TWI576107B - 釋放芳香化酶抑制劑及促孕素以治療子宮內膜異位症之非口服劑型 - Google Patents

釋放芳香化酶抑制劑及促孕素以治療子宮內膜異位症之非口服劑型 Download PDF

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Publication number
TWI576107B
TWI576107B TW100111100A TW100111100A TWI576107B TW I576107 B TWI576107 B TW I576107B TW 100111100 A TW100111100 A TW 100111100A TW 100111100 A TW100111100 A TW 100111100A TW I576107 B TWI576107 B TW I576107B
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anastrozole
ivr
dosage form
release
dose
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TW100111100A
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TW201201799A (en
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歐德 帕卡林
魯道夫 納賽
亨氏 施米茨
克利絲丁 塔林
哈利 卡萊寧
漢利卡 卡羅連恩
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拜耳知識產權公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
TW100111100A 2010-03-31 2011-03-30 釋放芳香化酶抑制劑及促孕素以治療子宮內膜異位症之非口服劑型 TWI576107B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102010003494A DE102010003494A1 (de) 2010-03-31 2010-03-31 Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose

Publications (2)

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TW201201799A TW201201799A (en) 2012-01-16
TWI576107B true TWI576107B (zh) 2017-04-01

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TW100111100A TWI576107B (zh) 2010-03-31 2011-03-30 釋放芳香化酶抑制劑及促孕素以治療子宮內膜異位症之非口服劑型
TW105118443A TW201632184A (zh) 2010-03-31 2011-03-30 釋放芳香化酶抑制劑及促孕素以治療子宮內膜異位症之非口服劑型

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TW105118443A TW201632184A (zh) 2010-03-31 2011-03-30 釋放芳香化酶抑制劑及促孕素以治療子宮內膜異位症之非口服劑型

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Country Link
US (2) US20130131027A1 (enExample)
EP (1) EP2552404B1 (enExample)
JP (2) JP6012048B2 (enExample)
KR (1) KR20130010047A (enExample)
CN (1) CN103002873B (enExample)
AR (1) AR080861A1 (enExample)
AU (1) AU2011234587B2 (enExample)
BR (1) BR112012024739A2 (enExample)
CA (1) CA2794790A1 (enExample)
CL (1) CL2012002722A1 (enExample)
CO (1) CO6630125A2 (enExample)
CR (1) CR20120493A (enExample)
CU (1) CU20120145A7 (enExample)
CY (1) CY1116187T1 (enExample)
DE (1) DE102010003494A1 (enExample)
DK (1) DK2552404T3 (enExample)
DO (1) DOP2012000255A (enExample)
EA (1) EA025582B1 (enExample)
EC (1) ECSP12012176A (enExample)
ES (1) ES2533101T3 (enExample)
GT (1) GT201200267A (enExample)
HR (1) HRP20150294T1 (enExample)
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MA (1) MA34099B1 (enExample)
ME (1) ME02159B (enExample)
MX (1) MX2012011329A (enExample)
MY (1) MY160353A (enExample)
NZ (1) NZ602698A (enExample)
PE (1) PE20130524A1 (enExample)
PH (1) PH12012501944A1 (enExample)
PL (1) PL2552404T3 (enExample)
PT (1) PT2552404E (enExample)
RS (1) RS53876B1 (enExample)
SG (1) SG184111A1 (enExample)
SI (1) SI2552404T1 (enExample)
TN (1) TN2012000468A1 (enExample)
TW (2) TWI576107B (enExample)
UA (1) UA109655C2 (enExample)
UY (1) UY33303A (enExample)
WO (1) WO2011120925A1 (enExample)
ZA (1) ZA201206869B (enExample)

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US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
WO2015179782A1 (en) 2014-05-22 2015-11-26 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2016191738A1 (en) * 2015-05-27 2016-12-01 Quest Diagnostics Investments Llc Methods for mass spectrometric quantitation of analytes extracted from a microsampling device
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
JP6936801B2 (ja) * 2015-12-21 2021-09-22 バイエル・オーイュー 薬剤送達装置の製造方法およびその方法に従って製造された薬剤送達装置
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
CN109248166A (zh) * 2017-07-13 2019-01-22 国家卫生计生委科学技术研究所 阿那曲唑储库型阴道环的制备及应用
US10918649B2 (en) 2019-06-21 2021-02-16 The Population Council, Inc. System for providing birth control
US20240122885A1 (en) * 2021-02-12 2024-04-18 The Regents Of The University Of California Endometriosis-Related Methods and Compositions
EP4482467A1 (en) * 2022-02-22 2025-01-01 Celanese EVA Performance Polymers LLC Intravaginal ring device for the delivery of aromatase inhibitor
CN115804762B (zh) * 2022-12-20 2024-05-31 浙江大学 一种巨噬细胞膜包覆的异位子宫内膜靶向纳米粒、制备方法及应用

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WO2003015872A2 (en) * 2001-08-17 2003-02-27 Metris Therapeutics Limited Intravaginal administration of an aromatase inhibitor for the treatment of oestrogen-dependent proliferative disorders
CN1747736A (zh) * 2003-02-05 2006-03-15 阿斯利康(瑞典)有限公司 包含芳化酶抑制剂、孕激素和雌激素组合的组合物及其治疗子宫内膜异位症的用途

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WO2003015872A2 (en) * 2001-08-17 2003-02-27 Metris Therapeutics Limited Intravaginal administration of an aromatase inhibitor for the treatment of oestrogen-dependent proliferative disorders
CN1747736A (zh) * 2003-02-05 2006-03-15 阿斯利康(瑞典)有限公司 包含芳化酶抑制剂、孕激素和雌激素组合的组合物及其治疗子宫内膜异位症的用途

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Publication number Publication date
HRP20150294T1 (hr) 2015-06-19
ES2533101T3 (es) 2015-04-07
CU20120145A7 (es) 2013-05-31
EP2552404B1 (de) 2015-01-21
PE20130524A1 (es) 2013-04-26
MA34099B1 (fr) 2013-03-05
CL2012002722A1 (es) 2013-01-18
JP2013523683A (ja) 2013-06-17
US20130131027A1 (en) 2013-05-23
AU2011234587A1 (en) 2012-10-25
EA025582B1 (ru) 2017-01-30
US20150359802A1 (en) 2015-12-17
RS53876B1 (sr) 2015-08-31
IL222056A (en) 2016-03-31
HK1179531A1 (en) 2013-10-04
JP6012048B2 (ja) 2016-10-25
CO6630125A2 (es) 2013-03-01
EA201201358A1 (ru) 2013-04-30
CN103002873B (zh) 2015-02-18
ME02159B (me) 2015-10-20
GT201200267A (es) 2014-06-04
SI2552404T1 (sl) 2015-04-30
CR20120493A (es) 2012-11-22
UY33303A (es) 2011-10-31
TW201201799A (en) 2012-01-16
DE102010003494A1 (de) 2011-10-06
PH12012501944A1 (en) 2017-01-06
TN2012000468A1 (en) 2014-01-30
CA2794790A1 (en) 2011-10-06
SG184111A1 (en) 2012-10-30
DOP2012000255A (es) 2013-04-30
ZA201206869B (en) 2016-01-27
CY1116187T1 (el) 2017-02-08
KR20130010047A (ko) 2013-01-24
AU2011234587B2 (en) 2015-07-09
EP2552404A1 (de) 2013-02-06
UA109655C2 (uk) 2015-09-25
CN103002873A (zh) 2013-03-27
MY160353A (en) 2017-02-28
DK2552404T3 (en) 2015-03-30
JP2016164200A (ja) 2016-09-08
AR080861A1 (es) 2012-05-16
ECSP12012176A (es) 2012-10-30
TW201632184A (zh) 2016-09-16
MX2012011329A (es) 2012-11-30
NZ602698A (en) 2014-08-29
PL2552404T3 (pl) 2015-05-29
BR112012024739A2 (pt) 2016-06-07
WO2011120925A1 (de) 2011-10-06
PT2552404E (pt) 2015-03-30

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