim Vetmedica Gmbh Intranasal vector vaccine against porcine epidemic diarrhea
IT201900007060A1 (it) 2019-05-21 2020-11-21 St Superiore Di Sanita Cellule tumorali ingegnerizzate e loro usi
IT201900012540A1 (it) 2019-07-22 2021-01-22 Humanitas Mirasole Spa Inibitori di CHI3L1 e loro usi
JP2023513135A (ja) 2020-02-06 2023-03-30 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 抗ラブドウイルス抗体を検出するのに有用なポリペプチド
AU2021356630A1 (en) 2020-10-05 2023-06-08 Boehringer Ingelheim Vetmedica Gmbh Fusion protein useful for vaccination against rotavirus
JP2023544403A (ja) 2020-10-05 2023-10-23 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド サーコウイルス科カプシドタンパク質を含む融合タンパク質、及びそれから構成されるキメラウイルス様粒子
US20240050555A1 (en) 2022-04-05 2024-02-15 Boehringer Ingelheim Vetmedica Gmbh Immunogenic composition useful for vaccination against rotavirus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86354A0 (en) * 1987-05-22 1988-11-15 Orion Yhtymae Oy Episomal vector for the expression of selected dna fragments coding for optional polypeptides in mammalian cells and methods for the production thereof
DE69034078T2 (de) * 1989-03-21 2004-04-01 Vical, Inc., San Diego Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
US5643578A (en) * 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit

Also Published As

Publication number Publication date
JP3608642B2 (ja) 2005-01-12
YU12894A (sh) 1997-12-05
HRP940175A2 (en) 1997-04-30
FI954329A0 (fi) 1995-09-14
SK114295A3 (en) 1996-02-07
PL310677A1 (en) 1995-12-27
HU9502702D0 (en) 1995-11-28
HUT73397A (en) 1996-07-29
WO1994021797A1 (en) 1994-09-29
BG63126B1 (bg) 2001-04-30
JPH10113194A (ja) 1998-05-06
FI954329A (fi) 1995-09-14
BG100006A (bg) 1996-12-31
SI9420014A (en) 1996-08-31
AU5788994A (en) 1994-09-22
NZ263680A (en) 1997-05-26
AU676258B2 (en) 1997-03-06
CN1119458A (zh) 1996-03-27
NO953649D0 (no) 1995-09-15
EP0620277A1 (en) 1994-10-19
JPH0795888A (ja) 1995-04-11
IL108915A0 (en) 1994-06-24
CZ237395A3 (en) 1996-02-14
JP2812352B2 (ja) 1998-10-22
PL178626B1 (pl) 2000-05-31
BR9406007A (pt) 1996-01-02
NO953649L (no) 1995-11-17
DZ1759A1 (fr) 2002-02-17
RO117710B1 (ro) 2002-06-28
CA2119175A1 (en) 1994-09-19
CZ290315B6 (cs) 2002-07-17

Similar Documents

Publication Publication Date Title
UA42715C2 (uk) Полінуклеотидна вакцина на основі плазмідної днк, імуногенна композиція(варіанти)
DE3276241D1 (en) Expression of polypeptides in yeast
DE3279030D1 (en) Novel vector plasmids
EP0249676A3 (en) Method for the expression of genes in plants
AU6893587A (en) Recombinant dna sequences, vectors containing them and method for the use thereof
DE2862496D1 (en) Method for polypeptide production involving expression of a heterologous gene, recombinant microbial cloning vehicle containing said gene and bacterial culture transformed by said cloning vehicle
AU604743B2 (en) Phosphinothricin-resistance gene, and its use
UA13380A (uk) Спосіб одержаhhя лейкоцитарhого іhтерфероhу
GB9118759D0 (en) Recombinant dna
CA2072007A1 (en) Cloning Vector for Use in Lactic Acid Bacteria and a Method for Constructing the Same
IE843270L (en) Methionine-prochymosin plasmid.
DE3277631D1 (en) Recombinant plasmid and microorganism containing same
EP0316677A3 (en) Method for cloning in lactic acid bacteria
KR910001046A (ko) 비융합 단백질을 제조하기 위한 미생물내 발현용 발현벡터
DE3380878D1 (en) Method of heterologous cloning of gene in bacillus microorganism
ES8306176A1 (es) Procedimiento para la preparacion de un vector hibrido y la clonacion de adn-ajeno en organismos hospetantes.
EP0068647A3 (en) Plasmids, plasmid hosts, and their preparation
DE3570694D1 (en) Recombinant saccharomyces
JPS5756495A (en) Novel dna-introduction vector and recombinant dna
EP0245218A3 (en) A plasmid vector for expression in bacillus and used for cloning the structural gene which codes for the human growth hormone and a method of producing the hormone
GB2067574B (en) Microbiologically prepared polypeptide with the amino acid sequence of proinsulin of a primate dna and plasmids which code for this sequence microorganisms which contain this genetic information and processes for their preparation
WO1993018151A1 (fr) Element transposable originaire d'une bacterie du genre brevibacterium
HK192795A (en) A novel system of inducible positive regulation of use for production of heterologous proteins
EP0248207A3 (en) Gene for gentamycin resistance and its use as a marker
EP0038156A3 (en) A plasmid and its microbiological preparation