TWI777924B - 抗ｂｃｍａ抗體，結合ｂｃｍａ及ｃｄ３之雙特異性抗原結合分子及其用途 - Google Patents

抗ｂｃｍａ抗體，結合ｂｃｍａ及ｃｄ３之雙特異性抗原結合分子及其用途 Download PDF

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TWI777924B
TWI777924B TW105126031A TW105126031A TWI777924B TW I777924 B TWI777924 B TW I777924B TW 105126031 A TW105126031 A TW 105126031A TW 105126031 A TW105126031 A TW 105126031A TW I777924 B TWI777924 B TW I777924B
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bcma
antibody
seq
antigen
cells
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TW201718651A (zh
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庫丹達拉姆 皮拉瑞斯提
艾瑞克 鮑德溫
戈登 包爾斯
羅沙 卡多索
里卡多 阿塔爾
弗朗索瓦 高德特
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比利時商健生藥品公司
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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TW105126031A 2015-08-17 2016-08-16 抗ｂｃｍａ抗體，結合ｂｃｍａ及ｃｄ３之雙特異性抗原結合分子及其用途 TWI777924B (zh)

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US201562206246P 2015-08-17 2015-08-17
US62/206,246 2015-08-17

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TWI777924B true TWI777924B (zh) 2022-09-21

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TW111126438A TWI811023B (zh) 2015-08-17 2016-08-16 抗bcma抗體，結合bcma及cd3之雙特異性抗原結合分子及其用途
TW112124028A TW202406935A (zh) 2015-08-17 2016-08-16 抗bcma抗體，結合bcma及cd3之雙特異性抗原結合分子及其用途
TW105126031A TWI777924B (zh) 2015-08-17 2016-08-16 抗ｂｃｍａ抗體，結合ｂｃｍａ及ｃｄ３之雙特異性抗原結合分子及其用途

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TW112124028A TW202406935A (zh) 2015-08-17 2016-08-16 抗bcma抗體，結合bcma及cd3之雙特異性抗原結合分子及其用途

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US (1) US10072088B2 (OSRAM)
EP (3) EP3757131A1 (OSRAM)
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KR (2) KR102890745B1 (OSRAM)
CN (1) CN108350076B (OSRAM)
AR (1) AR105724A1 (OSRAM)
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SI3337824T1 (sl) 2020-10-30
IL298041A (en) 2023-01-01
CN108350076B (zh) 2022-06-07
AU2016308567A1 (en) 2018-03-08
SV2018005634A (es) 2018-06-26
US20170051068A1 (en) 2017-02-23
JP2023027228A (ja) 2023-03-01
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US10072088B2 (en) 2018-09-11
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