TW200906830A - Novel macrocyclic inhibitors of hepatitis C virus replication - Google Patents

Novel macrocyclic inhibitors of hepatitis C virus replication Download PDF

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Publication number
TW200906830A
TW200906830A TW097116495A TW97116495A TW200906830A TW 200906830 A TW200906830 A TW 200906830A TW 097116495 A TW097116495 A TW 097116495A TW 97116495 A TW97116495 A TW 97116495A TW 200906830 A TW200906830 A TW 200906830A
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TW
Taiwan
Prior art keywords
compound
ifn
formula
group
dose
Prior art date
Application number
TW097116495A
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English (en)
Chinese (zh)
Inventor
Lawrence M Blatt
Lin Pan
Scott D Seiwert
Steven W Andrews
Pierre Martin
Andreas Schumacher
Leonid Beigelman
Jyanwei Liu
Kevin R Condroski
Yutong Jiang
Robert Kaus
April Kennedy
Timothy Kercher
Michael Lyon
Bin Wang
Original Assignee
Intermune Inc
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc, Array Biopharma Inc filed Critical Intermune Inc
Publication of TW200906830A publication Critical patent/TW200906830A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
TW097116495A 2007-05-03 2008-05-05 Novel macrocyclic inhibitors of hepatitis C virus replication TW200906830A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91589607P 2007-05-03 2007-05-03
US95763007P 2007-08-23 2007-08-23
US1564407P 2007-12-20 2007-12-20

Publications (1)

Publication Number Publication Date
TW200906830A true TW200906830A (en) 2009-02-16

Family

ID=39638815

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097116495A TW200906830A (en) 2007-05-03 2008-05-05 Novel macrocyclic inhibitors of hepatitis C virus replication

Country Status (22)

Country Link
US (1) US20090155209A1 (cg-RX-API-DMAC7.html)
EP (2) EP2177523A1 (cg-RX-API-DMAC7.html)
JP (1) JP2010528987A (cg-RX-API-DMAC7.html)
KR (1) KR20100024920A (cg-RX-API-DMAC7.html)
CN (1) CN101784549A (cg-RX-API-DMAC7.html)
AP (1) AP2009005053A0 (cg-RX-API-DMAC7.html)
AR (1) AR066448A1 (cg-RX-API-DMAC7.html)
AU (1) AU2008247509A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0811020A2 (cg-RX-API-DMAC7.html)
CA (1) CA2686138A1 (cg-RX-API-DMAC7.html)
CL (1) CL2008001274A1 (cg-RX-API-DMAC7.html)
CO (1) CO6251243A2 (cg-RX-API-DMAC7.html)
EA (1) EA200971026A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP099780A (cg-RX-API-DMAC7.html)
IL (1) IL201757A0 (cg-RX-API-DMAC7.html)
MA (1) MA31496B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009011867A (cg-RX-API-DMAC7.html)
NZ (1) NZ581606A (cg-RX-API-DMAC7.html)
SG (1) SG174809A1 (cg-RX-API-DMAC7.html)
TN (1) TN2009000457A1 (cg-RX-API-DMAC7.html)
TW (1) TW200906830A (cg-RX-API-DMAC7.html)
WO (1) WO2008137779A2 (cg-RX-API-DMAC7.html)

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US20090155209A1 (en) 2009-06-18
MX2009011867A (es) 2010-03-22
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