UA109172C2 - Поліморфна форма 2-(5-бром-4-(4-циклопропілнафталін-1-іл)-4h-1,2,4-триазол-3-ілтіо)оцтової кислоти (варіанти) та її застосування - Google Patents
Поліморфна форма 2-(5-бром-4-(4-циклопропілнафталін-1-іл)-4h-1,2,4-триазол-3-ілтіо)оцтової кислоти (варіанти) та її застосування Download PDFInfo
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- UA109172C2 UA109172C2 UAA201309551A UAA201309551A UA109172C2 UA 109172 C2 UA109172 C2 UA 109172C2 UA A201309551 A UAA201309551 A UA A201309551A UA A201309551 A UAA201309551 A UA A201309551A UA 109172 C2 UA109172 C2 UA 109172C2
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- polymorphic form
- bromo
- acetic acid
- crystalline
- cyclopropylnaphthalen
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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- Animal Behavior & Ethology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061428660P | 2010-12-30 | 2010-12-30 | |
| PCT/US2011/067657 WO2012092395A2 (en) | 2010-12-30 | 2011-12-28 | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA109172C2 true UA109172C2 (xx) | 2015-07-27 |
Family
ID=46381300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| UAA201309551A UA109172C2 (xx) | 2010-12-30 | 2011-12-28 | Поліморфна форма 2-(5-бром-4-(4-циклопропілнафталін-1-іл)-4h-1,2,4-триазол-3-ілтіо)оцтової кислоти (варіанти) та її застосування |
Country Status (29)
| Country | Link |
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| US (6) | US8546436B2 (ru) |
| EP (1) | EP2658846B1 (ru) |
| JP (2) | JP5781627B2 (ru) |
| KR (1) | KR101541629B1 (ru) |
| CN (1) | CN103298796B (ru) |
| AR (1) | AR084639A1 (ru) |
| AU (1) | AU2011352129B2 (ru) |
| BR (1) | BR112013016982A2 (ru) |
| CA (1) | CA2817249C (ru) |
| CY (1) | CY1118621T1 (ru) |
| DK (1) | DK2658846T3 (ru) |
| EA (1) | EA022301B1 (ru) |
| ES (1) | ES2614914T3 (ru) |
| HR (1) | HRP20170187T1 (ru) |
| HU (1) | HUE031766T2 (ru) |
| IL (1) | IL226367A (ru) |
| LT (1) | LT2658846T (ru) |
| MX (1) | MX2013007505A (ru) |
| MY (1) | MY172534A (ru) |
| NZ (1) | NZ610104A (ru) |
| PL (1) | PL2658846T3 (ru) |
| PT (1) | PT2658846T (ru) |
| RS (1) | RS55667B1 (ru) |
| SG (1) | SG190902A1 (ru) |
| SI (1) | SI2658846T1 (ru) |
| TW (1) | TWI452037B (ru) |
| UA (1) | UA109172C2 (ru) |
| WO (1) | WO2012092395A2 (ru) |
| ZA (1) | ZA201303253B (ru) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2563207T3 (es) | 2010-01-08 | 2016-03-11 | Ardea Biosciences, Inc. | Formas polimorfas, cristalinas y en mesofases de 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4H-1,2,4-triazol-3-iltio)acetato de sodio y sus usos |
| WO2011126852A2 (en) | 2010-03-30 | 2011-10-13 | Ardea Biosciences, Inc. | Treatment of gout |
| LT2582683T (lt) | 2010-06-15 | 2018-06-11 | Ardea Biosciences, Inc. | Podagros ir hiperuricemijos gydymas |
| HUE031766T2 (en) | 2010-12-30 | 2017-07-28 | Ardea Biosciences Inc | Polymorphs of 2- (5-Bromo-4- (4-cyclopropylnaphthalen-1-yl) -4H-1,2,4-triazol-3-ylthio) acetic acid and uses thereof |
| AR091651A1 (es) * | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| JP6026914B2 (ja) * | 2013-02-12 | 2016-11-16 | ルネサスエレクトロニクス株式会社 | 半導体装置の製造方法 |
| CN104447589B (zh) * | 2013-11-20 | 2017-01-11 | 广东东阳光药业有限公司 | 一种尿酸调节剂的制备方法及其中间体 |
| CN103588716A (zh) * | 2013-11-22 | 2014-02-19 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的新晶型及其制备方法 |
| JP6470761B2 (ja) * | 2013-11-22 | 2019-02-13 | クリスタル ファーマテック カンパニー、リミテッドＣｒｙｓｔａｌ Ｐｈａｒｍａｔｅｃｈ Ｃｏ．， Ｌｔｄ． | レシヌラドおよびそのナトリウム塩の結晶形態 |
| CN103613552A (zh) * | 2013-12-02 | 2014-03-05 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法 |
| CN103626710A (zh) * | 2013-12-20 | 2014-03-12 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的共晶及其制备方法 |
| US9969701B2 (en) | 2013-12-20 | 2018-05-15 | Crystal Pharmatech Co., Ltd. | Salts and co-crystals of lesinurad |
| CN103755651A (zh) * | 2013-12-23 | 2014-04-30 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法 |
| CN104557748A (zh) * | 2014-01-25 | 2015-04-29 | 广东东阳光药业有限公司 | 硫代-1,2,4-三唑衍生物的新的固体形态 |
| CN105622531A (zh) | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| WO2016203436A1 (en) * | 2015-06-19 | 2016-12-22 | Dr. Reddy's Laboratories Limited | Amorphous and amorphous solid dispersion of lesinurad and their preparation |
| EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
| CN105017169A (zh) * | 2015-06-30 | 2015-11-04 | 安徽万邦医药科技有限公司 | 一种4-（4-环丙基萘-1-基）-5-硫代-[1,2,4]三唑烷-3-酮的制备方法及其中间体（4-环丙基萘-1-基）-氨基甲酸乙酯 |
| WO2017036884A1 (en) | 2015-08-28 | 2017-03-09 | Sandoz Ag | A lesinurad, free form / lesinurad ethyl ester co-crystal |
| CN107176930B (zh) * | 2016-03-11 | 2020-12-01 | 广东赛烽医药科技有限公司 | 2-[5-溴-4-(4-氟代环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基]乙酸化合物及其应用 |
| CN107266377A (zh) * | 2016-04-08 | 2017-10-20 | 浙江京新药业股份有限公司 | 一种urat1抑制剂的轴手性对映体的多晶型 |
| CN107298657A (zh) * | 2016-04-15 | 2017-10-27 | 浙江京新药业股份有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型ii |
| CN107298658A (zh) * | 2016-04-15 | 2017-10-27 | 浙江京新药业股份有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型v |
| CN107298659A (zh) * | 2016-04-15 | 2017-10-27 | 浙江京新药业股份有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型iv |
| CN107298660A (zh) * | 2016-04-15 | 2017-10-27 | 浙江京新药业股份有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型iii |
| CN107337649B (zh) * | 2016-04-29 | 2020-10-16 | 四川科伦药物研究院有限公司 | 一种乙酸钠水合物无定型及其制备方法和用途 |
| CA3030392C (en) | 2016-07-29 | 2023-12-12 | Toray Industries, Inc. | Solid preparation having improved light stability |
| EP3281941B1 (en) | 2016-08-11 | 2019-07-24 | Zentiva K.S. | Process for preparing 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid |
| CA3042738A1 (en) * | 2016-11-10 | 2018-05-17 | Apotex Inc. | Novel crystalline forms of lesinurad |
| EP3372592A1 (en) | 2017-03-07 | 2018-09-12 | Zentiva, k.s. | Solid forms of lesinurad amine salts |
| CN106905250A (zh) * | 2017-03-07 | 2017-06-30 | 江苏艾立康药业股份有限公司 | 一种雷西纳德的新晶型 |
| EP3315494A1 (en) | 2017-04-19 | 2018-05-02 | Química Sintética, S.A. | Amorphous form of lesinurad and processes for its preparation |
| WO2018211532A1 (en) * | 2017-05-18 | 2018-11-22 | Msn Laboratories Private Limited, R&D Center | Novel solid state forms of 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-yl)thio)acetic acid and its process for preparation thereof |
| WO2019001325A1 (zh) * | 2017-06-28 | 2019-01-03 | 苏州科睿思制药有限公司 | 雷西纳得的晶型xv及其制备方法 |
| EP3498697A1 (en) | 2017-12-12 | 2019-06-19 | Química Sintética, S.A. | Novel salts and polymorphs of lesinurad |
| CN111527073B (zh) * | 2017-12-15 | 2022-03-15 | 南京明德新药研发有限公司 | 一种4-(萘-1-基)-4h-1,2,4-三唑类类化合物的晶型、盐型及其制备方法 |
| CN109970667A (zh) * | 2017-12-27 | 2019-07-05 | 徐州万邦金桥制药有限公司 | 一种雷西纳德的精制方法 |
| CN111153862B (zh) * | 2020-01-19 | 2021-07-06 | 北京鑫开元医药科技有限公司海南分公司 | 一种雷西纳德的精制方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004123642A (ja) | 2002-10-04 | 2004-04-22 | Shimizu Pharmaceutical Co Ltd | 電解質組成物 |
| US20050100637A1 (en) | 2003-11-12 | 2005-05-12 | Robert Murray | Carbohydrate and electrolyte replacement composition |
| ATE540677T1 (de) | 2004-08-25 | 2012-01-15 | Ardea Biosciences Inc | S-triazolyl alpha mercaptoacetanilide als hemmer der reversen transkriptase von hiv |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| KR101411806B1 (ko) | 2007-11-27 | 2014-06-24 | 아디아 바이오사이언스즈 인크. | 신규한 화합물 및 조성물과 사용 방법 |
| AU2009289647C1 (en) * | 2008-09-04 | 2013-03-21 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8173690B2 (en) | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| ES2563207T3 (es) | 2010-01-08 | 2016-03-11 | Ardea Biosciences, Inc. | Formas polimorfas, cristalinas y en mesofases de 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4H-1,2,4-triazol-3-iltio)acetato de sodio y sus usos |
| HUE031766T2 (en) | 2010-12-30 | 2017-07-28 | Ardea Biosciences Inc | Polymorphs of 2- (5-Bromo-4- (4-cyclopropylnaphthalen-1-yl) -4H-1,2,4-triazol-3-ylthio) acetic acid and uses thereof |
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2011
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- 2011-12-28 DK DK11853861.0T patent/DK2658846T3/en active
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- 2011-12-28 MX MX2013007505A patent/MX2013007505A/es active IP Right Grant
- 2011-12-28 SI SI201131098A patent/SI2658846T1/sl unknown
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- 2011-12-28 EP EP11853861.0A patent/EP2658846B1/en active Active
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- 2011-12-28 EA EA201370150A patent/EA022301B1/ru not_active IP Right Cessation
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- 2011-12-28 AR ARP110104990 patent/AR084639A1/es unknown
- 2011-12-28 US US13/339,283 patent/US8546436B2/en active Active
- 2011-12-28 WO PCT/US2011/067657 patent/WO2012092395A2/en active Application Filing
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- 2011-12-28 BR BR112013016982A patent/BR112013016982A2/pt not_active IP Right Cessation
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2014
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