TWI569814B - 標靶藥物遞送及提升ｓｉＲＮＡ活性用脂溶性維生素化合物 - Google Patents

標靶藥物遞送及提升ｓｉＲＮＡ活性用脂溶性維生素化合物 Download PDF

Info

Publication number
TWI569814B
TWI569814B TW101120844A TW101120844A TWI569814B TW I569814 B TWI569814 B TW I569814B TW 101120844 A TW101120844 A TW 101120844A TW 101120844 A TW101120844 A TW 101120844A TW I569814 B TWI569814 B TW I569814B
Authority
TW
Taiwan
Prior art keywords
pharmaceutical carrier
lipid
peg
mmol
sirna
Prior art date
Application number
TW101120844A
Other languages
English (en)
Chinese (zh)
Other versions
TW201313256A (zh
Inventor
新津洋司郎
約瑟夫Ｅ 潘恩
侯政
約翰Ａ 葛堤
史利達Ｃ 納嘉拉堅
維克多 諾波夫
理查Ｐ 威特
默漢麥德 阿瑪狄恩
羅倫Ａ 派羅曼
田中康進
凡歐里特 寇派恩
佩利亞 卡馬利
Original Assignee
日東電工股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日東電工股份有限公司 filed Critical 日東電工股份有限公司
Publication of TW201313256A publication Critical patent/TW201313256A/zh
Application granted granted Critical
Publication of TWI569814B publication Critical patent/TWI569814B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyethers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
TW101120844A 2011-06-08 2012-06-08 標靶藥物遞送及提升ｓｉＲＮＡ活性用脂溶性維生素化合物 TWI569814B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161494840P 2011-06-08 2011-06-08
US201161494710P 2011-06-08 2011-06-08

Publications (2)

Publication Number Publication Date
TW201313256A TW201313256A (zh) 2013-04-01
TWI569814B true TWI569814B (zh) 2017-02-11

Family

ID=46317540

Family Applications (2)

Application Number Title Priority Date Filing Date
TW101120844A TWI569814B (zh) 2011-06-08 2012-06-08 標靶藥物遞送及提升ｓｉＲＮＡ活性用脂溶性維生素化合物
TW105140746A TWI712422B (zh) 2011-06-08 2012-06-08 標靶藥物遞送及提升ｓｉＲＮＡ活性用脂溶性維生素化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW105140746A TWI712422B (zh) 2011-06-08 2012-06-08 標靶藥物遞送及提升ｓｉＲＮＡ活性用脂溶性維生素化合物

Country Status (20)

Country Link
EP (2) EP2998289B1 (cg-RX-API-DMAC7.html)
JP (3) JP5873553B2 (cg-RX-API-DMAC7.html)
KR (3) KR102038300B1 (cg-RX-API-DMAC7.html)
CN (3) CN103857654B (cg-RX-API-DMAC7.html)
AU (2) AU2012267467B8 (cg-RX-API-DMAC7.html)
CA (2) CA3094645C (cg-RX-API-DMAC7.html)
CY (2) CY1117433T1 (cg-RX-API-DMAC7.html)
DK (2) DK2718261T3 (cg-RX-API-DMAC7.html)
ES (2) ES2570184T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20191463T8 (cg-RX-API-DMAC7.html)
HU (1) HUE045821T2 (cg-RX-API-DMAC7.html)
LT (1) LT2998289T (cg-RX-API-DMAC7.html)
PL (2) PL2718261T3 (cg-RX-API-DMAC7.html)
PT (1) PT2998289T (cg-RX-API-DMAC7.html)
RS (1) RS59380B1 (cg-RX-API-DMAC7.html)
RU (2) RU2769872C2 (cg-RX-API-DMAC7.html)
SI (1) SI2998289T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201900523T1 (cg-RX-API-DMAC7.html)
TW (2) TWI569814B (cg-RX-API-DMAC7.html)
WO (1) WO2012170952A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963424B2 (en) 2011-06-08 2018-05-08 Nitto Denko Corporation Cationic lipids for therapeutic agent delivery formulations

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101967868B1 (ko) * 2010-06-17 2019-08-19 닛토덴코 가부시키가이샤 신장 섬유증 치료 물질
US9579338B2 (en) 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
SI2773326T1 (sl) 2011-11-04 2019-04-30 Nitto Denko Corporation Metoda za sterilno proizvodnjo delcev lipidno-nukleinske kisline
TWI654997B (zh) * 2012-06-08 2019-04-01 日商日東電工股份有限公司 用於治療劑輸送配方之脂質
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
JP6076076B2 (ja) 2012-12-21 2017-02-08 日東電工株式会社 組織再生促進剤
US9365610B2 (en) 2013-11-18 2016-06-14 Arcturus Therapeutics, Inc. Asymmetric ionizable cationic lipid for RNA delivery
JP6486955B2 (ja) 2013-11-18 2019-03-20 アークトゥルス セラピューティクス， インコーポレイテッド Ｒｎａ送達のためのイオン化可能なカチオン性脂質
WO2015152332A1 (ja) 2014-04-02 2015-10-08 日東電工株式会社 標的化分子およびその使用
CN106573062B (zh) 2014-06-17 2020-08-25 日东电工株式会社 细胞凋亡诱导剂
EP2966068A1 (en) * 2014-07-08 2016-01-13 Incella GmbH Synthesis and use of amino lipids
CN104174034A (zh) * 2014-08-20 2014-12-03 南京大学 肝星状细胞靶向的基因药物输送载体及其制备方法和应用
JP5934848B1 (ja) * 2014-10-30 2016-06-15 Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 局所投与用リポプレックスの新規製造方法及び該リポプレックスを使用する抗腫瘍剤
AU2015350561B2 (en) * 2014-11-18 2020-01-30 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
US11045488B2 (en) 2014-12-26 2021-06-29 Nitto Denko Corporation RNA interference agents for GST-π gene modulation
US10167253B2 (en) 2015-06-24 2019-01-01 Nitto Denko Corporation Ionizable compounds and compositions and uses thereof
JP7041616B2 (ja) * 2015-09-14 2022-03-24 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム リポカチオン性デンドリマーおよびその使用
CN105194689A (zh) * 2015-10-10 2015-12-30 湖南中楚博生物科技有限公司 一种基于siRNA的双偶联复合物
ES2985317T3 (es) * 2016-05-16 2024-11-05 Univ Texas Composiciones para la distribución de ARNt en nanopartículas y procedimientos de uso de las mismas
EP3458032A4 (en) * 2016-05-16 2019-12-25 The Board of Regents of The University of Texas System CATIONIC SULFONAMIDE AMINOLIPIDS AND AMPHIPHILE ZWITTERIONIC AMINOLIPIDS
JP6833456B2 (ja) 2016-11-02 2021-02-24 日東電工株式会社 皮膚線維症処置剤
US10383952B2 (en) 2016-12-21 2019-08-20 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
US10526284B2 (en) 2016-12-21 2020-01-07 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
CN110831586B (zh) * 2017-05-23 2023-06-13 密执安大学评议会 二甲基-壬四烯基-三甲基-环己基化合物及其用途
EP3638215A4 (en) 2017-06-15 2021-03-24 Modernatx, Inc. RNA FORMULATIONS
CA3071968A1 (en) 2017-08-04 2019-02-07 Kyowa Kirin Co., Ltd. Nucleic acid-containing lipid nanoparticle
CA3073211A1 (en) 2017-08-31 2019-03-07 Modernatx, Inc. Methods of making lipid nanoparticles
US11298371B2 (en) 2017-10-11 2022-04-12 Nitto Denko Corporation Regulation of nucleic acid molecule expression
BR112020008451A2 (pt) 2017-11-06 2020-12-01 Nitto Denko Corporation composto fusogênico, composição, composições farmacêutica e para uso na distribuição de um agente ativo, e, método para prevenir, melhorar ou tratar uma doença ou condição
JP2021521279A (ja) * 2018-04-11 2021-08-26 ニュー メキシコ テック ユニバーシティ リサーチ パーク コーポレーション 薬物送達における使用のための脂質プロドラッグ
EP3805198B1 (en) 2018-06-08 2023-09-20 FUJIFILM Corporation Compound, salt thereof and lipid particles
US12357580B2 (en) 2018-06-19 2025-07-15 The Board Of Regents Of The University Of Texas System Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids
EP3848050A4 (en) * 2018-08-22 2022-06-08 Nitto Denko Corporation DRUG USING AN HSP47 INHIBITOR TO INCREASE SENSITIVITY TO A CHEMOTHERAPY DRUG
EP3846857A4 (en) 2018-09-04 2022-10-12 The Board Of Regents Of The University Of Texas System COMPOSITIONS AND METHODS FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACIDS
JP7425066B2 (ja) 2018-09-04 2024-01-30 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 核酸を臓器特異的送達するための組成物および方法
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
CN110124049B (zh) * 2019-04-29 2023-09-22 大连医科大学 聚乙二醇化芬维a胺前体药物及其用途
WO2020246581A1 (ja) 2019-06-07 2020-12-10 富士フイルム株式会社 脂質組成物
KR102228271B1 (ko) 2019-07-16 2021-03-17 한국과학기술연구원 항암활성을 갖는 면역조절 단백질-siRNA 복합체
CN111248152A (zh) * 2020-03-17 2020-06-09 上海市中医医院 一种肝硬化腹水动物模型及其构建方法
MX2022013081A (es) * 2020-04-23 2022-11-10 Purdue Research Foundation Compuestos para el tratamiento de sars.
KR102361479B1 (ko) * 2020-06-18 2022-02-11 고려대학교 산학협력단 ｓｉＲＮＡ의 생성 및 기능 증진 활성을 갖는 ＣＭＴＲ１의 신규용도
KR20230042464A (ko) * 2020-06-24 2023-03-28 브리스톨-마이어스 스큅 컴퍼니 지질의 합성 방법
EP4171578A4 (en) * 2020-06-24 2024-08-07 Bristol-Myers Squibb Company METHOD FOR THE PRODUCTION OF CATIONIC LIPIDS
IL299197A (en) 2020-06-24 2023-02-01 Bristol Myers Squibb Co A process for the synthesis of targeting molecules
US20230277457A1 (en) * 2020-08-06 2023-09-07 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2022034946A1 (ko) 2020-08-14 2022-02-17 한국과학기술연구원 항암활성을 갖는 면역조절 단백질-siRNA 복합체
KR20230054672A (ko) * 2020-08-20 2023-04-25 쑤저우 아보젠 바이오사이언시스 컴퍼니 리미티드 지질 화합물 및 지질 나노입자 조성물
CN114306278A (zh) * 2021-12-30 2022-04-12 上海纳米技术及应用国家工程研究中心有限公司 一种EV装载CPP-siRNA纳米颗粒的制备方法及其产品和应用
CN114805113B (zh) * 2022-01-22 2023-09-15 苏州天澜生物材料科技有限公司 一种安全高效的可降解脂质纳米颗粒及其制备方法和应用
CN114522244B (zh) * 2022-01-28 2023-09-01 浙江大学医学院附属第四医院 视黄酸修饰的lytac分子及其制备方法和应用
WO2023167336A1 (ja) 2022-03-03 2023-09-07 国立大学法人九州大学 線維化疾患の治療又は予防のための医薬組成物
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
WO2024160829A1 (en) * 2023-01-31 2024-08-08 BioNTech SE Compositions and methods
EP4480943A1 (en) * 2023-06-22 2024-12-25 Oz Biosciences New class of lipids for delivering active ingredients into cells
WO2025006799A1 (en) 2023-06-27 2025-01-02 Capstan Therapeutics, Inc. Extracorporeal and ex vivo engineering of select cell populations from peripheral blood
CN117185942B (zh) * 2023-07-04 2025-09-12 清华大学 一种可用于靶向肺部递送广谱中和抗体的脂质纳米颗粒及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010061880A1 (ja) * 2008-11-26 2010-06-03 中外製薬株式会社 ベシクル製剤

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501729A (en) 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
JPS6189286A (ja) * 1984-10-08 1986-05-07 Tokuyama Soda Co Ltd 液晶組成物
JPS61136584A (ja) * 1984-12-07 1986-06-24 Tokuyama Soda Co Ltd 液晶組成物
US6153737A (en) 1990-01-11 2000-11-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US5214136A (en) 1990-02-20 1993-05-25 Gilead Sciences, Inc. Anthraquinone-derivatives oligonucleotides
US5138045A (en) 1990-07-27 1992-08-11 Isis Pharmaceuticals Polyamine conjugated oligonucleotides
US6335434B1 (en) 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6235886B1 (en) 1993-09-03 2001-05-22 Isis Pharmaceuticals, Inc. Methods of synthesis and use
JP3029354B2 (ja) * 1992-12-22 2000-04-04 三菱電機株式会社 ディジタルビデオ信号符号化装置および復号化装置
DE69433036T2 (de) 1993-09-03 2004-05-27 Isis Pharmaceuticals, Inc., Carlsbad Aminoderivatisierte nukleoside und oligonukleoside
FR2714382B1 (fr) * 1993-12-27 1996-02-02 Roussel Uclaf Phospholipides vecteur de molécule active, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques.
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
CA2187626C (en) 1994-04-13 2009-11-03 Michael G. Kaplitt Aav-mediated delivery of dna to cells of the nervous system
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
DE19640092A1 (de) * 1996-09-28 1998-04-16 Beiersdorf Ag Strukturen mit Lipid-Doppelmembranen, in deren lipophilen Bereich längerkettige Moleküle eintauchen oder durch hydrophobe Wechselwirkungen an solche Moleküle angedockt sind
DE19641672A1 (de) * 1996-10-10 1998-04-16 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen auf der Basis von ethylenoxidfreien und propylenoxidfreien Emulgatoren zur Herstellung von Mikroemulsionsgelen
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6586524B2 (en) 2001-07-19 2003-07-01 Expression Genetics, Inc. Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
CA2464346A1 (en) * 2001-10-30 2003-05-08 Nektar Therapeutics Al, Corporation Water-soluble polymer conjugates of retinoic acid
AUPR894201A0 (en) 2001-11-19 2001-12-13 Women's And Children's Hospital Respiratory delivery for gene therapy and lentiviral delivery particle
US20050106731A1 (en) 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
CA2521407A1 (en) * 2003-03-31 2004-10-21 Vectramed, Inc. Polymeric drug agents for the treatment of fibrotic disorders
JP2006254877A (ja) * 2005-03-18 2006-09-28 Fukuoka Prefecture 糖脂質を含んだキャリア及びそれを用いた遺伝子導入法
AU2006259415B2 (en) * 2005-06-15 2012-08-30 Massachusetts Institute Of Technology Amine-containing lipids and uses thereof
CA2656228C (en) * 2006-06-30 2016-02-09 Hokkaido System Science Co., Ltd. Composition for nucleic-acid transfection
US20100215588A1 (en) 2007-04-26 2010-08-26 Rami Skaliter Therapeutic delivery of inhibitory nucleic acid molecules to the respiratory system
TW200918099A (en) * 2007-09-14 2009-05-01 Nitto Denko Corp Drug carriers
WO2009059450A1 (en) * 2007-11-05 2009-05-14 Shanghai Jiaotong University Peptide ligand directed drug delivery
CA2732412C (en) * 2008-07-30 2014-12-09 Lei Yu Retinoid-targeted drug carriers
CA2736368A1 (en) * 2008-09-12 2010-03-18 Nitto Denko Corporation Imaging agents of fibrotic diseases
KR101710505B1 (ko) * 2009-09-15 2017-02-27 노벨리언 테라퓨틱스 인코포레이티드 리피드 비히클에 9-시스-레티닐 에스테르를 포함하는 약제 처방
TWI658830B (zh) * 2011-06-08 2019-05-11 日東電工股份有限公司 Ｈｓｐ47表現調控強化用類視色素脂質體
JP6301742B2 (ja) * 2014-06-05 2018-03-28 ヨシモトポール株式会社 鋼管ポールおよびその設置方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010061880A1 (ja) * 2008-11-26 2010-06-03 中外製薬株式会社 ベシクル製剤

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963424B2 (en) 2011-06-08 2018-05-08 Nitto Denko Corporation Cationic lipids for therapeutic agent delivery formulations
US10532975B2 (en) 2011-06-08 2020-01-14 Nitto Denko Corporation Cationic lipids for therapeutic agent delivery formulations
US11084779B2 (en) 2011-06-08 2021-08-10 Nitto Denko Corporation Cationic lipids for therapeutic agent delivery formulations

Also Published As

Publication number Publication date
CN103857654B (zh) 2017-03-15
PT2998289T (pt) 2019-09-19
JP6232083B2 (ja) 2017-11-15
AU2012267467B2 (en) 2017-06-01
JP2016153477A (ja) 2016-08-25
AU2017203075A1 (en) 2017-06-01
EP2718261B1 (en) 2016-02-24
JP5873553B2 (ja) 2016-03-01
LT2998289T (lt) 2019-10-25
KR102038300B1 (ko) 2019-10-31
CN107082747A (zh) 2017-08-22
CA2837101C (en) 2020-12-15
RU2017135548A (ru) 2019-02-08
RS59380B1 (sr) 2019-11-29
JP2014529328A (ja) 2014-11-06
KR102029654B1 (ko) 2019-10-08
EP2998289A1 (en) 2016-03-23
WO2012170952A3 (en) 2013-04-11
WO2012170952A4 (en) 2013-05-30
KR20140033492A (ko) 2014-03-18
RU2632888C2 (ru) 2017-10-11
CN107043334A (zh) 2017-08-15
WO2012170952A2 (en) 2012-12-13
HUE045821T2 (hu) 2020-01-28
CN103857654A (zh) 2014-06-11
CN107082747B (zh) 2020-11-20
PL2718261T3 (pl) 2016-08-31
DK2718261T3 (en) 2016-03-29
PL2998289T3 (pl) 2020-01-31
AU2012267467A1 (en) 2014-01-16
EP2998289B1 (en) 2019-08-07
WO2012170952A9 (en) 2013-02-21
KR20180134424A (ko) 2018-12-18
CA3094645C (en) 2023-01-03
RU2013158456A (ru) 2015-07-20
TW201313256A (zh) 2013-04-01
JP6590888B2 (ja) 2019-10-16
AU2012267467A8 (en) 2017-06-15
RU2769872C2 (ru) 2022-04-07
EP2718261A2 (en) 2014-04-16
TW201711706A (zh) 2017-04-01
ES2743540T3 (es) 2020-02-19
TWI712422B (zh) 2020-12-11
AU2012267467B8 (en) 2017-06-15
KR20180134425A (ko) 2018-12-18
HRP20191463T1 (hr) 2019-11-15
CA3094645A1 (en) 2012-12-13
KR102029657B1 (ko) 2019-10-08
ES2570184T3 (es) 2016-05-17
CN107043334B (zh) 2020-06-16
RU2017135548A3 (cg-RX-API-DMAC7.html) 2021-01-14
SMT201900523T1 (it) 2019-11-13
JP2018065804A (ja) 2018-04-26
AU2017203075B2 (en) 2019-02-07
CA2837101A1 (en) 2012-12-13
CY1117433T1 (el) 2017-04-26
DK2998289T3 (da) 2019-09-16
SI2998289T1 (sl) 2019-11-29
HRP20191463T8 (hr) 2020-02-21
CY1123807T1 (el) 2021-10-29

Similar Documents

Publication Publication Date Title
TWI569814B (zh) 標靶藥物遞送及提升ｓｉＲＮＡ活性用脂溶性維生素化合物
US9963424B2 (en) Cationic lipids for therapeutic agent delivery formulations
US10100004B2 (en) Compounds for targeting drug delivery and enhancing siRNA activity