TWI812047B - 用於多工偵測與眼科病況有關的對偶基因之方法 - Google Patents

用於多工偵測與眼科病況有關的對偶基因之方法 Download PDF

Info

Publication number
TWI812047B
TWI812047B TW111108208A TW111108208A TWI812047B TW I812047 B TWI812047 B TW I812047B TW 111108208 A TW111108208 A TW 111108208A TW 111108208 A TW111108208 A TW 111108208A TW I812047 B TWI812047 B TW I812047B
Authority
TW
Taiwan
Prior art keywords
seq
cdata
sequence
detection
months
Prior art date
Application number
TW111108208A
Other languages
English (en)
Chinese (zh)
Other versions
TW202223098A (zh
Inventor
蕾 趙
趙善英
李津
Original Assignee
美商阿韋利諾美國實驗有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商阿韋利諾美國實驗有限公司 filed Critical 美商阿韋利諾美國實驗有限公司
Publication of TW202223098A publication Critical patent/TW202223098A/zh
Application granted granted Critical
Publication of TWI812047B publication Critical patent/TWI812047B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Eye Examination Apparatus (AREA)
TW111108208A 2013-11-15 2014-11-17 用於多工偵測與眼科病況有關的對偶基因之方法 TWI812047B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361905051P 2013-11-15 2013-11-15
US61/905,051 2013-11-15

Publications (2)

Publication Number Publication Date
TW202223098A TW202223098A (zh) 2022-06-16
TWI812047B true TWI812047B (zh) 2023-08-11

Family

ID=53058284

Family Applications (3)

Application Number Title Priority Date Filing Date
TW111108208A TWI812047B (zh) 2013-11-15 2014-11-17 用於多工偵測與眼科病況有關的對偶基因之方法
TW103139861A TWI755350B (zh) 2013-11-15 2014-11-17 用於多工偵測與眼科病況有關的對偶基因之方法
TW112128794A TW202346604A (zh) 2013-11-15 2014-11-17 用於多工偵測與眼科病況有關的對偶基因之方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW103139861A TWI755350B (zh) 2013-11-15 2014-11-17 用於多工偵測與眼科病況有關的對偶基因之方法
TW112128794A TW202346604A (zh) 2013-11-15 2014-11-17 用於多工偵測與眼科病況有關的對偶基因之方法

Country Status (9)

Country Link
US (2) US11525160B2 (enExample)
EP (2) EP3068908B1 (enExample)
JP (2) JP6672147B2 (enExample)
KR (3) KR20230007558A (enExample)
CN (2) CN113604551A (enExample)
AU (2) AU2014348279B2 (enExample)
SG (1) SG10201804076RA (enExample)
TW (3) TWI812047B (enExample)
WO (1) WO2015073978A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101251538B1 (ko) 2009-04-17 2013-04-08 (주)아벨리노 아벨리노 각막이상증 진단용 프라이머
KR101125212B1 (ko) 2010-10-01 2012-03-21 (주)아벨리노 아벨리노 각막이상증 진단용 시스템
US10889850B2 (en) 2013-03-15 2021-01-12 Avellino Lab Usa, Inc. Methods for improved isolation of genomic DNA templates for allele detection
KR102240332B1 (ko) * 2013-03-15 2021-04-14 아벨리노 랩 유에스에이, 인크. 대립유전자 검출을 위한 게놈 dna 주형의 개선된 단리 방법
KR20230007558A (ko) 2013-11-15 2023-01-12 아벨리노 랩 유에스에이, 인크. 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법
WO2017083852A1 (en) 2015-11-13 2017-05-18 MOORE, Tara Methods for the treatment of corneal dystrophies
CN106480200A (zh) * 2016-10-25 2017-03-08 北京亿昊基因技术有限公司 一种快速高效的与角膜营养不良相关基因突变位点的检测方法
CN108085375B (zh) * 2016-11-07 2020-10-16 北京华大通瀛科技有限公司 检测角膜营养不良基因多态性位点的基因型的方法及其试剂盒
KR102701188B1 (ko) 2017-04-10 2024-08-30 아벨리노 랩 유에스에이, 인크. 각막 이상증과 관련된 대립유전자의 다중 검출을 위한 방법
CN107523635A (zh) * 2017-10-09 2017-12-29 湖南大地同年生物科技有限公司 一种tgfbi基因多态性快速检测试剂盒及其检测方法
CN107858420A (zh) * 2017-11-17 2018-03-30 奥斯汀生命科学技术公司 用于诊断人TGFβI基因124位点变异引起角膜营养不良的引物探针及检测方法
KR200487603Y1 (ko) 2018-02-01 2018-12-05 백병하 선풍기용 공기정화기구
CN108796062A (zh) * 2018-06-06 2018-11-13 无锡正则精准医学检验有限公司 一种检测tgfbi基因多态性的试剂盒
CN109406469B (zh) * 2018-10-24 2021-04-09 中国医科大学 基于蛋白结合诱导dna双链变构的检测色氨酸的方法
KR102241836B1 (ko) * 2019-06-14 2021-04-21 솔젠트 (주) 듀얼 체크 올리고를 이용한 유전자 다형성 검사 방법
CN113088569A (zh) * 2020-01-09 2021-07-09 北京中因科技有限公司 一种多重荧光定量pcr试剂盒
CN118240929A (zh) * 2020-07-28 2024-06-25 首都医科大学附属北京同仁医院 一种检测tgfbi基因突变的试剂盒
CN115820837A (zh) * 2022-11-04 2023-03-21 温州谱希基因科技有限公司 一种角膜营养不良的pcr检测试剂盒及其应用
CN118222692A (zh) * 2022-12-21 2024-06-21 北京中因医学检验实验室有限公司 一种人tgfbi基因分型检测的引物探针组合物及其应用
CN117417997B (zh) * 2023-10-26 2025-07-29 上海谱希和光基因科技有限公司 一种诊断圆锥角膜的基因组生物标志物组合
TWI879353B (zh) * 2023-12-27 2025-04-01 台南應用科技大學 兩對交叉引子的多目標設計方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374850A (zh) * 2006-01-18 2009-02-25 株式会社美迪基尼斯 用于角膜营养不良诊断的dna芯片
CN102459593A (zh) * 2009-04-17 2012-05-16 阿维利诺株式会社 用于诊断阿维利诺角膜营养不良的引物

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
WO1997046714A1 (en) 1996-06-04 1997-12-11 University Of Utah Research Foundation Monitoring hybridization during pcr
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6018713A (en) 1997-04-09 2000-01-25 Coli; Robert D. Integrated system and method for ordering and cumulative results reporting of medical tests
JP3380744B2 (ja) 1998-05-19 2003-02-24 株式会社日立製作所 センサおよびこれを利用した測定装置
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6171112B1 (en) 1998-09-18 2001-01-09 Wyngate, Inc. Methods and apparatus for authenticating informed consent
AU4135600A (en) 1999-03-29 2000-10-16 Genset Prostate cancer associated human fibronectin gene and biallelic markers
US6270970B1 (en) 1999-05-14 2001-08-07 Promega Corporation Mixed-bed solid phase and its use in the isolation of nucleic acids
ATE381626T1 (de) 2000-04-13 2008-01-15 Univ Georgetown Genetische diagnose zur feststellung von qt- verlängerungen als unerwünschte reaktion auf arzneimittel
US8438042B2 (en) 2002-04-25 2013-05-07 National Biomedical Research Foundation Instruments and methods for obtaining informed consent to genetic tests
CA2451919A1 (en) 2001-08-09 2003-02-20 Curagen Corporation Nucleic acids, polypeptides, single nucleotide polymorphisms and methods of use thereof
WO2003046526A1 (de) 2001-11-28 2003-06-05 Graffinity Pharmaceuticals Ag Spr-sensorflächenträger
US6943417B2 (en) 2003-05-01 2005-09-13 Clemson University DNA-based memory device and method of reading and writing same
US20050019757A1 (en) 2003-06-12 2005-01-27 Stolarchuk Danylo J. Contaminant detection apparatus
WO2005015198A1 (ja) 2003-08-06 2005-02-17 Nippon Telegraph And Telephone Corporation 多孔質材料を用いた分子の検出方法ならびに該多孔質材料及び該多孔質材料の製造方法
CA2544129A1 (en) 2003-10-22 2005-05-06 The Regents Of The University Of California Methods for preparing and functionalizing nanoparticles
EP1682675A2 (en) 2003-10-28 2006-07-26 Bayer HealthCare AG Methods and compositions for the response prediction of malignant neoplasia to treatment
EP1541528A1 (en) 2003-12-08 2005-06-15 Institut Jozef Stefan Quasi-one-dimensional polymers based on the metal-chalcogen-halogen system
US20060057604A1 (en) 2004-03-15 2006-03-16 Thinkfar Nanotechnology Corporation Method for electrically detecting oligo-nucleotides with nano-particles
NZ551786A (en) 2004-05-19 2011-03-31 Vp Holding Llc Optical sensor with layered plasmon structure for enhanced detection of chemical groups by surface enhanced raman scattering
US7713849B2 (en) 2004-08-20 2010-05-11 Illuminex Corporation Metallic nanowire arrays and methods for making and using same
US7332329B2 (en) 2004-09-24 2008-02-19 Wisconsin Alumni Research Foundation Versatile substrate for SPR detection
US20080267946A1 (en) 2005-03-08 2008-10-30 Medigenes Co., Ltd Pharmaceutical Composition for Treating Avellino Cornea Dystrophy Comprising an Antibody Against Tgf-Beta
JP2006250668A (ja) 2005-03-10 2006-09-21 Tatsuro Endo 非標識バイオチップ
EP1715326A1 (en) 2005-04-22 2006-10-25 Universität Heidelberg Sensor chip with connected non-metallic particles comprising a metallic coating
US20070154903A1 (en) 2005-06-23 2007-07-05 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
KR20070076532A (ko) * 2006-01-18 2007-07-24 메디제네스(주) 각막이영양증 진단용 ｄｎａ 칩
WO2007109702A2 (en) 2006-03-21 2007-09-27 Washington State University Research Foundation Genetic polymorphisms in the corticotropin-releasing hormone(crh) gene as markers for improving beef marbling score and/or subcutaneous fat depth
EP1932922A1 (de) 2006-12-13 2008-06-18 Desitin Arzneimittel GmbH Schnelltest zum Nachweis von DNA-Sequenzen
EP2115123A4 (en) * 2007-01-16 2010-07-07 Applied Biosystems Llc SELECTIVE LYSE OF SPERM CELLS
US7898658B2 (en) 2007-01-23 2011-03-01 The Regents Of The University Of California Platform for chemical and biological sensing by surface-enhanced Raman spectroscopy
KR100891096B1 (ko) 2007-02-13 2009-03-31 삼성전자주식회사 올리고머 프로브 어레이 및 이의 제조 방법
JP5222599B2 (ja) 2007-07-20 2013-06-26 株式会社日立ハイテクノロジーズ 核酸分析デバイス及びそれを用いた核酸分析装置
CN101144812B (zh) 2007-10-17 2012-02-22 中国科学院光电技术研究所 一种局域表面等离子体生化传感器的制作方法
US20120231537A1 (en) 2008-04-30 2012-09-13 Gradalis, Inc. Highly Pure Plasmid DNA Preparations
KR101041606B1 (ko) * 2009-08-18 2011-06-15 (주)아벨리노 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩 및 이의 제조방법
US8865402B2 (en) 2009-08-26 2014-10-21 Clemson University Research Foundation Nanostructured substrates for surface enhanced raman spectroscopy (SERS) and detection of biological and chemical analytes by electrical double layer (EDL) capacitance
KR20110037379A (ko) * 2009-10-06 2011-04-13 주식회사 크라운진 실시간 중합효소 연쇄반응과 고해상도 융해 분석을 이용한 아벨리노 각막이상증 검사 방법 및 이를 위한 검사 키트
KR101125212B1 (ko) * 2010-10-01 2012-03-21 (주)아벨리노 아벨리노 각막이상증 진단용 시스템
KR20230007558A (ko) 2013-11-15 2023-01-12 아벨리노 랩 유에스에이, 인크. 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법
KR20250068794A (ko) 2013-12-12 2025-05-16 더 브로드 인스티튜트, 인코퍼레이티드 게놈 편집을 위한 ｃｒｉｓｐｒ-ｃａｓ 시스템 및 조성물의 전달, 용도 및 치료적 응용

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374850A (zh) * 2006-01-18 2009-02-25 株式会社美迪基尼斯 用于角膜营养不良诊断的dna芯片
CN102459593A (zh) * 2009-04-17 2012-05-16 阿维利诺株式会社 用于诊断阿维利诺角膜营养不良的引物

Also Published As

Publication number Publication date
KR102483783B1 (ko) 2022-12-30
TW201610167A (zh) 2016-03-16
JP7077289B2 (ja) 2022-05-30
US20160319357A1 (en) 2016-11-03
TW202223098A (zh) 2022-06-16
AU2014348279A1 (en) 2016-06-09
CN105899681B (zh) 2021-06-22
US11525160B2 (en) 2022-12-13
KR20230007558A (ko) 2023-01-12
KR20210099204A (ko) 2021-08-11
AU2014348279B2 (en) 2021-02-18
TW202346604A (zh) 2023-12-01
KR20160079117A (ko) 2016-07-05
AU2021202884A1 (en) 2021-06-03
WO2015073978A9 (en) 2016-06-23
EP3068908A2 (en) 2016-09-21
WO2015073978A2 (en) 2015-05-21
JP2017501685A (ja) 2017-01-19
JP2020039339A (ja) 2020-03-19
AU2021202884B2 (en) 2023-04-06
CN105899681A (zh) 2016-08-24
EP3872192A1 (en) 2021-09-01
TWI755350B (zh) 2022-02-21
EP3068908A4 (en) 2017-08-23
US20230348984A1 (en) 2023-11-02
AU2014348279A9 (en) 2016-07-28
SG10201804076RA (en) 2018-06-28
JP6672147B2 (ja) 2020-03-25
WO2015073978A3 (en) 2015-07-16
EP3068908B1 (en) 2021-01-06
CN113604551A (zh) 2021-11-05
KR102293785B1 (ko) 2021-08-26

Similar Documents

Publication Publication Date Title
US20230348984A1 (en) Methods for multiplex detection of alleles associated with ophthalmic conditions
KR102701188B1 (ko) 각막 이상증과 관련된 대립유전자의 다중 검출을 위한 방법
EP3486328B1 (en) Methods for improved isolation of genomic dna templates for allele detection
HK40009141A (en) Methods for improved isolation of genomic dna templates for allele detection
HK40009141B (en) Methods for improved isolation of genomic dna templates for allele detection
HK1228464B (zh) 用於与眼科状况有关的等位基因的多重检测的方法
HK1216034B (en) Methods for improved isolation of genomic dna templates for allele detection

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees