UA42715C2 - Полінуклеотидна вакцина на основі плазмідної днк, імуногенна композиція(варіанти) - Google Patents
Полінуклеотидна вакцина на основі плазмідної днк, імуногенна композиція(варіанти)Info
- Publication number
- UA42715C2 UA42715C2 UA95094152A UA95094152A UA42715C2 UA 42715 C2 UA42715 C2 UA 42715C2 UA 95094152 A UA95094152 A UA 95094152A UA 95094152 A UA95094152 A UA 95094152A UA 42715 C2 UA42715 C2 UA 42715C2
- Authority
- UA
- Ukraine
- Prior art keywords
- plasmid dna
- variants
- polynucleotide vaccine
- immunogenic composition
- terminator
- Prior art date
Links
- 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 title abstract 2
- 239000013612 plasmid Substances 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title 1
- 230000035897 transcription Effects 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 108010006025 bovine growth hormone Proteins 0.000 abstract 1
- 229940065638 intron a Drugs 0.000 abstract 1
- 229930027917 kanamycin Natural products 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Полінуклеотидна вакцина на основі плазмідної ДНК містить регуляторну послідовність, яка являє собою промотор цитомегаловірусу з послідовністю інтрону А (1,63 т.п.н.), термінатор транскрипції, що являє собою термінатор транскрипції бичачого гормону росту (0,55 т.п.н.), бактеріальну область початку реплікації, що являє собою ori (0,64 т.п.н.) та маркер, що визначається, що являє собою ген стійкості до канаміцину (1,30 т.п.н.).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3238393A | 1993-03-18 | 1993-03-18 | |
| US8998593A | 1993-07-08 | 1993-07-08 | |
| PCT/US1994/002751 WO1994021797A1 (en) | 1993-03-18 | 1994-03-14 | Nucleic acid pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA42715C2 true UA42715C2 (uk) | 2001-11-15 |
Family
ID=26708344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA95094152A UA42715C2 (uk) | 1993-03-18 | 1994-03-14 | Полінуклеотидна вакцина на основі плазмідної днк, імуногенна композиція(варіанти) |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0620277A1 (uk) |
| JP (2) | JP2812352B2 (uk) |
| CN (1) | CN1119458A (uk) |
| AU (1) | AU676258B2 (uk) |
| BG (1) | BG63126B1 (uk) |
| BR (1) | BR9406007A (uk) |
| CA (1) | CA2119175A1 (uk) |
| CZ (1) | CZ290315B6 (uk) |
| DZ (1) | DZ1759A1 (uk) |
| FI (1) | FI954329A0 (uk) |
| HR (1) | HRP940175A2 (uk) |
| HU (1) | HUT73397A (uk) |
| IL (1) | IL108915A0 (uk) |
| NO (1) | NO953649L (uk) |
| NZ (1) | NZ263680A (uk) |
| PL (1) | PL178626B1 (uk) |
| RO (1) | RO117710B1 (uk) |
| SI (1) | SI9420014A (uk) |
| SK (1) | SK114295A3 (uk) |
| UA (1) | UA42715C2 (uk) |
| WO (1) | WO1994021797A1 (uk) |
| YU (1) | YU12894A (uk) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849719A (en) * | 1993-08-26 | 1998-12-15 | The Regents Of The University Of California | Method for treating allergic lung disease |
| US6911216B1 (en) | 1994-10-12 | 2005-06-28 | Genzyme Corporation | Targeted delivery via biodegradable polymers |
| US5736524A (en) * | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| DE19512142A1 (de) * | 1995-03-31 | 1996-10-02 | Immuno Ag | Infektiöser cDNA-Klon des Tick-Borne Enzephalitis (TBE)-Virus, davon abgeleiteter rekombinanter Impfstoff und Herstellung desselben sowie ein pharmazeutisches Produkt, das eine replizierbare Nukleinsäure enthält |
| US6083925A (en) | 1995-06-07 | 2000-07-04 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
| US6019980A (en) | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
| US6017897A (en) * | 1995-06-07 | 2000-01-25 | Pasteur Merieux Connaught Canada | Nucleic acid respiratory syncytial virus vaccines |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| FR2751225B1 (fr) * | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique aviaire |
| US6204250B1 (en) | 1996-11-22 | 2001-03-20 | The Mount Sinai Medical Center Of The City Of New York | Immunization of infants |
| AU722326B2 (en) * | 1997-02-14 | 2000-07-27 | Merck & Co., Inc. | Polynucleotide vaccine formulations |
| US6517843B1 (en) | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
| UA78180C2 (uk) | 1997-10-03 | 2007-03-15 | Меріаль | Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти |
| FR2772047B1 (fr) | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
| US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
| US6693087B1 (en) | 1998-08-20 | 2004-02-17 | Aventis Pasteur Limited | Nucleic acid molecules encoding POMP91A protein of Chlamydia |
| EP1105490A1 (en) | 1998-08-20 | 2001-06-13 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein c of chlamydia |
| US6881723B1 (en) | 1998-11-05 | 2005-04-19 | Powderject Vaccines, Inc. | Nucleic acid constructs |
| US7691389B2 (en) | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| US7618797B2 (en) | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| AU3593200A (en) | 1999-02-09 | 2000-08-29 | Powderject Vaccines, Inc. | (mycobacterium tuberculosis), immunization |
| US6943152B1 (en) | 1999-06-10 | 2005-09-13 | Merial | DNA vaccine-PCV |
| JP2001151698A (ja) * | 1999-09-10 | 2001-06-05 | Nichiko Pharmaceutical Co Ltd | インフルエンザワクチン |
| AU1013601A (en) | 1999-10-22 | 2001-05-08 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
| US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
| US6852705B2 (en) | 2000-01-21 | 2005-02-08 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
| US7078388B2 (en) | 2000-01-21 | 2006-07-18 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
| EP1792995A3 (en) | 2000-05-08 | 2007-06-13 | Sanofi Pasteur Limited | Chlamydia secretory locus orf and uses thereof |
| CA2408328C (en) | 2000-05-10 | 2012-04-17 | Aventis Pasteur Limited | Immunogenic polypeptides encoded by mage minigenes and uses thereof |
| AU2005248361B2 (en) | 2004-05-18 | 2010-03-11 | Vical Incorporated | Influenza virus vaccine composition and methods of use |
| US8202967B2 (en) | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| CA2687888A1 (en) * | 2007-05-31 | 2008-12-11 | Becton, Dickinson And Company | Sequences and methods for detecting influenza a and influenza b virus |
| US8354230B2 (en) * | 2007-12-21 | 2013-01-15 | Quest Diagnostics Investments Inc. | Multiplex detection assay for influenza and RSV viruses |
| EP2318044B1 (en) | 2008-08-01 | 2015-12-02 | Gamma Vaccines Pty Limited | Influenza vaccines |
| US8894997B2 (en) | 2009-04-30 | 2014-11-25 | Vanderbilt University | Monoclonal antibodies to influenza H1N1 virus uses thereof |
| SG168423A1 (en) * | 2009-07-13 | 2011-02-28 | Agency Science Tech & Res | Influenza detection method and kit therefor |
| TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物 |
| AR083533A1 (es) | 2010-10-22 | 2013-03-06 | Boehringer Ingelheim Vetmed | Proteinas de hemaglutinina 5 (h5) para el tratamiento y prevencion de las infecciones de gripe |
| AR088028A1 (es) | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
| WO2013033092A2 (en) | 2011-09-03 | 2013-03-07 | Boehringer Ingelheim Vetmedica Gmbh | Streptococcus suis pilus antigens |
| US10383835B2 (en) | 2012-03-14 | 2019-08-20 | The Regents Of The University Of California | Treatment of inflammatory disorders in non-human mammals |
| ES2689878T3 (es) | 2013-02-21 | 2018-11-16 | Boehringer Ingelheim Vetmedica Gmbh | Proteínas H5 del virus de la gripe H5N1 para su uso como un medicamento |
| KR102379951B1 (ko) * | 2013-03-18 | 2022-03-31 | 오시벡스 에스에이에스 | 인플루엔자 핵단백질 백신 |
| US9987348B2 (en) | 2013-09-25 | 2018-06-05 | Zoetis Services Llc | PCV2B divergent vaccine composition and methods of use |
| KR20160132494A (ko) | 2014-04-03 | 2016-11-18 | 베링거잉겔하임베트메디카인코퍼레이티드 | 돼지 유행성 설사 바이러스 백신 |
| BR112017028224A2 (pt) | 2015-08-31 | 2018-09-11 | Boehringer Ingelheim Vetmedica Gmbh | composição, e, método para proteger um leitão contra uma doença associada a pestivírus. |
| AU2016323106A1 (en) | 2015-09-16 | 2018-03-29 | Boehringer Ingelheim Animal Health USA Inc. | Salmonella Choleraesuis-Salmonella Typhimurium vaccines |
| CN109715219B (zh) | 2016-09-20 | 2024-03-01 | 勃林格殷格翰动物保健有限公司 | 犬腺病毒载体 |
| EP3515480A1 (en) | 2016-09-20 | 2019-07-31 | Boehringer Ingelheim Vetmedica GmbH | New swine influenza vaccine |
| UY37406A (es) | 2016-09-20 | 2018-03-23 | Boehringer Ingelheim Vetmedica Gmbh | Nuevo sitio de inserción orf70 de ehv |
| CA3036293A1 (en) | 2016-09-20 | 2018-03-29 | Boehringer Ingelheim Vetmedica Gmbh | New promoters |
| MX2019005136A (es) | 2016-11-03 | 2019-06-20 | Boehringer Ingelheim Vetmedica Gmbh | Vacuna contra el parvovirus porcino y el virus del sindrome respiratorio reproductivo porcino y metodos de produccion de esta. |
| KR102669319B1 (ko) | 2016-11-03 | 2024-05-28 | 베링거잉겔하임베트메디카게엠베하 | 돼지 파보바이러스에 대한 백신 |
| WO2018140766A2 (en) | 2017-01-30 | 2018-08-02 | Boehringer Ingelheim Vetmedica, Inc. | Porcine coronavirus vaccines |
| CA3068052A1 (en) | 2017-07-12 | 2019-01-17 | Boheringer Ingelheim Animal Health Usa Inc. | Senecavirus a immunogenic compositions and methods thereof |
| KR20200057742A (ko) | 2017-09-23 | 2020-05-26 | 베링거잉겔하임베트메디카게엠베하 | 파라믹소바이러스과 발현 시스템 |
| WO2019092027A1 (en) | 2017-11-09 | 2019-05-16 | Boehringer Ingelheim Vetmedica Gmbh | Sapelovirus immunogenic compositions and uses thereof |
| CN111712575B (zh) | 2018-02-23 | 2024-07-19 | 勃林格殷格翰动物保健有限公司 | 表达外源猫副粘病毒基因的重组病毒载体系统及由其制备的疫苗 |
| MX2020009722A (es) | 2018-03-19 | 2021-01-29 | Boehringer Ingelheim Vetmedica Gmbh | Nuevo sitio de insercion ul43 de ehv. |
| CN111867625A (zh) | 2018-03-19 | 2020-10-30 | 勃林格殷格翰动物保健有限公司 | 具有失活ul18和/或ul8的新ehv |
| CA3091982A1 (en) | 2018-03-26 | 2019-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Method of producing an immunogenic composition |
| WO2020058327A1 (en) | 2018-09-20 | 2020-03-26 | Boehringer Ingelheim Vetmedica Gmbh | Modified pedv spike protein |
| EP3852800A1 (en) | 2018-09-20 | 2021-07-28 | Boehringer Ingelheim Vetmedica GmbH | Intranasal vector vaccine against porcine epidemic diarrhea |
| IT201900007060A1 (it) | 2019-05-21 | 2020-11-21 | St Superiore Di Sanita | Cellule tumorali ingegnerizzate e loro usi |
| IT201900012540A1 (it) | 2019-07-22 | 2021-01-22 | Humanitas Mirasole Spa | Inibitori di CHI3L1 e loro usi |
| WO2021158878A1 (en) | 2020-02-06 | 2021-08-12 | Boehringer Ingelheim Animal Health USA Inc. | Polypeptides useful for detecting anti-rhabdovirus antibodies |
| CA3195910A1 (en) | 2020-10-05 | 2022-04-14 | Boehringer Ingelheim Vetmedica Gmbh | Fusion protein useful for vaccination against rotavirus |
| US20220160864A1 (en) | 2020-10-05 | 2022-05-26 | Boehringer Ingelheim Animal Health USA Inc. | Fusion protein comprising circoviridae capsid protein, and chimeric virus-like particles composed thereof |
| US20240050555A1 (en) | 2022-04-05 | 2024-02-15 | Boehringer Ingelheim Vetmedica Gmbh | Immunogenic composition useful for vaccination against rotavirus |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86354A0 (en) * | 1987-05-22 | 1988-11-15 | Orion Yhtymae Oy | Episomal vector for the expression of selected dna fragments coding for optional polypeptides in mammalian cells and methods for the production thereof |
| ATE240401T1 (de) * | 1989-03-21 | 2003-05-15 | Vical Inc | Expression von exogenen polynukleotidsequenzen in wirbeltieren |
| US5643578A (en) * | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
-
1994
- 1994-03-09 EP EP94200605A patent/EP0620277A1/en not_active Withdrawn
- 1994-03-09 IL IL10891594A patent/IL108915A0/xx unknown
- 1994-03-14 HU HU9502702A patent/HUT73397A/hu unknown
- 1994-03-14 BR BR9406007A patent/BR9406007A/pt not_active Application Discontinuation
- 1994-03-14 NZ NZ263680A patent/NZ263680A/en unknown
- 1994-03-14 CN CN94191485A patent/CN1119458A/zh active Pending
- 1994-03-14 WO PCT/US1994/002751 patent/WO1994021797A1/en active IP Right Grant
- 1994-03-14 CZ CZ19952373A patent/CZ290315B6/cs not_active IP Right Cessation
- 1994-03-14 SK SK1142-95A patent/SK114295A3/sk unknown
- 1994-03-14 SI SI9420014A patent/SI9420014A/sl not_active IP Right Cessation
- 1994-03-14 PL PL94310677A patent/PL178626B1/pl unknown
- 1994-03-14 UA UA95094152A patent/UA42715C2/uk unknown
- 1994-03-14 RO RO95-01622A patent/RO117710B1/ro unknown
- 1994-03-16 DZ DZ940021A patent/DZ1759A1/fr active
- 1994-03-16 CA CA002119175A patent/CA2119175A1/en not_active Abandoned
- 1994-03-17 HR HR08/089,985A patent/HRP940175A2/xx not_active Application Discontinuation
- 1994-03-17 AU AU57889/94A patent/AU676258B2/en not_active Ceased
- 1994-03-17 YU YU12894A patent/YU12894A/sh unknown
- 1994-03-18 JP JP6049102A patent/JP2812352B2/ja not_active Expired - Fee Related
-
1995
- 1995-09-14 FI FI954329A patent/FI954329A0/fi unknown
- 1995-09-15 NO NO953649A patent/NO953649L/no not_active Application Discontinuation
- 1995-09-18 BG BG100006A patent/BG63126B1/bg unknown
-
1997
- 1997-10-22 JP JP29013797A patent/JP3608642B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BG63126B1 (bg) | 2001-04-30 |
| BR9406007A (pt) | 1996-01-02 |
| SK114295A3 (en) | 1996-02-07 |
| WO1994021797A1 (en) | 1994-09-29 |
| JPH0795888A (ja) | 1995-04-11 |
| RO117710B1 (ro) | 2002-06-28 |
| EP0620277A1 (en) | 1994-10-19 |
| NO953649D0 (no) | 1995-09-15 |
| HUT73397A (en) | 1996-07-29 |
| FI954329A (fi) | 1995-09-14 |
| NO953649L (no) | 1995-11-17 |
| CN1119458A (zh) | 1996-03-27 |
| SI9420014A (en) | 1996-08-31 |
| AU676258B2 (en) | 1997-03-06 |
| HU9502702D0 (en) | 1995-11-28 |
| JPH10113194A (ja) | 1998-05-06 |
| JP2812352B2 (ja) | 1998-10-22 |
| CZ237395A3 (en) | 1996-02-14 |
| IL108915A0 (en) | 1994-06-24 |
| BG100006A (bg) | 1996-12-31 |
| PL178626B1 (pl) | 2000-05-31 |
| YU12894A (sh) | 1997-12-05 |
| PL310677A1 (en) | 1995-12-27 |
| AU5788994A (en) | 1994-09-22 |
| DZ1759A1 (fr) | 2002-02-17 |
| JP3608642B2 (ja) | 2005-01-12 |
| CZ290315B6 (cs) | 2002-07-17 |
| FI954329A0 (fi) | 1995-09-14 |
| HRP940175A2 (en) | 1997-04-30 |
| CA2119175A1 (en) | 1994-09-19 |
| NZ263680A (en) | 1997-05-26 |
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