TWI738632B - 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 - Google Patents

穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 Download PDF

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TWI738632B
TWI738632B TW104135105A TW104135105A TWI738632B TW I738632 B TWI738632 B TW I738632B TW 104135105 A TW104135105 A TW 104135105A TW 104135105 A TW104135105 A TW 104135105A TW I738632 B TWI738632 B TW I738632B
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concentration
pharmaceutical composition
sucrose
seq
vegf antibody
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TW104135105A
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TW201625221A (zh
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惠湘 張
查爾斯 伯林
艾洛克Ｋ 庫爾司拉斯薩
宇鴻 曾
力 萬
拉曼 阿拉尼
彼得 賽斯提格
沃納 舒密特
瑪格麗特 吉凱法
詹姆斯 瓦柏頓
安德列斯 維奇賽柏格
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瑞士商諾華公司
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/522—CH1 domain
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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TW104135105A 2014-11-07 2015-10-26 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 TWI738632B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462076770P 2014-11-07 2014-11-07
US62/076,770 2014-11-07
US201462088061P 2014-12-05 2014-12-05
US62/088,061 2014-12-05

Publications (2)

Publication Number Publication Date
TW201625221A TW201625221A (zh) 2016-07-16
TWI738632B true TWI738632B (zh) 2021-09-11

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TW104135105A TWI738632B (zh) 2014-11-07 2015-10-26 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
TW104135104A TWI705827B (zh) 2014-11-07 2015-10-26 治療眼部疾病之方法
TW110133255A TWI806150B (zh) 2014-11-07 2015-10-26 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
TW109132401A TWI761959B (zh) 2014-11-07 2015-10-26 治療眼部疾病之方法

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Application Number Title Priority Date Filing Date
TW104135104A TWI705827B (zh) 2014-11-07 2015-10-26 治療眼部疾病之方法
TW110133255A TWI806150B (zh) 2014-11-07 2015-10-26 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
TW109132401A TWI761959B (zh) 2014-11-07 2015-10-26 治療眼部疾病之方法

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US (5) US10035850B2 (show.php)
EP (2) EP3215123A1 (show.php)
JP (6) JP6667519B2 (show.php)
KR (4) KR20240161204A (show.php)
CN (4) CN106999581A (show.php)
AU (6) AU2015342818B2 (show.php)
BR (2) BR112017008093A2 (show.php)
CA (1) CA2966646A1 (show.php)
CL (2) CL2017001117A1 (show.php)
CO (1) CO2017004596A2 (show.php)
EA (1) EA201790989A1 (show.php)
EC (1) ECSP17034829A (show.php)
ES (1) ES3051145T3 (show.php)
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IL (5) IL251642B (show.php)
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RU (1) RU2722643C2 (show.php)
SG (3) SG11201702954XA (show.php)
TN (1) TN2017000128A1 (show.php)
TW (4) TWI738632B (show.php)
WO (2) WO2016073918A1 (show.php)

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