TW203559B - - Google Patents
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- TW203559B TW203559B TW080103981A TW80103981A TW203559B TW 203559 B TW203559 B TW 203559B TW 080103981 A TW080103981 A TW 080103981A TW 80103981 A TW80103981 A TW 80103981A TW 203559 B TW203559 B TW 203559B
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- Prior art keywords
- drug
- water
- pharmaceutical composition
- lecithin
- patent application
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/514,012 US5091188A (en) | 1990-04-26 | 1990-04-26 | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
Publications (1)
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TW203559B true TW203559B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-04-11 |
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TW080103981A TW203559B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-04-26 | 1991-05-22 |
Country Status (16)
Families Citing this family (225)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705187A (en) * | 1989-12-22 | 1998-01-06 | Imarx Pharmaceutical Corp. | Compositions of lipids and stabilizing materials |
US5399363A (en) * | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
US5552160A (en) * | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
WO1993015731A1 (en) * | 1992-02-14 | 1993-08-19 | Robert Lamb | Phosphate derivatives of vitamin e to protect cells from effects of aging and injury |
DE4221268C2 (de) * | 1992-06-26 | 1997-06-12 | Lancaster Group Ag | Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut |
US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
US5336507A (en) * | 1992-12-11 | 1994-08-09 | Sterling Winthrop Inc. | Use of charged phospholipids to reduce nanoparticle aggregation |
US20030073642A1 (en) * | 1993-02-22 | 2003-04-17 | American Bioscience, Inc. | Methods and formulations for delivery of pharmacologically active agents |
US20070117862A1 (en) * | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
FR2702160B1 (fr) * | 1993-03-02 | 1995-06-02 | Biovecteurs As | Vecteurs particulaires synthétiques et procédé de préparation. |
DE19609538A1 (de) * | 1996-03-11 | 1997-09-18 | Basf Ag | Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung |
DE4322158C2 (de) * | 1993-07-03 | 1997-04-10 | Rhone Poulenc Rorer Gmbh | Phospholipidische Zusammensetzung sowie Verwendung einer derartigen Zusammensetzung |
US5393461A (en) * | 1993-10-04 | 1995-02-28 | Rtd Corporation | Preparation of stable aqueous emulsions of water-insoluble particles |
US5747001A (en) * | 1995-02-24 | 1998-05-05 | Nanosystems, L.L.C. | Aerosols containing beclomethazone nanoparticle dispersions |
WO1996025918A1 (en) * | 1995-02-24 | 1996-08-29 | Nanosystems L.L.C. | Aerosols containing nanoparticle dispersions |
DE19511276C2 (de) * | 1995-03-27 | 1999-02-18 | Immuno Ag | Adjuvans auf der Basis kolloidaler Eisenverbindungen |
US5788959A (en) | 1995-04-24 | 1998-08-04 | University Of Maryland, Baltimore County | Drug delivery device and method for employing the same |
US5785975A (en) * | 1995-06-26 | 1998-07-28 | Research Triangle Pharmaceuticals | Adjuvant compositions and vaccine formulations comprising same |
US5931809A (en) * | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
US5834025A (en) | 1995-09-29 | 1998-11-10 | Nanosystems L.L.C. | Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions |
AU709262B2 (en) | 1995-10-17 | 1999-08-26 | Board Of Regents, The University Of Texas System | Insoluble drug delivery |
US7255877B2 (en) * | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
CA2263102C (en) | 1996-08-22 | 2006-08-15 | Research Triangle Pharmaceuticals Ltd. | Compositions comprising microparticles of water-insoluble substances and method for preparing same |
US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
US8137684B2 (en) | 1996-10-01 | 2012-03-20 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US20070185032A1 (en) * | 1996-12-11 | 2007-08-09 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
CA2275525C (en) * | 1996-12-20 | 2011-02-08 | Kevin J. Brodbeck | Gel composition and methods |
FR2757768B1 (fr) * | 1996-12-27 | 1999-04-02 | Biovector Therapeutics Sa | Vecteur particulaire homeocharge et composition pharmaceutique ou cosmetique le contenant |
SI0990440T1 (sl) * | 1997-02-27 | 2009-04-30 | Novartis Ag | Farmacevtski sestavek, ki obsega 2-amino-2-(2-(4-oktilfenil)etil)propan-1,3-diol, lecitin in saharid |
AU7133898A (en) * | 1997-04-18 | 1998-11-13 | Vertex Pharmaceuticals Incorporated | Nanosized aspartyl protease inhibitors |
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
KR100904931B1 (ko) * | 1997-06-27 | 2009-06-29 | 아브락시스 바이오사이언스, 엘엘씨 | 나노 입자 및 그의 제조 방법 |
US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
NZ504894A (en) * | 1997-12-02 | 2002-12-20 | Powderject Vaccines Inc | Crystalline vaccine and adjuvant compositions jointly and separately administered to animals using a transdermal or transmucosally delivery technique |
US20010003580A1 (en) * | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
ES2201673T3 (es) * | 1998-02-11 | 2004-03-16 | Rtp Pharma Corporation | Combinacion de esteroides y acidos grasos poiinsaturados para el tratamiento de estados inflamatorios. |
US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
SE9801287D0 (sv) * | 1998-04-14 | 1998-04-14 | Astra Ab | Incorporation of active substances in carrier matrixes |
CN1245955C (zh) | 1998-05-29 | 2006-03-22 | 斯凯伊药品加拿大公司 | 热保护微粒组合物及其最终蒸汽灭菌的方法 |
US7343710B2 (en) * | 1998-07-03 | 2008-03-18 | I.D.A Limited | Method and apparatus for controlling pests |
GB9814507D0 (en) * | 1998-07-03 | 1998-09-02 | Univ Southampton | A method and apparatus for controlling pests |
DE69912441T2 (de) | 1998-08-19 | 2004-08-19 | Skyepharma Canada Inc., Verdun | Injizierbare wässerige propofoldispersionen |
CA2347369A1 (en) * | 1998-10-19 | 2000-04-27 | Powderject Vaccines, Inc. | Minimal promoters and uses thereof |
US6881723B1 (en) | 1998-11-05 | 2005-04-19 | Powderject Vaccines, Inc. | Nucleic acid constructs |
US6180136B1 (en) * | 1998-11-10 | 2001-01-30 | Idexx Laboratories, Inc. | Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US20040141925A1 (en) * | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
RU2233654C2 (ru) * | 1998-11-20 | 2004-08-10 | Ртп Фарма Инк. | Диспергируемые стабилизированные фосфолипидом микрочастицы |
US6251886B1 (en) | 1998-12-07 | 2001-06-26 | Schering Corporation | Methods of using temozolomide in the treatment of cancers |
US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
DE19901687B4 (de) * | 1999-01-18 | 2006-06-01 | Grünenthal GmbH | Opioide Analgetika mit kontrollierter Wirkstofffreisetzung |
KR100359252B1 (ko) * | 1999-12-21 | 2002-11-04 | 주식회사 엘지생명과학 | 항원을 포함하는 고체상 미세입자 및 이를 포함하는 제제 |
US7022320B1 (en) | 1999-02-09 | 2006-04-04 | Powderject Vaccines, Inc. | Mycobacterium tuberculosis immunization |
US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
AU3606100A (en) * | 1999-02-26 | 2000-09-14 | Idexx Laboratories, Inc. | Methods for administering pharmacologically active compounds to vertebrates |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6511814B1 (en) | 1999-03-26 | 2003-01-28 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6551842B1 (en) | 1999-03-26 | 2003-04-22 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6602719B1 (en) | 1999-03-26 | 2003-08-05 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
PL197817B1 (pl) * | 1999-07-16 | 2008-04-30 | Unilever Nv | Tłuszcz twardej osnowy odpowiedni do stabilizowania rozlewnej dyspersji oraz rozlewna dyspersja tłuszczowa |
CN100406004C (zh) | 1999-08-24 | 2008-07-30 | 特瓦制药工业有限公司 | 疫苗组合物及其制药用途 |
US6592869B2 (en) | 1999-08-24 | 2003-07-15 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
EP1214059B1 (en) * | 1999-09-21 | 2005-05-25 | Skyepharma Canada Inc. | Surface modified particulate compositions of biologically active substances |
US20050032226A1 (en) * | 1999-10-01 | 2005-02-10 | Natan Michael J. | Encoded nanoparticles in paper manufacture |
US6919009B2 (en) * | 1999-10-01 | 2005-07-19 | Nanoplex Technologies, Inc. | Method of manufacture of colloidal rod particles as nanobarcodes |
US20040178076A1 (en) * | 1999-10-01 | 2004-09-16 | Stonas Walter J. | Method of manufacture of colloidal rod particles as nanobarcodes |
US20040209376A1 (en) * | 1999-10-01 | 2004-10-21 | Surromed, Inc. | Assemblies of differentiable segmented particles |
US7045049B1 (en) * | 1999-10-01 | 2006-05-16 | Nanoplex Technologies, Inc. | Method of manufacture of colloidal rod particles as nanobar codes |
US7225082B1 (en) * | 1999-10-01 | 2007-05-29 | Oxonica, Inc. | Colloidal rod particles as nanobar codes |
US7196066B1 (en) * | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
GB0009773D0 (en) * | 2000-04-19 | 2000-06-07 | Univ Cardiff | Particulate composition |
AU2001257115B2 (en) | 2000-04-20 | 2005-01-27 | Rtp Pharma Inc. | Improved water-insoluble drug particle process |
DE60133270T2 (de) | 2000-05-10 | 2009-04-23 | Jagotec Ag | Zerkleinerung mittels mahlkörper |
EP2036540A3 (en) | 2000-06-16 | 2009-12-16 | Jagotec AG | Improved injectable dispersions of propofol |
WO2002017883A2 (en) | 2000-08-31 | 2002-03-07 | Rtp Pharma Inc. | Milled particles |
DE10145910A1 (de) * | 2000-09-18 | 2002-06-20 | Registrar University Of Delhi | Ophtalmologische Formulierung mit verlangsamter Freisetzung und langer Verweildauer sowie Herstellungsverfahren hierfür |
CA2423336C (en) * | 2000-09-20 | 2011-03-08 | Rtp Pharma Inc. | Stabilised fibrate microparticles |
US8586094B2 (en) * | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
US20100173876A1 (en) * | 2000-12-19 | 2010-07-08 | The Board Of Regents Of The University Of Texas System | Oil-based nsaid compositions and methods for making and using same |
SI1343529T1 (sl) | 2000-12-19 | 2009-04-30 | Univ Texas | NSAID formulacije, ki vsebujejo lecitinska olja, za zaščito gastrointestinalnega trakta in zagotovitev povečanja terapevtske aktivnosti |
US20040077604A1 (en) * | 2001-12-19 | 2004-04-22 | Lenard Lichtenberger | Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity |
US7037528B2 (en) * | 2000-12-22 | 2006-05-02 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US20040022862A1 (en) * | 2000-12-22 | 2004-02-05 | Kipp James E. | Method for preparing small particles |
US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
US20050048126A1 (en) * | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US9700866B2 (en) * | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US6977085B2 (en) * | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
US7193084B2 (en) * | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
US8067032B2 (en) * | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US6884436B2 (en) * | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
US20030096013A1 (en) * | 2000-12-22 | 2003-05-22 | Jane Werling | Preparation of submicron sized particles with polymorph control |
US6951656B2 (en) * | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US20020150615A1 (en) * | 2001-02-12 | 2002-10-17 | Howard Sands | Injectable pharmaceutical composition comprising microdroplets of a camptothecin |
US6497896B2 (en) | 2001-02-12 | 2002-12-24 | Supergen, Inc. | Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin |
US6509027B2 (en) | 2001-02-12 | 2003-01-21 | Supergen, Inc. | Injectable pharmaceutical composition comprising coated particles of camptothecin |
EP1361867B1 (en) * | 2001-02-22 | 2007-03-21 | Jagotec AG | Fibrate-statin combinations with reduced fed-fasted effects |
JP2005511477A (ja) * | 2001-03-19 | 2005-04-28 | プラエシス ファーマシューティカルズ インコーポレーテッド | 持続放出のための医薬調合物 |
DK1389089T3 (da) * | 2001-03-27 | 2009-12-21 | Phares Pharm Res Nv | Fremgangsmådeog sammensætning til solubilisering af en biologisk aktiv forbindelse med lav vandoplöselighed |
AU2002307090A1 (en) * | 2001-04-03 | 2002-10-21 | Surromed, Inc. | Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples |
CA2441108A1 (en) * | 2001-04-05 | 2002-10-17 | Universite Laval | Process for making delivery matrix and uses thereof |
GB0114532D0 (en) * | 2001-06-14 | 2001-08-08 | Jagotec Ag | Novel compositions |
US6676958B2 (en) | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
US7758890B2 (en) | 2001-06-23 | 2010-07-20 | Lyotropic Therapeutics, Inc. | Treatment using dantrolene |
GB0119480D0 (en) * | 2001-08-09 | 2001-10-03 | Jagotec Ag | Novel compositions |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
GB0122318D0 (en) * | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
IL160570A0 (en) * | 2001-09-26 | 2004-07-25 | Baxter Int | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
US7112340B2 (en) * | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
EP1446103B1 (en) * | 2001-10-19 | 2015-12-23 | Idexx Laboratories, Inc. | Injectable compositions for the controlled delivery of pharmacologically active compound |
US20030129242A1 (en) * | 2002-01-04 | 2003-07-10 | Bosch H. William | Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer |
KR100836035B1 (ko) * | 2002-02-19 | 2008-06-09 | (주)아모레퍼시픽 | 포화 및 불포화 레시틴 함유 나노에멀젼 및 이를 함유하는화장료 조성물 |
CA2479665C (en) * | 2002-03-20 | 2011-08-30 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
US20080220075A1 (en) * | 2002-03-20 | 2008-09-11 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
US7101566B2 (en) * | 2002-06-28 | 2006-09-05 | Ethicon, Inc. | Polymer coated microparticles for sustained release |
US20050169979A1 (en) * | 2002-07-03 | 2005-08-04 | Dov Michaeli | Liposomal vaccine |
US20040247661A1 (en) * | 2002-07-03 | 2004-12-09 | Dov Michaeli | Liposomal vaccine |
US7838034B2 (en) * | 2002-07-30 | 2010-11-23 | Grunenthal Gmbh | Intravenous pharmaceutical form of administration |
SI1551876T1 (sl) | 2002-10-16 | 2011-07-29 | Purdue Pharma Lp | Protitelesa, ki se vežejo na celično povezan CA 125/0722P, in postopki za njihovo uporabo |
RU2331424C2 (ru) * | 2002-12-13 | 2008-08-20 | Джеготек Аг | Топический состав, содержащий наночастицы спиронолактона |
BR0215979A (pt) * | 2002-12-13 | 2005-11-01 | Jagotec Ag | Formulação de espironolactona nanoparticulada tópica, uso de nanossuspensões de espironolactona, sistema de rede cristalina, e, processo para a preparação de uma formulação de espironolactona nanoparticulada tópica |
US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
ES2862337T3 (es) | 2003-03-04 | 2021-10-07 | Lyotropic Therapeutics Inc | Composiciones de dantroleno |
WO2004113869A2 (en) * | 2003-06-17 | 2004-12-29 | Surromed, Inc. | Labeling and authentication of metal objects |
DE10327839A1 (de) * | 2003-06-20 | 2005-01-05 | Arvinmeritor Gmbh | Fahrzeugdachmodul |
BRPI0414970A2 (pt) * | 2003-06-24 | 2012-12-11 | Baxter Int | método para transporte de drogas ao cérebro |
US8986736B2 (en) * | 2003-06-24 | 2015-03-24 | Baxter International Inc. | Method for delivering particulate drugs to tissues |
US20080051373A1 (en) * | 2003-07-31 | 2008-02-28 | The Board Of Regents Of The University Of Texas System | Parenteral preparations of GI-safer phospholipid-associated anti-inflammatories and methods of preparation and use |
US20050049209A1 (en) * | 2003-08-06 | 2005-03-03 | Chen Andrew Xian | Pharmaceutical compositions for delivering macrolides |
JP2005097295A (ja) * | 2003-09-01 | 2005-04-14 | Wakunaga Pharmaceut Co Ltd | ビタミン安定液剤 |
PL1663321T3 (pl) | 2003-09-22 | 2013-07-31 | Baxter Int | Wysokociśnieniowa sterylizacja do końcowego sterylizowania preparatów farmaceutycznych i wyrobów medycznych |
US20060003002A1 (en) * | 2003-11-03 | 2006-01-05 | Lipocine, Inc. | Pharmaceutical compositions with synchronized solubilizer release |
CA2549966A1 (en) * | 2003-12-24 | 2005-07-07 | Ltt Bio-Pharma Co., Ltd. | Drug-containing nanoparticle, process for producing the same and parenterally administered preparation from the nanoparticle |
CN1913871A (zh) * | 2004-01-29 | 2007-02-14 | 巴克斯特国际公司 | 用于提高中枢神经系统投递的抗-逆转录病毒药剂的纳米悬浮液 |
JP2007520555A (ja) * | 2004-02-05 | 2007-07-26 | バクスター・インターナショナル・インコーポレイテッド | 自己安定化剤の使用により調製された分散剤 |
EP1730516A1 (en) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Method and device for evaluation of pharmaceutical compositions |
US20060160823A1 (en) * | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
CN1988887A (zh) * | 2004-05-28 | 2007-06-27 | 先灵公司 | 包含泊沙康唑的注射用药物混悬剂 |
US20060009469A1 (en) * | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
EP1763576A2 (en) * | 2004-06-15 | 2007-03-21 | Baxter International Inc. | Ex-vivo application of solid microparticulate therapeutic agents |
WO2006034147A2 (en) * | 2004-09-16 | 2006-03-30 | Abraxis Bioscience, Inc. | Compositions and methods for the preparation and administration of poorly water soluble drugs |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
MX2007015183A (es) * | 2005-06-14 | 2008-02-19 | Baxter Int | Formulaciones farmaceuticas para minimizar las interacciones farmaco-farmaco. |
JP2009516003A (ja) * | 2005-11-15 | 2009-04-16 | バクスター・インターナショナル・インコーポレイテッド | リポキシゲナーゼ阻害剤の組成物 |
US8709379B2 (en) | 2006-03-29 | 2014-04-29 | Scitech Development, Llc | Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery |
US20080299210A1 (en) * | 2006-04-13 | 2008-12-04 | Min Wei | Stable nanosized amorphous drug |
CN101453982B (zh) | 2006-05-30 | 2011-05-04 | 精达制药公司 | 两件式内部通道渗透递送系统流动调节器 |
US20080181957A1 (en) * | 2006-06-23 | 2008-07-31 | Min Wei | Increased amorphous stability of poorly water soluble drugs by nanosizing |
WO2008013822A2 (en) * | 2006-07-26 | 2008-01-31 | The Board Of Regent Of The University Of Texas System | Parenteral preparations of gi-safer phospholipid-associated anti-inflammatories and methods of preparation and use |
JP5048773B2 (ja) | 2006-08-09 | 2012-10-17 | インターシア セラピューティクス,インコーポレイティド | 浸透圧式デリバリーシステム及びピストンアセンブリー |
US20110021592A1 (en) * | 2006-09-14 | 2011-01-27 | Shlomo Magdassi | Organic nanoparticles obtained from microemulsions by solvent evaporation |
AR063704A1 (es) | 2006-09-14 | 2009-02-11 | Makhteshim Chem Works Ltd | Nanoparticulas de pesticida obtenida obtenidas a partir de microemulsiones y nanoemulsiones |
US20100062073A1 (en) * | 2006-11-29 | 2010-03-11 | Ronald Arthur Beyerinck | Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein |
WO2008080047A2 (en) * | 2006-12-23 | 2008-07-03 | Baxter International Inc. | Magnetic separation of fine particles from compositions |
WO2008125940A2 (en) * | 2007-04-17 | 2008-10-23 | Pfizer Products Inc. | Nanoparticles comprising non-crystalline drug |
PL2157967T3 (pl) | 2007-04-23 | 2013-06-28 | Intarcia Therapeutics Inc | Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania |
US20100080852A1 (en) * | 2007-05-03 | 2010-04-01 | Ronald Arthur Beyerinck | Phamaceutical composition comprising nanoparticles and casein |
WO2008135828A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
WO2008135855A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
WO2008137960A1 (en) * | 2007-05-07 | 2008-11-13 | Questor Pharmaceuticals, Inc. | Nasal administration of benzodiazepines |
US8530463B2 (en) * | 2007-05-07 | 2013-09-10 | Hale Biopharma Ventures Llc | Multimodal particulate formulations |
US20080293814A1 (en) * | 2007-05-22 | 2008-11-27 | Deepak Tiwari | Concentrate esmolol |
US8722736B2 (en) * | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
US20080292663A1 (en) * | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
US8426467B2 (en) * | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
WO2008149192A2 (en) * | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
WO2008149230A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate |
US20080319039A1 (en) * | 2007-06-25 | 2008-12-25 | Jacqueline Rose Bersch | Unit dosage forms of temozolomide |
EP2178518A2 (en) * | 2007-07-13 | 2010-04-28 | Bend Research, Inc | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
CN101827613A (zh) | 2007-09-27 | 2010-09-08 | 免疫疫苗技术有限公司 | 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用 |
US9233078B2 (en) * | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
US9724362B2 (en) * | 2007-12-06 | 2017-08-08 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
PL2244783T3 (pl) * | 2008-01-22 | 2020-08-24 | Board Of Regents, The University Of Texas System | Kompozycje lotnego anestetyku i sposoby stosowania |
WO2009102467A2 (en) | 2008-02-13 | 2009-08-20 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
EP2259798B1 (en) | 2008-03-05 | 2013-12-11 | Baxter International Inc. | Surface-modified particles and methods for targeted drug delivery |
CA2718416C (en) * | 2008-03-13 | 2018-01-02 | Mallinckrodt Inc. | Multi-function, foot-activated controller for imaging system |
AU2009228093B2 (en) * | 2008-03-28 | 2014-08-07 | Neurelis, Inc. | Administration of benzodiazepine compositions |
CA2723918C (en) | 2008-06-05 | 2018-01-09 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
GB2462022B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof |
TW201026716A (en) | 2008-12-23 | 2010-07-16 | Pharmasset Inc | Nucleoside analogs |
KR20110099138A (ko) * | 2008-12-23 | 2011-09-06 | 파마셋 인코포레이티드 | 뉴클레오시드 포스포르아미데이트 |
US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
US11304960B2 (en) * | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
CN109394689A (zh) * | 2009-05-05 | 2019-03-01 | 德州大学系统董事会 | 挥发性麻醉剂的新型制剂及其用于减轻炎症的使用方法 |
US10952965B2 (en) * | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
KR20150006083A (ko) | 2009-09-28 | 2015-01-15 | 인타르시아 세라퓨틱스 인코포레이티드 | 실질 항정상태 약물 전달의 신속 확립 및/또는 종결 |
PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
UY33312A (es) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidato de nucleosido de purina |
EP2752422B1 (en) | 2010-03-31 | 2017-08-16 | Gilead Pharmasset LLC | Stereoselective synthesis of phosphorus containing actives |
ES2716158T3 (es) | 2010-11-30 | 2019-06-10 | Gilead Pharmasset Llc | 2'-spiro-nucleótidos para el tratamiento de hepatitis C |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
EP2646107A2 (en) | 2010-12-01 | 2013-10-09 | Spinal Modulation Inc. | Agent delivery systems for selective neuromodulation |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
EP3415139B8 (en) | 2011-06-14 | 2022-05-18 | Neurelis, Inc. | Administration of benzodiazepine |
CN103957888B (zh) | 2011-09-29 | 2017-11-21 | PLx 制药公司 | 用于将药物沿胃肠道靶向释放的pH依赖性载体、其组合物及其制备和应用 |
US10105435B2 (en) | 2011-10-06 | 2018-10-23 | Immunovaccine Technologies Inc. | Liposome compositions comprising an adjuvant that activates or increases the activity of TLR2 and uses thereof |
WO2013138334A1 (en) | 2012-03-12 | 2013-09-19 | Advanced Bioadjuvants, Llc | Adjuvant and vaccine compositions |
CN105611921A (zh) | 2013-03-15 | 2016-05-25 | 维普詹尼克斯公司 | 新型镇痛组合物 |
RU2541156C1 (ru) * | 2013-07-09 | 2015-02-10 | Общество с ограниченной ответственностью Научно-производственное объединение "Клеточные технологии" | Трансдермальное антигельминтное средство на основе кремнийорганических ниосом с альбендазолом |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
WO2016033556A1 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
AU2016270984B2 (en) | 2015-06-03 | 2021-02-25 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
WO2016205423A2 (en) | 2015-06-15 | 2016-12-22 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
EP3178479A1 (en) * | 2015-12-08 | 2017-06-14 | Verano Ilac Sanayi Ve Ticaret A.S. | An injectable composition of ricobendazole |
JP7077237B2 (ja) | 2016-05-16 | 2022-05-30 | インターシア セラピューティクス,インコーポレイティド | グルカゴン受容体選択的ポリペプチド及びその使用方法 |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
EP3544614A4 (en) | 2016-11-28 | 2020-08-05 | Lipocine Inc. | TESTOSTERONE UNDECANOATE ORAL TREATMENT |
IL267736B2 (en) | 2017-01-03 | 2024-03-01 | Intarcia Therapeutics Inc | Methods involving continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
CA3107214A1 (en) | 2018-07-20 | 2020-01-23 | Lipocine Inc. | Liver disease |
EP4125820A4 (en) | 2020-03-26 | 2024-04-10 | PLx Opco Inc. | Pharmaceutical carriers capable of ph dependent reconstitution and methods for making and using same |
US11992483B2 (en) | 2021-03-31 | 2024-05-28 | Cali Biosciences Us, Llc | Emulsions for local anesthetics |
CN116687847B (zh) * | 2023-06-26 | 2024-03-29 | 石家庄四药有限公司 | 一种药物微晶注射液及其制备方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1502774A (en) * | 1974-06-25 | 1978-03-01 | Nat Res Dev | Immunological preparations |
GB1578776A (en) * | 1976-06-10 | 1980-11-12 | Univ Illinois | Hemoglobin liposome and method of making the same |
US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
US4298594A (en) * | 1978-04-14 | 1981-11-03 | Arthur D. Little, Inc. | Xenobiotic delivery vehicles, method of forming them and method of using them |
DE2856333C2 (de) * | 1978-12-27 | 1983-09-22 | A. Nattermann & Cie GmbH, 5000 Köln | Oral einnehmbare Arzneimittel mit entzündungshemmender Wirkung |
US4421747A (en) * | 1978-12-27 | 1983-12-20 | A. Nattermann & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
US4378354A (en) * | 1978-12-27 | 1983-03-29 | A. Nattermann & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
DE2914788A1 (de) * | 1979-04-11 | 1980-10-16 | Nattermann A & Cie | Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung |
US4345588A (en) * | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
JPS562353A (en) * | 1979-06-20 | 1981-01-12 | Ricoh Co Ltd | Novel disazo compound and its preparation |
CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
AR220263A1 (es) * | 1980-02-19 | 1980-10-15 | Bago Lab Sa | Procedimiento para obtener una preparacion inyectable de sulfonamida potenciada de baja irritabilidad |
US4331654A (en) * | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
US5030453A (en) * | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
US4515736A (en) * | 1983-05-12 | 1985-05-07 | The Regents Of The University Of California | Method for encapsulating materials into liposomes |
US4622219A (en) * | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
US4492720A (en) * | 1983-11-15 | 1985-01-08 | Benjamin Mosier | Method of preparing microspheres for intravascular delivery |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
JPS60208910A (ja) * | 1984-03-31 | 1985-10-21 | Green Cross Corp:The | 水難溶性薬物・リン脂質複合体の製造方法 |
JPS6176414A (ja) * | 1984-09-21 | 1986-04-18 | Shionogi & Co Ltd | リポソーム製剤の製法 |
US4761288A (en) * | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
JPH0688911B2 (ja) * | 1985-06-06 | 1994-11-09 | 国立予防衛生研究所長 | インフルエンザワクチン及びその製造方法 |
JPH0617309B2 (ja) * | 1985-11-29 | 1994-03-09 | 株式会社ビタミン研究所 | アドリアマイシン包埋リポソ−ム製剤 |
AU7128887A (en) * | 1986-02-10 | 1987-08-25 | Liposome Technology, Inc. | Controlled-release liposome delivery system |
US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
US4806350A (en) * | 1986-04-18 | 1989-02-21 | Norden Laboratories, Inc. | Vaccine formulation |
JPS62278241A (ja) * | 1986-05-26 | 1987-12-03 | Shoei Kagaku Kogyo Kk | ボンデイングワイヤ |
US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
CA1338736C (fr) * | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation |
DK175531B1 (da) * | 1986-12-15 | 2004-11-22 | Nexstar Pharmaceuticals Inc | Leveringsvehikel med amphiphil-associeret aktiv bestanddel |
US4839111A (en) * | 1987-02-02 | 1989-06-13 | The University Of Tennessee Research Corporation | Preparation of solid core liposomes |
FR2651680B1 (fr) * | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | Nouveau procede de preparation de microparticules lipidiques. |
GB8921222D0 (en) * | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
-
1990
- 1990-04-26 US US07/514,012 patent/US5091188A/en not_active Expired - Lifetime
-
1991
- 1991-04-23 EP EP91908933A patent/EP0533690B1/en not_active Expired - Lifetime
- 1991-04-23 JP JP50885491A patent/JP3261129B2/ja not_active Expired - Lifetime
- 1991-04-23 KR KR1019920702656A patent/KR0159114B1/ko not_active Expired - Lifetime
- 1991-04-23 DK DK91908933T patent/DK0533690T3/da active
- 1991-04-23 RU RU9292016352A patent/RU2100030C1/ru active
- 1991-04-23 CA CA002078990A patent/CA2078990C/en not_active Expired - Lifetime
- 1991-04-23 ES ES91908933T patent/ES2134776T3/es not_active Expired - Lifetime
- 1991-04-23 AU AU78528/91A patent/AU7852891A/en not_active Abandoned
- 1991-04-23 AT AT91908933T patent/ATE181234T1/de not_active IP Right Cessation
- 1991-04-23 DE DE69131349T patent/DE69131349T2/de not_active Expired - Lifetime
- 1991-04-23 WO PCT/US1991/002804 patent/WO1991016068A1/en active IP Right Grant
- 1991-04-25 ZA ZA913122A patent/ZA913122B/xx unknown
- 1991-04-26 MX MX2553291A patent/MX25532A/es unknown
- 1991-05-22 TW TW080103981A patent/TW203559B/zh not_active IP Right Cessation
-
1994
- 1994-09-12 US US08/304,225 patent/USRE35338E/en not_active Expired - Lifetime
-
1999
- 1999-07-20 GR GR990401915T patent/GR3030825T3/el unknown
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USRE35338E (en) | 1996-09-24 |
KR0159114B1 (ko) | 1998-12-01 |
DK0533690T3 (da) | 1999-11-22 |
DE69131349T2 (de) | 1999-11-18 |
ZA913122B (en) | 1992-04-29 |
JP3261129B2 (ja) | 2002-02-25 |
GR3030825T3 (en) | 1999-11-30 |
AU7852891A (en) | 1991-11-11 |
EP0533690B1 (en) | 1999-06-16 |
US5091188A (en) | 1992-02-25 |
ATE181234T1 (de) | 1999-07-15 |
CA2078990C (en) | 2002-06-04 |
EP0533690A1 (en) | 1993-03-31 |
CA2078990A1 (en) | 1991-10-27 |
JPH05507685A (ja) | 1993-11-04 |
WO1991016068A1 (en) | 1991-10-31 |
ES2134776T3 (es) | 1999-10-16 |
DE69131349D1 (de) | 1999-07-22 |
RU2100030C1 (ru) | 1997-12-27 |
EP0533690A4 (en) | 1993-04-14 |
MX25532A (es) | 1993-10-01 |
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