CN103002873B - 用于治疗子宫内膜异位症的释放芳香化酶抑制剂和孕激素的肠外剂型 - Google Patents

用于治疗子宫内膜异位症的释放芳香化酶抑制剂和孕激素的肠外剂型 Download PDF

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Publication number
CN103002873B
CN103002873B CN201180017806.6A CN201180017806A CN103002873B CN 103002873 B CN103002873 B CN 103002873B CN 201180017806 A CN201180017806 A CN 201180017806A CN 103002873 B CN103002873 B CN 103002873B
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China
Prior art keywords
anastrozole
endometriosis
release
estrogen
treatment
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Expired - Fee Related
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CN201180017806.6A
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English (en)
Chinese (zh)
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CN103002873A (zh
Inventor
A·帕卡林
R·克瑙斯
H·施米茨
C·塔林
H·朱卡雷恩
H·科罗莱恩
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Bayer Pharma AG
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Bayer Pharma AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201180017806.6A 2010-03-31 2011-03-28 用于治疗子宫内膜异位症的释放芳香化酶抑制剂和孕激素的肠外剂型 Expired - Fee Related CN103002873B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102010003494A DE102010003494A1 (de) 2010-03-31 2010-03-31 Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
DE102010003494.0 2010-03-31
PCT/EP2011/054737 WO2011120925A1 (de) 2010-03-31 2011-03-28 Parenterale arzneiform, die aromatasehemmer und gestagene freisetzt, für die behandlung von endometriose

Publications (2)

Publication Number Publication Date
CN103002873A CN103002873A (zh) 2013-03-27
CN103002873B true CN103002873B (zh) 2015-02-18

Family

ID=44021822

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CN201180017806.6A Expired - Fee Related CN103002873B (zh) 2010-03-31 2011-03-28 用于治疗子宫内膜异位症的释放芳香化酶抑制剂和孕激素的肠外剂型

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US (2) US20130131027A1 (enExample)
EP (1) EP2552404B1 (enExample)
JP (2) JP6012048B2 (enExample)
KR (1) KR20130010047A (enExample)
CN (1) CN103002873B (enExample)
AR (1) AR080861A1 (enExample)
AU (1) AU2011234587B2 (enExample)
BR (1) BR112012024739A2 (enExample)
CA (1) CA2794790A1 (enExample)
CL (1) CL2012002722A1 (enExample)
CO (1) CO6630125A2 (enExample)
CR (1) CR20120493A (enExample)
CU (1) CU20120145A7 (enExample)
CY (1) CY1116187T1 (enExample)
DE (1) DE102010003494A1 (enExample)
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DO (1) DOP2012000255A (enExample)
EA (1) EA025582B1 (enExample)
EC (1) ECSP12012176A (enExample)
ES (1) ES2533101T3 (enExample)
GT (1) GT201200267A (enExample)
HR (1) HRP20150294T1 (enExample)
IL (1) IL222056A (enExample)
MA (1) MA34099B1 (enExample)
ME (1) ME02159B (enExample)
MX (1) MX2012011329A (enExample)
MY (1) MY160353A (enExample)
NZ (1) NZ602698A (enExample)
PE (1) PE20130524A1 (enExample)
PH (1) PH12012501944A1 (enExample)
PL (1) PL2552404T3 (enExample)
PT (1) PT2552404E (enExample)
RS (1) RS53876B1 (enExample)
SG (1) SG184111A1 (enExample)
SI (1) SI2552404T1 (enExample)
TN (1) TN2012000468A1 (enExample)
TW (2) TW201632184A (enExample)
UA (1) UA109655C2 (enExample)
UY (1) UY33303A (enExample)
WO (1) WO2011120925A1 (enExample)
ZA (1) ZA201206869B (enExample)

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US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (sr) 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
CN107850568A (zh) * 2015-05-27 2018-03-27 奎斯特诊断投资有限公司 用于质谱定量由微量取样装置提取的分析物的方法
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
CN108430453B (zh) * 2015-12-21 2023-03-17 拜耳股份有限公司 制造药物递送装置的方法和根据该方法制成的药物递送装置
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
CN109248166A (zh) * 2017-07-13 2019-01-22 国家卫生计生委科学技术研究所 阿那曲唑储库型阴道环的制备及应用
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US20240122885A1 (en) * 2021-02-12 2024-04-18 The Regents Of The University Of California Endometriosis-Related Methods and Compositions
US20230263724A1 (en) * 2022-02-22 2023-08-24 Celanese Eva Performance Polymers Llc Intravaginal Ring Device for the Delivery of Aromatase Inhibitor
CN115804762B (zh) * 2022-12-20 2024-05-31 浙江大学 一种巨噬细胞膜包覆的异位子宫内膜靶向纳米粒、制备方法及应用

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US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
CN1747736A (zh) * 2003-02-05 2006-03-15 阿斯利康(瑞典)有限公司 包含芳化酶抑制剂、孕激素和雌激素组合的组合物及其治疗子宫内膜异位症的用途

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WO2002072106A2 (en) * 2001-01-26 2002-09-19 Pharmacia Italia Spa Combined method for treating hormono-dependent disorders with exemestane
CN1747736A (zh) * 2003-02-05 2006-03-15 阿斯利康(瑞典)有限公司 包含芳化酶抑制剂、孕激素和雌激素组合的组合物及其治疗子宫内膜异位症的用途
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol

Also Published As

Publication number Publication date
CR20120493A (es) 2012-11-22
GT201200267A (es) 2014-06-04
JP2013523683A (ja) 2013-06-17
DE102010003494A1 (de) 2011-10-06
PH12012501944A1 (en) 2017-01-06
MA34099B1 (fr) 2013-03-05
HRP20150294T1 (hr) 2015-06-19
AU2011234587A1 (en) 2012-10-25
CU20120145A7 (es) 2013-05-31
TWI576107B (zh) 2017-04-01
US20130131027A1 (en) 2013-05-23
TW201632184A (zh) 2016-09-16
PT2552404E (pt) 2015-03-30
TN2012000468A1 (en) 2014-01-30
EP2552404B1 (de) 2015-01-21
EA025582B1 (ru) 2017-01-30
TW201201799A (en) 2012-01-16
NZ602698A (en) 2014-08-29
DK2552404T3 (en) 2015-03-30
PL2552404T3 (pl) 2015-05-29
WO2011120925A1 (de) 2011-10-06
CN103002873A (zh) 2013-03-27
CL2012002722A1 (es) 2013-01-18
AU2011234587B2 (en) 2015-07-09
BR112012024739A2 (pt) 2016-06-07
SI2552404T1 (sl) 2015-04-30
HK1179531A1 (en) 2013-10-04
EP2552404A1 (de) 2013-02-06
UA109655C2 (uk) 2015-09-25
CY1116187T1 (el) 2017-02-08
ES2533101T3 (es) 2015-04-07
KR20130010047A (ko) 2013-01-24
AR080861A1 (es) 2012-05-16
SG184111A1 (en) 2012-10-30
UY33303A (es) 2011-10-31
MY160353A (en) 2017-02-28
ZA201206869B (en) 2016-01-27
CO6630125A2 (es) 2013-03-01
DOP2012000255A (es) 2013-04-30
ECSP12012176A (es) 2012-10-30
IL222056A (en) 2016-03-31
JP6012048B2 (ja) 2016-10-25
ME02159B (me) 2015-10-20
CA2794790A1 (en) 2011-10-06
JP2016164200A (ja) 2016-09-08
EA201201358A1 (ru) 2013-04-30
MX2012011329A (es) 2012-11-30
PE20130524A1 (es) 2013-04-26
RS53876B1 (sr) 2015-08-31
US20150359802A1 (en) 2015-12-17

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