TWI750139B - 用於預防或治療ｈｉｖ感染之三特異性及/或三價結合蛋白 - Google Patents

用於預防或治療ｈｉｖ感染之三特異性及/或三價結合蛋白 Download PDF

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TWI750139B
TWI750139B TW105134405A TW105134405A TWI750139B TW I750139 B TWI750139 B TW I750139B TW 105134405 A TW105134405 A TW 105134405A TW 105134405 A TW105134405 A TW 105134405A TW I750139 B TWI750139 B TW I750139B
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seq
amino acid
acid sequence
sequence
cdr
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TW105134405A
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TW201730210A (zh
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志勇 楊
蓋瑞 那貝爾
玲 徐
蓉 魏
華偉 邱
約亨 貝寧格
約亨 古柏
艾寇爾 拉歐
沃爾夫 藍區諾
克里斯汀 比爾
克里斯汀 藍格
馬克 康納斯
約翰 馬斯可拉
理查 古柏
金海 黃
尼可 多莉亞羅斯
東清 周
彼得 鄺
榮多 權
阿瑪連得 佩古
曼加卡拉希 阿索肯
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法商賽諾菲公司
美國衛生及公共服務部
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
TW105134405A 2015-10-25 2016-10-25 用於預防或治療ｈｉｖ感染之三特異性及/或三價結合蛋白 TWI750139B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201562246113P 2015-10-25 2015-10-25
US62/246,113 2015-10-25
EP16305211.1 2016-02-24
EP16305211 2016-02-24
US201662322029P 2016-04-13 2016-04-13
US62/322,029 2016-04-13
US201662331169P 2016-05-03 2016-05-03
US62/331,169 2016-05-03

Publications (2)

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TW201730210A TW201730210A (zh) 2017-09-01
TWI750139B true TWI750139B (zh) 2021-12-21

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TW105134405A TWI750139B (zh) 2015-10-25 2016-10-25 用於預防或治療ｈｉｖ感染之三特異性及/或三價結合蛋白
TW113100534A TW202442675A (zh) 2015-10-25 2016-10-25 用於預防或治療hiv感染之三特異性及/或三價結合蛋白
TW110126977A TW202219064A (zh) 2015-10-25 2016-10-25 用於預防或治療ｈｉｖ感染之三特異性及／或三價結合蛋白

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TW113100534A TW202442675A (zh) 2015-10-25 2016-10-25 用於預防或治療hiv感染之三特異性及/或三價結合蛋白
TW110126977A TW202219064A (zh) 2015-10-25 2016-10-25 用於預防或治療ｈｉｖ感染之三特異性及／或三價結合蛋白

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US (4) US20190054182A1 (OSRAM)
EP (2) EP3819310A1 (OSRAM)
JP (3) JP7169190B2 (OSRAM)
KR (1) KR102687212B1 (OSRAM)
CN (4) CN116789841A (OSRAM)
AR (1) AR106466A1 (OSRAM)
AU (2) AU2016347058B2 (OSRAM)
BR (1) BR112018008011A2 (OSRAM)
CA (1) CA3002664A1 (OSRAM)
CL (1) CL2018001065A1 (OSRAM)
CO (1) CO2018005337A2 (OSRAM)
CR (1) CR20180288A (OSRAM)
DO (1) DOP2018000102A (OSRAM)
EA (1) EA201891028A1 (OSRAM)
ES (1) ES2894304T3 (OSRAM)
HR (1) HRP20211528T1 (OSRAM)
HU (1) HUE056608T2 (OSRAM)
IL (2) IL301140A (OSRAM)
MA (1) MA42641A1 (OSRAM)
MX (2) MX2018005048A (OSRAM)
MY (1) MY192278A (OSRAM)
NZ (1) NZ781602A (OSRAM)
PE (1) PE20181167A1 (OSRAM)
PH (1) PH12018500873A1 (OSRAM)
PL (1) PL3365366T3 (OSRAM)
RS (1) RS62437B1 (OSRAM)
SG (1) SG11201803324VA (OSRAM)
SI (1) SI3365366T1 (OSRAM)
TW (3) TWI750139B (OSRAM)
UY (1) UY36965A (OSRAM)
WO (1) WO2017074878A1 (OSRAM)

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