UA126284C2 - Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування - Google Patents

Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування Download PDF

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Publication number
UA126284C2
UA126284C2 UAA201908753A UAA201908753A UA126284C2 UA 126284 C2 UA126284 C2 UA 126284C2 UA A201908753 A UAA201908753 A UA A201908753A UA A201908753 A UAA201908753 A UA A201908753A UA 126284 C2 UA126284 C2 UA 126284C2
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amino acid
acid sequence
shi
zeg
rgo
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UAA201908753A
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Ukrainian (uk)
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Девід Джозе Саймон Лейн
Дэвид Джозе Саймон Лейн
Метью Полард
Ентоні Джерард Дойл
Энтони Джерард Дойл
Лінн Дороті Поултон
Линн Дороти Поултон
Адам Уільям Кларк
Адам Уильям Кларк
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Сефалон, Інк.
Сефалон, Инк.
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Publication of UA126284C2 publication Critical patent/UA126284C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869Interleukin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/54Interleukins [IL]
    • G01N2333/5443IL-15

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
UAA201908753A 2016-12-21 2017-12-21 Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування UA126284C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662437143P 2016-12-21 2016-12-21
PCT/US2017/067917 WO2018119246A1 (en) 2016-12-21 2017-12-21 Antibodies that specifically bind to human il-15 and uses thereof

Publications (1)

Publication Number Publication Date
UA126284C2 true UA126284C2 (uk) 2022-09-14

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UAA201908753A UA126284C2 (uk) 2016-12-21 2017-12-21 Антитіла, які специфічно зв'язуються з людським il-15, та їхнє застосування

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EP (2) EP3558369B1 (cg-RX-API-DMAC7.html)
JP (2) JP7155126B2 (cg-RX-API-DMAC7.html)
KR (2) KR20190097094A (cg-RX-API-DMAC7.html)
CN (1) CN110234349B (cg-RX-API-DMAC7.html)
AR (1) AR110414A1 (cg-RX-API-DMAC7.html)
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HU (1) HUE071878T2 (cg-RX-API-DMAC7.html)
IL (1) IL267113B2 (cg-RX-API-DMAC7.html)
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DK3558369T3 (da) 2025-05-19
BR112019012570A2 (pt) 2019-11-26
CN110234349B (zh) 2024-03-22
PT3558369T (pt) 2025-05-06
US20200270339A1 (en) 2020-08-27
SI3558369T1 (sl) 2025-06-30
MA47130B1 (fr) 2025-05-30
AU2017382850A1 (en) 2019-07-04
CL2019001729A1 (es) 2019-09-13
JP2020501583A (ja) 2020-01-23
US12410247B2 (en) 2025-09-09
MX2019007357A (es) 2019-09-05
PL3558369T3 (pl) 2025-06-23
JP2022176324A (ja) 2022-11-25
KR20190097094A (ko) 2019-08-20
RS66900B1 (sr) 2025-07-31
AR110414A1 (es) 2019-03-27
LT3558369T (lt) 2025-07-25
MD3558369T2 (ro) 2025-08-31
KR20230135691A (ko) 2023-09-25
PH12019501453A1 (en) 2020-06-15
CA3046387A1 (en) 2018-06-28
JP7155126B2 (ja) 2022-10-18
WO2018119246A1 (en) 2018-06-28
MX2023014081A (es) 2023-12-06
IL267113B1 (en) 2024-05-01
EP4585261A3 (en) 2025-08-13
IL267113B2 (en) 2024-09-01
KR102706743B1 (ko) 2024-09-19
IL267113A (en) 2019-08-29
EA201991514A1 (ru) 2019-12-30
AU2017382850B2 (en) 2024-11-21
FI3558369T3 (fi) 2025-05-02
ES3026508T3 (en) 2025-06-11
EP4585261A2 (en) 2025-07-16
ZA201903848B (en) 2023-02-22
PE20191497A1 (es) 2019-10-21
AU2025201185A1 (en) 2025-03-13
HUE071878T2 (hu) 2025-09-28
BR112019012570A8 (pt) 2023-01-24
EP3558369A4 (en) 2020-09-09
MA47130A (fr) 2019-10-30
US11267883B2 (en) 2022-03-08
EP3558369A1 (en) 2019-10-30
US20220127352A1 (en) 2022-04-28
HRP20250482T1 (hr) 2025-06-20
EP3558369B1 (en) 2025-03-26
CN110234349A (zh) 2019-09-13

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