TW200528472A - Inhibitors of serine proteases, particularly HCV ns3-ns4a protease - Google Patents
Inhibitors of serine proteases, particularly HCV ns3-ns4a protease Download PDFInfo
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- TW200528472A TW200528472A TW093130680A TW93130680A TW200528472A TW 200528472 A TW200528472 A TW 200528472A TW 093130680 A TW093130680 A TW 093130680A TW 93130680 A TW93130680 A TW 93130680A TW 200528472 A TW200528472 A TW 200528472A
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- Prior art keywords
- ring
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- aryl
- heteroaryl
- heterocyclyl
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- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
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- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51015603P | 2003-10-10 | 2003-10-10 | |
| US51376803P | 2003-10-23 | 2003-10-23 |
Publications (1)
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| TW200528472A true TW200528472A (en) | 2005-09-01 |
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Family Applications (1)
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| TW093130680A TW200528472A (en) | 2003-10-10 | 2004-10-08 | Inhibitors of serine proteases, particularly HCV ns3-ns4a protease |
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| EP (2) | EP1692157B1 (enExample) |
| JP (2) | JP2007532474A (enExample) |
| KR (2) | KR20060130027A (enExample) |
| CN (1) | CN101857631A (enExample) |
| AU (1) | AU2004282148A1 (enExample) |
| CA (1) | CA2541634A1 (enExample) |
| IL (1) | IL174863A0 (enExample) |
| MX (1) | MXPA06004006A (enExample) |
| NO (1) | NO20062101L (enExample) |
| NZ (1) | NZ546663A (enExample) |
| RU (1) | RU2006115558A (enExample) |
| TW (1) | TW200528472A (enExample) |
| WO (1) | WO2005037860A2 (enExample) |
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-
2004
- 2004-10-08 KR KR1020067006901A patent/KR20060130027A/ko not_active Ceased
- 2004-10-08 NZ NZ546663A patent/NZ546663A/en not_active IP Right Cessation
- 2004-10-08 CN CN201010183514A patent/CN101857631A/zh active Pending
- 2004-10-08 AU AU2004282148A patent/AU2004282148A1/en not_active Abandoned
- 2004-10-08 EP EP04794554.8A patent/EP1692157B1/en not_active Expired - Lifetime
- 2004-10-08 MX MXPA06004006A patent/MXPA06004006A/es active IP Right Grant
- 2004-10-08 RU RU2006115558/04A patent/RU2006115558A/ru not_active Application Discontinuation
- 2004-10-08 CA CA002541634A patent/CA2541634A1/en not_active Abandoned
- 2004-10-08 JP JP2006534377A patent/JP2007532474A/ja active Pending
- 2004-10-08 KR KR1020117029638A patent/KR20120010278A/ko not_active Ceased
- 2004-10-08 EP EP10183579A patent/EP2361925A1/en not_active Withdrawn
- 2004-10-08 TW TW093130680A patent/TW200528472A/zh unknown
- 2004-10-08 WO PCT/US2004/033238 patent/WO2005037860A2/en not_active Ceased
- 2004-10-12 US US10/964,214 patent/US7208600B2/en not_active Expired - Fee Related
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2006
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2007
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2011
- 2011-08-18 JP JP2011179106A patent/JP2011246487A/ja active Pending
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| US20050137140A1 (en) | 2005-06-23 |
| NO20062101L (no) | 2006-07-05 |
| MXPA06004006A (es) | 2006-06-28 |
| WO2005037860A2 (en) | 2005-04-28 |
| US7208600B2 (en) | 2007-04-24 |
| JP2007532474A (ja) | 2007-11-15 |
| IL174863A0 (en) | 2008-02-09 |
| US20070161789A1 (en) | 2007-07-12 |
| CN101857631A (zh) | 2010-10-13 |
| KR20120010278A (ko) | 2012-02-02 |
| EP1692157B1 (en) | 2013-04-17 |
| CA2541634A1 (en) | 2005-04-28 |
| WO2005037860A3 (en) | 2005-11-10 |
| RU2006115558A (ru) | 2007-11-20 |
| EP2361925A1 (en) | 2011-08-31 |
| NZ546663A (en) | 2010-01-29 |
| AU2004282148A1 (en) | 2005-04-28 |
| KR20060130027A (ko) | 2006-12-18 |
| JP2011246487A (ja) | 2011-12-08 |
| US8039623B2 (en) | 2011-10-18 |
| EP1692157A2 (en) | 2006-08-23 |
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