TW200808739A - Quinazolines for PDK1 inhibition - Google Patents

Quinazolines for PDK1 inhibition Download PDF

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Publication number
TW200808739A
TW200808739A TW096112158A TW96112158A TW200808739A TW 200808739 A TW200808739 A TW 200808739A TW 096112158 A TW096112158 A TW 096112158A TW 96112158 A TW96112158 A TW 96112158A TW 200808739 A TW200808739 A TW 200808739A
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Taiwan
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group
substituted
alkyl
amine
doc
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TW096112158A
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English (en)
Chinese (zh)
Inventor
Savithri Ramurthy
Xiaodong Lin
Sharadha Subramanian
Alice C Rico
Xiaojing M Wang
Rama Jain
Jeremy M Murray
Stephan E Basham
Robert L Warne
Wei Shu
Yasheen Zhou
Jeffrey Dove
Mina Aikawa
Payman Amiri
Weibo Wang
Johanna M Jansen
Allan S Wagman
Keith B Pfister
Simon C Ng
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Novartis Vaccines & Diagnostic
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Publication of TW200808739A publication Critical patent/TW200808739A/zh

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
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  • Organic Chemistry (AREA)
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  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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TW096112158A 2006-04-06 2007-04-04 Quinazolines for PDK1 inhibition TW200808739A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79030406P 2006-04-06 2006-04-06

Publications (1)

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TW200808739A true TW200808739A (en) 2008-02-16

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TW096112158A TW200808739A (en) 2006-04-06 2007-04-04 Quinazolines for PDK1 inhibition

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US (1) US7932262B2 (enExample)
EP (1) EP2004615A2 (enExample)
JP (1) JP2009532486A (enExample)
KR (1) KR20080111114A (enExample)
CN (1) CN101454294A (enExample)
AR (1) AR060358A1 (enExample)
AU (1) AU2007235339A1 (enExample)
BR (1) BRPI0710521A2 (enExample)
CA (1) CA2648529A1 (enExample)
CR (1) CR10427A (enExample)
EA (1) EA200870415A1 (enExample)
EC (1) ECSP088823A (enExample)
GT (1) GT200800202A (enExample)
MA (1) MA30358B1 (enExample)
MX (1) MX2008012852A (enExample)
NO (1) NO20084665L (enExample)
PE (1) PE20080059A1 (enExample)
SM (1) SMP200800059B (enExample)
TN (1) TNSN08375A1 (enExample)
TW (1) TW200808739A (enExample)
WO (1) WO2007117607A2 (enExample)
ZA (1) ZA200808307B (enExample)

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UY31137A1 (es) * 2007-06-14 2009-01-05 Smithkline Beecham Corp Derivados de quinazolina como inhibidores de la pi3 quinasa
WO2009007984A2 (en) * 2007-07-11 2009-01-15 Hetero Drugs Limited An improved process for erlotinib hydrochloride
EP2226315A4 (en) 2007-12-28 2012-01-25 Carna Biosciences Inc 2-aminoquinazoline DERIVATIVE
WO2009087127A1 (en) * 2008-01-11 2009-07-16 F. Hoffmann-La Roche Ag Modulators for amyloid beta
WO2009131173A1 (ja) 2008-04-23 2009-10-29 協和発酵キリン株式会社 2-アミノキナゾリン誘導体
NZ588511A (en) 2008-05-23 2012-04-27 Novartis Ag Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
WO2009155121A2 (en) * 2008-05-30 2009-12-23 Amgen Inc. Inhibitors of pi3 kinase
US20100121052A1 (en) * 2008-06-20 2010-05-13 Rama Jain Novel compounds for treating proliferative diseases
CN102333533A (zh) * 2008-12-29 2012-01-25 佛维雅制药公司 取代的喹唑啉化合物
WO2012044090A2 (ko) * 2010-09-29 2012-04-05 크리스탈지노믹스(주) 단백질 키나제 억제 활성을 갖는 신규한 아미노퀴나졸린 화합물
WO2013050527A1 (en) 2011-10-05 2013-04-11 H. Lundbeck A/S Quinazoline derivatives as pde10a enzyme inhibitors
KR101360948B1 (ko) * 2012-01-17 2014-02-12 한국과학기술연구원 신규한 2-아미노퀴나졸린 유도체 및 이를 유효성분으로 포함하는 항암제
GB201216017D0 (en) * 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
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GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
PL3122358T3 (pl) 2014-03-26 2021-06-14 Astex Therapeutics Ltd. Połączenia inhibitorów fgfr i cmet w leczeniu nowotworu
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JP6385584B2 (ja) 2014-12-24 2018-09-05 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖの処置のための縮合ピリミジン化合物
TWI770552B (zh) 2014-12-24 2022-07-11 美商基利科學股份有限公司 喹唑啉化合物
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
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