JP7169190B2 - Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 - Google Patents

Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 Download PDF

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JP7169190B2
JP7169190B2 JP2018521308A JP2018521308A JP7169190B2 JP 7169190 B2 JP7169190 B2 JP 7169190B2 JP 2018521308 A JP2018521308 A JP 2018521308A JP 2018521308 A JP2018521308 A JP 2018521308A JP 7169190 B2 JP7169190 B2 JP 7169190B2
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sequence
cdr
amino acid
acid sequence
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JP2018537966A5 (OSRAM
JP2018537966A (ja
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ヂ－ヨン・ヤン
ゲイリー・ジェイ・ナベル
リン・シュ
ロニー・ウェイ
ファーウェイ・チウ
ヨッヘン・ベーニンガ
ヨッヘン・クルイプ
エアコーレ・ラオ
ディルク・ヴルフ・ロイシュナー
クリスティアン・バイル
クリスティアン・ランゲ
マーク・コナーズ
ジョン・アール・マスコラ
リチャード・エー・クープ
ジン・ホアン
ニコル・エー・ドリア－ローズ
トンキン・チョウ
ピーター・ディー・クォン
トゥ・ヤン・クォン
アマレンドラ・ペグー
マンガイアーカラシィ・アソカン
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2018521308A 2015-10-25 2016-10-24 Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 Active JP7169190B2 (ja)

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JP2021016190A JP7328267B2 (ja) 2015-10-25 2021-02-04 Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質
JP2023061823A JP7724814B2 (ja) 2015-10-25 2023-04-06 Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質

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US201562246113P 2015-10-25 2015-10-25
US62/246,113 2015-10-25
EP16305211.1 2016-02-24
EP16305211 2016-02-24
US201662322029P 2016-04-13 2016-04-13
US62/322,029 2016-04-13
US201662331169P 2016-05-03 2016-05-03
US62/331,169 2016-05-03
PCT/US2016/058540 WO2017074878A1 (en) 2015-10-25 2016-10-24 Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection

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JP2018537966A JP2018537966A (ja) 2018-12-27
JP2018537966A5 JP2018537966A5 (OSRAM) 2019-11-21
JP7169190B2 true JP7169190B2 (ja) 2022-11-10

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JP2018521308A Active JP7169190B2 (ja) 2015-10-25 2016-10-24 Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質
JP2021016190A Active JP7328267B2 (ja) 2015-10-25 2021-02-04 Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質
JP2023061823A Active JP7724814B2 (ja) 2015-10-25 2023-04-06 Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質

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JP2023061823A Active JP7724814B2 (ja) 2015-10-25 2023-04-06 Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質

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US (4) US20190054182A1 (OSRAM)
EP (2) EP3819310A1 (OSRAM)
JP (3) JP7169190B2 (OSRAM)
KR (1) KR102687212B1 (OSRAM)
CN (4) CN116789841A (OSRAM)
AR (1) AR106466A1 (OSRAM)
AU (2) AU2016347058B2 (OSRAM)
BR (1) BR112018008011A2 (OSRAM)
CA (1) CA3002664A1 (OSRAM)
CL (1) CL2018001065A1 (OSRAM)
CO (1) CO2018005337A2 (OSRAM)
CR (1) CR20180288A (OSRAM)
DO (1) DOP2018000102A (OSRAM)
EA (1) EA201891028A1 (OSRAM)
ES (1) ES2894304T3 (OSRAM)
HR (1) HRP20211528T1 (OSRAM)
HU (1) HUE056608T2 (OSRAM)
IL (2) IL301140A (OSRAM)
MA (1) MA42641A1 (OSRAM)
MX (2) MX2018005048A (OSRAM)
MY (1) MY192278A (OSRAM)
NZ (1) NZ781602A (OSRAM)
PE (1) PE20181167A1 (OSRAM)
PH (1) PH12018500873A1 (OSRAM)
PL (1) PL3365366T3 (OSRAM)
RS (1) RS62437B1 (OSRAM)
SG (1) SG11201803324VA (OSRAM)
SI (1) SI3365366T1 (OSRAM)
TW (3) TWI750139B (OSRAM)
UY (1) UY36965A (OSRAM)
WO (1) WO2017074878A1 (OSRAM)

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JP2021072847A (ja) * 2015-10-25 2021-05-13 サノフイＳａｎｏｆｉ Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質

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