TWI433681B - 具有極度延遲時間／作用型態之新穎胰島素衍生物（二） - Google Patents

具有極度延遲時間／作用型態之新穎胰島素衍生物（二） Download PDF

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Publication number
TWI433681B
TWI433681B TW098100283A TW98100283A TWI433681B TW I433681 B TWI433681 B TW I433681B TW 098100283 A TW098100283 A TW 098100283A TW 98100283 A TW98100283 A TW 98100283A TW I433681 B TWI433681 B TW I433681B
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TW
Taiwan
Prior art keywords
arg
pro
lys
asp
insulin
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TW098100283A
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English (en)
Chinese (zh)
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TW200942257A (en
Inventor
Paul Habermann
Gerhard Seipke
Roland Kurrle
Guenter Mueller
Mark Sommerfeld
Norbert Tennagels
Georg Tschank
Ulrich Werner
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102008003566A external-priority patent/DE102008003566A1/de
Priority claimed from DE200810025007 external-priority patent/DE102008025007A1/de
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of TW200942257A publication Critical patent/TW200942257A/zh
Application granted granted Critical
Publication of TWI433681B publication Critical patent/TWI433681B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW098100283A 2008-01-09 2009-01-07 具有極度延遲時間／作用型態之新穎胰島素衍生物（二） TWI433681B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008003566A DE102008003566A1 (de) 2008-01-09 2008-01-09 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE200810025007 DE102008025007A1 (de) 2008-05-24 2008-05-24 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil

Publications (2)

Publication Number Publication Date
TW200942257A TW200942257A (en) 2009-10-16
TWI433681B true TWI433681B (zh) 2014-04-11

Family

ID=40473425

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098100283A TWI433681B (zh) 2008-01-09 2009-01-07 具有極度延遲時間／作用型態之新穎胰島素衍生物（二）

Country Status (20)

Country Link
US (1) US8633156B2 (OSRAM)
EP (1) EP2229406B1 (OSRAM)
JP (1) JP5695909B2 (OSRAM)
KR (1) KR20100111683A (OSRAM)
CN (1) CN101970476B (OSRAM)
AR (1) AR070119A1 (OSRAM)
AU (1) AU2009203810B2 (OSRAM)
BR (1) BRPI0907119A2 (OSRAM)
CA (1) CA2711752A1 (OSRAM)
CL (1) CL2009000018A1 (OSRAM)
CO (1) CO6290770A2 (OSRAM)
IL (1) IL206843A0 (OSRAM)
MA (1) MA31997B1 (OSRAM)
NZ (1) NZ586589A (OSRAM)
PA (1) PA8811501A1 (OSRAM)
PE (1) PE20091305A1 (OSRAM)
TW (1) TWI433681B (OSRAM)
UY (1) UY31597A1 (OSRAM)
WO (1) WO2009087082A2 (OSRAM)
ZA (1) ZA201003927B (OSRAM)

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CN102711804B (zh) 2009-11-13 2015-09-16 赛诺菲-安万特德国有限公司 包含glp-1激动剂和甲硫氨酸的药物组合物
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CN109456400A (zh) 2012-07-23 2019-03-12 西兰制药公司 胰高血糖素类似物
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
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CN105849122B (zh) 2013-11-06 2021-04-30 西兰制药公司 Gip-glp-1双重激动剂化合物及方法
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US9895424B2 (en) 2014-01-09 2018-02-20 Sanofi Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
JP6735674B2 (ja) 2014-01-09 2020-08-05 サノフイＳａｎｏｆｉ インスリンアスパルトの安定化された医薬製剤
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TWI705973B (zh) 2014-10-29 2020-10-01 丹麥商西蘭製藥公司 Ｇｉｐ促效劑化合物及方法
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TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
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Also Published As

Publication number Publication date
CA2711752A1 (en) 2009-07-16
CN101970476B (zh) 2014-08-27
CO6290770A2 (es) 2011-06-20
BRPI0907119A2 (pt) 2015-07-14
HK1148542A1 (en) 2011-09-09
EP2229406A2 (de) 2010-09-22
AR070119A1 (es) 2010-03-17
WO2009087082A3 (de) 2009-09-24
US8633156B2 (en) 2014-01-21
PE20091305A1 (es) 2009-09-26
CN101970476A (zh) 2011-02-09
IL206843A0 (en) 2010-12-30
NZ586589A (en) 2012-04-27
JP5695909B2 (ja) 2015-04-08
UY31597A1 (es) 2009-08-31
AU2009203810A1 (en) 2009-07-16
TW200942257A (en) 2009-10-16
MA31997B1 (fr) 2011-01-03
AU2009203810B2 (en) 2013-07-25
PA8811501A1 (es) 2009-09-17
CL2009000018A1 (es) 2009-06-05
KR20100111683A (ko) 2010-10-15
JP2011509269A (ja) 2011-03-24
ZA201003927B (en) 2011-04-28
EP2229406B1 (de) 2015-04-22
US20110173722A1 (en) 2011-07-14
WO2009087082A2 (de) 2009-07-16

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