EA201201358A1 - Парентеральная лекарственная форма, высвобождающая ингибиторы ароматазы и гестагены для лечения эндометриоза - Google Patents

Парентеральная лекарственная форма, высвобождающая ингибиторы ароматазы и гестагены для лечения эндометриоза

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Publication number
EA201201358A1
EA201201358A1 EA201201358A EA201201358A EA201201358A1 EA 201201358 A1 EA201201358 A1 EA 201201358A1 EA 201201358 A EA201201358 A EA 201201358A EA 201201358 A EA201201358 A EA 201201358A EA 201201358 A1 EA201201358 A1 EA 201201358A1
Authority
EA
Eurasian Patent Office
Prior art keywords
endometriosis
treatment
gestagenes
growing
aromatase inhibitors
Prior art date
Application number
EA201201358A
Other languages
English (en)
Other versions
EA025582B1 (ru
Inventor
Арто Паккалин
Рудольф Кнауте
Хайнц Шмитц
Кристине Таллинг
Харри Юкараинен
Хенриикка Королаинен
Original Assignee
Байер Интеллекчуал Проперти Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44021822&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201201358(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Интеллекчуал Проперти Гмбх filed Critical Байер Интеллекчуал Проперти Гмбх
Publication of EA201201358A1 publication Critical patent/EA201201358A1/ru
Publication of EA025582B1 publication Critical patent/EA025582B1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Данное изобретение для лечения эндометриоза относится к парентеральной лекарственной форме (системе доставки) для контролируемого высвобождения ингибитора ароматазы (AI) при ежедневной скорости высвобождения, которая не вызывает стимулирования яичников путем негативной обратной связи оси яичник-гипофиз (что может вызвать секрецию гонадотропинов и стимуляцию фолликулярного роста яичников) и гестагена при ежедневной скорости высвобождения ниже дозы ингибирования овуляции, что обеспечивает эффективность контрацепции на основе местного воздействия (например, уменьшение в количестве и загущение цервикальной слизи, ослабляющей продвижение спермы, влияние на эндометрий и на трубную подвижность, ослабляющее имплантацию и перенос яйцеклеток).
EA201201358A 2010-03-31 2011-03-28 Интравагинальное кольцо, высвобождающее анастрозол и левоноргестрел для лечения эндометриоза EA025582B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010003494A DE102010003494A1 (de) 2010-03-31 2010-03-31 Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
PCT/EP2011/054737 WO2011120925A1 (de) 2010-03-31 2011-03-28 Parenterale arzneiform, die aromatasehemmer und gestagene freisetzt, für die behandlung von endometriose

Publications (2)

Publication Number Publication Date
EA201201358A1 true EA201201358A1 (ru) 2013-04-30
EA025582B1 EA025582B1 (ru) 2017-01-30

Family

ID=44021822

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201358A EA025582B1 (ru) 2010-03-31 2011-03-28 Интравагинальное кольцо, высвобождающее анастрозол и левоноргестрел для лечения эндометриоза

Country Status (41)

Country Link
US (2) US20130131027A1 (ru)
EP (1) EP2552404B1 (ru)
JP (2) JP6012048B2 (ru)
KR (1) KR20130010047A (ru)
CN (1) CN103002873B (ru)
AR (1) AR080861A1 (ru)
AU (1) AU2011234587B2 (ru)
BR (1) BR112012024739A2 (ru)
CA (1) CA2794790A1 (ru)
CL (1) CL2012002722A1 (ru)
CO (1) CO6630125A2 (ru)
CR (1) CR20120493A (ru)
CU (1) CU20120145A7 (ru)
CY (1) CY1116187T1 (ru)
DE (1) DE102010003494A1 (ru)
DK (1) DK2552404T3 (ru)
DO (1) DOP2012000255A (ru)
EA (1) EA025582B1 (ru)
EC (1) ECSP12012176A (ru)
ES (1) ES2533101T3 (ru)
GT (1) GT201200267A (ru)
HK (1) HK1179531A1 (ru)
HR (1) HRP20150294T1 (ru)
IL (1) IL222056A (ru)
MA (1) MA34099B1 (ru)
ME (1) ME02159B (ru)
MX (1) MX2012011329A (ru)
MY (1) MY160353A (ru)
NZ (1) NZ602698A (ru)
PE (1) PE20130524A1 (ru)
PL (1) PL2552404T3 (ru)
PT (1) PT2552404E (ru)
RS (1) RS53876B1 (ru)
SG (1) SG184111A1 (ru)
SI (1) SI2552404T1 (ru)
TN (1) TN2012000468A1 (ru)
TW (2) TW201632184A (ru)
UA (1) UA109655C2 (ru)
UY (1) UY33303A (ru)
WO (1) WO2011120925A1 (ru)
ZA (1) ZA201206869B (ru)

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PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
CA2987323A1 (en) * 2015-05-27 2016-12-01 Quest Diagnostics Investments Llc Methods for mass spectrometric quantitation of analytes extracted from a microsampling device
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
JP6936801B2 (ja) * 2015-12-21 2021-09-22 バイエル・オーイュー 薬剤送達装置の製造方法およびその方法に従って製造された薬剤送達装置
CA3020153A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
CN109248166A (zh) * 2017-07-13 2019-01-22 国家卫生计生委科学技术研究所 阿那曲唑储库型阴道环的制备及应用
US10918649B2 (en) 2019-06-21 2021-02-16 The Population Council, Inc. System for providing birth control
US20240122885A1 (en) * 2021-02-12 2024-04-18 The Regents Of The University Of California Endometriosis-Related Methods and Compositions
CN115804762B (zh) * 2022-12-20 2024-05-31 浙江大学 一种巨噬细胞膜包覆的异位子宫内膜靶向纳米粒、制备方法及应用

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Also Published As

Publication number Publication date
TN2012000468A1 (en) 2014-01-30
TW201201799A (en) 2012-01-16
UA109655C2 (uk) 2015-09-25
CO6630125A2 (es) 2013-03-01
HRP20150294T1 (hr) 2015-06-19
HK1179531A1 (en) 2013-10-04
CN103002873B (zh) 2015-02-18
TWI576107B (zh) 2017-04-01
BR112012024739A2 (pt) 2016-06-07
CL2012002722A1 (es) 2013-01-18
GT201200267A (es) 2014-06-04
SI2552404T1 (sl) 2015-04-30
JP2016164200A (ja) 2016-09-08
CA2794790A1 (en) 2011-10-06
DE102010003494A1 (de) 2011-10-06
UY33303A (es) 2011-10-31
RS53876B1 (en) 2015-08-31
CY1116187T1 (el) 2017-02-08
PL2552404T3 (pl) 2015-05-29
CU20120145A7 (es) 2013-05-31
ECSP12012176A (es) 2012-10-30
DK2552404T3 (en) 2015-03-30
MA34099B1 (fr) 2013-03-05
SG184111A1 (en) 2012-10-30
PE20130524A1 (es) 2013-04-26
ES2533101T3 (es) 2015-04-07
EP2552404A1 (de) 2013-02-06
AR080861A1 (es) 2012-05-16
KR20130010047A (ko) 2013-01-24
JP2013523683A (ja) 2013-06-17
US20130131027A1 (en) 2013-05-23
IL222056A (en) 2016-03-31
MY160353A (en) 2017-02-28
WO2011120925A1 (de) 2011-10-06
AU2011234587B2 (en) 2015-07-09
EA025582B1 (ru) 2017-01-30
CR20120493A (es) 2012-11-22
CN103002873A (zh) 2013-03-27
NZ602698A (en) 2014-08-29
JP6012048B2 (ja) 2016-10-25
AU2011234587A1 (en) 2012-10-25
ZA201206869B (en) 2016-01-27
TW201632184A (zh) 2016-09-16
MX2012011329A (es) 2012-11-30
EP2552404B1 (de) 2015-01-21
PT2552404E (pt) 2015-03-30
ME02159B (me) 2015-10-20
DOP2012000255A (es) 2013-04-30
US20150359802A1 (en) 2015-12-17

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