UA129537C2 - Сполука-коагоніст gip/glp1 - Google Patents
Сполука-коагоніст gip/glp1 Download PDFInfo
- Publication number
- UA129537C2 UA129537C2 UAA202100210A UAA202100210A UA129537C2 UA 129537 C2 UA129537 C2 UA 129537C2 UA A202100210 A UAA202100210 A UA A202100210A UA A202100210 A UAA202100210 A UA A202100210A UA 129537 C2 UA129537 C2 UA 129537C2
- Authority
- UA
- Ukraine
- Prior art keywords
- ethoxy
- amino
- aib
- acetyl
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/56—Protease inhibitors from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862702072P | 2018-07-23 | 2018-07-23 | |
| US201862730563P | 2018-09-13 | 2018-09-13 | |
| US201862740596P | 2018-10-03 | 2018-10-03 | |
| PCT/US2019/042822 WO2020023386A1 (en) | 2018-07-23 | 2019-07-22 | Gip/glp1 co-agonist compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA129537C2 true UA129537C2 (uk) | 2025-05-28 |
Family
ID=67620523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA202100210A UA129537C2 (uk) | 2018-07-23 | 2019-07-22 | Сполука-коагоніст gip/glp1 |
Country Status (26)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015095406A1 (en) | 2013-12-18 | 2015-06-25 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| AR113486A1 (es) * | 2017-12-21 | 2020-05-06 | Lilly Co Eli | Análogos de incretina y sus usos |
| MA53382A (fr) * | 2018-07-23 | 2021-06-02 | Lilly Co Eli | Composés co-agonistes de gip/glp1 |
| JP2021530544A (ja) * | 2018-07-23 | 2021-11-11 | イーライ リリー アンド カンパニー | 糖尿病のためのｇｉｐ／ｇｌｐ１共アゴニストを使用する方法 |
| US20220411461A1 (en) | 2019-08-19 | 2022-12-29 | Eli Lilly And Company | Methods of making incretin analogs |
| WO2021150673A1 (en) * | 2020-01-23 | 2021-07-29 | Eli Lilly And Company | Gip/glp1 co-agonist compounds |
| AU2021229621B2 (en) | 2020-03-06 | 2023-08-31 | Sanofi | Peptides as selective GIP receptor agonists |
| WO2021198229A1 (en) | 2020-03-31 | 2021-10-07 | Antaros Medical Ab | Selective gip receptor agonists comprising a chelating moiety for imaging and therapy purposes |
| TW202216746A (zh) | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | 長效型ｇｌｐ－１／ｇｉｐ雙重促效劑 |
| CA3184723A1 (en) | 2020-07-22 | 2022-01-27 | Patrick J. KNERR | Glp-1 and gip receptor co-agonists |
| JP7581385B2 (ja) | 2020-07-22 | 2024-11-12 | ノヴォ ノルディスク アー／エス | 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬 |
| TW202229323A (zh) | 2020-10-17 | 2022-08-01 | 印度商太陽製藥工業有限公司 | 新型glp-1/gip雙重促效劑 |
| TWI790850B (zh) * | 2020-12-18 | 2023-01-21 | 美商美國禮來大藥廠 | 雙重澱粉素及降鈣素受體促效劑及其用途 |
| KR20230124035A (ko) * | 2020-12-22 | 2023-08-24 | 일라이 릴리 앤드 캄파니 | 치료 펩티드 제제 |
| KR102691149B1 (ko) | 2021-01-20 | 2024-08-05 | 바이킹 테라퓨틱스 인코포레이티드 | 대사 및 간 질환 치료를 위한 조성물 및 방법 |
| EP4294423A1 (en) * | 2021-02-17 | 2023-12-27 | Eli Lilly and Company | Gip/glp1 dual agonist therapeutic methods |
| AR125086A1 (es) * | 2021-03-23 | 2023-06-07 | Lilly Co Eli | Composiciones que contienen análogos de incretina y usos de estas |
| US12215133B2 (en) | 2021-03-25 | 2025-02-04 | Brightgene Bio-Medical Technology Co., Ltd. | GIP and GLP-1 dual receptor agonist, pharmaceutical composition, and use |
| JP2024511107A (ja) * | 2021-03-25 | 2024-03-12 | ブライトジーン バイオ－メディカル テクノロジー カンパニー リミテッド | Ｇｉｐとｇｌｐ－１の二重受容体作動薬、医薬組成物および使用 |
| CN115181173A (zh) * | 2021-04-02 | 2022-10-14 | 深圳市健元医药科技有限公司 | 一种Tirzepatide的制备方法 |
| KR20240004943A (ko) | 2021-05-07 | 2024-01-11 | 일라이 릴리 앤드 캄파니 | 침식성 정제 |
| CN113332416B (zh) * | 2021-05-17 | 2022-02-22 | 宁波大学 | 丙谷二肽在制备治疗非酒精性脂肪肝药物中的应用 |
| CN117866050A (zh) * | 2021-05-28 | 2024-04-12 | 广东众生睿创生物科技有限公司 | 多肽的制备及其应用 |
| CN117440964A (zh) * | 2021-06-01 | 2024-01-23 | 南京知和医药科技有限公司 | 一种glp-1r和gipr双重靶向激动作用的多肽衍生物及其制备方法和用途 |
| CN117794946A (zh) | 2021-06-09 | 2024-03-29 | 斯克利普斯研究所 | 长效双重gip/glp-1肽缀合物及使用方法 |
| WO2023031455A1 (en) | 2021-09-06 | 2023-03-09 | Sanofi Sa | New peptides as potent and selective gip receptor agonists |
| AU2022347024A1 (en) | 2021-09-15 | 2024-05-02 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| CN118234742A (zh) * | 2021-12-01 | 2024-06-21 | 江苏恒瑞医药股份有限公司 | Glp-1和gip受体双重激动剂的药物组合物及其用途 |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| JP2025512980A (ja) * | 2022-04-07 | 2025-04-22 | 広東衆生睿創生物科技有限公司 | 糖尿病、肥満症およびその関連疾患を治療および／または予防するための医薬品の調製における、ポリペプチドの医薬的使用 |
| IL318349A (en) * | 2022-07-13 | 2025-03-01 | Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd | Glp-1/gip dual agonist, preparation method and use thereof |
| CR20250068A (es) | 2022-08-29 | 2025-03-27 | Lilly Co Eli | Composiciones para suministro oral |
| JP2025531200A (ja) * | 2022-09-15 | 2025-09-19 | イーライ リリー アンド カンパニー | Ｇｉｐ及びｇｌｐ－１二重アゴニスト化合物 |
| CN120569401A (zh) * | 2022-11-21 | 2025-08-29 | 伊莱利利公司 | 制备gip/glp1双重激动剂的方法 |
| US20240270821A1 (en) | 2023-01-31 | 2024-08-15 | Eli Lilly And Company | Gip/glp1/gcg tri-receptor agonists and uses thereof |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2024252367A2 (en) | 2023-06-09 | 2024-12-12 | Sun Pharmaceutical Industries Limited | Novel glp-1/gip dual and glp-1/gcg dual receptor agonists |
| WO2025005743A1 (ko) * | 2023-06-30 | 2025-01-02 | 주식회사 휴온스랩 | Glp 유사체를 유효성분으로 포함하는 비만 예방 또는 치료용 약학적 조성물 |
| WO2025087353A1 (zh) * | 2023-10-26 | 2025-05-01 | 齐鲁制药有限公司 | 具有多重激动活性的多肽及其应用 |
| WO2025108381A1 (zh) * | 2023-11-22 | 2025-05-30 | 杭州中美华东制药有限公司 | Glp-1r/gipr双靶点激动剂在制备动物药中的用途 |
| KR20250083391A (ko) | 2023-11-30 | 2025-06-10 | 노보 노르디스크 에이/에스 | Glp-1, gip, 및 아밀린 수용체의 삼중작용제 |
| CN117624333A (zh) * | 2023-12-05 | 2024-03-01 | 江苏师范大学 | 一类GLP-1受体、glucagon受体和GIP受体三激动多肽化合物及其应用 |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025140581A1 (zh) * | 2023-12-29 | 2025-07-03 | 杭州中美华东制药有限公司 | Glp-1/gip双激动剂的固相合成方法 |
| WO2025147633A2 (en) * | 2024-01-05 | 2025-07-10 | Indiana University Research And Technology Corporation | Gip/glp-1 co-agonists and their associated prodrugs |
| WO2025149039A1 (zh) * | 2024-01-12 | 2025-07-17 | 杭州中美华东制药有限公司 | 长效glp-1/gip双激动剂的药物组合物 |
| WO2025149041A1 (zh) * | 2024-01-12 | 2025-07-17 | 杭州中美华东制药有限公司 | 长效glp-1/gip双激动剂的鼻腔递送药物组合物 |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012138941A1 (en) * | 2011-04-05 | 2012-10-11 | Longevity Biotech, Inc. | Compositions comprising glucagon analogs and methods of making and using the same |
| EA028665B1 (ru) | 2012-05-03 | 2017-12-29 | Зилэнд Фарма А/С | Соединения - двойные агонисты gip-glp-1 и способы |
| BR112014031671A2 (pt) * | 2012-06-21 | 2018-08-07 | Hoffmann La Roche | análogos de glucagon exibindo atividade de receptor gip |
| AR092873A1 (es) * | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
| JP2016521253A (ja) * | 2013-03-15 | 2016-07-21 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | 持続性作用を有するプロドラッグ |
| MX369259B (es) | 2013-05-02 | 2019-11-04 | Novo Nordisk As | Dosificacion oral de compuestos peptido similar al glaucon-1 (glp-1). |
| WO2015067715A2 (en) * | 2013-11-06 | 2015-05-14 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| JP6657230B2 (ja) * | 2014-09-24 | 2020-03-04 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | インクレチン−インスリンコンジュゲート |
| JOP20200119A1 (ar) * | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| WO2016198604A1 (en) * | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as dual glp-1 /glucagon receptor agonists |
| US20170112897A1 (en) * | 2015-10-23 | 2017-04-27 | Cedars-Sinai Medical Center | Methods for treating brain insulin resistance |
| TWI622596B (zh) * | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| US10221965B2 (en) * | 2015-12-22 | 2019-03-05 | Engineered Controls International, Llc | Noise reducing filler valve |
| TWI767095B (zh) * | 2017-12-21 | 2022-06-11 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| MA53382A (fr) * | 2018-07-23 | 2021-06-02 | Lilly Co Eli | Composés co-agonistes de gip/glp1 |
-
2019
- 2019-07-22 MA MA053382A patent/MA53382A/fr unknown
- 2019-07-22 TW TW110125507A patent/TWI810606B/zh active
- 2019-07-22 KR KR1020247011528A patent/KR20240051304A/ko active Pending
- 2019-07-22 UA UAA202100210A patent/UA129537C2/uk unknown
- 2019-07-22 TW TW108125887A patent/TWI735917B/zh active
- 2019-07-22 MX MX2021000793A patent/MX2021000793A/es unknown
- 2019-07-22 KR KR1020217002322A patent/KR102351313B1/ko active Active
- 2019-07-22 EP EP25155884.7A patent/EP4549454A3/en active Pending
- 2019-07-22 TW TW113140754A patent/TW202523681A/zh unknown
- 2019-07-22 CN CN202411661780.4A patent/CN119504975A/zh active Pending
- 2019-07-22 US US16/518,468 patent/US11084861B2/en active Active
- 2019-07-22 CN CN201980049095.7A patent/CN112469731B/zh active Active
- 2019-07-22 CA CA3107345A patent/CA3107345A1/en active Pending
- 2019-07-22 SG SG11202100128UA patent/SG11202100128UA/en unknown
- 2019-07-22 MY MYPI2021000294A patent/MY197569A/en unknown
- 2019-07-22 WO PCT/US2019/042822 patent/WO2020023386A1/en not_active Ceased
- 2019-07-22 CR CR20210040A patent/CR20210040A/es unknown
- 2019-07-22 KR KR1020217007140A patent/KR20210031533A/ko not_active Ceased
- 2019-07-22 EP EP19753218.7A patent/EP3827015A1/en active Pending
- 2019-07-22 JP JP2020545276A patent/JP6920559B2/ja active Active
- 2019-07-22 CA CA3178366A patent/CA3178366A1/en active Pending
- 2019-07-22 JO JOP/2021/0016A patent/JOP20210016A1/ar unknown
- 2019-07-22 TW TW112115808A patent/TWI863239B/zh active
- 2019-07-22 AU AU2019311000A patent/AU2019311000B2/en active Active
- 2019-07-22 BR BR112020026671-0A patent/BR112020026671A2/pt unknown
- 2019-07-22 PE PE2021000081A patent/PE20211637A1/es unknown
-
2020
- 2020-12-29 IL IL279827A patent/IL279827A/en unknown
-
2021
- 2021-01-13 ZA ZA2021/00235A patent/ZA202100235B/en unknown
- 2021-01-19 CO CONC2021/0000453A patent/CO2021000453A2/es unknown
- 2021-01-20 DO DO2021000016A patent/DOP2021000016A/es unknown
- 2021-01-20 PH PH12021550154A patent/PH12021550154A1/en unknown
- 2021-01-20 CL CL2021000158A patent/CL2021000158A1/es unknown
- 2021-01-21 SA SA521421080A patent/SA521421080B1/ar unknown
- 2021-01-22 EC ECSENADI20214913A patent/ECSP21004913A/es unknown
- 2021-07-02 US US17/366,998 patent/US12252524B2/en active Active
- 2021-07-26 JP JP2021121693A patent/JP7626530B2/ja active Active
- 2021-08-16 ZA ZA2021/05821A patent/ZA202105821B/en unknown
- 2021-09-01 ZA ZA2021/06369A patent/ZA202106369B/en unknown
-
2023
- 2023-05-02 AU AU2023202709A patent/AU2023202709A1/en not_active Abandoned
- 2023-09-08 JP JP2023145813A patent/JP2023171775A/ja active Pending
-
2024
- 2024-10-18 US US18/919,541 patent/US20250051415A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA129537C2 (uk) | Сполука-коагоніст gip/glp1 | |
| UA129947C2 (uk) | Спосіб застосування коагоніста gip/glp1 при діабеті | |
| UA126656C2 (uk) | Біспецифічна конструкція антитіла до psma і cd3, яке залучають t-клітини | |
| UA121662C2 (uk) | Химерний інсектицидний білок, інгібіторний відносно лускокрилих шкідників | |
| UA126563C2 (uk) | Химерний нейротоксин | |
| UA116217C2 (uk) | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону | |
| UA121093C2 (uk) | Конструкція, яка містить токсиген, що кодує пестицидний білок, і спосіб її застосування для знищення напівтвердокрилих шкідників | |
| UA126549C2 (uk) | Композиція і спосіб для з'єднання позаклітинних доменів типу і та типу іі як гетерологічного химерного білка | |
| UA129203C2 (uk) | Сполуки-агоністи gipr | |
| UA126281C2 (uk) | Антитіла проти сигнал-регуляторного білка альфа та способи їх застосування | |
| UA128472C2 (uk) | B7-h4 антитіла і методи їх використання | |
| UA124734C2 (uk) | Антитіло проти с5 і його застосування | |
| UA126441C2 (uk) | Химерні антигенні рецептори, націлені на bcma, та способи їх застосування | |
| UA127450C2 (uk) | Рекомбінантний поліпептид, що зв'язується з cd123 | |
| UA123763C2 (uk) | Фармацевтична композиція для контролю або лікування захворювання або порушення, пов’язаного з fgf19 | |
| AU2016244333A1 (en) | DLL3 modulators and methods of use | |
| UA124293C2 (uk) | Рослина, яка має біологічну активність гаплоїдного індуктора, і спосіб її застосування | |
| HU230679B1 (en) | Mammalian interleukin-12 p40 and interleukin b30, combinations thereof, antibodies, uses in pharmaceutical compositions | |
| HU230629B1 (hu) | Emlős citokin: interleukin-B30 és rokon molekulák | |
| UA123432C2 (uk) | Димер та спосіб його застосування для лікування метаболічних розладів | |
| CN110087671A (zh) | 具有优化的活性比率的fgf21化合物/glp-1r激动剂组合 | |
| UA122671C2 (uk) | Композиція, що містить рекомбінантні клітини bacillus і фунгіцид | |
| UA114173C2 (uk) | Пристрій та спосіб для проведення проточної цитометрії | |
| UA119226C2 (uk) | Антитіло, яке специфічно зв'язується з axl, та його застосування як продукту для адресної доставки при лікуванні раку | |
| UA128281C2 (uk) | Одержання маїсу, стійкого до північної плямистості листя |