TWI643622B - 用於治療乾眼症及其他眼部相關疾病之janus激酶抑制劑 - Google Patents
用於治療乾眼症及其他眼部相關疾病之janus激酶抑制劑 Download PDFInfo
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- TWI643622B TWI643622B TW106111786A TW106111786A TWI643622B TW I643622 B TWI643622 B TW I643622B TW 106111786 A TW106111786 A TW 106111786A TW 106111786 A TW106111786 A TW 106111786A TW I643622 B TWI643622 B TW I643622B
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- TW
- Taiwan
- Prior art keywords
- pyrrolo
- pyrazol
- pyrimidin
- alkyl
- phenyl
- Prior art date
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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Landscapes
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10224208P | 2008-10-02 | 2008-10-02 | |
| US61/102,242 | 2008-10-02 |
Publications (2)
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| TW201801731A TW201801731A (zh) | 2018-01-16 |
| TWI643622B true TWI643622B (zh) | 2018-12-11 |
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| TW106111786A TWI643622B (zh) | 2008-10-02 | 2009-10-01 | 用於治療乾眼症及其他眼部相關疾病之janus激酶抑制劑 |
| TW098133430A TWI591068B (zh) | 2008-10-02 | 2009-10-01 | 用於治療乾眼症及其他眼部相關疾病之janus激酶抑制劑 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| TW098133430A TWI591068B (zh) | 2008-10-02 | 2009-10-01 | 用於治療乾眼症及其他眼部相關疾病之janus激酶抑制劑 |
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| US (4) | US20100113416A1 (https=) |
| EP (2) | EP3042655A1 (https=) |
| JP (5) | JP2012504639A (https=) |
| AR (2) | AR073530A1 (https=) |
| CA (2) | CA3064247A1 (https=) |
| CL (1) | CL2009001884A1 (https=) |
| CY (1) | CY1117317T1 (https=) |
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| ES (1) | ES2564203T3 (https=) |
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| JP2018044012A (ja) | 2018-03-22 |
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| JP2015127332A (ja) | 2015-07-09 |
| HRP20160330T1 (hr) | 2016-05-06 |
| RS54651B1 (sr) | 2016-08-31 |
| SI2349260T1 (sl) | 2016-05-31 |
| JP2020050682A (ja) | 2020-04-02 |
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| ES2564203T3 (es) | 2016-03-18 |
| PT2349260E (pt) | 2016-03-07 |
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| EP3042655A1 (en) | 2016-07-13 |
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| EP2349260A1 (en) | 2011-08-03 |
| US20170087158A1 (en) | 2017-03-30 |
| TW201018689A (en) | 2010-05-16 |
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