TWI333422B - Oral pharmaceutical preparations comprising ion exchange resins with active substance loading and pseudoplastic gel-former thickeners - Google Patents
Oral pharmaceutical preparations comprising ion exchange resins with active substance loading and pseudoplastic gel-former thickeners Download PDFInfo
- Publication number
- TWI333422B TWI333422B TW092114643A TW92114643A TWI333422B TW I333422 B TWI333422 B TW I333422B TW 092114643 A TW092114643 A TW 092114643A TW 92114643 A TW92114643 A TW 92114643A TW I333422 B TWI333422 B TW I333422B
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- Taiwan
- Prior art keywords
- acid
- preparation
- ion exchange
- cellulose
- intellectual property
- Prior art date
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- 239000013543 active substance Substances 0.000 title description 17
- 239000003456 ion exchange resin Substances 0.000 title description 13
- 229920003303 ion-exchange polymer Polymers 0.000 title description 13
- 239000002562 thickening agent Substances 0.000 title description 2
- 239000008183 oral pharmaceutical preparation Substances 0.000 title 1
- -1 sylvestite Polymers 0.000 claims description 40
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- 238000002360 preparation method Methods 0.000 claims description 25
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10224086A DE10224086A1 (de) | 2002-05-31 | 2002-05-31 | Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200406230A TW200406230A (en) | 2004-05-01 |
| TWI333422B true TWI333422B (en) | 2010-11-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092114643A TWI333422B (en) | 2002-05-31 | 2003-05-30 | Oral pharmaceutical preparations comprising ion exchange resins with active substance loading and pseudoplastic gel-former thickeners |
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| Country | Link |
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| US (1) | US8545829B2 (enExample) |
| EP (1) | EP1513500B1 (enExample) |
| JP (2) | JP5350574B2 (enExample) |
| KR (3) | KR20120123607A (enExample) |
| CN (1) | CN1671361B (enExample) |
| AR (2) | AR039861A1 (enExample) |
| AT (1) | ATE421317T1 (enExample) |
| AU (1) | AU2003242545B2 (enExample) |
| BR (2) | BR0311511A (enExample) |
| CA (1) | CA2487648C (enExample) |
| CR (1) | CR7598A (enExample) |
| DE (2) | DE10224086A1 (enExample) |
| DK (1) | DK1513500T3 (enExample) |
| ES (1) | ES2319115T3 (enExample) |
| HR (1) | HRP20041219B1 (enExample) |
| IL (2) | IL165322A0 (enExample) |
| MX (1) | MXPA04011820A (enExample) |
| MY (1) | MY140953A (enExample) |
| NO (1) | NO333939B1 (enExample) |
| PL (1) | PL207269B1 (enExample) |
| PT (1) | PT1513500E (enExample) |
| RU (1) | RU2380091C2 (enExample) |
| SI (1) | SI1513500T1 (enExample) |
| TW (1) | TWI333422B (enExample) |
| UA (1) | UA84270C2 (enExample) |
| WO (1) | WO2003101422A2 (enExample) |
| ZA (1) | ZA200409616B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004001558A1 (de) * | 2004-01-10 | 2005-08-18 | Bayer Healthcare Ag | Arzneimittel zur topischen Applikation bei Tieren |
| WO2006061700A2 (en) * | 2004-12-06 | 2006-06-15 | Themis Laboratories Private Limited | Rapid disintegrating taste masked compositions and a process for its preparations |
| DE102005025900A1 (de) * | 2005-06-06 | 2006-12-07 | Basf Ag | Verfahren zur Entfernung von Salzen aus einem Alkoxycarbonylaminotriazin enthaltenden Reaktionsgemisch |
| US20080051332A1 (en) * | 2005-11-18 | 2008-02-28 | Nastech Pharmaceutical Company Inc. | Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone |
| CN100360131C (zh) * | 2006-01-24 | 2008-01-09 | 新昌国邦化学工业有限公司 | 一种掩味恩诺沙星的生产方法 |
| US20070248564A1 (en) * | 2006-04-25 | 2007-10-25 | Roxane Laboratories, Inc. | Formulation of sodium polystyrene sulfonate suspension for the treatment of hyperkalemia |
| CN103349659A (zh) * | 2006-09-26 | 2013-10-16 | 塔罗制药北美有限公司 | 液体药物组合物以及应用 |
| DE102006049520A1 (de) | 2006-10-20 | 2008-04-24 | Bayer Healthcare Ag | Verfahren zur Herstellung von Pradofloxacin |
| US20080118570A1 (en) * | 2006-11-20 | 2008-05-22 | Zhi Liu | Polymer coated drug-ion exchange resins and methods |
| CN103550214A (zh) * | 2008-03-26 | 2014-02-05 | 塔罗制药北美有限公司 | 用于口服药剂的稳定脂质组合物 |
| PL2544532T3 (pl) | 2010-03-12 | 2017-08-31 | Monsanto Technology Llc | Agrochemiczne kompozycje żelowe |
| EA023294B1 (ru) * | 2010-05-19 | 2016-05-31 | Астеллас Фарма Инк. | Фармацевтическая композиция, содержащая солифенацин |
| BR112014009547A8 (pt) | 2011-10-19 | 2018-01-23 | Scherer Technologies Llc R P | composição farmacêutica para administração oral, e, sistema de liberação para a administração oral de uma composição farmacêutica bifásica |
| FR2998305B1 (fr) * | 2012-11-22 | 2015-02-20 | Henkel Ag & Co Kgaa | Substances actives contenant des groupes sulfonates ameliorant la puissance de lavage primaire |
| KR101697095B1 (ko) * | 2015-09-30 | 2017-01-18 | 주식회사 포스코 | 더스트 막힘을 방지할 수 있는 배가스 청정 라인의 실탱크 |
| ES2956316T3 (es) | 2018-04-25 | 2023-12-19 | Elanco Animal Health Gmbh | Proceso para la hidrólisis de ésteres carboxílicos de quinolona |
| KR102923598B1 (ko) * | 2019-07-15 | 2026-02-09 | 한미약품 주식회사 | 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 포함하는 액상 시럽제제 및 이의 제조방법 |
| CN114249749B (zh) * | 2022-01-08 | 2024-03-22 | 天象生物药业邢台有限责任公司 | 一种马波沙星甲酸盐的转化方法 |
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| US614622A (en) * | 1898-11-22 | Machine for making billets | ||
| JPS60204713A (ja) | 1984-03-30 | 1985-10-16 | Zenyaku Kogyo Kk | 水性懸濁組成物 |
| GB8618847D0 (en) | 1986-08-01 | 1986-09-10 | Smith Kline French Lab | Pharmaceutical formulations |
| DE3719764A1 (de) * | 1987-06-13 | 1988-12-22 | Bayer Ag | Ionenaustauscherharze beladen mit chinoloncarbonsaeurederivaten, ihre herstellung und verwendung |
| US5338732A (en) | 1991-06-18 | 1994-08-16 | Bristol-Myers Squibb Company | Megestrol acetate formulation |
| FI941941L (fi) * | 1991-10-28 | 1994-04-27 | Procter & Gamble | Sakeutus-emulgointiainejärjestelmä juomia varten |
| JP3207494B2 (ja) | 1992-04-02 | 2001-09-10 | ロート製薬株式会社 | 水性懸濁製剤 |
| DE4319649A1 (de) * | 1993-03-18 | 1994-09-22 | Asta Medica Ag | Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe |
| PL186737B1 (pl) * | 1996-02-23 | 2004-02-27 | Bayer Ag | Kwasy 8-cyjano-1-cyklopropylo-7-/2, 8-diazabicyklo [ 4.3.0 ] nonan-8-ylo/-6-fluoro-1,4-dihydro-4-okso-3-chinolinokarboksylowe i ich pochodne, sposób ich wytwarzania, środki medyczne je zawierające i ich zastosowanie do wytwarzania środków medycznychi antybakteryjnych |
| US5980882A (en) * | 1997-04-16 | 1999-11-09 | Medeva Pharmaceuticals Manufacturing | Drug-resin complexes stabilized by chelating agents |
| DE19854357A1 (de) * | 1998-11-25 | 2000-05-31 | Bayer Ag | Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| DK1200129T3 (da) * | 1999-07-14 | 2009-01-12 | Schering Plough Ltd | Smagsmaskering af orale, flydende quinolonfremstillinger ved anvendelse af ionbytterharpikser |
| GB9930058D0 (en) | 1999-12-20 | 2000-02-09 | Novartis Ag | Organic compounds |
| GB0020089D0 (en) * | 2000-08-15 | 2000-10-04 | Smithkline Beecham Biolog | Vaccine Composition |
| DE10134719A1 (de) * | 2001-07-17 | 2003-02-06 | Bayer Ag | Pharmazeutische Zubereitungen enthaltend wirkstoffbeladene Ionentauscherharze |
| US7001667B2 (en) * | 2002-07-17 | 2006-02-21 | Ppg Industries Ohio, Inc. | Alkyd-based free radical wood coating compositions |
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2002
- 2002-05-31 DE DE10224086A patent/DE10224086A1/de not_active Withdrawn
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2003
- 2003-05-19 DE DE50311123T patent/DE50311123D1/de not_active Expired - Lifetime
- 2003-05-19 WO PCT/EP2003/005228 patent/WO2003101422A2/de not_active Ceased
- 2003-05-19 CA CA2487648A patent/CA2487648C/en not_active Expired - Lifetime
- 2003-05-19 BR BR0311511-9A patent/BR0311511A/pt active IP Right Grant
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- 2003-05-19 UA UA20041210942A patent/UA84270C2/ru unknown
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- 2003-05-19 DK DK03755931T patent/DK1513500T3/da active
- 2003-05-19 KR KR10-2004-7019371A patent/KR20050010015A/ko not_active Ceased
- 2003-05-28 AR ARP030101867A patent/AR039861A1/es not_active Application Discontinuation
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2004
- 2004-11-22 IL IL165322A patent/IL165322A/en active IP Right Grant
- 2004-11-24 CR CR7598A patent/CR7598A/es not_active Application Discontinuation
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2010
- 2010-10-20 JP JP2010235021A patent/JP2011012087A/ja not_active Withdrawn
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2016
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